Lectures and seminars Opponent seminar Maria Alcolea
Epithelial cell fate transitions; an oesophageal tale.
Welcome to a seminar with Dr Maria Alcolea, the Wellcome-MRC Cambridge Stem Cell Institute
Title: Epithelial cell fate transitions; an oesophageal tale.
Time: Thursday June 15th at 3.15 pm
Place: Ragnar Granit lecture hall, entrance floor in Biomedicum, Karolinska Institutet, Solna
Speaker: Dr Maria Alcolea
Host: Maria Genander (CMB)
Maria has made several highly innovative contributions to science in the area of epithelial tissue maintenance and tumor initiation. Maria is currently a Principal Investigator at the Wellcome-MRC Cambridge Stem Cell Institute and affiliate to the Oncology Department, University of Cambridge.
A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium.
McGinn J, Hallou A, Han S, Krizic K, Ulyanchenko S, Iglesias-Bartolome R, England FJ, Verstreken C, Chalut KJ, Jensen KB, Simons BD, Alcolea MP
Nat Cell Biol 2021 May;23(5):511-525
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Colom B, Alcolea MP, Piedrafita G, Hall MWJ, Wabik A, Dentro SC, Fowler JC, Herms A, King C, Ong SH, Sood RK, Gerstung M, Martincorena I, Hall BA, Jones PH
Nat Genet 2020 Jun;52(6):604-614
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.
Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH
Nat Cell Biol 2014 Jun;16(6):615-22
A single progenitor population switches behavior to maintain and repair esophageal epithelium.
Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH
Science 2012 Aug;337(6098):1091-3