Lectures and seminars Opponent seminar: Jan Kaslin

14-12-2023 2:00 pm - 3:00 pm Add to iCal
Campus Solna Room: D1012, Biomedicum, Solnavägen 9, Karolinska Institutet, Solna

Title: Regrow with the flow: force and flow regulate neural progenitor quiescence following spinal cord injury.

Welcome to opponent seminar with

Professor Jan Kaslin from Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia.

When: December 14 at 2pm

Where: In room D1012 in Biomedicum level 10, Solnavägen 9

Host: András Simon

Regrow with the flow: force and flow regulate neural progenitor quiescence following spinal cord injury

Regenerative vertebrates, such as zebrafish and salamanders, exhibit near complete recovery from traumatic spinal cord injuries. This process requires tissue remodelling and reactivation of quiescent neural progenitors to replace lost and defective tissues. Using zebrafish models of spinal cord injury and high speed live imaging and biosensors, we show that flow and tissue remodelling generate distinct biomechanical forces that orchestrate and drive the neural progenitor activation and local repair. We identify specifically located mechanically gated cation channels on the membrane and cilia of the neural progenitors and the downstream transcriptional programmes that trigger exit from quiescence. Furthermore, we show that biomechanical sensing also is an important mechanism in control of normal spinal cord development and growth.

Prof Jan Kaslin is a group leader at the Australian Regenerative Medicine Institute (ARMI) Monash University. He is head of the neural plasticity and repair lab. A/Prof Kaslin completed his PhD at Abo Akademi University in 2004 (Finland). He was awarded Novartis Excelon Prize as best thesis in Neuroscience 2005. For his postdoctoral training, he worked in the lab Prof. Director Michael Brand’s laboratory at the Max Planck Institute for Cell Biology and Genetics, Dresden, Germany and Center for regenerative therapies Dresden (Technical University of Dresden). During, his post-doc he pioneered studies on neural stem cells and CNS repair in fish models. He was awarded the and Erdi fellowship and established his lab at ARMI in 2012. The team uses fish models to reveal mechanisms that control neural stem cells and regeneration. The Kaslin lab aims to understand the damage and repair processes in the central nervous system (CNS) with the aim to unlock the endogenous repair potential. This research vision builds on a systematic cross-disciplinary approach involving purposely built disease models, multi-omics methods and in vivo imaging to decipher disease pathology and repair at genome, gene, cell and organ level.