Lectures and seminars OnkPat Friday Seminar: Rethinking DNA Replication as an Anticancer Target - From Super-Resolution Imaging to Drug Discovery

Host: Sean Rudd, Department of Oncology-Pathology.

Related publications

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics.
Sosenko Piscitello A, Nilsson AS, Hawgood M, Sayyid AH, Dionellis VS, Giglio G, Urién B, Bajgain P, Ntallis SG, Bartek J, Halazonetis TD, Lemmens B
Nat Commun 2025 Sep;16(1):8268

Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures.
Hawgood M, Urién B, Agostinho A, Thiagarajan P, Giglio G, Yang Y, Zhang X, Quijada G, Fonseca M, Bartek J, Blom H, Lemmens B
EMBO J 2025 Oct;():

Biography

Bennie Lemmens is an Assistant Professor at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet and Group Leader at SciLifeLab in Sweden. Trained as a geneticist, his research operates at the interface of chemical biology, genetics, and advanced imaging, with a central focus on DNA replication, genome stability, and cancer biology. His group has pioneered conditional protein degradation systems to dissect the mechanisms of targeted cancer therapies and introduced 3D-SPARK microscopy to quantitatively map DNA synthesis in time and space. His interdisciplinary research program, recognized with an international ASPIRE Award for Innovative Cancer Research, aims to uncover the molecular principles of DNA replication fidelity and cancer drug resistance.