Lectures and seminars OnkPat Extra Seminar: Julian Lum
Autophagy in Cancer Immunity
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“Autophagy in Cancer Immunity”
Julian Lum, PhD
Deeley Research Centre, BC Cancer, Victoria, BC, Canada
Host: Katja Pokrovskaja Tamm
One of the goals in Julian’s research is to develop new strategies to genetically enhance T cell metabolism as a means to overcome the suppressive metabolic environment in tumors. Julian’s team aims to understand how the metabolic ecosystem in tumors impact host antitumor immunity, and, specifically, autophagy-mediated control of immune responses in ovarian cancer. Dr. Lum’s laboratory is using unique human tissue resources at BC Cancer to interrogate and uncover the metabolomics features of tumor-infiltrating lymphocytes to identify pathways that could be genetically or pharmacologically modified to enhance T cell responses.
The second area is to understand how radiation therapy alters immune responses to cancer. Currently Dr. Lum is investigating new immunotherapy combinations with radiation (e.g. external bead, brachytherapy, radio-targeting ligands) including a Phase 1 trial of focal radiation and checkpoint blockade for ovarian cancer.
Kilgour MK, … Lum JJ. 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer. Sci Adv. 2021 Jan 20;7(4):eabe1174. PMID: 33523930 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer (nih.gov)
Carleton G, Lum JJ. Autophagy metabolically suppresses CD8+ T cell antitumor immunity. Autophagy. 2019 Jun 14:1-2. PubMed PMID: 31170865. https://doi.org/10.1080/15548627.2019.1628545
MacPherson S, Kilgour M, Lum JJ. DeVorkin L, … , Lum JJ. Autophagy Regulation of Metabolism Is Required for CD8(+) T Cell Anti-tumor Immunity. Cell Rep. 2019 Apr9;27(2):502-513.e5. PubMed PMID: 30970253. https://doi.org/10.1016/j.celrep.2019.03.037
Understanding lymphocyte metabolism for use in cancer immunotherapy. FEBS J. 2018 Jul;285(14):2567-2578. Epub 2018 Apr 17. Review. PubMed PMID: 29611301. https://doi.org/10.1111/febs.14454