Lectures and seminars MolMet webinar: Min Jiang | Westlake University
Welcome to the MolMet webinar with Min Jiang from the Westlake University. Title: "Generation of a Mouse Model with Mitochondrial Disease Caused by mtDNA Mutation and Investigation of Its Pathogenic Mechanisms".
Dr Min Jiang | Principal Investigator | Westlake University | China
Generation of a Mouse Model with Mitochondrial Disease Caused by mtDNA Mutation and Investigation of Its Pathogenic Mechanisms
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Mitochondria play a crucial role in cellular energy metabolism and provide the majority of ATP via the oxidative phosphorylation system (OXPHOS). This system requires a functional collaboration between the nuclear genome and the mitochondrial genome (mtDNA), and diseases affecting OXPHOS function can be caused by mutations in both genomes. Mutations in mtDNA have a prevalence of ~1/5000, but our understanding of the disease mechanisms are often still limited.
Dr. Min Jiang is a Principal Investigator at the Mitochondrial Biology Laboratory, Westlake University. Here, she will discuss the use of DddA-derived cytosine base editors (DdCBEs) to edit mammalian mtDNA, both in cells and mice. DdCBEs technology is a promising novel approach to edit mammalian mtDNA, opening new avenues to both understand and potentially treating mitochondrial diseases.