Conferences and symposiums MolMet webinar. Michal Minczuk Cambridge University, MRC MBU
Welcome to the MolMet seminar with Dr Michal Minczuk, from Cambridge University.
Title: "The potential of mitochondrial genome engineering"
Speaker
Michal Minczuk, MRC Mitochondrial Biology Unit at Cambridge University
Title
"The potential of mitochondrial genome engineering"
Location
Ragnar Granit Lecture Hall (A0325)
Time
09:00 - 10:00 am
Further reading
Mitochondria are subject to unique genetic control by both nuclear DNA and their own genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple copies. In humans, mutations in mtDNA can lead to devastating, heritable, multi-system diseases that display different tissue-specific presentation at any stage of life. Despite rapid advances in nuclear genome engineering, for years, mammalian mtDNA has remained resistant to genetic manipulation, hampering our ability to understand the mechanisms that underpin mitochondrial disease. I will present recent developments in the genetic modification of mammalian mtDNA and discuss the progress towards using genome editing technologies, such as programmable nucleases and base editors, in basic research and for the treatment of hereditary mitochondrial disease.
Papers
https://www.nature.com/articles/s41576-021-00432-x
https://www.nature.com/articles/s41467-022-28358-w
https://www.nature.com/articles/s41551-022-00968-1