Lectures and seminars MolMet Webinar: Karin Busch
Welcome to the MolMet webinar with Professor Karin Busch from the University of Münster, Germany.
Her research focuses on understanding the organisation of the oxidative phosphorylation system, implementing biophysical and biochemical tools.
Title: "Plasticity of Mitochondrial ATP Synthase in Health and Disease".
Speaker
Professor Karin Busch, Westfälische Wilhelms-Universität Münster, Germany
Title
"Plasticity of Mitochondrial ATP Synthase in Health and Disease"
Join the webinar
Zoom Meeting ID: 674 9165 3785
Further reading
Mitochondrial ATP synthase is the last enzyme of the oxidative phosphorylation system. Depending on physiological conditions, it is active in ATP synthesis (forward), or ATP hydrolysis (reverse) mode. In addition, the enzyme's spatio-temporal organization contributes to shape the cristae architecture. Several super-numerous subunits are in involved in regulating these features: subunits IF1 controls forward and reverse activity, subunits e, g, k (DAPIT) promote dimerisation and oligomerisation. The stoichiometry and activity of these regulatory subunits change with metabolic conditions, aging, and disease.
We will shed light on the significance of some of these subunits under different conditions and demonstrate their effect on ATP synthase activity, assembly and cristae shaping function. In particular, we will highlight the plasticity of the spatio-temporal organization of ATP synthase in situ and how this affected by the process of aging.