Lectures and seminars Micro-symposium: Advanced therapies for Future Medicines

We are entering a transformational period in biomedical research, where technologies to read and write biological information have finally reached the scale and complexity of the organs we study. Gene editing, synthetic biology, synthetic vectors, single-cell biology, computational protein and cell engineering, AI and machine learning are all converging to a new paradigm of biomedical research. We are learning how to program our proteins, cells and tissues. Programmable drugs based on synthetic DNA and RNA will soon become the dominant class of medicines. They are poised to democratize drug development, radically narrowing the gap between basic discovery and clinical trial.

However, to fully realize the potential of this new paradigm, we must invest in foundational capabilities: Vector development, formulation screening, pre-GMP and GMP manufacturing, GLP animal studies, intellectual property management, …

Several interconnected initiatives are underway at karolinska to adress these challenges, which will be presented at the micro-symposium.

Programme

14:00 – 14:15 Sten Linnarsson: “Future medicines”

14:15 – 14:30 Matti Sällberg: ”Karolinska initiatives in Future Medicines”

14:30 – 15:15 Margherita Zamboni: ”Decoding injury responsive enhancers in the CNS for cell state targeting”

15:15 – 16:00 Knut Steffensen:  “Karolinska ATMP-centrum: gen- och cellterapi från forskning till klinik”

16:00 – 16:45 Samir El Andaloussi: “Targeted delivery of gene editors and RNA therapeutics using engineered nanoparticles”

16:45 – 17:00 Final remarks