Lectures and seminars MBB Seminar: Tomas Mustelin
Welcome to a seminar with Prof. Tomas Mustelin, University of Washington. Title: "Lupus pathogenesis: crossing the LINE1?".
"Lupus pathogenesis: crossing the LINE1?"
Prof. Tomas Mustelin, University of Washington
Dr. Mustelin has been a professor since 1999 and has published over 230 papers. During a 10-year sabbatical in the biotech industry, he served as Vice President and directed research and discovery of novel therapeutics; his teams delivered 24 candidate therapeutics into clinical trials, many of which are efficacious in phase 2 and 3 clinical trials in patients with serious immune-mediated diseases and hematopoietic malignancies. His current research is focused on elucidating the molecular underpinnings of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV), primary Sjögren’s syndrome (pSS), and other autoimmune conditions. Another interest is the hypothesis that long interspersed nuclear elements (LINE1) drive type I interferon production in SLE and related diseases by triggering specific nucleic acid sensors. It will be verified that this pathway operates in SLE and pSS patients, and it will also be tested if inhibition of the LINE1 reverse transcriptase will stop IFN production and be therapeutically beneficial for patients.