Lectures and seminars MBB lectures
Welcome to MBB lectures with Prof. Veronique Miron, University of Toronto, Canada and Prof. Tanja Kulhmann, Institute of Neuropathology, Münster University, Germany.
Title
"Central nervous system white matter vulnerability with aging"
Speaker
Prof. Veronique Miron, University of Toronto, Canada
Title
"Mechanisms of disease progression in Multiple sclerosis"
Speaker
Prof. Tanja Kuhlmann, Institute of Neuropathology, Münster University, Germany
Host
Gonçalo Castelo- Branco, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
About the speakers
Prof. Tanja Kuhlmann studied medicine at the University of Göttingen, Germany where she received her medical degree in 1998. She specialized in neuropathology and worked as medical resident and research fellow in different neuropathological departments in Germany and as a post-doc at McGill, Canada in the research groups of Dr. Jack Antel and Dr. Alan Peterson. In 2008, she became senior consultant and associate professor for neuropathology at the University Hospital Münster, Germany. Her key research interests are mechanisms leading to axonal and oligodendroglial pathology in demyelinating diseases. In recent years she focused her research on iPSC technology and the derivation of human CNS cells from iPSC to study disease mechanisms. She has published several publications in well known international journals on the topic of MS pathology, especially on oligodendroglial loss and remyelination as well as studies using iPSC-derived oligodendrocytes and neurons to understand disease mechanisms in demyelinating and neurodegenerative diseases.
Selected publications
- Windener F, Grewing L, Thomas C, Dorion MF, Otteken M, Kular L, Jagodic M, Antel J, Albrecht S, Kuhlmann T. Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS. Acta Neuropathol. 2024 May 9;147(1):82. doi: 10.1007/s00401-024-02733-x. PMID: 38722375; PMCID: PMC11082024.
- Klotz L, Antel J, Kuhlmann T. Inflammation in multiple sclerosis: consequences for remyelination and disease progression. Nat Rev Neurol. 2023 May;19(5):305-320. doi: 10.1038/s41582-023-00801-6. Epub 2023 Apr 14. PMID: 37059811.
- Kessler W, Thomas C, Kuhlmann T. Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss. Acta Neuropathol. 2023 Dec;146(6):817-828. doi: 10.1007/s00401-023-02645-2. Epub 2023 Oct 28. PMID: 37897549; PMCID: PMC10628007.
- Kuhlmann T, Moccia M, Coetzee T, Cohen JA, Correale J, Graves J, Marrie RA, Montalban X, Yong VW, Thompson AJ, Reich DS; International Advisory Committee on Clinical Trials in Multiple Sclerosis. Multiple sclerosis progression: time for a new mechanism-driven framework. Lancet Neurol. 2023 Jan;22(1):78-88. doi: 10.1016/S1474-4422(22)00289-7. Epub 2022 Nov 18. PMID: 36410373; PMCID: PMC10463558.
- Chanoumidou K, Hernández-Rodríguez B, Windener F, Thomas C, Stehling M, Mozafari S, Albrecht S, Ottoboni L, Antel J, Kim KP, Velychko S, Cui QL, Xu YKT, Martino G, Winkler J, Schöler HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T. One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2. Stem Cell Reports. 2021 Apr 13;16(4):771-783. doi: 10.1016/j.stemcr.2021.03.001. Epub 2021 Mar 25. PMID: 33770499; PMCID: PMC8072064.
Prof Veronique Miron is the John David Eaton Chair of Multiple Sclerosis Research and Full Professor at the BARLO Multiple Sclerosis Centre and University of Toronto Department of Immunology, and Medical Research Council Senior Research Fellow at The United Kingdom Dementia Research Institute at The University of Edinburgh. Prof Miron completed her PhD at The Montreal Neurological Institute at McGill University, Canada, then her postdoc at the Centre for Regenerative Medicine in Edinburgh, UK. Through a Medical Research Council Career Development Award, she then established her lab at The University of Edinburgh, focusing on understanding the mechanisms that regulate myelin health across the lifespan and in neurological disorders such as multiple sclerosis and cerebral palsy, with a particular focus on the role of microglia. Her team has discovered new ways in which microglia adopt regenerative properties to drive remyelination, repair factors they secrete, and unexpected damaging and protective roles in regulating myelin health.
Selected publications
- Kent SA, Miron VE. Microglia regulation of central nervous system myelin health and regeneration. Nat Rev Immunol. 2024 Jan;24(1):49-63. doi: 10.1038/s41577-023-00907-4. Epub 2023 Jul 14. PMID: 37452201.
- Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, Lloyd AF, Forbes LH, Mahmood A, Skripuletz T, Gudi V, Febery JA, Johnson JA, Fowler JH, Kuhlmann T, Williams A, Chandran S, Stangel M, Howden AJM, Hardingham GE, Miron VE. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun. 2023 Jun 8;14(1):3372. doi: 10.1038/s41467-023-39046-8. PMID: 37291151; PMCID: PMC10250470.
- McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. Microglia regulate central nervous system myelin growth and integrity. Nature. 2023 Jan;613(7942):120-129. doi: 10.1038/s41586-022-05534-y. Epub 2022 Dec 14. PMID: 36517604; PMCID: PMC9812791.
- Lloyd A, Davies C, Holloway R, Labrak Y, Ireland G, Carradori D, Dillenburg A, Borger E, Soong D, Richardson J, Kuhlmann T, Williams A, Pollard J, des Rieux A, Priller J, Miron VE (2019). Central nervous system regeneration requires microglia death and repopulation. Nature Neuroscience doi: 10.1038/s41593-019-0418-z
- Rojo R, Raper A, Ozdemir DO, Lefevre L, Grabert K, Wollscheid-Lengeling E, BradfordB, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham G, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C (2019). Deletion of CSF1R enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications. doi:10.1038/s41467-019-11053-8