Lectures and seminars MBB invited talk: Prof. Anne-Sophie Korganow
Genetic and cellular approach in anti-phospholipid syndrome
Prof. Anne-Sophie Korganow will give a seminar entitled "Genetic and cellular approach in anti-phospholipid syndrome" at Karolinska Institute.
Prof. Korganow is the head of the Clinical Immunology Department in Strasbourg University Hospital. She is a distinguished clinician and researcher on autoimmune diseases, especially lupus and anti-phospholipid syndrome.
She described for the first time and discovered during her PhD thesis (under the supervision of C Benoist and D Mathis) the role of B cells and of specific autoantibodies in a new model of rheumatoid arthritis (the K/B NOD model, see Cell 1996 and Immunity 1999). She described the importance of co-signaling via TLRs and BCR in mice with B cells transgenic for a human rheumatoid factor, during Borrelia burgdorferi infection (JCI 2005). More recently and now on, she focuses on the analysis of B cells and autoreactive B cells in humans. She confirmed the non-fortuitous presence and the maturation of B cells in human thymus, and their role as antigen presenting cells for some tissue specific antigens (JACI 2016). She demonstrated the impairment of B cells from lupus patients, to respond to TLR9 signaling, as earlier as in the transitional stage (JCI Insights 2018, J Autoimmunity 2019, Frontiers in Immunology 2020). She explores the significance of autoimmunity in PIDs since 2011 (J Autoimmunity 2011, JACI 2017, JOCI 2017, 2019).
Join Zoom Meeting: https://ki-se.zoom.us/j/67555334753