Lectures and seminars Lecture: "Inducing a Schwann cell-like repair phenotype in oligodendrocytes enables axonal regrowth after injury"
Welcome to a lecture with Prof. Dr. Claire Jacob, Johannes Gutenberg University Mainz. Hosted by Gonçalo Castelo- Branco, Department of Medical Biochemistry and Biophysics, Karolinska Institutet.
Title
"Inducing a Schwann cell-like repair phenotype in oligodendrocytes enables axonal regrowth after injury"
Speaker
Prof. Dr. Claire Jacob, Johannes Gutenberg University Mainz, Faculty of Biology, Institute of Developmental Biology and Neurobiology
Claire Jacob is a Professor of Cellular Neurobiology at the Johannes Gutenberg University Mainz, Germany, since 2018. Prof. Jacob’s research group investigates how chromatin-remodeling enzymes control the maintenance and regeneration of the nervous system after an injury, focusing on the functions of myelinating cells, Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system, in these processes.
Selected Publications:
Schwann Cell Development and Myelination.
Salzer J, Feltri ML, Jacob C
Cold Spring Harb Perspect Biol 2024 Mar;():
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Duman M, Vaquié A, Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C
Nat Commun 2020 Jul;11(1):3420
Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration.
Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, Falquet L, Bartesaghi L, Chrast R, Lamy CM, Bang S, Lee SR, Jeon NL, Ruff S, Jacob C
Cell Rep 2019 Jun;27(11):3152-3166.e7
Modeling PNS and CNS Myelination Using Microfluidic Chambers.
Vaquié A, Sauvain A, Jacob C
Methods Mol Biol 2018 ;1791():157-168
Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.
Brügger V, Duman M, Bochud M, Münger E, Heller M, Ruff S, Jacob C
Nat Commun 2017 Jan;8():14272
Jacob C, Christen CN, Pereira J, Somandin C, Baggiolini A, Lötscher P, Özçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P & Suter U (2011). Schwann cell survival and myelination are critically dependent on HDAC1 and HDAC2 function. Nature Neuroscience 14: 429-436
Host
Gonçalo Castelo- Branco, Department of Medical Biochemistry and Biophysics, Karolinska Institutet