Lectures and seminars KI Infection Biology Network Seminar: ”Mechanisms and concepts in early antiviral host defense”

05-03-2024 2:00 pm Add to iCal
Karolinska University Hospital, Solna BioClinicum, Karolinska University Hospital Solna, Room J3:14 Kerstin Hagenfeldt

Welcome to a seminar with Professor Sören Riis Paludan PhD, DMSc, Aarhus University, Denmark; ”Mechanisms and concepts in early antiviral host defense”. Tuesday 5 March at 14.00-14.50, join us for coffee and mingle from 13.45!

Speaker

Professor Sören Riis Paludan PhD, DMSc, Aarhus University, Denmark

 Title

”Mechanisms and concepts in early antiviral host defense”

Also available through Zoom

Follow the link here

Contact

Kristina Broliden kristina.broliden@ki.se and Jens Karlsson jens.karlsson@ki.se


Biography of Professor Sören Riis Paludan

Professor Paludan has developed a research program that centers on understanding how the innate immune system senses virus infections, and how it contributes to host defense and disease development. A particular focus of the lab is on viral infections at epithelial surfaces and in the brain. He is currently professor in virology and immunology at Aarhus University, Denmark, Lundbeck Foundation professor and director of the Center for Immunology of Viral infections (CiViA), funded by the Danish National Research Foundation.  

Laboratory: https://biomed.au.dk/Paludan-lab/        CiViA: https://biomed.au.dk/civia

Selected publications

  1. Reyahi A, Studahl M, Skouboe MK,… Paludan SR. An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis. 2023. JCI Insight, 8;8(21):e173066.
  2. Ren F, Narita R, Rashidi AS,… Paludan SR. ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2. EMBO J. 2023. 30:e113118.
  3. Fruhwürth S, Reinert LS, Öberg C,… Paludan SR. TREM2 is downregulated by HSV1 in microglia and involved in antiviral defense in the brain. 2023. Science Advances. 9:eadf5808.
  4. Paludan SR, Mogensen TH. Innate immunological pathways in COVID-19 pathogenesis. Science Immunology. 2022;7:eabm5505.
  5. Reinert LS, Rashidi AS, Tran DN, et al… , Paludan SR. Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I interferon production. 2021. Journal of Clinical Investigation. 131:e136824.
  6. Paludan SR, Pradeu T, Master S, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulationNature Reviews Immunology. 2021. 21:137-150.
  7. Zhang BC, Nandakumar R, Reinert LS,… Paludan SR. STEEP mediates STING ER exit and activation of signaling. Nature Immunology. 2020. 21:868-879.
  8. Bodda C, Reinert LS, Fruhwürth S,… Paludan SR. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. The Journal of Experimental Medicine.  2020. 217:e20191422.
  9. Nandakumar R, Tschismarov R, Meissner F,… Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling. Nature Microbiology. 2019. 4:701-713.
  10. Paludan SR, Reinert LS, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature Reviews Immunology. 2019. 19:141-153.

 

Contact

Kristina Broliden Professor/Senior Physician