Lectures and seminars KBH Astrid Seminar "Understanding and Preventing Radiation Induced Late Complications to the Growing Skeleton"
Welcome to the KBH Astrid seminar series. On Wednesday 13 December. The seminar will be hold by Phillip Newton.
Phillip Newton, PhD, Department of Women's and Children's Health, Division of Pediatric Oncology and Surgery, Karolinska Institutet.
"Understanding and Preventing Radiation Induced Late Complications to the Growing Skeleton"
Radiotherapy is commonly used as a childhood cancer treatment but can impair future skeletal growth by directly damaging the organs responsible for bone elongation: narrow cartilage discs called growth plates. Growth plates house epiphyseal stem cells, which give rise to columns of cartilage cells (chondrocytes) that are required to fuel long-bone growth. Using clonal genetic tracing in mice to visualise the cellular recovery within growth plates after irradiation, we made two inter-connected observations: radiation dose-dependently (i) prevents a larger proportion of chondrocytes from further dividing and, (ii) causes remaining chondrocytes to generate significantly increased numbers of columns. Hence, we found that growth plate chondrocytes have the ability to functionally compensate for the lost column-forming cells. These findings improve our understanding of the healing process occurring in growth plates following irradiation, and may allow us to devise better treatment strategies for children undergoing radiotherapy.