Lectures and seminars Karolinska Institutet Infection Biology Network Seminar with Nina van Sorge, Netherlands Reference Laboratory for Bacterial Meningitis
"Get dressed for battle! The Staphylococcal Sugar Coat in Host-Pathogen Interaction"
Welcome to a new seminar in the Karolinska Institutet Infection Biology Network Seminar Series, on Thursday 3 October 2024 at 13:00, Solna.
Speaker/presenter
Nina van Sorge, Professor in Translational Microbiology and Head of the Netherlands Reference Laboratory for Bacterial Meningitis, NL
About
The van Sorge lab is committed to clarifying the molecular pathogenesis of bacterial infections across the entire disease process, ranging from pathogen acquisition to systemic disease.
Over the past decade, the lab has focused predominantly on the human pathogens Staphylococcus aureus and Group A Streptococcus (Strep A) as these represent bacterial species of great medical importance; both pathogens have priority status with the World Health Organization for development of new therapeutics and vaccines. In particular, we have studied the role of glycosylated bacterial surface structures and their interaction with innate C-type lectin receptors and (vaccine-induced) antibodies.
With this research, research in the van Sorge lab spans the entire spectrum from molecule to organism to patients to identify new (antibody-based) strategies to prevent and combat bacterial infections. Applied techniques include bacterial and host molecular genetics, protein chemistry, glycobiology, immunological models and in vitro and in vivo infection models.
Recent publications
Glycan-specific IgM is critical for human immunity to Staphylococcus aureus.
Hendriks A, Kerkman PF, Varkila MRJ, Haitsma Mulier JLG, Ali S, Ten Doesschate T, van der Vaart TW, de Haas CJC, Aerts PC, Cremer OL, Bonten MJM, Nizet V, Liu GY, Codée JDC, Rooijakkers SHM, van Strijp JAG, van Sorge NM
Cell Rep Med 2024 Sep;5(9):101734
Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasive Streptococcus pyogenes 2009-2023, the Netherlands: a molecular epidemiological study.
Rümke LW, Davies MA, Vestjens SMT, van der Putten BCL, Bril-Keijzers WCM, van Houten MA, Rots NY, Wijmenga-Monsuur AJ, van der Ende A, de Gier B, Vlaminckx BJM, van Sorge NM
J Clin Microbiol 2024 Aug;():e0076624