Lectures and seminars Faculty event: Marike Gabrielson
Speaker: Marike Gabrielson
Title: The biology of mammographic density, breast cancer risk and prevention – results from the KARMA cohort and KARISMA clinical trial
Mammographic breast density is one of the strongest risk factors for breast cancer, and women with high breast density have a 4-6 fold increased breast cancer risk as compared to women with low density. Dense breasts have more fibroglandular tissue and less fatty tissue. From an epidemiological perspective, many factors that influence risk of breast cancer are associated with density. However, the biological links between breast density and breast cancer risk remain largely unknown.
The anti-oestrogenic drug tamoxifen is used to prevent recurrence of breast cancer. It also decreases the density, and the amount of density decrease is a good proxy for tamoxifen therapy response. Although commonly used, very little is known about the protective mechanisms of tamoxifen in the breast. And it is not known how the fibroglandular tissue “disappears” in woman treated with tamoxifen.
In this talk, I will present the work on identifying biological determinants of mammographic density and risk using the KARMA breast cancer cohort. I will also present the first results from the biopsy-study within the KARISMA clinical trial for dose-determination of tamoxifen in healthy women. Finally, I will present some future projects I am planning as part of my two Cancerfonden grants that started 2022, where the overall aim is to investigate the biology of tamoxifen for primary prevention of breast cancer.
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