Lectures and seminars External MBB Seminar: Peter Tessarz "Metabolism, Epigenetics and Ageing: Connecting the dots"

Dr. Tessarz and his team use two different model systems to address the question of how histones modulate transcriptional processes and how chromatin changes with age. Using budding yeast as a model, they address mechanistic consequences of chromatin alterations on transcriptional processes and lifespan. Embryonic and adult stem cells serve as a model to investigate the interplay of environment, metabolism on epigenetics and ageing. To do this they employ a variety of different methodologies, including biochemistry, genetics and genomics.

Selected publications

NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution.
Mylonas C, Tessarz P
RNA Biol 2019 Sep;16(9):1156-1165

Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells.
Mylonas C, Tessarz P
Life Sci Alliance 2018 Jun;1(3):e201800085

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.
Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, et al
Nature 2014 Jan;505(7484):564-8

Histone core modifications regulating nucleosome structure and dynamics.
Tessarz P, Kouzarides T
Nat. Rev. Mol. Cell Biol. 2014 Nov;15(11):703-8