Lectures and seminars Drug Discovery Seminar: "Targeting the oncogenic TGFβ signaling pathway in cancer to inhibit invasion and metastasis"
Welcome to join this Drug Discovery Seminar with Maréne Landström from Umeå University. Hosted by the Drug Discovery and Development Platform.
Maréne Landström, Umeå University
Maréne Landström is a professor in Pathology at Department of Medical Biosciences, Umeå University, Sweden. She has made her postdoctoral training at the Ludwig Institute of Cancer Research, Uppsala Branch and have also been a group leader at Department of Immunology, Genetics and Pathology, Uppsala University before taking on her current position.
Targeting the oncogenic TGFβ signaling pathway in cancer to inhibit invasion and metastasis
Transforming growth factor beta (TGFb) is frequently overexpressed in several forms of cancer including prostate cancer and this has been shown to correlate with poor prognosis. TGFb is transducing its canonical and non-canonical signals via its transmembrane TGFb Type II and Type I receptors (TbRII/TbRI) which are serine-threonine kinases. We have found that the TbRI undergoes proteolytic cleavage in cancer cells in a manner dependent on the ubiquitin-ligase tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6). The intracellular domain of TbRI (TbRI-ICD) is released from the cell membrane, soluble and is transported to the nucleus in some specific forms of cancer to promote expression of genes causing invasion and metastatic growth. In collaboration with SciLifeLab DDD we have generated potential therapeutic antibodies to target this pathway which we are investigating the function of, in our established preclinical models for prostate cancer.
SciLifeLab Drug Discovery Seminars
SciLifeLab Drug Discovery Seminars, hosted by the DDD platform, is a series of educational lectures about recent developments, technologies, and trends in drug discovery and development that aims to enlighten, and spark a discussion, within the Swedish drug discovery community.