Lectures and seminars Discover the combinatorial power of genetics and epigenetics at single-base resolution from limited DNA

29-11-2023 1:00 pm - 2:00 pm Add to iCal
Campus Solna CMM Lecture Hall (Visionsgatan 18, ground floor), and zoom

Maja Jagodic's research group welcomes you to an interesting technology development seminar. The topic of the seminar is within the field of genetics and epigenetics, with speaker Dan Brudzewsky, PhD and Field Application Scientist, biomodal UK.

Dan Brudzewsky holds a PhD degree in Medical Genetics from the University of Copenhagen, and received postdoctoral training at the University of Helsinki, Imperial College London, and University of Coimbra. He has a broad experience in research areas such as oncology, immunology, immune-oncology, and ophthalmology.  During the past seven years, he has worked in biotech helping laboratories adapt novel technologies in genomics, such as biomodal’s duet multiomics solution. 

Title of speech: Discover the combinatorial power of genetics and epigenetics at single-base resolution from limited DNA  

 

Abstract

DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology in health and disease. The interaction of genetics with the epigenome plays a causal role in cell fate, ageing, and disease development.

We introduce duet multiomics solution, a single base-resolution sequencing methodology that sequences complete genetics and cytosine modifications in a single workflow, enabling the identification of genetic variants and quantification of modified cytosine levels in a single experiment, at high accuracy for both genetics and epigenetics. This method is compatible with low quantities of input material, enabling the measurement of genetics and methylation in cfDNA, increasing the information available to identify traces of disease using liquid biopsy. The phased nature of the technology, whereby genetic and epigenetic information is available simultaneously on the same DNA fragment, enables the study of genetic and epigenetic co-variation such as in allele-specific methylation (ASM), whereby differential methylation patterns are observed between heterozygous variants. This technology enables simultaneous multiomic information to be gathered unlike ever before and will help to understand the dynamism of biology throughout health and disease.

 

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