Lectures and seminars CMB Guest Seminar: Professor David M. Gilbert
Regulation of Replication Timing and Chromosome Architecture.
10:00 in Eva & Georg Klein.
Guest: Professor David M. Gilbert, San Diego Biomedical Research Institute, San Diego, CA, USA.
When: November 22nd, 10.00-11.00
Where: Eva & Georg Klein in Biomedicum
Title: “Regulation of Replication Timing and Chromosome Architecture”
Dr. Gilbert’s work focuses on the regulation of DNA replication and the re-modeling of chromosome structure and transcription during differentiation of human and mouse embryonic stem cells. He recently discovered Early Replication Control Elements (ERCEs) that co-regulate replication, transcription and chromatin architecture of replication domains and that the temporal order of replication is necessary to maintain the global epigenome.
Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.
Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM
Cell 2019 02;176(4):816-830.e18
Replication timing maintains the global epigenetic state in human cells.
Klein KN, Zhao PA, Lyu X, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga SI, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM
Science 2021 04;372(6540):371-378