Lectures and seminars CLINICUM Seminar: Are E-values too optimistic or too pessimistic? Both and neither!

14-12-2023 11:00 am - 12:00 pm Add to iCal
Karolinska University Hospital, Solna Sir Richard Doll salen på Eugeniahemmet

Welcome to a seminar about The E value, a popular tool to assess the sensitivity to unmeasured confounding; the higher the E value, the stronger the unmeasured confounding must be to 'explain away' an observed relationship. However, despite its popularity, the E value has also been highly debated and criticized.

Ioannidis et al (2019) argued that a high E value can give an unjustifiably optimistic impression, and Greenland (2020) argued that a small E value may give an unnecessarily pessimistic.This criticism may seem contradictory and leave the analyst wondering whether the E values should be interpreted as too optimistic or too pessimistic. In this presentation, we will try to reconcile these criticisms and use a real data example to argue that both interpretations are valid. The presentation will be largely non-technical and focus on basic conceptual issues.