Lectures and seminars CIM Seminar series - “Peptide-free MHC class I molecules at the cell surface”

21-06-2023 1:00 pm - 2:00 pm Add to iCal
Campus Flemingsberg https://ki-se.zoom.us/j/68087244683?pwd=SUNCQ3RMUFVWNFFydUpSMXIxZ2xSZz09&from=addon

Welcome to the seminar series organized by the Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge (MedH) with the title: “Peptide-free MHC class I molecules at the cell surface”


Professor Sebastian Springer, Constructor University, Bremen. 


“Peptide-free MHC class I molecules at the cell surface.”

Attend online or on site

On site in Månen 9Q, 9th floor, ANA Futura, KI Campus Flemingsberg.

Online via Zoom.

Meeting ID: 680 8724 4683
Passcode: 215907

About the speaker

The research of Professor Springer is focused on the areas of immunology, molecular cell biology, and biochemistry, specifically on the intracellular transport of membrane proteins of the immune system, and its regulation. A major focus in on the role of MHC cI and the factors that regulate its structure and cycling within cells. Further details can be found here.

Key references:

  1. Saikia, Ankur, et al. "Fast peptide exchange on major histocompatibility complex class I molecules by acidic stabilization of a peptide‐empty intermediate." Protein Science 31.12 (2022): e4478.
  2. Dirscherl, Cindy, et al. "Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers." Journal of Cell Science 135.9 (2022): jcs259489
  3. Jantz-Naeem, Nouria, and Sebastian Springer. "Venus flytrap or pas de trois? The dynamics of MHC class I molecules." Current Opinion in Immunology 70 (2021): 82-89.
  4. Saini, Sunil Kumar, et al. "Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells." Science immunology 4.37 (2019): eaau9039.
  5. Moritz, Andreas, et al. "High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A* 02: 01 molecules." Science Immunology 4.37 (2019): eaav0860.


If you have any questions, concerns, or feedback regarding the CIM seminar series, please contact any of the following CIM members: