Lectures and seminars Cell and Tumor Biology Seminar: "Harnessing epigenetic deregulation for precision medicine in glioblastoma" with Prof. Silvia Marino

Title

"Harnessing epigenetic deregulation for precision medicine in glioblastoma"

Speaker

Professor Silvia Marino, Queen Mary University of London

Prof. Marino’s research focus on glioblastoma (GBM) and medulloblastoma (MB), the most common malignant brain tumours in adults and children, respectively. Her lab uses stem cell models and organoids to understand tumor initiating events focusing on characterizing key deregulated epigenetic mechanisms driving their growth.

Recent publications:

Lineage specification in glioblastoma is regulated by METTL7B.

Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J, Lim YM, Brandner S, Nelander S, Badodi S, Marino S.Cell Rep. 2024 Jun 25;43(6):114309. doi: 10.1016/j.celrep.2024.114309. 

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape.

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L, Sheer D, Barnes M, Brandner S, Nelander S, Movahedi K, Marino S.Elife. 2022 Nov 22;11:e77335. doi: 10.7554/eLife.77335.PMID: 36412091

Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma. S Badodi, N Pomella, YM Lim, S Brandner, G Morrison, SM Pollard, X Zhang, NR Zabet, S Marino. Neuro Oncol. 2022 Feb 25:noac052. doi: 10.1093/neuonc/noac052. PMID: 35213723; PMCID: PMC9340634.

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma. C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, T El Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry, F Marelli-Berg, S Brandner, S Marino. Nat Commun. 2021 Oct 21;12(1):6130. doi: 10.1038/s41467-021-26297-6. PMID: 34675201; PMCID: PMC8531305.

Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. S Badodi, N Pomella, X Zhang, G Rosser, J Whittingham, MV Niklison-Chirou, YM Lim, S Brandner, G Morrison, SM Pollard, CD Bennett, SC Clifford, A Peet, MA Basson, S Marino. Nat Commun. 2021 Apr 12;12(1):2148. doi: 10.1038/s41467-021-22379-7. PMID: 33846320; PMCID: PMC8042111.

Host

Margareta Wilhelm, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet