Lectures and seminars CBB biostatistics seminar with Liesbeth De Wreede
Centre for bioinformatics and biostatistics presents a biostatistics seminar. The seminar is held in English.
Title
Dynamics of excess mortality during the Covid-19 pandemic in the Netherlands – impact of vaccination and infection analysed through a multi-state model incorporating relative survival
Abstract
The Covid-19 pandemic has led to excess mortality, with reported excess deaths higher than those directly attributed to Covid-19. Evaluating pandemic-related mortality should not rely solely on cause-of-death data. We studied the impact of infection with and vaccination against Covid-19 on excess mortality in persons aged 65 or older in the Netherlands during 2020-2021 by incorporating relative survival modelling into an extensive multi-state model that accounts for vaccination, infection, and death. We applied this model to nationwide data from Statistics Netherlands (CBS).
This seminar will show the utility of relative survival methods beyond the traditional context of modeling cancer patient excess mortality, offering perspectives on their broader application to understanding complex mortality patterns.
About the speaker
Liesbeth de Wreede is an assistant professor in medical statistics at Leiden University Medical Center (the Netherlands). She has extensive experience in survival analysis, both in methods development and in clinical collaborations, mainly in the field of (hemato-)oncology.