BEGIN:VCALENDAR VERSION:2.0 PRODID:-//ki.se//NONSGML Event Calendar//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT DTSTART:20260421T130000Z DTEND:20260421T140000Z DTSTAMP:20260420T194411Z UID:239474 DESCRIPTION:KI Pain Network (KIPN) are pleased to invite you to the next KIPN seminar on 21 April 21 2026\, in room Ragnar Granit\, Biomedicum entrance floor.\r\n\r\nSpeakers\nGiancarlo de la Torre Canales\n Postdoctoral Researcher\n Phone: +46852488057\n Email: giancarlo.de.la.torre.canales@ki.se\n Department: Department of Dental Medicine\r\n\r\nMatthew Hunt\n Postdoctoral Researcher\n Email: matthew.hunt.2@ki.se\n Department: Department of Medicine\, Solna\r\n\r\nRefreshments will be served. We look forward to seeing many of you there!\r\n\r\nHost/Contact\nAndrea Carmine Belin\n Principal Researcher\n Phone: +46852487051\n Email: andrea.carmine.belin@ki.se\n Department: Department of Neuroscience\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/ki-pain-network-seminar CREATED:20260414T061200Z LAST-MODIFIED:20260420T114913Z STATUS:CONFIRMED SUMMARY:KI Pain Network Seminar END:VEVENT BEGIN:VEVENT DTSTART:20260422T120000Z DTEND:20260422T130000Z DTSTAMP:20260420T194411Z UID:238771 DESCRIPTION:Join the StratNeuro Seminar with Professor Qionghai Dai as he presents breakthroughs in mesoscale intravital fluorescence microscopy\, revealing large-scale cellular dynamics in living mammalian systems.\r\n\r\nMesoscale Intravital Fluorescence Microscopy\nQionghai Dai\n Affiliation: Qionghai Dai is a Professor at Tsinghua University\, the Academician of the Chinese Academy of Engineering\, Dean of the School of Information Science and Technology\, and the director of the Institute of Brain and Cognitive Sciences at Tsinghua University. He is also the chairman of Chinese Association for Artificial Intelligence. \;Biography: Qionghai’s research centers on the interdisciplinary study of optics\, informatics\, neuroscience\, and cognitive sciences\, with hundreds of journal papers published in Cell\, Nature\, Science\, etc. Specifically\, he has pioneered the development of mesoscale imaging systems and data analysis methods\, facilitating simultaneous multiscale intravital observation of biological dynamics spanning organelles\, cells\, tissues\, and organs across different pathological or physiological states at the system level. He is now working on system neuroscience\, artificial intelligence\, computational imaging\, large-scale data analysis methods\, and neuromorphic optoelectronic devices.\r\n\r\nBiology is a typical discipline covering multiple scales. While cryo-EM and super-resolution imaging enables intracellular imaging of proteins and organelles in microscale\, CT and MRI facilitates organ-level imaging in macroscale at tissue resolution. There has long been a missing gap of imaging instruments in mesoscale to observe the large-scale interactions of cells in the native mammalian environment during diverse pathological and physiological states. In this talk\, I will introduce our recent developed techniques such as scanning light field microscopy (Wu et al. 2021 Cell)\, digital adaptive optics (Wu et al. 2022 Nature)\, two-photon synthetic aperture microscopy (Zhao et al. 2023 Cell)\, confocal scanning light-field imaging (Lu et al. 2025 Nature Biotechnology) to overcome the barriers of intravital imaging\, with orders of magnitude improvement in spatiotemporal resolution\, imaging data throughput\, and orders of magnitude reduction in phototoxicity for long-term observations (Zhang et al. 2024 Cell). We believe the rapid development of mesoscale imaging opens up a new horizon for the study of large-scale intercellular interactions in mammals\, facilitating diverse applications in neuroscience\, immunology\, oncology\, and medicine. While we have exploited some preliminary applications\, we believe there is a great treasure awaits discovery.\r\n\r\nSelected Publications&\;nbsp\;1. Jiamin Wu*\, Zhi Lu*\, Dong Jiang*\, Yuduo Guo\, Hui Qiao\, Yi Zhang\, Tianyi Zhu\, Yeyi Cai\, Xu Zhang\, Karl Zhanghao\, Hao Xie\, Tao Yan\, Guoxun Zhang\, Xiaoxu Li\, Zheng Jiang\, Xing Lin\, Lu Fang\, Bing Zhou\, Peng Xi\, Jingtao Fan\, Qionghai Dai. "\;Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale"\;\, Cell (2021).2. Jiamin Wu*\, Yuduo Guo*\, Chao Deng*\, Anke Zhang\, Hui Qiao\, Zhi Lu\, Jiachen Xie\, Lu Fang\, Qionghai Dai. &\;nbsp\;"\;An integrated imaging sensor for aberration-corrected 3D photography"\;\, Nature (2022).3. Zhifeng Zhao*\, Yiliang Zhou*\, Bo Liu*\, Jing He*\, Jiayin Zhao\, Yeyi Cai\, Jingtao Fan\, Xinyang Li\, Zilin Wang\, Zhi Lu\, Jiamin Wu\, Hai Qi\, Qionghai Dai. "\;Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue"\;\, Cell (2023)4. Yuanlong Zhang*\, Mingrui Wang*\, Qiyu Zhu*\, Yuduo Guo\, Bo Liu\, Jiamin Li\, Xiao Yao\, Chui Kong\, Yi Zhang\, Yuchao Huang\, Hai Qi\, Jiamin Wu‡\, Zengcai V. Guo‡\, Qionghai Dai‡. “Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ”\, Cell (2024).5. Yuanlong Zhang*\, Lekang Yuan*\, Qiyu Zhu*\, Jiamin Wu\, Tobias Nöbauer\, Rujin Zhang\, Guihua Xiao\, Mingrui Wang\, Hao Xie\, Zengcai Guo\, Qionghai Dai‡\, Alipasha Vaziri‡. “A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice”\, Nature Biomedical Engineering (2024).6. Zhi Lu*\, Siqing Zuo*\, Minghui Shi*\, Jiaqi Fan\, Jingyu Xie\, Guihua Xiao\, Li Yu\, Jiamin Wu\, Qionghai Dai. "\;Long-term intravital subcellular imaging with confocal scanning light-field microscopy"\;\, Nature Biotechnology (2025).7. Jiaqi Fan*\, Yuling Wang*\, Lingbo Li*\, Jing He\, Zhifeng Zhao\, Fei Deng\, Guochuan Li\, Xinyang Li\, &\;nbsp\;Yiliang Zhou\, Jiayin Zhao\, Ning Huang\, Yixin Hu\, Yulong Li\, Jiamin Wu\, Lu Fang\, Qionghai Dai. "\;Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain"\;\, Nature Communications (2025).&\;nbsp\;\r\n\r\nHost\nPer Uhlén\n Professor\n Email: per.uhlen@ki.se\n Department: Department of Medical Biochemistry and Biophysics\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/stratneuro-seminar-with-professor-qionghai-dai CREATED:20260317T143914Z LAST-MODIFIED:20260317T151233Z STATUS:CONFIRMED SUMMARY:StratNeuro Seminar with Professor Qionghai Dai END:VEVENT BEGIN:VEVENT DTSTART:20260423T090000Z DTEND:20260423T100000Z DTSTAMP:20260420T194411Z UID:239529 DESCRIPTION:Title: From cell to systems: Navigating the Complex Landscape of Autism Spectrum Disorders. April 23 at 11:00 in room Ragnar Granit\, Biomedicum. \r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Gaia Novarino\, Institute of Science and Technology Austria (ISTA)\, Klosterneuburg\, AustriaTime:&\;nbsp\;23 April\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: From cell to systems: Navigating the Complex Landscape of Autism Spectrum DisordersAbstractAutism spectrum disorders (ASD) are a heterogeneous group of disorders rooted in genetic bases. Although genetic studies have identified many ASD-risk genes over the past few years\, it remains essentially unknown whether mutations in different genes result in similar molecular and cellular states within the brain. Over the past years\, we have generated a large cohort of ASD mouse models carrying mutations in top\, high-risk ASD genes. The cohort includes 11 mouse lines and span chromatin remodelers\, ubiquitin-related genes\, metabolically relevant genes\, and synaptic proteins. Employing these validated mouse models\, we performed simultaneous single nucleus RNA and ATAC sequencing across brain regions\, developmental stages\, and sexes\, totaling over 300 samples. We achieved this by pioneering an approach that allowed us to sequence RNA and DNA from the same nucleus on a large scale. With this unique dataset\, we could address precise questions regarding convergence and divergences across different ASD models\, time windows affected\, and sex differences.Lab website: https://novarinolab.wordpress.com/Recent publicationsImaging brain tissue architecture across millimeter to nanometer scales.Michalska JM\, Lyudchik J\, Velicky P\, Štefaničková H\, Watson JF\, Cenameri A\, Sommer C\, Amberg N\, Venturino A\, Roessler K\, Czech T\, Höftberger R\, Siegert S\, Novarino G\, Jonas P\, Danzl JGNat Biotechnol 2024 Jul\;42(7):1051-1064Dense 4D nanoscale reconstruction of living brain tissue.Velicky P\, Miguel E\, Michalska JM\, Lyudchik J\, Wei D\, Lin Z\, Watson JF\, Troidl J\, Beyer J\, Ben-Simon Y\, Sommer C\, Jahr W\, Cenameri A\, Broichhagen J\, Grant SGN\, Jonas P\, Novarino G\, Pfister H\, Bickel B\, Danzl JGNat Methods 2023 Aug\;20(8):1256-1265Effects of urban living environments on mental health in adults.Xu J\, Liu N\, Polemiti E\, Garcia-Mondragon L\, Tang J\, Liu X\, Lett T\, Yu L\, Nöthen MM\, Feng J\, Yu C\, Marquand A\, Schumann G\,&\;nbsp\;Nat Med 2023 Jun\;29(6):1456-1467Large neutral amino acid levels tune perinatal neuronal excitability and survival.Knaus LS\, Basilico B\, Malzl D\, Gerykova Bujalkova M\, Smogavec M\, Schwarz LA\, Gorkiewicz S\, Amberg N\, Pauler FM\, Knittl-Frank C\, Tassinari M\, Maulide N\, Rülicke T\, Menche J\, Hippenmeyer S\, Novarino GCell 2023 Apr\;186(9):1950-1967.e25RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-gaia-novarino CREATED:20260415T131932Z LAST-MODIFIED:20260420T102050Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Gaia Novarino END:VEVENT BEGIN:VEVENT DTSTART:20260429T140000Z DTEND:20260429T150000Z DTSTAMP:20260420T194411Z UID:239073 DESCRIPTION:This is part of the “Hot-topics in multimodal imaging” seminar series hosted by the Division of Imaging Core Facilities at the department of Clinical Neuroscience.\r\n\r\nTitle: Amyloid PET in the era of immunotherapy of Alzheimer'\;s diseaseSpeaker: Silvia Daniela Morbelli Professor of Nuclear Medicine at the University of Turin and Director of the Nuclear Medicine Unit at Città della Salute e della Scienza in Turin\, Italy. She also serves as Chair of the Education Council of the European Association of Nuclear Medicine (EANM).Professor Morbelli has extensive clinical and academic expertise in neuroimaging\, with a strong focus on neurodegenerative disorders\, particularly Alzheimer’s disease. Her research centers on imaging biomarkers for early diagnosis and prognosis\, as well as theranostic approaches.The seminar will be hosted by Andrea Varrone\, Imaging Core Facility\, Department of Clinical Neuroscience.\r\n\r\nJoin the seminar via Zoom\nhttps://ki-se.zoom.us/j/67408275223?pwd=SUpySGxWMFhabkNHK2JETmJDQSs3dz09\r\n\r\nHot-topics in multimodal imaging"\; is a seminar series hosted by the Division of Imaging Core Facilities with a focus on multimodal imaging\, which will cover the latest research in the fields Neurology\, Psychiatry and Cognitive Neuroscience and will give our audience an overview of the state-of-the-art instruments\, computational and AI assisted data analysis being applied in the field by top international researchers.See our seminar calendar here and join us on Zoom. Welcome!\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/amyloid-pet-in-the-era-of-immunotherapy-of-alzheimers-disease CREATED:20260325T140854Z LAST-MODIFIED:20260325T141035Z STATUS:CONFIRMED SUMMARY:Amyloid PET in the era of immunotherapy of Alzheimer's disease END:VEVENT BEGIN:VEVENT DTSTART:20260507T090000Z DTEND:20260507T100000Z DTSTAMP:20260420T194411Z UID:239539 DESCRIPTION:Title: From proteins to circuits: defining pyramidal neuron input architecture and remodeling in disease. May 7 at 11:00 in room Ragnar Granit\, Biomedicum. \r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Joris De Wit\, VIB-KU Leuven Center for Brain &\;amp\; Disease Research\, Leuven\, Belgium.Time:&\;nbsp\;7 May\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: From proteins to circuits: defining pyramidal neuron input architecture and remodeling in diseaseAbstractNeural circuits are composed of different types of neurons and the specific patterns of synaptic connectivity between them. The highly heterogeneous nature of neuronal cell types and their connections present a major challenge to the characterization of neural circuits at the molecular level. Progress in addressing this challenge has come from transcriptomic profiling techniques\, which enabled the characterization of the molecular composition of specific cell types within circuits. While single-cell transcriptomics have been instrumental in mapping cell-type diversity in the brain\, these approaches are poorly suited to capture the diversity and molecular identity of synapses. In this talk\, I will present our recent efforts to map synapse composition and diversity in neural circuits\, using fluorescent sorting of synaptosomes and synaptic proximity biotinylation approaches coupled with mass spectrometry. We analyze the postsynaptic proteome of CA1 hippocampal pyramidal neurons and characterize the specific molecular composition of their proximal and distal inputs. As CA1 pyramidal neurons are especially vulnerable in Alzheimer’s disease (AD)\, we use these approaches to map their postsynaptic protein composition in AppNL-G-F mice and detect early and progressive synaptic changes in AD. These proteomics approaches enable the dissection of synapse composition in intact neural circuits in health and disease\, and should be broadly applicable to other brain regions and neuron types.Recent publicationsSynaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons.Marcassa G\, Dascenco D\, Lorente-Echeverría B\, Daaboul D\, Vandensteen J\, Leysen E\, Baltussen L\, Howden AJM\, de Wit JNat Commun 2025 Jan\;16(1):228A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation.Verpoort B\, Amado L\, Vandensteen J\, Leysen E\, Dascenco D\, Vandenbempt J\, Lemmens I\, Wauman J\, Vennekens K\, Escamilla-Ayala A\, Freitas ACN\, Voets T\, Munck S\, Tavernier J\, Wierda K\, de Wit JDev Cell 2025 Sep\;60(18):2470-2486.e10A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.Lorente-Echeverría B\, Daaboul D\, Vandensteen J\, Marcassa G\, Naert W\, Vandenbempt J\, Leysen E\, Reverendo M\, Vlaeminck I\, Vervloessem L\, Lamote J\, Poovathingal S\, Davie K\, Wierda K\, Dascenco D\, Aerts S\, de Wit JSci Adv 2025 Oct\;11(43):eadx5140Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer'\;s disease.Calafate S\, Özturan G\, Thrupp N\, Vanderlinden J\, Santa-Marinha L\, Morais-Ribeiro R\, Ruggiero A\, Bozic I\, Rusterholz T\, Lorente-Echeverría B\, Dias M\, Chen WT\, Fiers M\, Lu A\, Vlaeminck I\, Creemers E\, Craessaerts K\, Vandenbempt J\, van Boekholdt L\, Poovathingal S\, Davie K\, Thal DR\, Wierda K\, Oliveira TG\, Slutsky I\, Adamantidis A\, De Strooper B\, de Wit JNat Neurosci 2023 Jun\;26(6):1021-1031LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.Libé-Philippot B\, Lejeune A\, Wierda K\, Louros N\, Erkol E\, Vlaeminck I\, Beckers S\, Gaspariunaite V\, Bilheu A\, Konstantoulea K\, Nyitrai H\, De Vleeschouwer M\, Vennekens KM\, Vidal N\, Bird TW\, Soto DC\, Jaspers T\, Dewilde M\, Dennis MY\, Rousseau F\, Comoletti D\, Schymkowitz J\, Theys T\, de Wit J\, Vanderhaeghen PCell 2023 Dec\;186(26):5766-5783.e25RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-joris-de-wit CREATED:20260416T062001Z LAST-MODIFIED:20260420T101937Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Joris de Wit END:VEVENT BEGIN:VEVENT DTSTART:20260507T110000Z DTEND:20260507T143000Z DTSTAMP:20260420T194411Z UID:234139 DESCRIPTION:Join us for this interdisciplinary seminar and register to explore the future of neurotechnology with leading experts from across Europe!\r\n\r\nNeurotechnology is rapidly changing how we understand\, measure\, and interact with the brain. This seminar brings together researchers from NeurotechEU working on some of the most exciting developments in the field—from brain–machine interfaces and rehabilitation robotics to wearable sleep technologies\, artificial neurons\, and soft robots for medical use. The talks highlight how combining neuroscience\, engineering\, and AI is opening new possibilities to restore function\, improve diagnosis\, and build smarter\, more human-centered healthcare technologies.&\;nbsp\;Programme:13:00 – 13:30 -&\;nbsp\;Neurorehabilitation Based on Brain–Machine Interfaces and Exoskeletons&\;nbsp\;José M. Azorín (Miguel Hernández University of Elche\, Spain)\r\n\r\nAbstract:Brain–machine interfaces (BMIs) allow direct communication between the brain and external devices such as robotic exoskeletons. In rehabilitation\, patients can use mental strategies like motor imagery—imagining a movement without performing it—to control these devices. This process can help stimulate the brain and support recovery of motor function. This talk will present BMI systems developed at the Universidad Miguel Hernández de Elche for controlling lower-limb exoskeletons and discuss their potential in neurorehabilitation.Bio:José M. Azorín is a Full Professor at Miguel Hernández University of Elche (Spain) and the Director of the Brain–Machine Interface Systems Lab. He leads the European affiliate of the NSF-funded BRAIN Center. His research focuses on brain–machine interfaces\, neurorobotics\, and rehabilitation robotics. He has led more than 30 research projects\, published over 300 papers\, and holds several patents. He is a Distinguished Lecturer of the IEEE Systems Council and President of AITADIS.&\;nbsp\;13:30 – 14:00 - Unravelling the Importance of Novel Data for the Future of Sleep MeasurementsAnna Sigríður Íslind (Reykjavík University\, Iceland)&\;nbsp\;\r\n\r\nAbstract:Sleep is still mainly measured using polysomnography\, which is complex and difficult to scale. This talk explores how new data sources—such as wearables\, mobile apps\, and patient-reported data—can improve how we study sleep. Based on the EU-funded Sleep Revolution project\, the talk presents results from large clinical studies across Europe that combine different types of data over several months. These approaches can lead to more realistic and personalized sleep assessment.&\;nbsp\;Bio:Anna Sigríður Íslind is the Professor of Computer Science at Reykjavík University and Director of the Center for Information Systems and Data Science Research. Her work focuses on digital health and AI in healthcare. She has published over 120 papers and was co-PI of the €15M Horizon 2020 Sleep Revolution project\, where she led the digitalisation efforts.&\;nbsp\;----- Coffee Break -----&\;nbsp\;14:30 – 15:00 -&\;nbsp\;Rewiring the Brain: How to Make Living Neurons Team Up with Hardware-Based Artificial NeuronsChristel Vanbesien (University of Lille\, France)\r\n\r\nAbstract:This talk looks at how to connect living neurons with artificial ones in closed-loop systems. Such systems are key for future neuroprostheses that can both read from and stimulate the nervous system. The presentation will highlight a highly energy-efficient artificial neuron developed in Lille using CMOS technology\, and discuss how these systems could help restore or enhance brain function.&\;nbsp\;Bio:Christel Vanbesien is a researcher at the University of Lille working at the interface of neuroscience and microelectronics. Her research focuses on artificial neurons and hybrid systems that connect biological and electronic components for neuroprosthetic applications.&\;nbsp\;15:00 – 15:30 -&\;nbsp\;Gentle Precision: Robotizing Neurotech&\;nbsp\;Jérémie Dequidt (University of Lille / Inria\, France)\r\n\r\nAbstract:Working with the brain requires tools that are both precise and gentle. This talk shows how soft and flexible robots can improve neurotechnologies\, making procedures safer and more effective. It will cover key challenges in handling delicate neural structures and present new solutions based on soft robotics and real-time simulation.&\;nbsp\;Bio:Jérémie Dequidt is a Full Professor at the University of Lille and a researcher at Inria (DEFROST team). His work focuses on soft robotics\, simulation\, and medical applications. He co-developed the SOFA simulation framework and works on robotic systems for minimally invasive procedures and medical training.&\;nbsp\;\r\n\r\n----- Coffee Break -----16:00 - 16:30 Session with studentsRegistrationTo attend in person\, register here.To attend online\, register here.\r\n\r\nHost\nJoana Braga Pereira\n Principal Researcher\n Email: joana.pereira@ki.se\n Department: Department of Clinical Neuroscience\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/stratneuro-neurotecheu-seminar-advances-in-neurotechnology-bridging-brain-data-and-machines CREATED:20260410T074504Z LAST-MODIFIED:20260420T115410Z STATUS:CONFIRMED SUMMARY:StratNeuro-NeurotechEU Seminar: "Advances in Neurotechnology: Bridging Brain, Data, and Machines" END:VEVENT BEGIN:VEVENT DTSTART:20260513T113000Z DTEND:20260513T153500Z DTSTAMP:20260420T194411Z UID:239147 DESCRIPTION:Welcome to the Taiwan Sweden Mini-Symposium\, bringing together researchers from Academia Sinica\, National Yang Ming Chiao Tung University\, and Karolinska Institutet. This afternoon will feature a series of talks on neural circuits and brain function\, highlighting current advances across both research communities.\r\n\r\nProgrammeFirst session13:30-13:45: Introduction.13:45-14:15: “Integration of progenitor cells from the adult brain into mature neural circuits”- Hwai-Jong Cheng (Academia Sinica)14:15-14:45: "\;Deconstruction of brainstem circuits controlling movement"\; - Li-Ju Hsu (KI)14:45-15:15: "\;Protein N-glycosylation regulates dendrite self -avoidance and pruning” - Cheng-Ting Chien (Academia Sinica)15:15-15:45: “Modular brain-body circuits regulating body weight and tissue homeostasis” - Alessandro Furlan (KI)15:45-16:00: coffee breakSecond session16:00-16:30: “Patterning the cerebral cortex by transcription factor gradients” - Shen-Ju Chou (Academia Sinica)16:30-17:00: “Cortico-basal ganglia circuits for sensorimotor functions” - Gilad Silberberg (KI)17:00-17:30: “Predicting Threat in Time: A New Role for the Hippocampus” - Cheng-Chang Lien (National Yang Ming Chiao Tung University)17:30-17:35: final words Shun-Fen Tzeng (NSTC)Organized at KI by:Li-Ju Hsu and Gilad Silberberg&\;nbsp\;&\;nbsp\;\r\n\r\nDocuments\n\nAbstracts from speakers based in Taiwan (PDF\, 211.79 KB)\n/media/157320/download\r\n\r\nThe Taiwan Sweden mini symposium is organised with the support of The Strategic Research Area Neuroscience (StratNeuro).\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/taiwan-sweden-mini-symposium CREATED:20260327T160117Z LAST-MODIFIED:20260327T161240Z STATUS:CONFIRMED SUMMARY:Taiwan Sweden mini-symposium END:VEVENT BEGIN:VEVENT DTSTART:20260521T090000Z DTEND:20260521T100000Z DTSTAMP:20260420T194411Z UID:239557 DESCRIPTION:Title: Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory Circuits. May 21 at 11:00 in room Ragnar Granit\, Biomedicum.\r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Csaba Földy\,&\;nbsp\;Brain Research Institute\, Zürich\, Switzerland.Time:&\;nbsp\;21 May\, 11:00–12:00Location:&\;nbsp\;Peter Reichard Lecture Hall\, Biomedicum (level 3)Title: Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory CircuitsAbstractContrary to traditional belief\, axon growth and circuit formation do not only occur in the developing brain\, but also in the adult brain. However\, the underlying mechanisms remain elusive. Understanding these mechanisms could provide insight into fundamental questions\, such as how brain circuits are maintained throughout life and how brain rewiring might be used for therapeutic and repair purposes. Recent work from our laboratory has identified two bHLH transcription regulators\, Id2 and Ascl4\, that can reactivate axonal wiring in mature neurons of the naive adult brain. In this talk\, I will discuss the underlying molecular programs and implications of this new wiring in the context of the hippocampus. These results suggest the existence of a transcriptomic program for adult brain wiring that may be applicable to different neuron types. They also demonstrate that adult brain rewiring can enhance cognitive functions\, such as learning and memory\, via the rewired hippocampal projection system.Recent publicationsMolecular Signatures of Id2- and Ascl4-Induced Wiring of Adult Hippocampal Neurons.Seng C\, Tamás B\, Kaur R\, Luo W\, Földy CJ Neurosci 2026 Feb\;46(7):Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.Luo W\, Egger M\, Cruz-Ochoa N\, Tse A\, Maloveczky G\, Tamás B\, Lukacsovich D\, Seng C\, Amrein I\, Lukacsovich T\, Wolfer D\, Földy CPNAS Nexus 2024 May\;3(5):pgae174Commissural dentate granule cell projections and their rapid formation in the adult brain.Egger M\, Luo W\, Cruz-Ochoa N\, Lukacsovich D\, Varga C\, Que L\, Maloveczky G\, Winterer J\, Kaur R\, Lukacsovich T\, Földy CPNAS Nexus 2023 Apr\;2(4):pgad088Pcdh11x controls target specification of mossy fiber sprouting.Luo W\, Cruz-Ochoa NA\, Seng C\, Egger M\, Lukacsovich D\, Lukacsovich T\, Földy CFront Neurosci 2022 \;16():888362Circuit formation in the adult brain.Seng C\, Luo W\, Földy CEur J Neurosci 2022 Aug\;56(3):4187-4213Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator\, Id2.Luo W\, Egger M\, Domonkos A\, Que L\, Lukacsovich D\, Cruz-Ochoa NA\, Szőcs S\, Seng C\, Arszovszki A\, Sipos E\, Amrein I\, Winterer J\, Lukacsovich T\, Szabadics J\, Wolfer DP\, Varga C\, Földy CProc Natl Acad Sci U S A 2021 Oct\;118(40):RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-csaba-foldy CREATED:20260416T113616Z LAST-MODIFIED:20260420T102438Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Csaba Földy END:VEVENT BEGIN:VEVENT DTSTART:20260521T090000Z DTEND:20260521T100000Z DTSTAMP:20260420T194411Z UID:239596 DESCRIPTION:Title: Early adversity promotes adolescent threat avoidance behaviors by enhancing prefrontal–amygdala communication through CRH⁺ glutamatergic neurons. May 21 at 11:00 in room Ragnar Granit\, Biomedicum.\r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Laura DeNardo\, University of California\, Los Angeles\, USATime:&\;nbsp\;16 June\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: Early adversity promotes adolescent threat avoidance behaviors by enhancing prefrontal–amygdala communication through CRH⁺&\;nbsp\;glutamatergic neuronsAbstractEarly life adversity (ELA)&\;nbsp\;has enduring impacts on emotion circuit function. Following early maltreatment\, neglect\, or&\;nbsp\;instability in the home\, individuals often exhibit&\;nbsp\;lifelong impairments in their evaluation and response to threats-hallmarks of mood and anxiety disorders. In affected individuals\, excessive threat avoidance can interfere with rewarding behaviors\, and these changes typically emerge during adolescence. However\, the neurodevelopmental mechanisms linking ELA to increased threat responses remain unclear. We identified a stress-sensitive medial prefrontal cortex (mPFC)-basolateral amygdala pathway that co-expresses corticotropin-releasing hormone (CRH) and glutamate.&\;nbsp\;We find that ELA strengthens this pathway and increases threat avoidance behavior during adolescence. Optogenetic inhibition and developmental CRH knockdown in this&\;nbsp\;pathway both&\;nbsp\;rescue ELA-induced elevations in adolescent avoidance\, whereas broadly reducing mPFC CRH&\;nbsp\;expression&\;nbsp\;in typically-reared mice mimics ELA phenotypes. Together\, our findings&\;nbsp\;indicate&\;nbsp\;that cell type-specific CRH signaling regulates developmental circuit plasticity\, biasing emotional circuit function and potentially contributing to psychiatric vulnerability.&\;nbsp\;Recent publicationsEarly adversity potentiates prefrontal-amygdala communication through CRH+ glutamatergic neurons.&\;nbsp\;Goodpaster CM\, Gongwer MW\, Shari M\, Klune CB\, Jones NS\, Ramirez M\, Alturki M-B\, Hundley R\, Utter J DeNardo LA#&\;nbsp\;(2025)&\;nbsp\;bioRxiv 10.64898/2025.12.23.696229Directed cell-type recruitment during consolidation of a remote memory.Zeidler Z\, Yu AL\, Seong MP\, Hundley R\, DeNardo LAbioRxiv 2025 Jun\;():Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.Gongwer MW\, Etienne F\, Moca EN\, Chappell MS\, Blagburn-Blanco SV\, Riley JP\, Enos AS\, Haratian M\, Qi A\, Rojo R\, Wilke SA\, Pridans C\, DeNardo LA\, De Biase LMRes Sq 2025 Jan\;():A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.Gongwer MW\, Qi A\, Enos AS\, Rueda SA\, Klune CB\, Shari M\, Kashay AQ\, Williams OH\, Hacking A\, Riley JP\, Wilke GA\, Yang Y\, Lu H\, Leuchter AF\, DeNardo LA\, Wilke SAbioRxiv 2025 Jan\;():A developmental brain-wide screen identifies retrosplenial cortex as a key player in the emergence of persistent memory.Jin B\, Gongwer MW\, Kearney BP\, Ohanian L\, Holden-Wingate L\, Le B\, Darmawan A\, Nakayama Y\, Mora SAR\, DeNardo LAbioRxiv 2024 Nov\;():RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-laura-denardo CREATED:20260417T101514Z LAST-MODIFIED:20260420T102228Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Laura DeNardo END:VEVENT BEGIN:VEVENT DTSTART:20260528T130000Z DTEND:20260528T140000Z DTSTAMP:20260420T194411Z UID:239632 DESCRIPTION:This is part of the “Hot-topics in multimodal imaging” seminar series hosted by the Division of Imaging Core Facilities at the department of Clinical Neuroscience.\r\n\r\nTitle: Imaging Neuroimmune Health in Stress-Related Disorders with PETSpeaker: Kelly Cosgrove\, PhD\, is the Charles B.G. Murphy Professor of Psychiatry and Professor of Neuroscience and of Radiology and Biomedical Imaging. Dr. Cosgrove uses neuroreceptor imaging techniques such as PET to gain insights into the brains of people with substance use disorders and other stress-related conditions. Her laboratory develops and applies innovative brain imaging methods to track changes in key neurochemicals over time\, to identify treatment targets for psychiatric disorders\, and to examine individual differences as well as sex- and gender-related differences.The seminar will be hosted by Granville Matheson\, Imaging Core Facilitiy\, Department of Clinical Neuroscience.\r\n\r\nJoin the seminar via Zoom\nhttps://ki-se.zoom.us/j/67408275223?pwd=SUpySGxWMFhabkNHK2JETmJDQSs3dz09\r\n\r\nHot-topics in multimodal imaging"\; is a seminar series hosted by the Division of Imaging Core Facilities with a focus on multimodal imaging\, which will cover the latest research in the fields Neurology\, Psychiatry and Cognitive Neuroscience and will give our audience an overview of the state-of-the-art instruments\, computational and AI assisted data analysis being applied in the field by top international researchers.See our seminar calendar here and join us on Zoom. Welcome!\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/imaging-neuroimmune-health-in-stress-related-disorders-with-pet CREATED:20260417T150216Z LAST-MODIFIED:20260417T150215Z STATUS:CONFIRMED SUMMARY:Imaging Neuroimmune Health in Stress-Related Disorders with PET END:VEVENT BEGIN:VEVENT DTSTART:20260602T220000Z DTEND:20260605T215959Z DTSTAMP:20260420T194411Z UID:236689 DESCRIPTION:The annual StratNeuro Retreat will bring together researchers from Karolinska Institutet\, Umeå University\, and the Royal Institute of Technology for 3 days of cutting-edge scientific presentations\, dynamic discussions\, and networking opportunities that foster collaboration.\r\n\r\n&\;nbsp\;The StratNeuro Retreat 2026 will take place at Djurönäset in the Stockholm Archipelago\, from June 3-5.3 June: Neuroscience PhD student day (limited spots available)4-5 June: Main retreat programMore information on the program and application process here.\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/stratneuro-retreat-2026 CREATED:20251210T133127Z LAST-MODIFIED:20260204T133618Z STATUS:CONFIRMED SUMMARY:StratNeuro Retreat 2026 END:VEVENT END:VCALENDAR