BEGIN:VCALENDAR VERSION:2.0 PRODID:-//ki.se//NONSGML Event Calendar//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT DTSTART:20261015T090000Z DTEND:20261015T100000Z DTSTAMP:20261009T012624Z UID:242449 DESCRIPTION:Title: "Molecular mechanisms governing AAV transduction of neuronal axons". October 15 at 11:00 in room Nils Ringertz\, Biomedicum.\r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Arpiar Saunders\,&\;nbsp\;Oregon Health and Science University (OHSU)\, Portland\, USA.Time:&\;nbsp\;15 October\, 11:00–12:00Location:&\;nbsp\;Nils Ringertz lecture hall\, Biomedicum (level 3)Title: Molecular mechanisms governing AAV transduction of neuronal axonsAbstractOur lab is broadly focused on understanding the cellular etiology of neurodevelopmental disorders. We pursue this goal by developing single-cell and single-virion genomics methods to systematically map the molecular and synaptic organization of neural circuits. In parallel\, we seek to define the molecular mechanisms that govern host–virus interactions within the complex cellular environment of the brain. My seminar will focus on this latter effort. I will introduce a genetic screening approach for identifying receptors and other host factors that control adeno-associated virus (AAV) transduction in primary brain cells. I will then describe a series of experiments defining the molecular mechanism responsible for presynaptic axonal uptake of “retrograde” AAV. Our results reveal an unexpected and highly conserved receptor pathway that enables more predictive use andclinical evaluation of this widely used vector for targeting neural projection systems.Recent publicationsDesign and assembly of combinatorial DNA barcodes for probebased genomics applications&\;nbsp\;Goode Z*\, Tiedemann E*\, Ben Ameur L\, Pavan K\, Young K\, Sek M\, Nevue A\, Zhu J\, Houghton J\, Fu Y\, Boisvert H and Saunders A.&\;nbsp\;(2026). bioRxiv.Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation.Feige L\, Young K\, Cerapio JP\, Kozaki T\, Kergoat L\, Libri V\, Ginhoux F\, Hasan M\, Ben Ameur L\, Chin G\, Goode Z\, Bourhy H\, Saunders ACell Rep 2025 Sep\;44(9):116159Ascertaining cells'\; synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries.Saunders A\, Huang KW\, Vondrak C\, Hughes C\, Smolyar K\, Sen H\, Philson AC\, Nemesh J\, Wysoker A\, Kashin S\, Sabatini BL\, McCarroll SANat Commun 2022 Nov\;13(1):6993Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.Saunders A\, Macosko EZ\, Wysoker A\, Goldman M\, Krienen FM\, de Rivera H\, Bien E\, Baum M\, Bortolin L\, Wang S\, Goeva A\, Nemesh J\, Kamitaki N\, Brumbaugh S\, Kulp D\, McCarroll SACell 2018 Aug\;174(4):1015-1030.e16RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-arpiar-saunders CREATED:20260903T080236Z LAST-MODIFIED:20260903T081056Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Arpiar Saunders END:VEVENT BEGIN:VEVENT DTSTART:20261118T080000Z DTEND:20261118T160000Z DTSTAMP:20261009T012624Z UID:238777 DESCRIPTION:Join our one-day symposium with StratRegen to explore the latest advances in stem cell research and genome engineering\, featuring leading experts and short talks in regenerative medicine.\r\n\r\nRegistrationYou need to register to the symposium. The registration link will be published here shortly.\r\n\r\nSpeakersMarianne Carlon\, KU LeuvenThomas Norman\, Memorial Sloan Kettering Cancer CenterFilipa Simões\, Oxford UniversityJulian Grünewald\, Technical University of MunichRandall Platt\, ETH ZürichDaniella Rylander\, Lund University+ short talks\r\n\r\nOrganisers\nKarl Carlström\n Assistant Professor\n Email: karl.carlstrom@ki.se\n Department: Department of Laboratory Medicine\r\n\r\nElin Gruyters\n Research Specialist\n Email: elin.gruyters@ki.se\n Department: Department of Medical Biochemistry and Biophysics\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/symposium-genome-engineering-and-stem-cells-in-regenerative-medicine CREATED:20260316T082049Z LAST-MODIFIED:20260316T082848Z STATUS:CONFIRMED SUMMARY:Symposium: Genome Engineering and Stem Cells in Regenerative Medicine END:VEVENT END:VCALENDAR