BEGIN:VCALENDAR VERSION:2.0 PRODID:-//ki.se//NONSGML Event Calendar//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT DTSTART:20260422T100000Z DTEND:20260422T110000Z DTSTAMP:20260418T071155Z UID:238785 DESCRIPTION:Welcome to a new seminar in the StratRegen Lunch Seminar Series on Wednesday\, 22nd of April 2026\, 12.00-13.00.\r\n\r\nThe Seminar will take place both in \r\n\r\nroom D1012 Biomedicum\, Campus Solna AND \r\n\r\nroom DNA 5105\, Neo (lobby floor)\, Campus Flemingsberg\r\n\r\n\r\n\r\nTitel: Defining the macrophage involvement in the pathogenesis and anemic state of low-risk myelodysplastic syndromes.Sadaf Fazeli (Pedro Moura lab)Department of Medicine\, Huddinge&\;nbsp\;Titel: Identifying targetable features of senescence resistance &\;amp\; escape following cancer therapy.Samir Morsli (Federico Pietrocola lab)Department of Cell and Molecular Biology&\;nbsp\;&\;nbsp\;&\;nbsp\;&\;nbsp\;Sandwiches and coffee will be provided.\r\n\r\nHosts\nDaniel Holl\n Senior Lab Manager\n Email: daniel.holl@ki.se\r\n\r\nEvelien Eenjes\n Research Specialist\n Email: evelien.eenjes@ki.se\r\n\r\nStratRegen supports researchers\, research programs and infrastructure at the Karolinska Institutet (KI) within the field of stem cells and regenerative medicine based on scope\, quality\, and the potential to strengthen and develop the field.\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/stratregen-seminar-series-with-sadaf-fazeli-samir-morsli-s CREATED:20260313T133002Z LAST-MODIFIED:20260331T190746Z STATUS:CONFIRMED SUMMARY:StratRegen Seminar Series with Sadaf Fazeli & Samir Morsli (S) END:VEVENT BEGIN:VEVENT DTSTART:20260422T100000Z DTEND:20260422T110000Z DTSTAMP:20260418T071155Z UID:238787 DESCRIPTION:Welcome to a new seminar in the StratRegen Lunch Seminar Series on Wednesday\, 22nd of April 2026\, 12.00-13.00.\r\n\r\nThe Seminar will take place both in \r\n\r\nroom D1012 Biomedicum\, Campus Solna AND \r\n\r\nroom DNA 5105\, NEO\, Campus Flemingsberg\r\n\r\n\r\n\r\nTitel: Defining the macrophage involvement in the pathogenesis and anemic state of low-risk myelodysplastic syndromes.Sadaf Fazeli (Pedro Moura lab)Department of Medicine\, Huddinge&\;nbsp\;Titel: Identifying targetable features of senescence resistance &\;amp\; escape following cancer therapy.Samir Morsli (Federico Pietrocola lab)Department of Cell and Molecular Biology&\;nbsp\;&\;nbsp\;Sandwiches and coffee will be provided.\r\n\r\nHosts\nDaniel Holl\n Senior Lab Manager\n Email: daniel.holl@ki.se\r\n\r\nEvelien Eenjes\n Research Specialist\n Email: evelien.eenjes@ki.se\r\n\r\nStratRegen supports researchers\, research programs and infrastructure at the Karolinska Institutet (KI) within the field of stem cells and regenerative medicine based on scope\, quality\, and the potential to strengthen and develop the field.\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/stratregen-seminar-series-with-sadaf-fazeli-samir-morsli-f CREATED:20260313T134536Z LAST-MODIFIED:20260331T192025Z STATUS:CONFIRMED SUMMARY:StratRegen Seminar Series with Sadaf Fazeli & Samir Morsli (F) END:VEVENT BEGIN:VEVENT DTSTART:20260423T090000Z DTEND:20260423T100000Z DTSTAMP:20260418T071155Z UID:239529 DESCRIPTION:Title: From cell to systems: Navigating the Complex Landscape of Autism Spectrum Disorders. April 23 at 11:00 in room Ragnar Granit\, Biomedicum. \r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Gaia Novarino\, Institute of Science and Technology Austria (ISTA)\, Klosterneuburg\, AustriaTime:&\;nbsp\;23 April\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: From cell to systems: Navigating the Complex Landscape of Autism Spectrum DisordersAbstractAutism spectrum disorders (ASD) are a heterogeneous group of disorders rooted in genetic bases. Although genetic studies have identified many ASD-risk genes over the past few years\, it remains essentially unknown whether mutations in different genes result in similar molecular and cellular states within the brain. Over the past years\, we have generated a large cohort of ASD mouse models carrying mutations in top\, high-risk ASD genes. The cohort includes 11 mouse lines and span chromatin remodelers\, ubiquitin-related genes\, metabolically relevant genes\, and synaptic proteins. Employing these validated mouse models\, we performed simultaneous single nucleus RNA and ATAC sequencing across brain regions\, developmental stages\, and sexes\, totaling over 300 samples. We achieved this by pioneering an approach that allowed us to sequence RNA and DNA from the same nucleus on a large scale. With this unique dataset\, we could address precise questions regarding convergence and divergences across different ASD models\, time windows affected\, and sex differences.Lab website: https://novarinolab.wordpress.com/Recent publicationsImaging brain tissue architecture across millimeter to nanometer scales.Michalska JM\, Lyudchik J\, Velicky P\, Štefaničková H\, Watson JF\, Cenameri A\, Sommer C\, Amberg N\, Venturino A\, Roessler K\, Czech T\, Höftberger R\, Siegert S\, Novarino G\, Jonas P\, Danzl JGNat Biotechnol 2024 Jul\;42(7):1051-1064Dense 4D nanoscale reconstruction of living brain tissue.Velicky P\, Miguel E\, Michalska JM\, Lyudchik J\, Wei D\, Lin Z\, Watson JF\, Troidl J\, Beyer J\, Ben-Simon Y\, Sommer C\, Jahr W\, Cenameri A\, Broichhagen J\, Grant SGN\, Jonas P\, Novarino G\, Pfister H\, Bickel B\, Danzl JGNat Methods 2023 Aug\;20(8):1256-1265Effects of urban living environments on mental health in adults.Xu J\, Liu N\, Polemiti E\, Garcia-Mondragon L\, Tang J\, Liu X\, Lett T\, Yu L\, Nöthen MM\, Feng J\, Yu C\, Marquand A\, Schumann G\,&\;nbsp\;Nat Med 2023 Jun\;29(6):1456-1467Large neutral amino acid levels tune perinatal neuronal excitability and survival.Knaus LS\, Basilico B\, Malzl D\, Gerykova Bujalkova M\, Smogavec M\, Schwarz LA\, Gorkiewicz S\, Amberg N\, Pauler FM\, Knittl-Frank C\, Tassinari M\, Maulide N\, Rülicke T\, Menche J\, Hippenmeyer S\, Novarino GCell 2023 Apr\;186(9):1950-1967.e25RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-gaia-novarino CREATED:20260415T131932Z LAST-MODIFIED:20260417T101856Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Gaia Novarino END:VEVENT BEGIN:VEVENT DTSTART:20260507T090000Z DTEND:20260507T100000Z DTSTAMP:20260418T071155Z UID:239539 DESCRIPTION:Title: From proteins to circuits: defining pyramidal neuron input architecture and remodeling in disease. May 7 at 11:00 in room Ragnar Granit\, Biomedicum. \r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Joris De Wit\, VIB-KU Leuven Center for Brain &\;amp\; Disease Research\, Leuven\, Belgium.Time:&\;nbsp\;7 May\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: From proteins to circuits: defining pyramidal neuron input architecture and remodeling in diseaseAbstractNeural circuits are composed of different types of neurons and the specific patterns of synaptic connectivity between them. The highly heterogeneous nature of neuronal cell types and their connections present a major challenge to the characterization of neural circuits at the molecular level. Progress in addressing this challenge has come from transcriptomic profiling techniques\, which enabled the characterization of the molecular composition of specific cell types within circuits. While single-cell transcriptomics have been instrumental in mapping cell-type diversity in the brain\, these approaches are poorly suited to capture the diversity and molecular identity of synapses. In this talk\, I will present our recent efforts to map synapse composition and diversity in neural circuits\, using fluorescent sorting of synaptosomes and synaptic proximity biotinylation approaches coupled with mass spectrometry. We analyze the postsynaptic proteome of CA1 hippocampal pyramidal neurons and characterize the specific molecular composition of their proximal and distal inputs. As CA1 pyramidal neurons are especially vulnerable in Alzheimer’s disease (AD)\, we use these approaches to map their postsynaptic protein composition in AppNL-G-F mice and detect early and progressive synaptic changes in AD. These proteomics approaches enable the dissection of synapse composition in intact neural circuits in health and disease\, and should be broadly applicable to other brain regions and neuron types.Recent publicationsSynaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons.Marcassa G\, Dascenco D\, Lorente-Echeverría B\, Daaboul D\, Vandensteen J\, Leysen E\, Baltussen L\, Howden AJM\, de Wit JNat Commun 2025 Jan\;16(1):228A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation.Verpoort B\, Amado L\, Vandensteen J\, Leysen E\, Dascenco D\, Vandenbempt J\, Lemmens I\, Wauman J\, Vennekens K\, Escamilla-Ayala A\, Freitas ACN\, Voets T\, Munck S\, Tavernier J\, Wierda K\, de Wit JDev Cell 2025 Sep\;60(18):2470-2486.e10A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.Lorente-Echeverría B\, Daaboul D\, Vandensteen J\, Marcassa G\, Naert W\, Vandenbempt J\, Leysen E\, Reverendo M\, Vlaeminck I\, Vervloessem L\, Lamote J\, Poovathingal S\, Davie K\, Wierda K\, Dascenco D\, Aerts S\, de Wit JSci Adv 2025 Oct\;11(43):eadx5140Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer'\;s disease.Calafate S\, Özturan G\, Thrupp N\, Vanderlinden J\, Santa-Marinha L\, Morais-Ribeiro R\, Ruggiero A\, Bozic I\, Rusterholz T\, Lorente-Echeverría B\, Dias M\, Chen WT\, Fiers M\, Lu A\, Vlaeminck I\, Creemers E\, Craessaerts K\, Vandenbempt J\, van Boekholdt L\, Poovathingal S\, Davie K\, Thal DR\, Wierda K\, Oliveira TG\, Slutsky I\, Adamantidis A\, De Strooper B\, de Wit JNat Neurosci 2023 Jun\;26(6):1021-1031LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.Libé-Philippot B\, Lejeune A\, Wierda K\, Louros N\, Erkol E\, Vlaeminck I\, Beckers S\, Gaspariunaite V\, Bilheu A\, Konstantoulea K\, Nyitrai H\, De Vleeschouwer M\, Vennekens KM\, Vidal N\, Bird TW\, Soto DC\, Jaspers T\, Dewilde M\, Dennis MY\, Rousseau F\, Comoletti D\, Schymkowitz J\, Theys T\, de Wit J\, Vanderhaeghen PCell 2023 Dec\;186(26):5766-5783.e25RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-joris-de-wit CREATED:20260416T062001Z LAST-MODIFIED:20260417T101933Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Joris de Wit END:VEVENT BEGIN:VEVENT DTSTART:20260521T090000Z DTEND:20260521T100000Z DTSTAMP:20260418T071155Z UID:239596 DESCRIPTION:Title: Early adversity promotes adolescent threat avoidance behaviors by enhancing prefrontal–amygdala communication through CRH⁺ glutamatergic neurons. May 21 at 11:00 in room Ragnar Granit\, Biomedicum.\r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Laura DeNardo\, University of California\, Los Angeles\, USATime:&\;nbsp\;16 June\, 11:00–12:00Location:&\;nbsp\;Ragnar Granit Lecture Hall\, Biomedicum (level 3)Title: Early adversity promotes adolescent threat avoidance behaviors by enhancing prefrontal–amygdala communication through CRH⁺&\;nbsp\;glutamatergic neuronsAbstractEarly life adversity (ELA)&\;nbsp\;has enduring impacts on emotion circuit function. Following early maltreatment\, neglect\, or&\;nbsp\;instability in the home\, individuals often exhibit&\;nbsp\;lifelong impairments in their evaluation and response to threats-hallmarks of mood and anxiety disorders. In affected individuals\, excessive threat avoidance can interfere with rewarding behaviors\, and these changes typically emerge during adolescence. However\, the neurodevelopmental mechanisms linking ELA to increased threat responses remain unclear. We identified a stress-sensitive medial prefrontal cortex (mPFC)-basolateral amygdala pathway that co-expresses corticotropin-releasing hormone (CRH) and glutamate.&\;nbsp\;We find that ELA strengthens this pathway and increases threat avoidance behavior during adolescence. Optogenetic inhibition and developmental CRH knockdown in this&\;nbsp\;pathway both&\;nbsp\;rescue ELA-induced elevations in adolescent avoidance\, whereas broadly reducing mPFC CRH&\;nbsp\;expression&\;nbsp\;in typically-reared mice mimics ELA phenotypes. Together\, our findings&\;nbsp\;indicate&\;nbsp\;that cell type-specific CRH signaling regulates developmental circuit plasticity\, biasing emotional circuit function and potentially contributing to psychiatric vulnerability.&\;nbsp\;Recent publicationsEarly adversity potentiates prefrontal-amygdala communication through CRH+ glutamatergic neurons.&\;nbsp\;Goodpaster CM\, Gongwer MW\, Shari M\, Klune CB\, Jones NS\, Ramirez M\, Alturki M-B\, Hundley R\, Utter J DeNardo LA#&\;nbsp\;(2025)&\;nbsp\;bioRxiv 10.64898/2025.12.23.696229Directed cell-type recruitment during consolidation of a remote memory.Zeidler Z\, Yu AL\, Seong MP\, Hundley R\, DeNardo LAbioRxiv 2025 Jun\;():Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.Gongwer MW\, Etienne F\, Moca EN\, Chappell MS\, Blagburn-Blanco SV\, Riley JP\, Enos AS\, Haratian M\, Qi A\, Rojo R\, Wilke SA\, Pridans C\, DeNardo LA\, De Biase LMRes Sq 2025 Jan\;():A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.Gongwer MW\, Qi A\, Enos AS\, Rueda SA\, Klune CB\, Shari M\, Kashay AQ\, Williams OH\, Hacking A\, Riley JP\, Wilke GA\, Yang Y\, Lu H\, Leuchter AF\, DeNardo LA\, Wilke SAbioRxiv 2025 Jan\;():A developmental brain-wide screen identifies retrosplenial cortex as a key player in the emergence of persistent memory.Jin B\, Gongwer MW\, Kearney BP\, Ohanian L\, Holden-Wingate L\, Le B\, Darmawan A\, Nakayama Y\, Mora SAR\, DeNardo LAbioRxiv 2024 Nov\;():RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-laura-denardo CREATED:20260417T101514Z LAST-MODIFIED:20260417T101953Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Laura DeNardo END:VEVENT BEGIN:VEVENT DTSTART:20260521T090000Z DTEND:20260521T100000Z DTSTAMP:20260418T071155Z UID:239557 DESCRIPTION:Title: Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory Circuits. May 21 at 11:00 in room Ragnar Granit\, Biomedicum.\r\n\r\nWelcome all members of Karolinska Institutet\, as well as researchers and trainees from KTH Royal Institute of Technology\, Stockholm University\, and other universities in the Stockholm region. We warmly encourage students\, postdocs\, and faculty to attend and engage with our distinguished guest.\r\n\r\nSpeaker:Csaba Földy\,&\;nbsp\;Brain Research Institute\, Zürich\, Switzerland.Time:&\;nbsp\;21 May\, 11:00–12:00Location:&\;nbsp\;Peter Reichard Lecture Hall\, Biomedicum (level 3)Title: Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory CircuitsAbstractContrary to traditional belief\, axon growth and circuit formation do not only occur in the developing brain\, but also in the adult brain. However\, the underlying mechanisms remain elusive. Understanding these mechanisms could provide insight into fundamental questions\, such as how brain circuits are maintained throughout life and how brain rewiring might be used for therapeutic and repair purposes. Recent work from our laboratory has identified two bHLH transcription regulators\, Id2 and Ascl4\, that can reactivate axonal wiring in mature neurons of the naive adult brain. In this talk\, I will discuss the underlying molecular programs and implications of this new wiring in the context of the hippocampus. These results suggest the existence of a transcriptomic program for adult brain wiring that may be applicable to different neuron types. They also demonstrate that adult brain rewiring can enhance cognitive functions\, such as learning and memory\, via the rewired hippocampal projection system.Recent publicationsMolecular Signatures of Id2- and Ascl4-Induced Wiring of Adult Hippocampal Neurons.Seng C\, Tamás B\, Kaur R\, Luo W\, Földy CJ Neurosci 2026 Feb\;46(7):Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.Luo W\, Egger M\, Cruz-Ochoa N\, Tse A\, Maloveczky G\, Tamás B\, Lukacsovich D\, Seng C\, Amrein I\, Lukacsovich T\, Wolfer D\, Földy CPNAS Nexus 2024 May\;3(5):pgae174Commissural dentate granule cell projections and their rapid formation in the adult brain.Egger M\, Luo W\, Cruz-Ochoa N\, Lukacsovich D\, Varga C\, Que L\, Maloveczky G\, Winterer J\, Kaur R\, Lukacsovich T\, Földy CPNAS Nexus 2023 Apr\;2(4):pgad088Pcdh11x controls target specification of mossy fiber sprouting.Luo W\, Cruz-Ochoa NA\, Seng C\, Egger M\, Lukacsovich D\, Lukacsovich T\, Földy CFront Neurosci 2022 \;16():888362Circuit formation in the adult brain.Seng C\, Luo W\, Földy CEur J Neurosci 2022 Aug\;56(3):4187-4213Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator\, Id2.Luo W\, Egger M\, Domonkos A\, Que L\, Lukacsovich D\, Cruz-Ochoa NA\, Szőcs S\, Seng C\, Arszovszki A\, Sipos E\, Amrein I\, Winterer J\, Lukacsovich T\, Szabadics J\, Wolfer DP\, Varga C\, Földy CProc Natl Acad Sci U S A 2021 Oct\;118(40):RefreshmentsSandwiches and coffee will be provided.RegistrationNo registration is needed.\r\n\r\nHost\nMichael Ratz\n Assistant Professor\n Email: michael.ratz@ki.se\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/frontiers-in-neural-circuits-seminar-series-with-csaba-foldy CREATED:20260416T113616Z LAST-MODIFIED:20260417T101730Z STATUS:CONFIRMED SUMMARY:Frontiers in Neural Circuits seminar series: with Csaba Földy END:VEVENT BEGIN:VEVENT DTSTART:20261118T080000Z DTEND:20261118T160000Z DTSTAMP:20260418T071155Z UID:238777 DESCRIPTION:Join our one-day symposium with StratRegen to explore the latest advances in stem cell research and genome engineering\, featuring leading experts and short talks in regenerative medicine.\r\n\r\nRegistrationYou need to register to the symposium. The registration link will be published here shortly.\r\n\r\nSpeakersMarianne Carlon\, KU LeuvenThomas Norman\, Memorial Sloan Kettering Cancer CenterFilipa Simões\, Oxford UniversityJulian Grünewald\, Technical University of MunichRandall Platt\, ETH ZürichDaniella Rylander\, Lund University+ short talks\r\n\r\nOrganisers\nKarl Carlström\n Assistant Professor\n Email: karl.carlstrom@ki.se\n Department: Department of Laboratory Medicine\r\n\r\nElin Gruyters\n Research Specialist\n Email: elin.gruyters@ki.se\n Department: Department of Medical Biochemistry and Biophysics\r\n\r\nPlease note that location\, time and information can be updated on the website.\r\nhttps://news.ki.se/calendar/symposium-genome-engineering-and-stem-cells-in-regenerative-medicine CREATED:20260316T082049Z LAST-MODIFIED:20260316T082848Z STATUS:CONFIRMED SUMMARY:Symposium: Genome Engineering and Stem Cells in Regenerative Medicine END:VEVENT END:VCALENDAR