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Thesis on survival extrapolation and its application on health technology assessment

Wed, 03 Sep 2025 10:59:17 +0200

A new thesis from Karolinska Institutet focuses on advanced statistical methods to better predict long-term patient outcomes, supporting healthcare decision-making. The application focused on chronic myeloid leukemia with the goal to inform clinical and policy insights.

Apply for grants from SFOepi autumn 2025

Fri, 22 Aug 2025 14:39:03 +0200

The Strategic Research Program in epidemiology (SFOepi) at Karolinska Institutet now announces funding for two types of grants; Consolidator Grant for junior researchers, Junior Scholar Grants in Epidemiology or Biostatistics.

Depression shown to be both cause and consequence of poor health

Fri, 22 Aug 2025 11:13:45 +0200

A large international study led by researchers at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, shows that major depressive disorder (MDD) not only increases risk for a wide range of diseases and social problems, but is also partly driven by factors such as loneliness, obesity, smoking, and chronic pain.

Rising colorectal cancer among young adults in Sweden

Thu, 14 Aug 2025 11:59:45 +0200

According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s. The study also shows that mortality is elevated in both younger and older patients for up to ten years after diagnosis.

ADHD medication benefits persist – but not like they used to

Wed, 25 Jun 2025 17:08:04 +0200

As ADHD medication use has surged in Sweden over the past decades, evidence is needed on whether the benefit of the medication remains consistent. A new study from Karolinska Institutet, published in JAMA Psychiatry, shows that while ADHD medication still helps reduce the risk of self-harm, unintentional injuries, traffic accidents, and criminal behavior, its protective effects have diminished over time as ADHD medication use has broadened to a wider group of patients.

Suganthi Jaganathan: "In Delhi, it is often hard to breathe"

Thu, 12 Jun 2025 11:31:37 +0200

Suganthi Jaganathan researches air pollution in India. Among other findings, she has shown that poor air quality caused 16.6 million deaths in India over a ten-year period.

Newborns with health problems are at higher risk of dying into adolescence

Tue, 10 Jun 2025 20:15:10 +0200

Infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence compared to children who were healthy as newborns. This is according to a new study from Karolinska Institutet published in the journal JAMA Pediatrics.

Thesis on clinically reliable AI for prostate cancer pathology

Tue, 10 Jun 2025 08:42:53 +0200

Prostate cancer is one of the most common cancers in men globally. Diagnosing prostate cancer involves examining tissue samples under a microscope, a process that can be inconsistent and yield different results by different pathologists for the same sample, potentially affecting patient treatment. In some unclear cases, extra testing called immunohistochemistry (IHC) is used, but it adds cost, time, and lab work.

Autism linked to elevated risk of Parkinson's disease

Tue, 27 May 2025 17:00:10 +0200

People with an autism diagnosis are at a higher risk of developing Parkinson’s disease early in life, a large-scale study from Karolinska Institutet published in JAMA Neurology reports. The researchers believe that the two conditions can share underlying biological mechanisms.

Thesis on health effects of tobacco exposure

Wed, 21 May 2025 13:35:34 +0200

Welcome to Anna Zettergren's defense of the thesis ”Tobacco Exposure and Health – From Fetal Life to Adulthood”.

Adult-onset type 1 diabetes increases risk of cardiovascular disease and death

Wed, 14 May 2025 09:00:14 +0200

A new study in the European Heart Journal shows that people who develop type 1 diabetes in adulthood have an increased risk of cardiovascular disease and death, and that those diagnosed later in life do not have a better prognosis than those diagnosed earlier. The study, conducted by researchers at Karolinska Institutet, points to smoking, poor glucose control and obesity as the main risk factors.

Fatty liver in pregnancy may increase risk of preterm birth

Fri, 09 May 2025 10:00:12 +0200

Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study from Karolinska Institutet published in the journal eClinicalMedicine.

International study maps the prevalence of inflammatory bowel disease (IBD)

Wed, 30 Apr 2025 17:12:44 +0200

The Consortium Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) now publish data on the global prevalence of inflammatory bowel disease (IBD) in Nature. Researchers from Karolinska Institutet have contributed to the study. While the number of people with incident IBD is relatively constant in Sweden, the prevalence is increasing and 1 per cent of the Swedish population is now estimated to have IBD.

Higher cigarette taxes may improve childhood survival

Wed, 30 Apr 2025 09:55:35 +0200

A higher tax on cigarettes in low and middle-income countries can help to reduce child mortality, especially amongst the poorest children, a new study led by researchers at Karolinska Institutet and published in The Lancet Public Health suggests.

Jonas F. Ludvigsson awarded the 2025 Solstickepriset for groundbreaking research about child health

Fri, 25 Apr 2025 11:05:41 +0200

Professor Jonas F Ludvigsson at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, and Örebro University Hospital has been awarded the Solstickepriset 2025.

KIB podcast: AIDS – yesterday, today and tomorrow

Fri, 25 Apr 2025 08:44:44 +0200

KI Professor Anna Mia Ekström joins the KIB podcast in a conversation about the Face of AIDS Film Archive, the unique film archive documenting the global HIV epidemic 1986-2021. We talk about the importance of the current political landscape in the fight against HIV and AIDS, the results achieved in terms of treatment and the very real risk that these results will be reversed. We talk about the role of documentation and activism: ‘We don't see that today [...] and we know that silence kills.'

Diagnostic accuracy in the Swedish National Patient Register

Fri, 04 Apr 2025 16:50:47 +0200

The Swedish National Patient Register (NPR) has long been a cornerstone for epidemiological research. Researchers at Karolinska Institutet have published a new review examining the validity of the register and found that it is good for most diagnoses and very good for surgical procedures.

ERA Curatorium Award for Young Investigators to Anne-Laure Faucon

Thu, 03 Apr 2025 08:26:20 +0200

The European Renal Association (ERA) just announced that Dr. Anne-Laure Faucon will receive the “ERAC Award for Young Investigators – Young Nephrologist”. The prize is awarded to a young nephrologist/researcher who has made a scientific contribution in the field of nephrology.

Blood test may rule out future dementia risk

Wed, 02 Apr 2025 08:51:24 +0200

Researchers at Karolinska Institutet have demonstrated how specific biomarkers in the blood can predict the development of dementia up to ten years before diagnosis, among older adults living independently in the community.

“To start a research career within medicine and health”

Mon, 31 Mar 2025 13:39:30 +0200

This week, the third edition of the book “To start a research career within medicine and health” ("Att börja forska inom medicin och hälsa") is released. Author is Jonas F Ludvigsson, pediatrician and professor at the Department of Medical Epidemiology and Biostatistics and the book is aimed at doctoral students and prospective researchers in medicine and health.

Three out of ten breast cancers are detected between screenings

Fri, 28 Mar 2025 13:23:47 +0100

In a new study, researchers from Karolinska Institutet have shown that so-called interval cancers, which are detected between two screening sessions, account for a significant proportion of breast cancer cases and that certain risk factors may increase the likelihood of developing this type of cancer. The study was published in the journal JAMA Oncology.

Thesis on causes of neurodevelopmental disorders

Tue, 25 Mar 2025 10:58:27 +0100

The debate on nature versus nurture has never ceased, particularly in discussions about neurodevelopmental conditions (NDCs) such as autism and attention-deficit hyperactivity disorder (ADHD). These lifelong conditions emerge in childhood, and while they mostly have genetic nature, environmental factors may play a role.

Fluoride in drinking water is associated with impaired childhood cognition

Fri, 07 Mar 2025 15:30:09 +0100

Elevated concentrations of fluoride can occur in well water, and in some countries, it is added to drinking water to counteract caries in the population. A study from Karolinska Institutet now supports a few previous studies indicating that exposure to fluoride during the fetal stage or early childhood may impair cognition in children. The study is published in the journal Environmental Health Perspectives.

Serious mental illness common in chronic kidney disease

Mon, 24 Feb 2025 13:42:47 +0100

A new study from Karolinska Institutet shows that severe mental illness is more common in patients with chronic kidney disease and negatively affects their health. The study has been published in the American Journal of Kidney Diseases.

Thesis on the interplay between inflammatory bowel disease and kidney diseases

Mon, 17 Feb 2025 10:21:42 +0100

A new thesis from Karolinska Institutet aims to advance our understanding of the bidirectional relationship between inflammatory bowel disease (IBD) and chronic kidney diseases (CKD) through large-scale epidemiological studies utilizing real-world data.

Call for interest for a collaborative Stockholm trio-UCL workshop in London

Mon, 27 Jan 2025 13:18:55 +0100

Stockholm Trio (Karolinska Institutet, KTH Royal Institute of Technology & Stockholm University) and University College London (UCL) invite you to express interest in two days of workshops in London, the 8-9 April 2025.

New NIH grant for the project "Autism in Preterm Birth"

Tue, 21 Jan 2025 16:00:14 +0100

Autism affects 2-3% of U.S. children and there is no cure. Both genetic and environmental factors contribute to its etiology. Researchers at the Karolinska Institutet and the Icahn School of Medicine at Mount Sinai have received an NIH grant of 2.5 million USD for the 5-year project "Autism in Preterm Birth".

Aging and Alzheimer's Disease - investigating drug effects

Tue, 21 Jan 2025 08:45:33 +0100

The geroscience hypothesis focuses on extending the healthy lifespan by targeting aging mechanisms. Recent advances in biomarkers for biological aging give rise to tools for measuring aging and assessing treatments. Alzheimer’s disease, a major health issue, may benefit from common drugs and early interventions.

Award for an important advancement in AI@KI to Sara Hägg

Fri, 17 Jan 2025 14:58:35 +0100

During the inauguration of the new initiative "Advances in Artificial Intelligence - AI@KI", on Dec 18, 2024, the first award for an important advancement in AI made at KI during the past year was handed out. Among many nominated candidates, Dr Sara Hägg was evaluated as the most outstanding contribution from a panel of reviewers.

Novel deep learning-based models for cancer histopathology image analysis

Wed, 15 Jan 2025 13:29:02 +0100

Histopathological evaluation of tumour specimens has long been essential in diagnosing breast cancer and guiding clinical decision-making. However, one of the key challenges in routine diagnostics include the inter-observer and inter-lab variabilities present in the assessment of prognostic markers that could lead to under- and over-treatment of patients.

Global study pinpoints genes for depression across ethnicities

Wed, 15 Jan 2025 08:10:32 +0100

New genetic risk factors for depression have been identified across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity. The world’s largest and most diverse genetic study ever of major depression has revealed nearly 300 previously unknown genetic links to the condition.

Celiac disease linked to chronic liver disease

Fri, 10 Jan 2025 07:52:07 +0100

Patients with celiac disease face an increased risk of developing any chronic liver disease. This risk increase can persist for at least 25 years after celiac diagnosis. The findings from a national study from Karolinska Institutet published in Lancet Regional Health - Europe underscore clinical vigilance to signs of liver disease in patients with celiac disease to prevent major adverse liver outcomes.

Combined screening can detect liver damage in diabetes patients

Fri, 13 Dec 2024 00:30:10 +0100

New research from Karolinska Institutet highlights the possibility of screening people with type 2 diabetes for liver damage at the same time as they undergo screening for eye disease. The study is published in Lancet Gastroenterology and Hepatology.

Chronic kidney disease: challenges in medication safety

Fri, 06 Dec 2024 09:26:29 +0100

One in ten adults in society suffer from chronic kidney disease (CKD), a disease characterized by progressive loss of kidney function. Altered kidney function can impact on the risk/benefit of many medications. People with advanced chronic kidney disease have to be careful about the medications they take because their kidneys don't work as well as they should. Some medications are not safe for them to take at all while others require dose adjustments or strict monitoring for safety.

MEB receives 120 millions in Swedish grants

Thu, 05 Dec 2024 08:58:05 +0100

Congratulations to the researchers at the Department of Medical Epidemiology and Biostatistics (MEB) who received a total of nearly 120 million SEK from the Swedish funding agencies (FORTE, the Swedish Research Council, the Swedish Cancer Society and the Erling-Persson Foundation)!

Project grant from The Swedish Heart Lung Foundation to Professor Jonas F. Ludvigsson

Tue, 03 Dec 2024 13:02:45 +0100

The Swedish Heart Lung Foundation (Hjärt-Lungfonden) has awarded Jonas F. Ludvigsson a 3-year-grant for the project ”Inflammatory bowel disease, inflammation and risk of cardiovascular disease”.

Epidemiology and health economics in gastrointestinal diseases

Tue, 03 Dec 2024 10:33:44 +0100

A new thesis from Karolinska Institutet shows the significant societal economic burdens posed by two chronic inflammatory gastrointestinal diseases; eosinophilic esophagitis (EoE) and microscopic colitis (MC). Both diseases cause long-term inflammation in the digestive system and can lead to additional health problems.

Multiple time-scales with flexible parametric survival models

Mon, 25 Nov 2024 16:52:44 +0100

A new thesis from Karolinska Institutet shows the effectiveness of flexible parametric survival models in modelling multiple time-scales, providing a robust tool for complex time-to-event data analysis. The models were tested in the context of myeloproliferative neoplasms, a group of chronic hematologic malignancies in which the bone marrow makes too many red blood cells, white blood cells, or platelets.

Isabell Brikell receives "Rising Star Award" from ACAMH

Tue, 12 Nov 2024 13:36:58 +0100

Dr Isabell Brikell has been awarded the Kathy Sylva ‘Rising Star’ Award 2024 from ACAMH - The Association for Child and Adolescent Health.

Weighty Matters – disentangling the Body Mass Index, metabolic health and aging connection

Fri, 08 Nov 2024 09:23:16 +0100

As global populations age and the prevalence of obesity and metabolic disorders rises, understanding the complex relationships between body mass index (BMI), metabolic health, and aging becomes increasingly critical.

Statistical and computational methods for analyzing omics data and predicting drug responses

Tue, 22 Oct 2024 11:33:26 +0200

Recent advancements in high-throughput sequencing technologies have enabled researchers to harness valuable omics data, paving the way for precision medicine. This approach aims to enhance diagnosis and treatment by tailoring therapies to individual patients, moving away from traditional, subjective methods. However, analyzing omics data for effective treatment personalization remains challenging due to disease variability and data complexity.

Prostate cancer – improving detection and reducing overtreatment

Tue, 08 Oct 2024 15:26:12 +0200

Prostate cancer is the most common cancer among men in Sweden, with about 10,000 new cases diagnosed annually. Despite advancements in diagnostics and treatments, managing prostate cancer remains challenging due to its often silent progression and the complexities surrounding early detection.

Svenska Läkaresällskapet awards Adjunct Professor Jana de Boniface their prestigious Jubilee Prize 2024

Mon, 07 Oct 2024 11:45:16 +0200

Svenska Läkaresällskapet (the Swedish Medical Society, SLS) has decided to award Jana de Boniface, adjunct professor at Karolinska Institutet and senior physician and surgeon at the surgery and oncology clinic, Capio St. Göran's Hospital, with their prestigious Jubilee Prize. The awardee is rewarded with SEK 175,000 and the SLS century medal in silver.

KI researcher Kyla McKay awarded the Bjarne Ahlströms Minnesfonds pris 2024

Thu, 26 Sep 2024 16:10:06 +0200

Kyla McKay, researcher in MS epidemiology and affiliated with the Department of Clinical Neuroscience, has been awarded the Bjarne Ahlström Minnesfonds pris in “Clinical Neurology - especially inflammatory mechanisms affecting central or peripheral nervous system function”.

Autism in young adulthood

Tue, 17 Sep 2024 14:08:26 +0200

Our understanding of autism has changed significantly in the past years. Previously viewed as a rare childhood disorder with a focus on deficits and pathology, autism is now recognized as a common, lifelong and heterogenous condition characterized by a broad spectrum of strengths and challenges. With increasing numbers of autistic adults and in particular females, a better understanding of autism in young adulthood for autistic females and males is warranted.

Seeking approaches to preventing dementia

Thu, 12 Sep 2024 09:00:12 +0200

Concurrent with the ageing global population is a growing need of preventative action on age-related diseases. Weili Xu is studying how cardiovascular disease and diabetes influence the risk of developing cognitive failure and dementia. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October.

Wants to personalise prostate cancer treatment

Fri, 06 Sep 2024 09:00:11 +0200

Prostate cancer accounts for more male deaths in Sweden than any other form of cancer. However, how the disease progresses and how fatal it is depend on the type of tumour. Olof Akre hopes to find better prognostic indicators that will help to personalise treatment. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October.

Hot flushes are associated with cardiovascular risk

Tue, 03 Sep 2024 17:04:39 +0200

Severe, lasting hot flushes during menopause are associated with atherosclerosis in the coronary artery, new research from Karolinska Institutet and Linköping University and published in the Journal of the American Heart Association reveals.

Increased risk of dementia after acute kidney injury

Mon, 26 Aug 2024 15:17:05 +0200

Acute kidney injury is associated with an increased risk of developing dementia, according to a new study published in the journal Neurology by researchers at Karolinska Institutet and others.

Seeking the factors that lead to illness and injury

Mon, 26 Aug 2024 09:00:11 +0200

Finding out who falls ill and why is essential to preventative action. Jette Möller conducts epidemiological research on our major health issues – cardiovascular disease, mental ill-health and injuries. Meet one of Karolinska Institutet's new professors who will participate in this year's installation ceremony at Aula Medica on 3 October.

Increasing incidence of cancer during pregnancy, yet maternal and perinatal risks are low

Thu, 22 Aug 2024 10:56:18 +0200

Although the incidence of cancer during pregnancy is increasing in Sweden, new studies from Karolinska Institutet show that women with breast cancer during pregnancy have good prognosis and low risks of adverse obstetric and perinatal outcomes.

Secondment to World Health Organization results valuable experience for epidemiologist

Wed, 21 Aug 2024 16:12:23 +0200

Epidemiologist Moa Herrgård has spent six months seconded to the World Health Organization’s (WHO) Regional Centre for Health Emergencies in Amman, Jordan. The overall focus of her work has been to enhance health emergency preparedness and response in the Eastern Mediterranean and Middle East Region. Looking back, she thinks the secondment has taught her a lot that will benefit work at KI.

Genetics of COPD important for lung function in young people

Tue, 13 Aug 2024 10:00:12 +0200

Certain genetic variants that have previously been linked to the lung disease COPD can explain reduced lung function already in children and adolescents, according to researchers at Karolinska Institutet. The results are presented in the Lancet's sister journal eClinicalMedicine together with fifteen other European research centres.

Professor and former Vice President Anders Ekbom has passed away

Wed, 31 Jul 2024 11:05:19 +0200

Anders Ekbom, Professor of Epidemiology and former Vice President of Karolinska Institutet, has died aged 76. He passed on 29 July after a long illness. Anders Ekbom had several roles and assignments at KI. ”His importance for Karolinska Institutet cannot be overestimated”, says KI’s President Annika Östman Wernerson.

Preventive strategies for cervical and vaginal cancer – do they work?

Fri, 24 May 2024 16:24:02 +0200

Cervical cancer is the fourth most common cancer in women worldwide, and the third most common cause of death of cancer in women. In 2022, the incidence was estimated to 660 000 new cases and 350 000 deaths. In Sweden, around 450-550 new cases are diagnosed each year, and the incidence has been fairly stable since the 1980s.

No link between paracetamol use during pregnancy and autism or ADHD in children

Tue, 09 Apr 2024 17:00:12 +0200

In the largest epidemiologic study to date of the risk of giving birth to a child with autism, ADHD or intellectual disability following acetaminophen use during pregnancy, researchers found no association. The study is now published in JAMA.

Key insights from statistical modelling of cancer patient life expectancy

Wed, 03 Apr 2024 09:09:56 +0200

With the progress in treatment for most cancer types, there is a growing interest to understand the overall impact of a cancer diagnosis throughout the remaining lifespan. In addition to conventional survival probabilities, estimating Life Expectancy following cancer diagnosis and Loss in Life Expectancy for cancer patients in comparison to if they did not have cancer provides valuable insights into the societal burden of cancer.

Bidirectional link between premenstrual disorders and perinatal depression

Thu, 28 Mar 2024 19:00:11 +0100

Women with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) have a higher risk of perinatal depression. Conversely, women with perinatal depression have a higher risk of developing premenstrual disorders. This is shown in a study from Karolinska Institutet published in the journal PLOS Medicine.

ADHD medication linked to reduced mortality

Tue, 12 Mar 2024 17:00:08 +0100

Researchers from Karolinska Institutet have shown a link between use of medication for ADHD and a reduced risk of premature death. The risk of death due to unnatural causes, such as accidents and overdoses, can be reduced by a quarter, according to the new study published in JAMA.

The Conversation article reached 2.4 million readers: "A very instructive process"

Thu, 15 Feb 2024 15:00:44 +0100

An article in The Conversation written by a KI researcher broke a record in the number of readers. Associate Professor Karin Modig's article on centenarian biomarkers received almost 2.4 million reads and was translated into several languages.

Epidemiologist seconded to WHO will bring valuable insights back to KI

Tue, 13 Feb 2024 10:17:04 +0100

The eastern mediterranean region is currently facing a brewing health crisis, brought on not least by the war in Gaza. The danger of spread of infectious diseases means that effective epidemiological surveillance and action is key. To assist in these efforts, the Centre for Health Crises has seconded epidemiologist Moa Herrgård via our membership in WHO’s Global Outbreak Alert and Response Network (GOARN).

Covid vaccine for pregnant women safe for newborn infants

Tue, 06 Feb 2024 17:00:13 +0100

No increased risks for babies, and for some serious neonatal complications lower risks. This is the result of the largest study to date on the safety of newborn babies whose mothers were vaccinated against COVID-19 during pregnancy. The study is a collaboration between Swedish and Norwegian researchers and is published in the journal JAMA.

Thesis on vulnerability to suicide among students and people with bipolar disorder

Fri, 02 Feb 2024 14:02:23 +0100

Suicide is one of the leading causes of death in young persons in Sweden and globally. The last decades have seen an increasing proportion of the youth population engaging in university level education. The university period usually coincides with other important life events such as moving away from home. Early adulthood is furthermore a period when severe mental disorders, such as bipolar disorder and schizophrenia, may become symptomatic.

Successful method support day for researchers at KI and Region Stockholm

Wed, 31 Jan 2024 13:29:22 +0100

On January 25, a method support day was organized by Clinicum to introduce researchers to the coordinated method support offered to researchers at KI and Region Stockholm. The meeting was held in the Sune Bergström Hall at Karolinska University Hospital.

Appeasing the wheezing: determinants and outcomes of respiratory disease in childhood

Fri, 26 Jan 2024 16:00:07 +0100

Asthma and cystic fibrosis are diseases which affect the lungs of children and adults. Previous research has shown that genetic and environmental factors during pregnancy and early childhood can contribute to the way children and young adults are affected by these lung diseases.

Inherited genetic mutations can predict interval breast cancer

Thu, 25 Jan 2024 17:06:19 +0100

An investigation conducted by researchers at Karolinska Institutet has led to a discovery in breast cancer diagnostics and treatments that could reshape screening programs and clinical approaches. The study, published in JAMA Oncology, unravels the impact of rare genetic variants on interval breast cancers, providing new insights into tailored screening strategies.

Unintentional weight loss associated with increased risk of cancer

Wed, 24 Jan 2024 17:29:26 +0100

Recent and unintentional weight loss is associated with an increased risk of a cancer diagnosis in the coming year, according to a new study in JAMA. Researchers from Karolinska Institutet and others behind the study urge healthcare professionals and the public to be vigilant about sudden and unintentional weight loss.

Mental illness in patients with chronic kidney disease

Fri, 12 Jan 2024 11:53:58 +0100

Chronic kidney disease (CKD) affects over 10% of adults worldwide. Mental health is an important yet under-recognized issue in patients with CKD. Depression is common and related to poor prognosis in CKD patients, but previous research has primarily focused on dialysis patients, leading to an insufficient understanding of depression in earlier stages of CKD.

Genetic epidemiology of depression subgroups and suicide attempts

Tue, 12 Dec 2023 14:50:17 +0100

Major Depressive Disorder (MDD) is a common mental disorder, affecting around 20% of the population worldwide. Several causes that can lead to MDD, and patients display a wide range of symptoms as well as responses to treatments. This diversity makes it challenging to pinpoint the root causes, understand the underlying mechanisms, and tailor treatments effectively. Suicide is a pressing public health concern, impacting not only individuals living with MDD but also the general population.

Ageing more slowly protects against dementia and stroke.

Fri, 08 Dec 2023 11:06:16 +0100

Some people seem to age faster than others. Whilst “chronological age” describes the time that has passed since someone was born, “biological age” tells us how old their body appears. We can measure biological age using standard clinical data such as blood test results and blood pressure readings. Alternatively, we can measure biological age using information about DNA methylation, which are marks on our DNA that change over time.

Genetic and environmental factors influencing the risk and course of eating disorders

Wed, 29 Nov 2023 13:29:05 +0100

Eating disorders are debilitating conditions characterized by dysregulated eating and/or weight-control behaviors leading to significant impairment of psychosocial functioning and/or physical health. Both environmental factors and variation in multiple genetic variants influence eating disorder etiology and maintenance.

New findings on long-term treatment of ADHD and link to cardiovascular disease

Tue, 28 Nov 2023 07:54:24 +0100

A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases. This is according to two new studies led by researchers from Karolinska Institutet and published in The Lancet Psychiatry and JAMA Psychiatry.

Gambling addiction may increase the risk of long-term sick leave

Mon, 20 Nov 2023 13:11:13 +0100

Gambling addiction can increase the risk of long-term sick leave for several years, according to a new study published in Psychological Medicine. Researchers from Karolinska Institutet behind the study point to the need to detect people with gambling addiction in time to avoid financial and health problems.

Benefits of adolescent fitness to future cardiovascular health possibly overestimated

Fri, 17 Nov 2023 17:00:04 +0100

There is a well-known relationship between good physical fitness at a young age and a lower risk of cardiovascular disease later in life. However, when researchers adjusted for familial factors by means of sibling analysis, they found a weaker association, although the link between high body mass index (BMI) and cardiovascular disease remained strong. The study, which was conducted by researchers from Karolinska Institutet and other universities, is published in JAMA Network Open.

Hugo Lagercrantz Award to Jonas F Ludvigsson

Sat, 11 Nov 2023 13:45:13 +0100

The award is presented by the Pediatric research foundation ”Stiftelsen Barnforskningen” at the Astrid Lindgren Children’s hospital.

Genetics and biomarkers of frailty

Mon, 06 Nov 2023 08:33:44 +0100

Frailty is an age-related state of physiological decline and is a strong predictor of disability and mortality. Researchers are trying to improve our understanding of the biology of frailty and to find ways of identifying frail older adults with the aim to improve individualized management of frailty.

Potential overtreatment during life-limiting illness and end of life in older adults

Mon, 30 Oct 2023 15:31:37 +0100

A new thesis from Karolinska Institutet advocates end-of-life care that prioritizes the highest possible quality of life, avoids unnecessary or preventable risks and respects patient wishes.

"We study chronic inflammatory diseases"

Fri, 27 Oct 2023 15:33:08 +0200

Meet Johan Askling, research group leader at the Division of Clinical Epidemiology (KEP), Department of medicine, Solna.

Long COVID most prevalent in the most seriously ill

Fri, 27 Oct 2023 07:00:05 +0200

A collaborative study involving researchers from Karolinska Institutet has charted the prevalence of severe physical symptom burden amongst Scandinavians for up to two years after a SARS-CoV-2 infection. Most affected were people who had a severe COVID-19 infection, while the researchers found no elevated prevalence of long COVID in those who had never been bedridden. The study is published in The Lancet Regional Health – Europe.

Dissertation on the possibilities of AI for precision diagnostics of tumour tissue

Mon, 23 Oct 2023 15:58:53 +0200

In recent years, there have been rapid advancements in the field of computational pathology, which refers to the application of computational methods in pathology workflows. Traditional pathology involves the study of diseases by examining tissues, organs, and bodily fluids. In computational pathology, digital pathology images are analyzed using computer algorithms to extract meaningful information.

Epidemiological studies on breast cancer risk factors and screening

Wed, 18 Oct 2023 14:10:29 +0200

A new thesis from Karolinska Institutet focuses on cancer prevention by investigating the factors and outcomes associated with false-positive mammography recalls, a fairly common event where women are called back for additional tests after an initial screening, but no cancer is detected during the follow-up. A second aim of the thesis was to further our understanding of the association between breast cancer risk factors in women and cancer risk among their relatives, particularly sisters.

Use of antidepressants and risk of manic episodes in children and adolescents

Wed, 27 Sep 2023 21:31:18 +0200

Mania is a possible but rare side effect of treatment with antidepressant medication in adults, but little has previously been known of this risk in depressed children and adolescents. A newly published paper in JAMA Psychiatry investigated this, finding no evidence of mania/hypomania induced by antidepressants by 12 weeks after treatment initiation. However, caution is necessary in treatment for children with more severe depression or where a parent has bipolar disorder.

Olof Stephansson's research group awarded for article on childbirth and bleeding

Thu, 21 Sep 2023 14:32:04 +0200

Olof Stephansson's research group receives Alvarenga's prize 2023 for the article: "Risk of postpartum hemorrhage with increasing first stage of labor duration" with the motto "How long it takes to give birth can affect the risk of bleeding". The prize is awarded by the Swedish Society of Medicine (Svenska Läkaresällskapet).

Comorbidity between neurodevelopmental disorders and childhood-onset type 1 diabetes

Thu, 21 Sep 2023 10:56:27 +0200

Childhood-onset type 1 diabetes (onset

Epidemiological aspects of type 1 diabetes: early life origins, childhood comorbidities, and adult outcomes

Thu, 21 Sep 2023 09:00:39 +0200

Type 1 diabetes is an autoimmune disease, often with onset during childhood, that requires lifelong insulin therapy due to the loss of pancreatic beta-cells.

Liver cancer and severe liver disease more common if a close relative has fatty liver disease

Fri, 08 Sep 2023 12:54:52 +0200

Close relatives of people with metabolic-associated fatty liver disease have a higher risk of developing liver cancer and dying from liver-related diseases, according to a national study from Karolinska Institutet published in The Journal of Hepatology. This means that family members could also benefit from the lifestyle advice that is currently only given to patients, the researchers conclude.

The general factor of psychopathology: precursors and consequences

Fri, 18 Aug 2023 16:08:25 +0200

It is quite common that individuals who have one psychiatric condition, also qualify for other psychiatric conditions. This observation questions the conventional belief that different diagnoses are independent, and instead implies the possibility of a set of factors that increases risks for several types of mental health problems.

New episodes of Riskzonen in August and September

Thu, 10 Aug 2023 10:05:27 +0200

The podcast Riskzonen, featuring well-known KI staff members Mattis Öberg and Emma Frans, is back with a new season! The four episodes were released in May and June, and after a brief break over summer, more episodes will now be released each Monday, starting on 28 August. Each episode features the topic health crisis, in one way or another, ranging from relief efforts in war to antibiotic resistance. The new season is made in collaboration with the Centre for Health Crises.

New study explains how air pollution increases the risk of dementia

Thu, 27 Jul 2023 10:56:56 +0200

Low concentrations of air pollutants are associated with poorer health, and previous research has found a link between air pollution and dementia risk. Researchers at Karolinska Institutet, among others, have now investigated this connection. The study, published in the journal Neurology, contributes to a better understanding of the biological mechanisms that might explain why air pollution seems to increase the risk of developing dementia.

The Viking disease can be due to gene variants inherited from Neanderthals

Wed, 14 Jun 2023 23:05:04 +0200

Many men in northern Europe over the age of 60 suffer from the so-called Viking disease, which means that the fingers lock in a bent position. Now researchers at Karolinska Institutet, together with colleagues, have used data from over 7,000 affected individuals to look for genetic risk factors for the disease. The findings, which have been published in Molecular Biology and Evolution, show that three of the strongest risk factors are inherited from Neanderthals.

Prognosis of nasopharyngeal carcinoma

Wed, 07 Jun 2023 13:19:02 +0200

Nasopharyngeal carcinoma (NPC) is a type of cancer that occurs in the nasopharynx, which is located behind the nose and above the back of the throat. NPC has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. NPC is difficult to detect early, and treatment usually involves radiation therapy, chemotherapy or a combination of the two.

Autistic adults at substantial risk of injuries and age-related conditions

Wed, 07 Jun 2023 08:45:07 +0200

Older autistic adults have a significantly higher risk of injury, especially self-inflicted, and physical conditions such as type 2 diabetes, anaemia, heart failure and COPD. This is according to a large-scale registry study from Karolinska Institutet published in The Lancet Healthy Longevity.

High risk of severe infections among individuals with nonalcoholic fatty liver disease

Mon, 29 May 2023 10:15:42 +0200

In a nationwide Swedish study involving more than 12,000 individuals with nonalcoholic fatty liver disease (NAFLD), researchers found a significantly increased risk of severe infections requiring hospital admission. The study was published in Clinical Gastroenterology and Hepatology.

Microscopic colitis and the risk of acute pancreatitis

Wed, 24 May 2023 10:33:11 +0200

In a nationwide Swedish study of more than 12,000 patients with microscopic colitis (MC), researchers from Sahlgrenska University Hospital and Karolinska Institutet found an increased risk of acute pancreatitis compared to the general population. The study has been published in The American Journal of Gastroenterology.

Apply for grants from SFOepi 2023

Tue, 09 May 2023 15:49:54 +0200

The Strategic Research Program in epidemiology (SFOepi) at Karolinska Institutet now announces funding for three different types of grants; Consolidator Grant for junior researchers, Junior Scholar Grants in Epidemiology or Biostatistics and small grants.

Beyond mammography – complementary methods in breast imaging

Tue, 09 May 2023 09:35:51 +0200

Breast cancer is the most common cancer among women and the likelihood of surviving the disease is higher if the cancer is detected early and the tumour is relatively small and not very aggressive.

Genomes from 240 mammalian species explain human disease risks

Fri, 28 Apr 2023 07:54:31 +0200

Why is it that certain mammals have an exceptional sense of smell, some hibernate, and yet others, including humans, are predisposed to disease? In a major international research project where researchers at Karolinska Institutet participated, has surveyed and analysed the genomes of 240 different mammals. The results, now published in 11 articles in the journal Science, shows which regions have important functions in mammals.

Adjuvant hormone therapy in breast cancer patients – why do women discontinue treatment and what are the consequences?

Thu, 27 Apr 2023 08:46:26 +0200

Breast cancer is the most common cancer affecting women and many women are being treated to prevent the cancer from returning, for example with adjuvant hormone therapy. This therapy is prescribed as a once-a-day pill for estrogen receptor-positive breast cancer patients (around 80% of all cases) for a duration of at least five years.

Systematic review on outcomes of hormonal treatment in youths with gender dysphoria

Wed, 19 Apr 2023 08:33:32 +0200

In a Swedish systematic review published in Acta Paediatrica, researchers from Karolinska Institutet, University of Gothenburg, Umeå University, and the Swedish agency for health technology assessment and assessment of social services, mapped the current knowledge of hormonal treatment in youths <18 years with gender dysphoria.

Colorectal cancer in the mother linked to adverse pregnancy outcome

Fri, 14 Apr 2023 08:37:34 +0200

In a nationwide Swedish study of 207 births to women with an earlier diagnosis of colorectal cancer (CRC), researchers found an increased risk of both maternal and neonatal adverse outcomes. The study was published in eClinicalMedicine and is a collaboration between Washington University in St Louis and Karolinska Institutet.

Prediction-driven decision rules, randomized control study design and survival analysis

Thu, 13 Apr 2023 09:20:16 +0200

Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use predictions based on predictive biomarker signatures to optimize treatment outcomes for increasingly specific subject groups.

People with obesity due to genetic predisposition have lower risk of cardiovascular disease

Thu, 06 Apr 2023 10:00:10 +0200

The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinicalMedicine.

Burden of depression across Scandinavia

Tue, 28 Mar 2023 08:53:01 +0200

A Scandinavian collaboration led by KI researchers shows that of individuals treated in specialist care for major depressive disorder (MDD), many have a severe prognosis, for instance experiencing recurrence, developing other psychiatric disorders, requiring inpatient treatment, and some even dying by suicide. This research was based on 273,000 individuals with MDD in Sweden, Denmark, and Norway. The findings are published in Lancet Regional Health Europe.

Method development for analyzing omics data to study complex diseases

Fri, 24 Mar 2023 14:02:04 +0100

In a new thesis from Karolinska Institutet, the focus was on the use of multiomics data in the discovery of disease signatures.

Risk of cervical cancer twice as high in women with mental illness

Fri, 24 Mar 2023 09:18:56 +0100

Women with mental illness, neuropsychiatric disability, or substance abuse are less likely to go for gynaecological smear tests for cervical cancer and run more than twice the risk of developing the disease. The findings are presented in Lancet Public Health by researchers from Karolinska Institutet, who stress the importance of proactively approaching these women as a preventative measure against cervical cancer.

Development and application of statistical models in cancer epidemiology

Wed, 08 Mar 2023 15:19:16 +0100

Competing risks and multi-state models allow us to study complex disease settings and answer composite research questions and should be used more widely in epidemiology.

Normal gastrointestinal biopsy not protective against later IBD

Fri, 24 Feb 2023 08:26:03 +0100

A Swedish study which followed more than 450,000 individuals after lower or upper gastrointestinal biopsy, suggests that symptoms of IBD (inflammatory bowel disease) may start significantly before disease shows up on biopsy. The results were published in the open access journal PLOS Medicine on Feb 23.

The risk of pregnancy complications for women with axial spondyloarthritis has decreased over time

Thu, 23 Feb 2023 14:48:29 +0100

Women with rheumatic diseases are at greater risk of complications during pregnancy and childbirth, but for women with axial spondyloarthritis the risks have decreased over the last ten years, according to a register study from Karolinska Institutet. This decrease coincided with an increased use of biologic drugs during the same period. The study was published in The Lancet Rheumatology.

Register-based studies of sex steroid hormones and psychiatric disorders

Thu, 09 Feb 2023 14:23:22 +0100

The interplay between sex steroid hormones, psychiatric- and neurodevelopmental disorders and adverse behavioral outcomes is in focus in a new thesis from Karolinska Institutet.

Nicotine exposure during pregnancy may increase risk of sudden infant death

Thu, 09 Feb 2023 06:00:05 +0100

Infants whose mothers have used snus (a moist oral tobacco product) during pregnancy run three times the risk of sudden infant death, according to a comprehensive registry study from Karolinska Institutet published in the journal Pediatric Research. The risk was much lower if the mother had stopped taking snus before the first antenatal visit. The researchers conclude that all types of nicotine products should be avoided during pregnancy.

Serious eating disorder ARFID is highly heritable, according to new twin study

Thu, 02 Feb 2023 11:11:52 +0100

ARFID is strongly influenced by genetic factors, according to a twin study examining this relatively new type of eating disorder. The study has been published in the journal JAMA Psychiatry by researchers at Karolinska Institutet.

Epidemiological studies on frailty and its associations with mortality, dementia, and polypharmacy

Wed, 01 Feb 2023 14:31:36 +0100

Frailty can be defined as an aging-related syndrome of physiological decline, characterized by marked vulnerability to adverse health outcomes. It is becoming an important public health concern as the aging population increases.

ADHD – from childhood into adulthood and older age

Wed, 25 Jan 2023 11:18:32 +0100

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by developmentally inappropriate levels of inattentiveness, hyperactivity, and impulsivity. Symptoms of ADHD often persist into adulthood and psychiatric comorbidities as well as adverse somatic outcomes can emerge across the lifespan.

Prostate cancer management: towards personalization with AI-assisted pathology and improved active surveillance

Tue, 24 Jan 2023 16:07:53 +0100

Prostate cancer is a major global health concern and is the most common cancer-related cause of death in Sweden. Prostate cancer screening using PSA reduces prostate cancer mortality but also leads to significant overdiagnosis and overtreatment of low-risk cancers. The pathological evaluation of prostate biopsies determines the therapeutic course of treatment for prostate cancer patients.

Overall quality of the Swedish Medical Birth Register is high

Mon, 09 Jan 2023 11:32:59 +0100

In a review paper published in the European Journal of Epidemiology, researchers from Karolinska Institutet and Lund University describe the content and quality of the Swedish Medical Birth Register (MBR), using original Medical Birth Register data, Swedish-language and international publications based on the register. The researchers conclude that the register contains high-quality pregnancy-related information on more than 5 million births during five decades.

Double embryo transfer in assisted reproduction increased the risk of complications in singleton births

Thu, 08 Dec 2022 12:44:47 +0100

The risk of complications in assisted reproduction is higher when two embryos are transferred, instead of one embryo. This has been shown in a study published in the journal JAMA Pediatrics, which included all births in Sweden 2007-2017.

Workplace dust and fumes may increase the risk of rheumatoid arthritis

Wed, 07 Dec 2022 09:39:14 +0100

Breathing in common workplace dust and fumes may increase the risk of developing severe rheumatoid arthritis, especially in combination with smoking and genetic susceptibility to the disease, suggests a new study from Karolinska Institutet published in The Annals of the Rheumatic Diseases.

Prostate cancer testing in Sweden - a study on cost and effectiveness

Wed, 30 Nov 2022 16:06:23 +0100

Prostate cancer constitutes an essential public health issue, as it is a major cause of male deaths. Early detection through an organised testing program with the prostate-specific antigen (PSA) test and systematic biopsy is not in place in most countries due to the risk of over-diagnosis and over-treatment of low-risk cancers. Now there are two proposed approaches to tackle this problem; magnetic resonance imaging (MRI) and the serum-based reflex test “Stockholm3”.

Developing Artificial Intelligence tools for breast cancer precision pathology

Mon, 28 Nov 2022 13:17:42 +0100

Breast cancer is the most common cancer type in women globally, but there is a continuous decline in mortality rates. A partial explanation for this may be that effective treatments are being developed for subgroups of breast cancer patients. It is still challenging to optimise treatment plans for every individual.

Oxygen deprivation at birth could increase risk of cardiovascular disease

Thu, 03 Nov 2022 09:21:46 +0100

An observational study at Karolinska Institutet shows that babies suffering oxygen-deficiency complications at birth are almost twice as likely to develop cardiovascular disease during childhood and early adulthood as those without such complications. Still, the absolute risk of cardiovascular disease is very low in young age. The findings are published in the journal The Lancet Regional Health – Europe.

Diverticular disease associated with cancer outside gastrointestinal tract

Fri, 28 Oct 2022 11:28:53 +0200

Through the ESPRESSO cohort, researchers from Massachusetts General Hospital, Boston, University of Newcastle, Australia, University of Washington, Seattle, and Karolinska Institutet examined the risk of cancer among 75,000 patients with a diagnosis of diverticular disease and colorectal histopathology. The paper is now published in JNCI, the Journal of the National Cancer Institute.

Autistic women have increased risk of mental illness

Wed, 26 Oct 2022 17:00:05 +0200

Autistic young men and women are more affected by psychiatric conditions and have an increased risk of being hospitalized as a result of their mental illness compared with non-autistic people. Autistic women are particularly vulnerable. This is shown by researchers from Karolinska Institutet in a study published in JAMA Psychiatry.

Epidemiology, prevention and control of hepatitis A virus infection in the European Union

Mon, 24 Oct 2022 11:47:02 +0200

Hepatitis A is an acute liver disease caused by the hepatitis A virus (HAV) and transmitted via the faecal-oral route through person-to-person transmission, contaminated food or water. While hepatitis A infection is mostly asymptomatic in children, the frequency and severity of symptoms increases with age, with the elderly and patients with other liver disease at risk of hospitalisation, acute liver failure and death.

Colonoscopy screening for colorectal cancer prevention not as effective as previously believed

Mon, 10 Oct 2022 08:57:10 +0200

A randomized study, known by the acronym NordICC – Northern - European Initiative on Colorectal Cancer - shows colonoscopy screening reduces the risk of colorectal cancer by 18 percent. The reduction is much smaller than experts previously assumed. The NordICC study is now published in the New England Journal of Medicine (NEJM).

Professor Jonas Ludvigsson awarded the "Gut Feeling" of the year 2022

Fri, 07 Oct 2022 08:54:55 +0200

During the Annual pediatric IBD meeting in Örebro on September 29-30, Jonas F Ludvigsson received this year’s honorary award "the Gut Feeling" SPGHN, the Swedish Association for Pediatric Gastroenterology, Hepatology and Nutrition, amidst the cheers of the audience. The prize is awarded after voting by pediatricians in Sweden.

Genetic and environmental factors contribute to the overlap between depression and endocrine-metabolic disorders

Wed, 28 Sep 2022 15:59:17 +0200

Depression is common in individuals with endocrine-metabolic disorders and vice versa. In a study involving 2.2 million people in the Swedish population, researchers at Karolinska Institutet confirmed that individuals with endocrine-metabolic disorders have increased rates of depression and found that there are also higher rates of depression in their siblings. The study is published in the American Journal of Psychiatry.

New knowledge about the link between infection during pregnancy and autism

Thu, 08 Sep 2022 00:30:06 +0200

Infections in pregnant women have been linked to an increased risk of neurodevelopmental conditions, such as autism, in the child later in life. But it does not seem to be the infections themselves that cause autism, researchers from Karolinska Institutet show in a study published in The Lancet Psychiatry.

Review and commentary on the national COVID-19 commission inquiry

Wed, 07 Sep 2022 09:20:45 +0200

Sweden initially chose a different disease prevention and control path during the pandemic than many other European countries. In June 2020, the Swedish Government established a national Commission to examine the management of COVID-19 in Sweden. In a review, Professor Jonas F Ludvigsson summarizes and comments on the findings of the commission inquiry. The review is published in Acta Paediatrica.

New findings suggest new omicron BA.2.75 is as susceptible to antibodies as the currently dominant variant

Fri, 02 Sep 2022 08:59:50 +0200

In a recent study researchers from Karolinska Institutet, among others, have characterised the new omicron variant BA.2.75, comparing its ability to evade antibodies against current and previous variants. The study, published in the journal The Lancet Infectious Diseases, suggests that BA.2.75 is not more resistant to antibodies than the currently dominating BA.5, which is positive news.

Gastroesophageal reflux disease and esophageal cancer

Tue, 30 Aug 2022 09:16:43 +0200

Esophageal cancer is the seventh most common cancer world-wide and a lethal malignancy causing a considerably high number of deaths. There is currently no promising method for prevention, early detection, or screening of esophageal cancer so most patients are diagnosed at an advanced stage, which is associated with a poor prognosis.

Svenska Läkaresällskapet awards Professor Jonas F Ludvigsson their prestigious Jubilee Prize

Mon, 22 Aug 2022 08:36:37 +0200

Svenska Läkaresällskapet (The Swedish Medical Society, SLS) has decided to award Professor Jonas F Ludvigsson at Karolinska Institutet with the society's prestigious Jubilee Award. The prize winner is awarded SEK 150,000 and the SLS century medal in silver.

Infertility and assisted reproductive techniques

Thu, 18 Aug 2022 13:39:00 +0200

In a new thesis from the Department of Medical Epidemiology and Biostatistics, Chen Wang used nationwide Swedish register data to assess the long-term health of children conceived with assisted reproductive techniques (ART) and attempted to develop prediction models of pregnancy complications among women undergoing ART.

Review paper about the Swedish Military Conscription Register

Mon, 11 Jul 2022 15:22:13 +0200

The Swedish Military Conscription Register contains data on some 2 million individuals. Conscripts underwent extensive testing, data that can be used in epidemiological research. Now researchers from Karolinska Institutet, Uppsala University and Lund University publish a review about the register in the European Journal of Epidemiology.

Machine learning methods for precision medicine

Fri, 01 Jul 2022 14:10:18 +0200

In precision medicine, predicting the risk of an event during a specific period may help, for example, to identify patients that need early preventive treatment. Modern machine learning (ML) techniques are therefore ideal for building these predictions.

Risk factors for severe COVID-19 complication in children investigated in Swedish population-based study

Wed, 22 Jun 2022 15:20:46 +0200

Severe acute COVID-19 is very rare in children, but SARS-CoV-2 infection can trigger a novel post infectious condition called Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C is a potentially serious condition, and so far, little has been known on risk factors for developing MIS-C.

End-stage liver disease in Ghana - a clinical epidemiological study

Fri, 10 Jun 2022 15:24:19 +0200

End-stage liver disease (ESLD), including advanced liver cirrhosis and primary liver cancer, is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic liver disease. There is a high disease burden and mortality globally, especially in sub-Saharan African (SSA) countries such as Ghana, where the primary cause of HCC and cirrhosis is infection with hepatitis B virus (HBV).

Taking 5-ARIs for BPH is not associated with increased mortality in prostate cancer

Tue, 31 May 2022 13:17:09 +0200

5-alpha-reductase inhibitors (5-ARIs), Finasteride and Dutasteride, are commonly used to treat lower urinary symptoms in older men with benign prostate hyperplasia. There has long been concern that these drugs may increase the risk of more aggressive forms of prostate cancer. In a new study recently published in JAMA Oncology, researchers at Karolinska Institutet found no increased risk of dying from prostate cancer for men treated with the drugs and lower risk with longer treatment duration.

Epidemiology of microscopic colitis – risk of associated disorders and death

Tue, 24 May 2022 08:58:21 +0200

Microscopic colitis is the most recently recognized inflammatory condition of the large intestine in which abnormal reactions of the immune system cause inflammation of the inner lining of the colon. At present, more than 10,000 people in Sweden are estimated to be living with the disease. Previously, insufficient awareness and knowledge of microscopic colitis have led to underdiagnosis of the disorder, leaving patients untreated.

Declines in reported cancers in early phase of COVID-19 pandemic in the Nordic countries

Wed, 27 Apr 2022 10:00:06 +0200

A study from Karolinska Institutet and the Nordic cancer registries shows that cancer notification rates declined in the Nordic countries during the early phase of the COVID-19 pandemic in April-May 2020 compared to previous years. In the fall of 2020, the cancer rates recovered in Denmark, Norway and Iceland, yet only partly in Sweden and Finland. In the Faroe Islands, the changes in cancer rates were not statistically significant. The study was published in International Journal of Cancer.

Systematic review of Ukrainian children’s health

Mon, 25 Apr 2022 13:47:53 +0200

Millions of Ukrainian children have been displaced, either internally or as refugees, by the war with Russia. A systematic review by researchers at Karolinska Institutet and Ukraine’s Sumy State University has compiled the scientific literature on children’s health in Ukraine. The study, which is published in the journal Acta Paediatrica, could prove useful for clinicians treating refugee children from Ukraine.

New study shows good mental health in young adults born after assisted reproduction

Wed, 15 Dec 2021 17:00:03 +0100

Use of assisted reproductive techniques (ART) does not lead to poorer mental health in children across adolescence and young adulthood, according to a large observational study led by researchers at Karolinska Institutet. The study, published in JAMA Psychiatry, found a slightly higher risk of obsessive-compulsive disorder for those born after ART but this was explained by parental background factors.

Good vaccine news counters online skepticism, but only for a limited time

Wed, 15 Dec 2021 08:10:18 +0100

Media coverage of positive vaccine research can have a positive effect on overall social media sentiment – countering vaccine misinformation – but the effects wane over time. Researchers at Oxford University and Karolinska Institutet have analysed social media to investigate associations between vaccine-related major news announcements, and attitudes towards vaccines.

Professor Catarina Almqvist Malmros awarded research prize from the Swedish Association for Allergology

Fri, 19 Nov 2021 14:04:23 +0100

Catarina Almqvist Malmros, pediatrician at Astrid Lindgren's Childrens Hospital and professor at Karolinska Institutet, receives a research prize from the Swedish Society of Medicine's section Swedish Association for Allergology.

Tuberculosis programs should focus more on young people, researchers say

Wed, 15 Sep 2021 00:30:05 +0200

Young people are at risk of falling seriously unwell with tuberculosis and spreading the disease. Therefore, researchers at Karolinska Institutet, among others, have mapped key factors that affect the treatment outcomes in 10- to 24-year-olds with tuberculosis in Brazil, where the disease is increasing. To deal with the global tuberculosis epidemic, researchers say that greater focus is needed on this age group in tuberculosis programs. The study is published in The Lancet Global Health.

Even low levels of air pollution can increase the risk of cardiovascular disease

Wed, 08 Sep 2021 17:41:50 +0200

Prolonged exposure to air pollution can be linked to an increased risk of stroke and coronary heart disease, even when levels are below the limits specified by the EU and WHO. This has been shown, among others, by researchers at Karolinska Institutet and Helmholtz Zentrum München in a large European study published in The Lancet Planetary Health.

Fatty liver more common in children of mothers with obesity

Mon, 19 Jul 2021 00:05:03 +0200

Children and young people whose mothers had a BMI greater than 30 during early pregnancy are at an increased risk of fatty liver disease. This is shown in a register-based study from Karolinska Institutet and Harvard University published in the journal Journal of Hepatology. As obesity rates increase also in women at a child-bearing age, more and more young people are at risk of developing fatty liver disease, the researchers say.

Adult ADHD is linked to numerous physical conditions

Wed, 07 Jul 2021 00:30:04 +0200

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet published in The Lancet Psychiatry.

Study on five million Swedes finds links between blood groups and disease risks

Tue, 27 Apr 2021 11:23:55 +0200

Researchers at Karolinska Institutet have found links between certain blood groups and a total of 49 diseases, including a new finding that having blood group B seems to be a protective factor against kidney stones. The study, which includes data on more than five million people and over 1,000 diseases, confirms previously identified connections between certain blood groups and increased risk of blood clots, bleeding conditions or pregnancy-induced hypertension. The result is published in eLife.

Large genetic study sheds light on the causes of hemorrhoids

Fri, 23 Apr 2021 11:23:12 +0200

Although hemorrhoids are a common health problem, relatively little is known about the field, possibly because many people find them difficult to talk about. Researchers linked to Karolinska Institutet have been involved in a study that has analysed the genomes of almost a million people and found previously unknown causes of severe hemorrhoids. The study, which is published in the journal Gut, also reveals links to other gastrointestinal diseases.

Professor Juan-Jesus Carrero receives ERA-EDTA award of excellence

Fri, 16 Apr 2021 15:50:03 +0200

The European Renal Association – European Dialysis and Transplant Association has just announced their annual awards and Professor Juan-Jesus Carrero from the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet will receive the ERA-EDTA Award for Research Excellence for his work in kidney epidemiology, on June 7, 2021 at the 58th ERA-EDTA Congress.

Chlamydia trachomatis infection in Sweden - new thesis sheds light on time trends, prevalence and risk factors

Mon, 22 Feb 2021 11:53:15 +0100

Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI), with about 127 million new cases estimated annually worldwide. Since it is an asymptomatic infection, individuals may carry it for a long time and unknowingly transmit the infection to others.

Opioid prescriptions remained elevated two years after critical care

Tue, 02 Feb 2021 15:00:04 +0100

Nearly 11 percent of people admitted to an intensive care unit in Sweden between 2010 and 2018 received opioid prescriptions on a regular basis for at least six months and up to two years after discharge. That is according to a study by researchers at Karolinska Institutet published in Critical Care Medicine. The findings suggest some may become chronic opioid users despite a lack of evidence of the drugs’ long-term effectiveness and risks linked to increased mortality.

Adaptation of the Charlson comorbidity index (CCI) for register-based research in Sweden

Thu, 14 Jan 2021 12:56:33 +0100

The Charlson co-morbidity index (CCI) is a disease index that was originally created to predict short-term mortality but is increasingly used as a proxy for comorbidity burden, and is often used as a co-variate, for instance in regression models. There are currently several available versions of the CCI. The existence of multiple morbidity indices creates confusion, increases the risk of mistakes and requires individual researchers to spend considerable time examining included codes.

Risk assessment and prevention of breast cancer

Fri, 08 Jan 2021 09:23:26 +0100

One woman in eight develops breast cancer during her lifetime in the Western world and although mammography screening reduces mortality by early detection, approximately one fourth of the women who develop breast cancer are diagnosed within two years after a negative screen.

Low risk of severe COVID-19 in children

Wed, 06 Jan 2021 23:08:44 +0100

So far, little research has been done on the risk of children being seriously affected by COVID-19 when the schools were open. A study from Karolinska Institutet has now shown that one child in 130,000 was treated in an intensive care unit on account of COVID-19 during the period March-June. The work has been published as a letter to the editor in New England Journal of Medicine.

Insights into nasopharyngeal carcinoma: risks and prognosis

Mon, 30 Nov 2020 13:17:10 +0100

Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It is known that the interaction of Epstein-Barr Virus infection, environmental and lifestyle factors, and genetic susceptibility, contributes to NPC carcinogenesis.

Attention-deficit/hyperactivity disorder and adverse health outcomes

Fri, 27 Nov 2020 16:37:37 +0100

Shihua Sun has investigated the associations between attention-deficit/hyperactivity disorder (ADHD) and specific adverse outcomes including asthma and premature death. In his thesis, Shihua included four studies to clarify the magnitude and etiology of the associations, as well as potential effects from medication treatment that may prevent poor prognosis.

Breast cancer risk - determinants and influence of mammographic features

Fri, 20 Nov 2020 13:36:37 +0100

In her thesis, Shadi Azam studied the association between established breast cancer risk factors with mammographic density change over time and mammographic microcalcifications by using data from the prospective KARMA cohort.

They are on the 2020 highly cited list

Wed, 18 Nov 2020 12:01:42 +0100

Thirteen researchers connected to Karolinska Institutet are on the 2020 list of highly cited researchers presented by Clarivate, the company behind Web of Science.

Case report of potential “long COVID” in children

Wed, 18 Nov 2020 09:09:36 +0100

Recent data suggest that adults may experience long-term symptoms after COVID-19 infection, but if such symptoms also occur in children is still unknown. Children tend to have milder COVID-19 than adults, but in a case-report from Sweden, Professor and pediatrician Jonas F Ludvigsson describes five children with potential “long COVID”. These findings, together with a systematic review of long COVID in children, are published in the journal Acta Paediatrica.

Early-life events linked to lung health in young adulthood

Thu, 12 Nov 2020 09:00:04 +0100

Early-life events, such as the exposure to air pollutants, increases the risk of chronic lung disease in young adulthood, according to new results by researchers at Karolinska Institutet, Sweden, published in the European Respiratory Journal and Thorax. The studies add to the growing evidence that chronic lung disease in adulthood can be traced back to childhood.

New major proteogenomic study on circulating proteins gives new insights for translational studies and drug development

Mon, 02 Nov 2020 11:58:02 +0100

A new paper shows that differences in plasma protein biomarker levels are controlled by hundreds of genetic variants across the human genome, and that these insights can be used to predict which drug targets that are likely to be effective future medicines. The study has been published in the October issue of Nature Metabolism.

Exposure to common parental mental illness linked to socioeconomic adversity among children

Tue, 27 Oct 2020 11:52:34 +0100

“An important finding of the study was that any type of parental mental illness strongly increased the risk of childhood socioeconomic adversity.” says Kyriaki Kosidou, researcher at KI and corresponding author of the newly published article about parental mental illness and its association with socioeconomic adversity among children in Sweden.

Emergence and maintenance of eating disorders - the influence of body mass, gastrointestinal and dietary factors

Mon, 26 Oct 2020 13:19:35 +0100

In her thesis, Camilla Wiklund aims to extend the knowledge about the relationship among body mass index (BMI), gastrointestinal complaints, and diet, and how these factors contribute to the emergence and maintenance of eating disorders.

Women with cervical cancer may have increased risk of injury during diagnostic workup

Wed, 21 Oct 2020 09:21:56 +0200

Among women participating in cervical cancer screening in Sweden, those with a diagnosis of invasive cervical cancer had an increased risk of iatrogenic injuries (as a consequence of medical intervention) and non-iatrogenic injuries (caused by accidents and self-harm) requiring hospitalization, according to results published in Cancer Epidemiology, Biomarkers & Prevention.

Improved survival for cancer patients in a large Nordic comparison

Mon, 19 Oct 2020 13:06:33 +0200

A comprehensive comparison of cancer survival between the Nordic countries shows improvements for all countries over time with previously observed differences attenuated. The reasons for these improvements are likely multifactorial. Previous studies comparing cancer survival between the Nordic countries have found marked differences, with a notably poorer survival in Danish patients.

Even mild fatty liver disease is linked to increased mortality

Mon, 12 Oct 2020 14:44:40 +0200

Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the scientific journal Gut.

SARS-CoV-2 during pregnancy was not associated with complications in neonates

Wed, 23 Sep 2020 17:14:29 +0200

In a study published in JAMA researchers at Karolinska Institutet and Karolinska University Hospital have examined the association between a positive SARS-CoV-2 test during pregnancy and complications in mothers and their newborn babies. Almost two out of three pregnant women who tested positive for SARS-CoV-2 were asymptomatic and the researchers found no higher prevalence of complications during delivery or of ill-health in the neonates. However, preeclampsia was more common in infected women.

The first eight months of Sweden’s COVID-19 strategy

Mon, 21 Sep 2020 09:01:47 +0200

Sweden chose a different pandemic strategy than its peer nations. This included the timing of pandemic-related actions, how parts of the healthcare system reacted to the pandemic, the legal framework for the relationship between the Government and other actors and actions taken with regard to schools. In a paper published in Acta Paediatrica, Professor Jonas F Ludvigsson presents a detailed timeline on how Sweden tackled COVID-19 during the eight months up to 1 September, 2020.

Molecular epidemiology studies on risk factors and aggressive breast cancer

Wed, 16 Sep 2020 09:05:06 +0200

In his thesis, Emilio Ugalde Morales uses a molecular epidemiology approach to investigate the association between risk factors and aggressive breast cancer defined by tumor characteristics, intrinsic subtypes, mode of detection, and survival.

Swine flu vaccination in pregnant women did not increase risk of autism in offspring

Tue, 01 Sep 2020 06:00:05 +0200

Two recent studies were unable to rule out that H1N1 (“swine flu”) vaccination (“Pandemrix”) and seasonal influenza vaccination given to pregnant women might be associated with autism spectrum disorder in the offspring. Now, a large study by researchers at Karolinska Institutet in Sweden, published in the journal Annals of Internal Medicine, refutes any such association.

Novel statistical methods for genome-wide association summary statistics

Fri, 28 Aug 2020 11:25:33 +0200

At the moment we live in an era where it is easier to generate data than to interpret them. The focus of Zheng Ning’s thesis is on methodology and analysis to exploit novel biological knowledge from published results of genome-wide association study (GWAS).

Frailty a better prognostic factor than age for predicting COVID-19 survival

Wed, 19 Aug 2020 08:12:14 +0200

New research from Karolinska Institutet shows that the degree of frailty, a measure of a person’s functional level before contracting the disease, can better predict COVID-19 survival than the patient’s age. The analysis of 250 multimorbid older adults who received care for COVID-19 at the Aging Theme at Karolinska University Hospital in Huddinge, Sweden also shows that three out of four of these patients survived. The study has been published in the scientific journal JAMDA.

Increased risk of small bowel cancer in individuals with celiac disease - but absolute numbers are low

Thu, 16 Jul 2020 13:28:47 +0200

Through a unique database, KI researchers have studied the risk of small bowel cancer in individuals with celiac disease. Principal investigator Louise Emilsson, affiliated researcher at the Department of Medical Epidemiology and Biostatistics, associate professor at HELSAM, Oslo University and co-author Jonas F Ludvigsson, professor at Karolinska Institutet, reflect on their work recently published in Gastroenterology.

Apgar score effective in assessing health of preterm infants

Thu, 02 Jul 2020 06:00:04 +0200

The vitality of preterm infants should be assessed with an Apgar score, a tool used to measure the health of newborns immediately after birth. That is the conclusion by researchers at Karolinska Institutet in Sweden who in a large observational study examined the value of Apgar scores for preterm infants. The findings are published in the New England Journal of Medicine.

Inflammatory bowel disease (IBD) and small bowel cancer – a binational study

Mon, 01 Jun 2020 14:42:29 +0200

In a population-based cohort study from Sweden and Denmark of patients with inflammatory bowel disease (IBD) during 1969-2017 and matched reference individuals from the general population, Ola Olén, Jonas F Ludvigsson and colleagues found that IBD patients had an increased risk of small bowel cancer.

Etiology and prognosis of gastric and esophageal cancer explored

Fri, 29 May 2020 15:53:21 +0200

The focus of Isabella Ekheden's thesis is on gastric and esophageal cancer – gastroesophageal cancers - that are some of the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance with the potential of lowering the disease burden.

Children unlikely to be the main drivers of the COVID-19 pandemic

Wed, 20 May 2020 10:22:44 +0200

It is highly likely that children can transmit the new coronavirus, which causes COVID-19, but several factors suggest that children are unlikely to be the main drivers of the pandemic. Opening up schools and kindergartens is unlikely to impact COVID-19 mortality rates in older people, according to a systematic review that spanned 47 publications and was conducted by researchers at Karolinska Institutet. The paper is published in the scientific journal Acta Paediatrica.

Personality, stress and risk of Parkinson's disease

Tue, 12 May 2020 11:40:38 +0200

The focus of Johanna Sieurin's thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD).

Artificial intelligence for streamlining prostate cancer diagnostics

Mon, 27 Apr 2020 13:09:26 +0200

The objective of Peter's thesis is to develop and improve technologies for prostate cancer diagnostics and to acquire knowledge related to these technologies that directly translate to clinical utility.

Celiac disease linked to increased mortality

Tue, 07 Apr 2020 17:13:00 +0200

People with celiac disease have increased risk of dying prematurely, despite increased awareness of the disease in recent years and better access to gluten-free food. This is according to a new study from Karolinska Institutet in Sweden and Columbia University in the U.S. published in the prestigious journal JAMA. Celiac disease was linked to increased risk of death from cardiovascular disease, cancer and respiratory disease.

Stress during cancer diagnostic workup

Thu, 02 Apr 2020 13:14:52 +0200

Qing Shen’s thesis aims to increase our understanding of cancer diagnostic workup, by investigating different stress-related health outcomes during the critical time period of cancer evaluation, diagnosis and treatment, and also provide evidence for a potential effective treatment approach to attenuate excessive risks of stress-related health outcomes.

Breast density, microcalcifications, and masses may be heritable traits

Thu, 02 Apr 2020 09:30:05 +0200

Some mammographic features - breast density, microcalcifications, and masses - are associated with increased breast cancer risk

Milder symptoms and better prognosis in children with COVID-19

Mon, 23 Mar 2020 17:16:12 +0100

Children infected with the new coronavirus generally have less severe symptoms than adults, they rarely need intensive care and very few child deaths have been reported. This according to a systematic review of COVID-19 in children, based on 45 relevant publications and performed by researchers at Karolinska Institutet. The review is published in the scientific journal Acta Paediatrica.

Polyps and Colorectal Cancer risk

Tue, 17 Mar 2020 07:00:04 +0100

Patients with polyps have a higher risk of colorectal cancer, and those with sessile serrated polyps, tubulovillous adenomas, and villous adenomas had a higher colorectal cancer mortality.

Prevention and prognosis of cervical cancer

Mon, 09 Mar 2020 11:41:00 +0100

Jiayao Lei’s thesis addresses research questions on prevention and prognosis of cervical cancer within the framework of the interplay of human papillomavirus (HPV), vaccination, and cervical screening, and also provides insights for evidence-based decision-making.

Socioeconomic inequalities and cardiovascular disease in Sweden

Mon, 02 Mar 2020 16:45:32 +0100

In her thesis, Ninoa Malki concludes that socioeconomic differences are associated with both incidence and mortality of cardiovascular disease in Sweden.

Crohn's disease linked to increased risk of colorectal cancer

Sat, 15 Feb 2020 03:00:00 +0100

Researchers from Karolinska Institutet, Örebro University and Aarhus University, Denmark, have published the largest study to date on the risk of colorectal cancer in Crohn's disease. The article is published in the journal The Lancet Gastroenterology Hepatology.

New measure of biological age can predict health risks

Tue, 11 Feb 2020 07:42:27 +0100

People age in different ways. Biological age is a metric that scientists use to predict health risks, the relevance of which can be enhanced by combining different markers. Particularly important markers are frailty and the epigenetic clock, write researchers from Karolinska Institutet in a study published in eLife.

600 000 SEK earmarked for research on prevention of suicide

Tue, 04 Feb 2020 13:16:33 +0100

The Swedish organisation Psykiatrifonden has just announced which projects will receive research funding by money earmarked for suicide preventative research donated by Suicide Zero. Lotfi Khemiri at Karolinska Institutet is responsible for one of the projects and is studying the connection between substance abuse and risk of suicide.

Thesis on DNA methylation and aging - a twin study

Mon, 13 Jan 2020 11:18:19 +0100

On Friday January 31, Yunzhang Wang will defend his thesis "DNA methylation and aging : a longitudinal study of old Swedish twins".

Thesis on association between neuroinflammation and ALS and MS

Tue, 03 Dec 2019 15:59:44 +0100

On Friday December 18, Elisa Longinetti will defend her thesis "Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation: nationwide epidemiological studies on etiology, comorbidities, and treatment"

Thesis on sex differences in cancer risk and survival

Wed, 20 Nov 2019 15:24:54 +0100

On Friday December 6, 2019 Cecilia Radkiewicz defended her thesis "Sex differences in cancer risk and survival".

Thesis on statistical models of breast cancer tumour growth and spread

Mon, 18 Nov 2019 11:07:38 +0100

On Tuesday December 10, Gabriel Isheden will defend his thesis Statistical models of breast cancer tumour growth and spread".

Low IQ, family history tied to treatment resistant schizophrenia

Tue, 12 Nov 2019 02:00:00 +0100

Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Molecular Psychiatry. The researchers say the findings could be important in efforts to design novel drug treatments that improve cognition.

Thesis on the comorbidity between ADHD disorder and other neurodevelopmental disorders: aetiology, treatment and outcomes

Wed, 25 Sep 2019 11:07:38 +0200

Title: The comorbidity between attention-deficit/hyperactivity disorder and other neurodevelopmental disorders: aetiology, treatment and outcomes

Thesis on risk prediction in prostate cancer diagnostics

Mon, 16 Sep 2019 10:36:46 +0200

Title: Risk prediction in prostate cancer diagnostics : current challenges and improvements

Thesis on socioeconomic influences on late-life health and mortality

Mon, 16 Sep 2019 10:36:46 +0200

Title: Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay

MEB biostatisticians awarded research environment grant for research in statistical methods for register-based research

Fri, 13 Sep 2019 11:44:44 +0200

A group of biostatistical scientists at the Department of Medical Epidemiology and Biostatistics (MEB) have been awarded a research environment grant of SEK 13 million from the Swedish Research Council for research into the development and application of statistical methods for register-based research.

The Swedish Society of Medicine awards ”Maternal Glycemic Control in Type 1 Diabetes and the Risk of Preterm Birth” the Alvarenga Prize 2019 for best medical paper

Fri, 23 Aug 2019 11:07:04 +0200

The paper's motto was: ”Among women with diabetes and high HbA1c, there is a risk that the fetus too early the outside world will see” The winning study was led by Professor Jonas F Ludvigsson, Department of Medical Epidemiology and Biostatistics, KI, and shows that pregnant women with type 1 diabetes are at increased risk of pregnancy complications, including preterm birth. With increasing HbA1c the risk of preterm birth increased further.

Statins can prevent liver cancer

Tue, 20 Aug 2019 08:23:06 +0200

Fat-soluble statins can prevent liver cancer and reduce mortality in patients with chronic viral hepatitis. These are findings from a study conducted by researchers at Karolinska Institutet in Sweden, among others. The study is published in Annals of Internal Medicine.

Increased risk of psychiatric disorders in children with IBD

Mon, 19 Aug 2019 17:03:13 +0200

Children with Inflammatory Bowel Disease (IBD) run a greater risk of psychiatric disorders, according to a new study from Karolinska Institutet in Sweden published in JAMA Pediatrics. The researchers claim that more psychological support and longer follow-up is needed for the children affected and their parents.

Psychiatric comorbidity contributes to increased mortality in ADHD

Wed, 07 Aug 2019 17:09:14 +0200

Psychiatric comorbidity may play an important role in the increased risk of premature death in people with ADHD (attention-deficit/hyperactivity disorder), according to a new extensive registry study conducted at Karolinska Institutet and Örebro University in Sweden. The results, which are published in JAMA Psychiatry, suggest that improved awareness and care of psychiatric comorbidities such as substance use disorders may help reduce serious outcomes associated with ADHD.

Jonas Ludvigsson published paper of the year in the American Journal of Gastroenterology

Tue, 16 Apr 2019 10:46:53 +0200

Review paper about important database - LISA

Mon, 01 Apr 2019 16:29:35 +0200

Painkillers during pregnancy unlikely to cause asthma

Mon, 18 Mar 2019 08:00:00 +0100

Low physical fitness in adolescence linked to higher risk of disability pension later in life

Tue, 12 Feb 2019 09:55:56 +0100

MEB scientists among Highly Cited Researchers

Fri, 21 Dec 2018 13:27:37 +0100

Jonas Ludvigsson top-ranked for research on celiac disease

Thu, 13 Dec 2018 13:21:48 +0100

New head of department for MEB

Mon, 03 Dec 2018 10:39:24 +0100

17 November: World Prematurity Day and medical research

Tue, 13 Nov 2018 12:04:26 +0100

High-risk HPV linked to improved survival in cervical cancer

Wed, 03 Oct 2018 09:51:30 +0200

Cinnamon Bun Day and celiac disease

Mon, 01 Oct 2018 08:53:53 +0200

Caesarean delivery, preterm birth and risk of food allergy - new article in Journal of Allergy and Clinical Immunology

Wed, 05 Sep 2018 14:17:06 +0200

Iceland’s president visits Karolinska Institutet

Thu, 18 Jan 2018 14:00:02 +0100

Polyunsaturated fatty acids linked to reduced allergy risk

Tue, 05 Dec 2017 15:34:33 +0100

Previous screening results important for smear-test decision after age 60

Wed, 25 Oct 2017 08:15:56 +0200

Strong emphasis on collaboration to tackle health challenges

Tue, 12 Sep 2017 18:00:07 +0200

Swedish snus can be as damaging to the fetus as smoking

Fri, 12 May 2017 11:12:44 +0200

Overweight in young men associated with severe liver disease in later life

Thu, 23 Mar 2017 15:59:37 +0100

51 million SEK to 13 researchers at the department

Wed, 04 Nov 2015 17:03:26 +0100

No link between atrial fibrillation and drinking coffee

Wed, 23 Sep 2015 08:00:00 +0200

Low resting heart rate associated with increased violent criminality

Thu, 10 Sep 2015 10:53:51 +0200

Extensive study of five-year mortality risk

Thu, 04 Jun 2015 13:55:37 +0200

Study questions beneficial effects of a Nordic diet on cardiovascular events

Thu, 21 May 2015 08:30:00 +0200

Per Hall awarded a framework grant in clinical therapy research

Mon, 08 Dec 2014 14:37:55 +0100

Causal link between antibiotics and childhood asthma dismissed

Mon, 01 Dec 2014 09:56:59 +0100

Two studies identify pre-cancerous state in the blood

Thu, 27 Nov 2014 11:45:35 +0100

Sara Hägg awarded stipend from Erik Rönnberg's Foundation

Wed, 12 Nov 2014 16:01:05 +0100

Riksbankens Jubileumsfond has awarded Sara Hägg a stipend from Erik Rönnberg's Foundation.

Scientists dismiss the link between epilepsy and the flu vaccine

Fri, 28 Dec 2012 00:00:00 +0100

Eating (milk) chocolate may lower risk of getting a stroke

Thu, 30 Aug 2012 00:00:00 +0200

Higher maternal age increases risk of autism

Wed, 02 May 2012 00:00:00 +0200