https://ki.se RSS News Listing https://news.ki.se/common-inexpensive-drug-halves-recurrence-in-colorectal-cancer A Swedish-led research team at Karolinska Institutet and Karolinska University Hospital has shown in a new randomized clinical trial that a low dose of the well-known medicine aspirin halves the risk of recurrence after surgery in patients with colon and rectal cancer with a certain type of genetic alteration in the tumor. Wed, 17 Sep 2025 23:00:14 +0200 https://news.ki.se/hoping-to-find-new-ways-to-prevent-the-spread-of-cancer It is the spread of tumours, metastases, which is the usual cause of cancer-related death. Jonas Fuxe researchers the mechanisms driving this process, with a focus on how cancer cells interact with their surroundings and mutate in order to take new paths. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 9 October. Fri, 12 Sep 2025 10:00:12 +0200 https://news.ki.se/rising-colorectal-cancer-among-young-adults-in-sweden According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s. The study also shows that mortality is elevated in both younger and older patients for up to ten years after diagnosis. Thu, 14 Aug 2025 11:59:45 +0200 https://news.ki.se/higher-risk-of-death-from-lymphoma-and-infections-in-rare-skin-cancer A new study by researchers at Karolinska Institutet and Karolinska University Hospital shows that patients diagnosed with the rare skin cancers mycosis fungoides and Sézary syndrome face a significantly higher risk of dying from lymphoma and infections compared to the general population. The study was recently published in the British Journal of Dermatology. Sat, 05 Jul 2025 18:03:46 +0200 https://news.ki.se/adults-who-have-survived-childhood-cancer-are-at-increased-risk-of-severe-covid-19 People who have survived cancer as children are at higher risk of developing severe COVID-19, even decades after their diagnosis. This is shown by a new study from Karolinska Institutet published in the journal The Lancet Regional Health – Europe. Fri, 04 Jul 2025 09:09:59 +0200 https://news.ki.se/ai-sharpens-pathologists-interpretation-of-tissue-samples Pathologists' examinations of tissue samples from skin cancer tumours improved when they were assisted by an AI tool. The assessments became more consistent and patients' prognoses were described more accurately. This is shown by a study led by Karolinska Institutet, conducted in collaboration with researchers from Yale University. Thu, 03 Jul 2025 17:00:08 +0200 https://news.ki.se/preparations-for-the-first-car-t-treatment-for-multiple-myeloma-in-routine-healthcare Karolinska University Hospital has, for the first time in Sweden, begun preparations to treat a patient with multiple myeloma using CAR-T cell therapy in routine healthcare – an advanced form of immunotherapy where the patient's own T-cells are programmed to attack cancer cells. The treatment is aimed at patients who no longer respond to previous treatment options and offers new hope for a difficult-to-treat blood cancer. Mon, 23 Jun 2025 15:03:01 +0200 https://news.ki.se/professor-hakan-mellstedt-has-passed-away Håkan Mellstedt, Professor at the Department of Oncology-Pathology, Karolinska Institutet, has passed away at the age of 82. He is mourned by his wife Eva and Håkan’s brother with family. He leaves behind a long and exceptionally successful legacy as a colleague, researcher, and friend. Tue, 17 Jun 2025 11:38:48 +0200 https://news.ki.se/new-strategy-for-the-treatment-of-severe-childhood-cancer Researchers at Karolinska Institutet and Lund University have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant enzyme inhibitors, they have converted cancer cells in mice into healthy nerve cells. The study is published in the journal Proceedings of the National Academy of Sciences (PNAS). Mon, 16 Jun 2025 21:00:13 +0200 https://news.ki.se/cervical-cancer-affects-both-the-mental-health-and-finances-of-families A new Swedish registry study shows that women who are affected by cervical cancer are not only at risk of mental health and financial difficulties themselves – their children and partners also appear to be negatively affected. The study is published in the prestigious scientific Journal of the National Cancer Institute. Tue, 10 Jun 2025 20:59:03 +0200 https://news.ki.se/2025-anders-jahre-award-goes-to-two-ki-researchers The prestigious Nordic Anders Jahre Award for 2025 goes this year to two researchers at Karolinska Institutet. Professor Sten Eirik Wælgaard Jacobsen is to receive the Anders Jahre Award for Medical Research for his work on normal and leukemic blood stem cells. William Nyberg is honoured with the Anders Jahre Award for Young Researchers for his work on the development of T-cell immunotherapy for cancer. Thu, 05 Jun 2025 10:58:32 +0200 https://news.ki.se/karolinska-ccc-first-in-sweden-to-renew-accreditation Karolinska Comprehensive Cancer Center (Karolinska CCC) will be the first center in Sweden to receive renewed accreditation. This milestone marks an important step in further strengthening the collaboration between Karolinska University Hospital and KI. Childhood cancer is now also part of Karolinska CCC. Fri, 30 May 2025 10:17:16 +0200 https://news.ki.se/long-partnership-with-johnson-johnson-paves-way-for-therapies-of-the-future The partnership between Johnson & Johnson Innovative Medicine (J&J) and Karolinska Institutet (KI) marks this year a decade of joint initiatives for promoting the development of tomorrow’s therapies. This long-standing collaboration between industry and academy has given rise to significant scientific advances in several fields of medicine. Mon, 19 May 2025 13:32:10 +0200 https://news.ki.se/promising-results-after-car-t-cell-therapy-for-leukemia-and-lymphoma Swedish cancer patients treated with CAR T-cell therapy show better survival rates and fewer side effects than seen in previous studies. This is shown in a new compilation of Swedish treatment results conducted by researchers in the SWECARNET network. Mon, 12 May 2025 16:11:06 +0200 https://news.ki.se/urine-test-could-reveal-prostate-cancer A newly published study involving researchers from Karolinska Institutet indicates that prostate cancer can be diagnosed at an early stage through a simple urine sample. With the aid of AI and extensive analyses of gene activity in tumours, they have identified new biomarkers of high diagnostic precision. Mon, 28 Apr 2025 18:00:12 +0200 https://news.ki.se/natural-killer-cells-remember-and-effectively-target-ovarian-cancer Researchers at Karolinska Institutet have uncovered a unique ability of a special subtype of natural killer cells in the immune system, called adaptive NK cells, to remember ovarian tumours and effectively attack them. The discovery, published in Cancer Immunology Research, could pave the way for new, more powerful immunotherapies for difficult-to-treat cancers. Mon, 28 Apr 2025 16:07:55 +0200 https://news.ki.se/christofer-juhlin-co-author-of-global-reference-standard The 5th edition of the World Health Organization (WHO) Classification of Endocrine and Neuroendocrine Tumors has now been officially published in print. This highly anticipated reference work is widely regarded as the global gold standard for tumor diagnosis, offering a comprehensive synthesis of traditional histopathology with cutting-edge digital and molecular pathology. Thu, 10 Apr 2025 11:18:33 +0200 https://news.ki.se/three-out-of-ten-breast-cancers-are-detected-between-screenings In a new study, researchers from Karolinska Institutet have shown that so-called interval cancers, which are detected between two screening sessions, account for a significant proportion of breast cancer cases and that certain risk factors may increase the likelihood of developing this type of cancer. The study was published in the journal JAMA Oncology. Fri, 28 Mar 2025 13:23:47 +0100 https://news.ki.se/new-mechanism-for-how-cells-handle-stress-discovered In a study published in Nature, researchers at Karolinska Institutet and SciLifeLab, among others, have identified a new mechanism for how cells deal with stress. This could have implications for treating certain hereditary, neurodegenerative diseases, but may also be relevant for future cancer treatment. Thu, 27 Mar 2025 16:00:10 +0100 https://news.ki.se/new-thesis-on-papillary-thyroid-cancer Helene Lindfors, PhD student at the Endocrine Surgery research group, the Department of Molecular Medicine and Surgery, will defend her thesis "Tumor burden, thyroglobulin and Ki-67 as prognostic indicators in papillary thyroid cancer" on April 2025. Main supervisor is Ivan Shabo. Thu, 27 Mar 2025 10:57:06 +0100 https://news.ki.se/ai-shows-how-drugs-affect-ovarian-cancer-cells In a study on ovarian cancer cells, researchers from Karolinska Institutet demonstrate how the tumor environment influences how cancer cells respond to drugs by using AI. The study has been published in the journal Communications Biology. Fri, 21 Mar 2025 14:48:26 +0100 https://news.ki.se/rolf-kiessling-receives-a-distinguished-award-for-immunotherapy-research Professor Rolf Kiessling at Karolinska Institutet has been selected as the recipient of the 2025 CIMT Lifetime Achievement Award for his groundbreaking discovery of natural killer (NK) cells, which has significantly advanced our understanding of the immune response to viruses and cancer cells. Thu, 20 Mar 2025 12:18:12 +0100 https://news.ki.se/new-biomarkers-may-improve-diagnosis-of-gallbladder-cancer Researchers at Karolinska Institutet and Karolinska University Hospital have identified biomarkers in the blood that can be used to distinguish gallbladder cancer from inflammation of the gallbladder. This could lead to fewer unnecessary operations and better treatment decisions for patients with suspected gallbladder cancer. The study has been published in the journal JHEP Reports. Mon, 03 Mar 2025 12:10:04 +0100 https://news.ki.se/new-understanding-of-cancer-drugs-can-improve-treatments Researchers from Karolinska Institutet have developed a new way to understand how cancer drugs interact with different forms of protein. The study has been published in Nature Communications. Wed, 26 Feb 2025 16:23:10 +0100 https://news.ki.se/immunotherapy-for-liver-cancer-can-be-improved-with-new-insights-into-immune-cells T-cells from the liver and lymph nodes show promising potential for future treatments of liver cancer, according to a new study. Researchers at Karolinska Institutet have investigated how immune cells react to tumor-specific antigens in the complex environment surrounding liver cancer. Thu, 30 Jan 2025 09:30:27 +0100 https://news.ki.se/in-memory-of-professor-eva-klein-1925-2025 Eminent cancer researcher and Karolinska Institutet professor Eva Klein has passed away at the age of 99. She is survived by her and her late husband Georg Klein’s three children. Eva Klein won numerous prizes and awards over the years for her important discoveries in cancer research. She was elected onto the Royal Swedish Academy of Science in 1987. Thu, 23 Jan 2025 09:15:12 +0100 https://news.ki.se/new-study-paves-way-for-immunotherapies-tailored-for-childhood-cancers Researchers at Karolinska Institutet and the Astrid Lindgren Children’s Hospital in Sweden have determined how children’s immune systems react to different kinds of cancer depending on their age. The study, which is published in the journal Cell, reveals significant differences between the immune response of children and adults, and has the potential to lead to new tailored treatments for children with cancer. Mon, 20 Jan 2025 17:00:09 +0100 https://news.ki.se/children-with-congenital-heart-defects-have-poorer-survival-following-cancer-diagnosis For children battling both congenital heart defects (CHD) and cancer, the road to recovery is far more precarious than previously understood, according to a new study published in the Journal of the National Cancer Institute. The research reveals that these children face a higher risk of death within five years after a cancer diagnosis compared to their peers without CHD. Although their survival rates have improved over recent decades, lymphoma mortality remains disproportionately high. Fri, 17 Jan 2025 08:59:31 +0100 https://news.ki.se/new-thesis-on-improving-early-detection-of-cancer Hi Elinor Nemlander, doctoral student at the Division of Family Medicine and Primary Care. On January 31 you will defend your thesis ”Early cancer detection through symptoms and signs”. What is the main focus of the thesis? Thu, 16 Jan 2025 17:05:34 +0100 https://news.ki.se/new-study-adds-important-insights-into-complex-childhood-cancer Researchers in the group of Associate Professor Ninib Baryawno, Department of Women's and Children's Health, KI, have made significant strides in the fight against pediatric cancer by studying tumors of the nervous system, particularly neuroblastoma. The study is published in Cancer Research, the journal of the American Association for Cancer. Wed, 15 Jan 2025 10:09:37 +0100 https://news.ki.se/radiotherapy-charged-with-new-energy Radiotherapy is a cornerstone of cancer care. However, in recent decades, Sweden has fallen behind in this area, both in terms of healthcare resources and research. Medicinsk Vetenskap has interviewed researchers who want to continue developing a bright idea. Tue, 14 Jan 2025 09:22:55 +0100 https://news.ki.se/local-radiation-effective-against-early-rectal-cancer Radiation oncologist Alexander Valdman conducts research at the Department of Oncology-Pathology at Karolinska Institutet. He works to ensure that patients with rectal cancer experience fewer side effects from their treatment. Tue, 14 Jan 2025 09:18:52 +0100 https://news.ki.se/memory-in-the-skin-hinders-healing-after-radiation Radiotherapy can cause long-term skin damage in cancer patients. New research shows that radiation creates a memory in skin cells that hinders healing, but also that antibodies can help restore the damage. Tue, 14 Jan 2025 09:16:47 +0100 https://news.ki.se/radiopharmaceuticals-being-tested-for-brain-tumours-in-children Neuroblastoma is a rare disease that affects children, often before the age of two. Some are born with the disease. Paediatric surgeon Jakob Stenman is investigating whether targeted radioactive drugs can slow down the disease in those with the most severe form. Tue, 14 Jan 2025 09:13:33 +0100 https://news.ki.se/ai-can-improve-ovarian-cancer-diagnoses A new international study led by researchers at Karolinska Institutet in Sweden shows that AI-based models can outperform human experts at identifying ovarian cancer in ultrasound images. The study is published in Nature Medicine. Thu, 02 Jan 2025 11:00:09 +0100 https://news.ki.se/new-method-could-improve-cervical-cancer-screening Analyses of self-tests for human papillomavirus (HPV) can be used to divide HPV-positive women into three risk groups, according to a new study from Karolinska Institutet and Queen Mary University of London published in PLOS Medicine. This method could be important for enhancing cervical cancer screening. Fri, 13 Dec 2024 11:53:19 +0100 https://news.ki.se/more-than-sek-80-million-from-the-swedish-childhood-cancer-foundation-for-ki-projects The Swedish Childhood Cancer Foundation is awarding more than SEK 80 million to Karolinska Institutet for paediatric oncology research in 2024. The allocation includes 29 projects run by researchers at KI. Thu, 12 Dec 2024 11:24:58 +0100 https://news.ki.se/first-molecule-identified-that-promotes-gut-healing-while-inhibiting-tumour-progression Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumour growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer. The results are published in the journal Nature. Wed, 20 Nov 2024 17:26:15 +0100 https://news.ki.se/ai-analysis-of-immune-cells-can-predict-breast-cancer-prognosis Researchers at Karolinska Institutet have investigated how well different AI models can predict the prognosis of triple-negative breast cancer by analysing certain immune cells inside the tumour. The study, published in the journal eClinicalMedicine, is an important step towards using AI in cancer care to improve patient health. Mon, 18 Nov 2024 14:26:28 +0100 https://news.ki.se/ai-method-for-detecting-biliary-tract-cancer-on-ivas-100-list The Royal Swedish Academy of Engineering Sciences (IVA) has published this year's 100 list of the most promising research projects from Sweden's colleges and universities. All applications to the list have been reviewed by IVA's expert group and the selected projects are considered to have great potential to benefit society. The list includes several projects involving researchers at Karolinska Institutet. Thu, 14 Nov 2024 17:18:09 +0100 https://news.ki.se/sek-675-million-from-the-swedish-cancer-society-to-two-researchers-at-nvs Congratulations to Linda Björkhem-Bergman and Erland Axelsson for their respective research grants! Fri, 08 Nov 2024 16:33:17 +0100 https://news.ki.se/nearly-80-million-sek-to-onkpat-researchers-from-the-swedish-cancer-society The Swedish Cancer Society has decided on the research grants for 2024. Researchers from the Department of Oncology-Pathology at Karolinska Institutet received a total of over 70 million SEK. Thu, 07 Nov 2024 12:47:23 +0100 https://news.ki.se/blocking-thbs1-with-antibodies-may-heal-radiotherapy-induced-skin-injury In a recently published study, researchers at Karolinska Institutet and KI University Hospital show that radiotherapy (RT) creates an "epigenetic memory" in skin fibroblasts which impairs skin healing in cancer survivors. They also found that by targeting this memory with antibodies the damage could be reversed. This finding can lead to new therapies for both preventing and treating RT-induced skin issues. Wed, 30 Oct 2024 11:26:26 +0100 https://news.ki.se/thuy-tran-receives-grant-from-erling-persson-foundation-to-develop-method-for-hard-to-treat-cancer Thuy Tran's research group at Karolinska Institutet has been awarded SEK 8 million over three years from the Erling-Persson Foundation to develop a precision-orientated, theranostic, method that integrates the diagnosis and treatment of advanced, solid tumours. Tue, 29 Oct 2024 14:21:21 +0100 https://news.ki.se/karin-holmsten-awarded-newly-established-scholarship-from-the-swedish-society-for-urological-oncology Karin Holmsten at Karolinska Institutet has been awarded Pfizer’s and the Swedish Society for Urological Oncology’s (SFUO) newly established research grant for oncologists in urology. The grant of 50,000 SEK was awarded on October 17th at SFUO’s annual meeting in Stockholm. Fri, 18 Oct 2024 07:49:19 +0200 https://news.ki.se/svenska-lakaresallskapet-awards-adjunct-professor-jana-de-boniface-their-prestigious-jubilee-prize-2024 Svenska Läkaresällskapet (the Swedish Medical Society, SLS) has decided to award Jana de Boniface, adjunct professor at Karolinska Institutet and senior physician and surgeon at the surgery and oncology clinic, Capio St. Göran's Hospital, with their prestigious Jubilee Prize. The awardee is rewarded with SEK 175,000 and the SLS century medal in silver. Mon, 07 Oct 2024 11:45:16 +0200 https://news.ki.se/two-innovation-environments-at-ki-win-vinnova-grants Vinnova is investing in precision medicine and awarding grant funding to six innovation environments. Two of them are at Karolinska Institutet, and both focus on treating cancer. The aim of the grants is to fund efforts to bring greater precision to the diagnosis and treatment of common diseases. Tue, 01 Oct 2024 11:25:36 +0200 https://news.ki.se/new-thesis-on-patients-preparedness-and-self-care-in-allogeneic-stem-cell-transplantation Hi Katarina Holmberg, doctoral student at the Division of Nursing. On October 11 you will defend your thesis ”Symptom burden, preparedness, self-efficacy and self-care in allogeneic haematopoietic cell transplantation”. What is the main focus of the thesis? Mon, 30 Sep 2024 16:16:42 +0200 https://news.ki.se/researching-how-a-virus-affects-aggressive-skin-cancer Merkel cell carcinoma is an aggressive and often fatal form of skin cancer. Weng-Onn Lui intends to find out how the Merkel cell polyomavirus influences tumour growth and the development of treatment resistance. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October. Wed, 18 Sep 2024 09:00:13 +0200 https://news.ki.se/discovery-of-a-new-tumor-cell-type-in-childhood-cancer Researchers from Karolinska Institutet has made a significant breakthrough in the study of childhood neuroblastoma, a type of cancer that begins before birth during the early stages of adrenal gland development. Wed, 11 Sep 2024 10:46:56 +0200 https://news.ki.se/ki-researchers-lead-a-pilot-hpv-self-screening-programme-in-ukraine Cervical cancer is a major global health problem. It ranks as the fourth most common cause of cancer-related deaths among women, despite the disease being largely preventable. Now, researchers from Karolinska Institutet have received funding from the UICC to investigate how an HPV self-screening programme can be implemented in war-torn Ukraine. Wed, 11 Sep 2024 10:38:54 +0200 https://news.ki.se/breaking-the-trend-skin-cancer-incidence-in-young-adults-declines The risk of skin cancer for adults under the age of 50 is now decreasing for the first time in Sweden, according to a study from Karolinska Institutet published in JAMA Dermatology. Mon, 09 Sep 2024 10:26:52 +0200 https://news.ki.se/wants-to-personalise-prostate-cancer-treatment Prostate cancer accounts for more male deaths in Sweden than any other form of cancer. However, how the disease progresses and how fatal it is depend on the type of tumour. Olof Akre hopes to find better prognostic indicators that will help to personalise treatment. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October. Fri, 06 Sep 2024 09:00:11 +0200 https://news.ki.se/working-to-improve-vaccine-efficacy-for-children-with-cancer Children who have undergone treatment for cancer often lose the protection against infection provided by previous vaccinations. Anna Nilsson is studying how cancer therapies affect the immune system in order to improve vaccination guidelines for these children. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October. Fri, 30 Aug 2024 09:00:07 +0200 https://news.ki.se/lower-hpv-vaccination-coverage-among-girls-with-mental-health-conditions Girls with mental illness or neurodevelopmental conditions are less likely than their peers to be vaccinated with the HPV vaccine that protects against future cervical cancer. This is according to a new registry study from Karolinska Institutet published in The Lancet Public Health. Thu, 29 Aug 2024 07:00:12 +0200 https://news.ki.se/precision-therapy-for-metastatic-prostate-cancer-improves-survival Men with metastatic castration-resistant prostate cancer should be treated primarily with second-generation hormone drugs, which offer better treatment response and longer life expectancy than chemotherapy. However, the effect depends on which mutations the patient’s tumour carries. This is shown by results from the ProBio study, led by researchers at Karolinska Institutet in Sweden. The findings are published in Nature Medicine. Tue, 20 Aug 2024 11:00:16 +0200 https://news.ki.se/new-guidelines-on-how-to-report-clinical-sequencing-data-help-doctors-make-decisions-about-cancer-treatment Personalized medicine is transforming cancer treatment by tailoring therapies to the genomic profile of each tumor. Next-generation sequencing (NGS) is key to this approach, but its complexity and inconsistent reporting have been hurdles. A recent paper in Annals of Oncology introduces new guidelines to standardize NGS reports, aiding clinicians in making informed decisions and improving patient outcomes. Fri, 16 Aug 2024 15:05:35 +0200 https://news.ki.se/the-2024-senior-jahre-award-goes-to-thomas-helleday Thomas Helleday, Professor of Chemical Biology at the Department of Oncology-Pathology, Karolinska Institutet, is awarded the 2024 Anders Jahre Award for Medical Research. He receives the prestigious Senior Jahre Award for his discoveries of mechanisms for cancer development in humans, which have been applied in the follow-up and treatment of patients. Thu, 15 Aug 2024 14:08:56 +0200 https://news.ki.se/prostate-cancer-blood-test-equally-effective-across-ethnic-groups The Stockholm3 blood test, developed by researchers at Karolinska Institutet, is equally effective at detecting prostate cancer in different ethnic groups, a new paper published in The Journal of Clinical Oncology reports. The test produces significantly better results than the current PSA standard. Tue, 23 Jul 2024 09:53:48 +0200 https://news.ki.se/new-strategy-can-improve-cell-therapy-against-cancer Researchers at the Center for Infectious Medicine at the Department of Medicine, Huddinge have developed a new strategy that can make cell therapy against cancer work longer in patients. The results are published in the journal Cell Stem Cell. Tue, 09 Jul 2024 08:03:41 +0200 https://news.ki.se/nanorobot-with-hidden-weapon-kills-cancer-cells Researchers at Karolinska Institutet have developed nanorobots that kill cancer cells in mice. The robot’s weapon is hidden in a nanostructure and is exposed only in the tumour microenvironment, sparing healthy cells. The study is published in the journal Nature Nanotechnology. Mon, 01 Jul 2024 11:00:10 +0200 https://news.ki.se/new-genetic-markers-for-adrenal-cancer-may-predict-survival A new study from Karolinska Institutet shows that 45 genes may play a crucial role in the prognosis of patients with adrenal cancer. The findings, published in the journal ESMO Open, give hope for a better diagnostic tool than is currently available. Thu, 27 Jun 2024 08:09:31 +0200 https://news.ki.se/newly-established-theranostics-trial-center-for-cancer-diagnostics-and-therapy On June 3rd, the Theranostics Trial Center (TTC) was inaugurated as a new section within the Department of Nuclear Medicine and Hospital Physics, Medical Diagnostics Karolinska (MDK) with an academic base within the Department of Oncology-Pathology at Karolinska Institutet. Tue, 04 Jun 2024 15:39:22 +0200 https://news.ki.se/new-test-detects-more-cases-of-cervical-cancer Researchers at Karolinska Institutet and the University of Innsbruck have developed a simpler and more effective screening method for cervical cancer than the method used today. A comprehensive study published in Nature Medicine shows that the test detects significantly more cancers and precancerous stages. Tue, 04 Jun 2024 11:00:12 +0200 https://news.ki.se/ki-is-part-of-the-scilake-cancer-knowledge-graph Researchers from the Clinical Genetics Group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, have set up a collaboration with the Centre for Research and Technology in Greece to make publicly available resources in biology and cancer more accessible to the research community. The teams are developing a first-of-its-kind cancer knowledge graph, as part of the SciLake Project involving partners across Europe. Mon, 03 Jun 2024 09:26:46 +0200 https://news.ki.se/subclass-of-stem-cells-replenish-platelets-more-rapidly Together with researchers from University of Oxford, researchers at Karolinska Institutet have demonstrated that a subclass of stem cells that are dedicated to the production of platelets replenish platelets through a distinct and shorter pathway than other stem cells. This is presented in a study published in the journal Nature Immunology. Mon, 03 Jun 2024 08:52:47 +0200 https://news.ki.se/specialist-centre-at-ki-delivers-expertise-in-radiation-emergency-medicine Society's preparedness to deal with crises and disasters needs to be constantly developed and adapted to changes in the world around us. As preparedness depends on up-to-date medical expertise, the Swedish National Board of Health and Welfare has established a number of knowledge and research centres for crisis preparedness around the country, located at universities, authorities or equivalent with links to clinical activities. Tue, 28 May 2024 11:10:09 +0200 https://news.ki.se/ki-initiates-collaboration-with-elekta-in-precision-medicine Karolinska Institutet and Karolinska University Hospital are launching another tripartite collaboration, this time with Elekta. The aim is to join forces in the field of cancer with a focus on radiation therapy and precision medicine. Mon, 27 May 2024 22:33:26 +0200 https://news.ki.se/bodys-message-in-a-bottle-delivers-targeted-cancer-treatment Researchers at Karolinska Institutet have succeeded in delivering targeted cancer treatment via small membrane bubbles that our cells use to communicate. A new study published in Nature Biomedical Engineering shows that the treatment reduces tumour growth and improves survival in mice. Mon, 20 May 2024 11:00:10 +0200 https://news.ki.se/early-genetic-development-of-the-brain-mapped In an article published in Nature, researchers from Karolinska Institutet present an atlas of the early development of the brain. The atlas can be used, among other things, to find out what went wrong in the development of brain tumors in children and also to find new treatments. Thu, 02 May 2024 11:47:53 +0200 https://news.ki.se/a-patient-centred-karolinska-ccc-day The 2024 Karolinska Comprehensive Cancer Centre Day draw a large number of experts in the field of cancer research from KI and Karolinska University Hospital. The theme this year was prevention, with particular attention directed to scientific advances and remaining challenges, as well as to how involving patients in prevention enhances quality of care. Tue, 23 Apr 2024 13:39:14 +0200 https://news.ki.se/angelique-bridges-the-world-of-clinic-research-and-teaching-at-kbh Angelique has a background in KI, where she obtained her medical degree, her path has been paved through many years of clinical service at Karolinska University Hospital and she is a specialist in both gynecology & obstetrics and gyneoncology. Tue, 16 Apr 2024 08:35:41 +0200 https://news.ki.se/ki-supports-translational-collaboration-on-pancreatic-cancer For 2 years the Translational Seed Funding Grant 2023 will support the collaborative project between the Schulte lab at Fyfa and the research team of Prof Matthias Löhr at CLINTEC. Thu, 11 Apr 2024 10:16:55 +0200 https://news.ki.se/popular-diabetes-drugs-do-not-increase-thyroid-cancer-risk-study-suggests Drugs known as GLP-1 analogues have become increasingly popular to treat diabetes and obesity, but there have been concerns that they might increase the risk of thyroid cancer. Now an extensive Scandinavian study led by researchers at Karolinska Institutet has found no evidence of such a link. The study is published in The BMJ. Wed, 10 Apr 2024 08:30:11 +0200 https://news.ki.se/the-swedish-childhood-cancer-fund-finances-eight-research-positions The Swedish Childhood Cancer Fund (Barncancerfonden) has decided to grant funding to eight research positions at KI for paediatric oncology research over the next two to six years. The goal is, among other things, to improve current treatment methods with the help of precision medicine that is based on the characteristics of the cancer and the individual child's genetics. Thu, 04 Apr 2024 12:32:38 +0200 https://news.ki.se/less-extensive-breast-cancer-surgery-results-in-fewer-swollen-arms It is possible to leave most of the lymph nodes in the armpit, even if one or two of them have metastases larger than two millimetres. This is shown in a trial enrolling women from five countries, led by researchers at Karolinska Institutet and published in the New England Journal of Medicine. The results open up for gentler surgery for patients with breast cancer. Thu, 04 Apr 2024 11:03:36 +0200 https://news.ki.se/a-new-hope-in-immunotherapy-against-cancer In a new study published in Molecular Oncology, researchers have discovered a novel mechanism to enhance the body’s immune response to tumors. The study is a result of collaboration between Sprint Bioscience, Karolinska institutet, the Luxembourg Institute of Health and Deciphera Pharmaceuticals, and was included as a manuscript in Yasmin Yu’s PhD thesis at the Department of Oncology-Pathology in 2021. Wed, 03 Apr 2024 11:08:21 +0200 https://news.ki.se/she-is-awarded-the-sjoberg-prize-for-laying-the-foundations-of-a-cancer-vaccine Catherine J. Wu, of the Dana-Farber Cancer Institute in Boston, USA, is a pioneer in research that may result in the development of personalised vaccines to treat cancer. She is now awarded the Sjöberg Prize, worth one million US dollars, for her work. Catherine J. Wu will give a lecture in Aula Medica at KI on April 12 in connection with the Karolinska CCC Day. Sat, 23 Mar 2024 15:03:03 +0100 https://news.ki.se/psychiatrist-ullakarin-nyberg-was-herself-affected-by-breast-cancer Ullakarin Nyberg is a researcher at the Center for Psychiatry Research at Karolinska Institutet. She also works clinically as a psychiatrist, part of the time at a unit for breast cancer patients. At the end of 2018, she contracted the disease herself. Thu, 21 Mar 2024 16:25:15 +0100 https://news.ki.se/exercise-tested-against-breast-cancer Can breast cancer patients who exercise get better results from their chemotherapy? And if so, should they receive treatment that includes exercise? This will be investigated in an international study led by researcher Jana de Boniface. Thu, 21 Mar 2024 16:12:13 +0100 https://news.ki.se/diet-and-breast-cancer-alcohol-increases-the-risk It is difficult to draw firm conclusions about how to eat and drink to avoid breast cancer. Dietary studies often rely on self-reporting, while dietary habits change over the course of a lifetime - both of which are complicated for researchers. But one link is well documented: even moderate alcohol consumption increases the risk of developing the disease, says Professor Alicja Wolk. Thu, 21 Mar 2024 15:58:16 +0100 https://news.ki.se/what-causes-breast-cancer There is a lot going on in breast cancer research. A new AI tool is trying to fine-tune the screening program, another is helping pathologists make diagnoses, and new drugs are being tested and approved. This could save more lives. But there is still no answer to the trickiest question of all: Why does breast cancer occur? Thu, 21 Mar 2024 15:44:36 +0100 https://news.ki.se/new-review-on-p53-biology-and-reactivation-in-blood-cancers In a recently published review in the journal Biomarker Research, Joanna Zawacka, Docent at the department of Oncology-Pathology discusses our current understanding of p53 biology in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Wed, 20 Mar 2024 12:43:05 +0100 https://news.ki.se/sweden-signs-new-cooperation-agreement-with-the-us-on-cancer-research Sweden and the USA have previously enjoyed strong collaboration in the field of cancer care and research, and now it is further strengthened through a bilateral agreement. The purpose is to promote exchange between the two countries in both cancer research and the implementation of this research within cancer care, including both prevention and improved quality of life. Tue, 19 Mar 2024 16:38:56 +0100 https://news.ki.se/future-cancer-treatment-and-fertility In recent years, the treatment landscape for solid tumors has undergone a notable change. With new cancer treatments, the future looks brighter for many young cancer patients, making fertility issues and future family planning an important aspect. Six specialists in oncology and onco-fertility at the Department of Oncology-Pathology join forces to compile knowledge and recommendations on this important issue. Wed, 13 Mar 2024 07:51:27 +0100 https://news.ki.se/ki-researcher-laura-baranello-awarded-erc-consolidator-grant KI researcher Laura Baranello has been awarded the prestigious ERC Consolidator Grant for her researches into the interaction between the cancer-driving protein MYC and topoisomerase enzymes. Her aim is to identify drugs for more targeted cancer therapy with fewer side-effects. Laura Baranello’s MYCinTOPshape project has been awarded approximately EUR 2 million to be spread over five years. Tue, 12 Mar 2024 15:48:06 +0100 https://news.ki.se/mobile-phone-users-who-talk-for-a-long-time-do-not-have-an-increased-risk-of-brain-tumours A large international research study, COSMOS, initiated by Karolinska Institutet and Imperial College London, UK, has studied over 250,000 mobile phone users to investigate whether those who use mobile phones a lot and for a long time have a higher risk of brain tumours than others. The study, published in Environment International, found no association between long-term cell phone use and the risk of brain tumors. Fri, 08 Mar 2024 13:15:20 +0100 https://news.ki.se/study-shows-how-oestrogen-protects-against-fatty-liver New research from Karolinska Institutet shows how oestrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic. The study, published in Molecular Systems Biology, shows how a new drug under development could become a future treatment for fatty liver disease and liver cancer. Fri, 08 Mar 2024 12:10:08 +0100 https://news.ki.se/two-ki-researchers-awarded-sek-19-million-from-the-swedish-childhood-cancer-fund Through a new call form, the Swedish Childhood Cancer Fund is funding two research programmes that will look at different types of unwanted side effects, primarily from chemotherapy. Precision medicine and the opportunities offered by the development of biomarkers are common to the two programmes, which are led by KI researchers Susanna Ranta and Kenny Rodriguez-Wallberg, respectively, and which now share SEK 19 million over four years. Thu, 07 Mar 2024 15:14:52 +0100 https://news.ki.se/new-insight-into-c-myc-protein-could-pave-the-way-for-new-cancer-treatments In a study published in Nature Communications, KI researchers have revealed a fascinating discovery that could be important in cancer treatments. This new insight involves c-MYC, a protein component that is central to cancer development. Thu, 29 Feb 2024 15:42:45 +0100 https://news.ki.se/unintentional-weight-loss-associated-with-increased-risk-of-cancer Recent and unintentional weight loss is associated with an increased risk of a cancer diagnosis in the coming year, according to a new study in JAMA. Researchers from Karolinska Institutet and others behind the study urge healthcare professionals and the public to be vigilant about sudden and unintentional weight loss. Wed, 24 Jan 2024 17:29:26 +0100 https://news.ki.se/towards-selective-drugs-to-improve-chemotherapy-efficacy Researchers at Karolinska Institutet and SciLifeLab demonstrate in a new study published in iScience how they can identify substances that can deactivate an enzyme responsible for chemotherapy resistance in cancer cells. These results can have importance to improve chemotherapy effectiveness for cancer patients. Thu, 18 Jan 2024 12:57:40 +0100 https://news.ki.se/review-article-describing-the-role-of-p53-as-a-target-for-novel-cancer-therapies The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by professor Klas G Wiman and colleagues at the Department of Oncology-Pathology describes how p53 could be used as a target for new cancer therapies. Tue, 19 Dec 2023 13:12:40 +0100 https://news.ki.se/extra-grants-from-the-swedish-cancer-society-to-ki-for-clinical-studies In clinical studies, new methods and treatments are tested on humans under controlled conditions. However, clinical treatment studies are often very expensive to carry out and require resources that allow many different professional groups to work together. The Swedish Cancer Society has now decided on an extra allocation of grants to ten researchers for clinical studies. Six of these are researchers at Karolinska Institutet. Mon, 18 Dec 2023 18:39:16 +0100 https://news.ki.se/ki-researchers-awarded-over-sek-35-million-by-the-swedish-childhood-cancer-fund The Swedish Childhood Cancer Fund's allocation reflects the needs that exist in areas such as new technology and precision medicines. This year's call for proposals means that SEK 125 million will be allocated to 62 projects in the field of childhood cancer, of which SEK 35,400,000 will go to researchers at Karolinska Institutet. Thu, 14 Dec 2023 16:49:12 +0100 https://news.ki.se/new-method-is-better-able-to-map-immune-response-and-paves-way-for-new-treatments A new method, developed at Karolinska Institutet, KTH Royal Institute of Technology and SciLifeLab, can identify unique immune cell receptors and their location in tissue, a study published in the journal Science reports. The researchers predict that the method will improve the ability to identify which immune cells contribute to disease processes and open up opportunities to develop novel therapies for numerous diseases. Fri, 08 Dec 2023 08:14:19 +0100 https://news.ki.se/new-study-questions-the-effectiveness-of-drugs-for-ovarian-protection-during-cancer-treatment A new study from Karolinska Institutet has found no evidence that a common drug used to protect the ovaries of women undergoing chemotherapy increases their chances of having children after cancer treatment. The study is published in eClinicalMedicine. Fri, 08 Dec 2023 07:23:07 +0100 https://news.ki.se/ai-can-identify-women-with-high-risk-of-breast-cancer-in-screening-examinations The use of AI makes it possible for women with a high risk of breast cancer to be identified in mammography screening examinations so that the cancer can be caught earlier. An international research group led from Karolinska Institutet in Sweden can now show that the method is effective in different European countries. The study is published in The Lancet Regional Health – Europe. Thu, 07 Dec 2023 00:30:05 +0100 https://news.ki.se/researchers-at-bionut-receive-grants-from-cancerfonden-2023 We wish to congratulate the six researchers at the Department of Biosciences and Nutrition (BioNut) at Karolinska Institutet, who has received funding from Cancerfonden for the years 2024 to 2026. Together the researchers at our department received more than SEK 21 millions. Fri, 17 Nov 2023 14:56:12 +0100 https://news.ki.se/researchers-take-new-ai-approach-to-analyse-tumours Researchers at Karolinska Institutet and SciLifeLab have combined artificial intelligence (AI) techniques used in satellite imaging and community ecology to interpret large amounts of data from tumour tissue. The method, presented in the journal Nature Communications, could contribute to more personalised treatment of cancer patients. Mon, 13 Nov 2023 16:35:59 +0100 https://news.ki.se/stefan-skare-receives-funding-from-the-swedish-childhood-cancer-fund KI researcher Stefan Skare receives funding from Barncancerfonden (the Swedish Childhood Cancer Fund) for the development of motion-robust MRI (magnetic resonance imaging) methods for examining awake children with brain and spinal cord tumors. The project receives a total of SEK 3.9 million over three years. Thu, 09 Nov 2023 18:00:34 +0100 https://news.ki.se/hired-as-experts-in-their-own-illness More and more researchers understand the importance of including the patients' experiences when planning scientific studies. Meet three people who have been hired as experts in their own illness. Thu, 09 Nov 2023 09:58:26 +0100 https://news.ki.se/dna-tangles-allow-for-targeted-cancer-therapy-via-topoisomerase-drug-treatment A new publication in Science Advances from researchers at Karolinska Institutet shows how to use a specific cancer trait to improve treatment of pancreatic tumors. Wed, 01 Nov 2023 12:46:57 +0100 https://news.ki.se/the-swedish-childhood-tumor-biobank-receives-grants-from-the-government-and-the-swedish-childhood-cancer-fund-for-national-precision-medicine-project The Swedish Childhood Tumor Biobank is a nationally established genomic biobank infrastructure in the field of childhood cancer that works to promote research on childhood tumors. Within the Genomic Medicine Sweden (GMS) Child Cancer project, the Swedish Childhood Tumor Biobank at KI and the Department of Oncology-Pathology receive SEK 5.13 million from the government. Tue, 10 Oct 2023 09:39:34 +0200 https://news.ki.se/immunotherapy-that-eliminates-mutated-cancer-cells-shows-promising-effect Researchers at Karolinska Institutet and the University of Oslo present a new type of immunotherapy that attacks cancer cells with a specific mutation. A study published in the journal Nature Cancer shows promising effects on patient cells in mice and offers hope for patients with acute myeloid leukaemia (AML), a cancer that has proven difficult to treat. Mon, 02 Oct 2023 17:08:50 +0200 https://news.ki.se/no-increase-in-cancer-risk-for-most-patients-with-reflux-disease Reflux disease manifests as acid regurgitation and heartburn and is a known risk factor for oesophageal cancer. However, a new study published in The BMJ by researchers at Karolinska Institutet now reports that the majority of patients do not have a higher risk of cancer. A large-scale study from three Nordic countries shows that the cancer risk is only elevated in patients whom gastroscopy reveals to have changes in the oesophageal mucosa. Wed, 13 Sep 2023 11:00:06 +0200 https://news.ki.se/more-cases-of-breast-cancer-can-be-found-with-the-help-of-ai One radiologist supported by AI detected more cases of breast cancer in screening mammography than two radiologists working together, reports the ScreenTrustCAD study from Karolinska Institutet in The Lancet Digital Health. The researchers say that AI is now ready to be implemented in breast cancer screening. Sat, 09 Sep 2023 00:30:07 +0200 https://news.ki.se/liver-cancer-and-severe-liver-disease-more-common-if-a-close-relative-has-fatty-liver-disease Close relatives of people with metabolic-associated fatty liver disease have a higher risk of developing liver cancer and dying from liver-related diseases, according to a national study from Karolinska Institutet published in The Journal of Hepatology. This means that family members could also benefit from the lifestyle advice that is currently only given to patients, the researchers conclude. Fri, 08 Sep 2023 12:54:52 +0200 https://news.ki.se/statins-linked-to-lower-risk-of-cancer-in-patients-with-ulcerative-colitis Cholesterol-lowering statins might protect patients with ulcerative colitis from developing and dying from colorectal cancer. Statin treatment was also associated with a lower risk of death regardless of cause in patients with ulcerative colitis or Crohn's disease. This is according to a study by researchers at Karolinska Institutet published in eClinicalMedicine. Fri, 01 Sep 2023 08:44:30 +0200 https://news.ki.se/antioxidants-stimulate-blood-flow-in-tumours Vitamin C and other antioxidants stimulate the formation of new blood vessels in lung cancer tumours, a new study from Karolinska Institutet published in The Journal of Clinical Investigation shows. The discovery corroborates the idea that dietary supplements containing antioxidants can accelerate tumour growth and metastasis. Thu, 31 Aug 2023 18:00:10 +0200 https://news.ki.se/modification-of-mrna-controls-cellular-protein-synthesis RNA has a central role in the cell's protein production. New research shows that RNA can be changed through various chemical modifications, the function of which is unknown to most. The study was carried out by researchers within Department of Cell and Molecular Biology and Department of Biosciences and Nutrition and published in the scientific journal Science Advances. Fri, 25 Aug 2023 09:40:29 +0200 https://news.ki.se/a-step-towards-solving-the-riddle-of-tumor-cell-invasion A study by researchers from Karolinska Institutet and physicians from Karolinska Hospital shows that a capsule of connective tissue around liver metastases from colorectal cancer improves patient survival and represents a healing response by the liver, not a phenomenon caused by the tumor itself. Tue, 22 Aug 2023 11:15:23 +0200 https://news.ki.se/new-mechanism-by-which-cancer-cells-survive-replication-stress Researchers from Karolinska Institutet have discovered a new molecular mechanism by which cancer cells safeguard themselves from oncogene-induced replication stress and propose a strategy to deactivate this protective mechanism. The study is published in the scientific journal Molecular Cell. Thu, 17 Aug 2023 13:15:14 +0200 https://news.ki.se/millions-to-ki-from-eu-for-new-research-projects Since the summer of 2022, KI has been granted approximately SEK 280 million for a total of 33 different projects. The funds come from several research programs within the EU, of which Horizon Europe, EU's framework program for research and innovation, is the largest. Mon, 14 Aug 2023 12:32:05 +0200 https://news.ki.se/maurice-michel-awarded-the-eppendorf-award-for-young-european-investigators Assistant Professor Maurice Michel has received the Eppendorf Award for Young European Investigators 2023 for his research on artificial functions of DNA repair enzymes. Mon, 26 Jun 2023 10:44:01 +0200 https://news.ki.se/sek-30-million-for-new-centre-of-excellence-at-ki Five researchers at Karolinska Institutet are awarded 30 million Swedish kronor from the Swedish Research Council (VR) to establish a so-called centre of excellence for further development of cell-based cancer treatments. The funds will be distributed over five years, with the potential for another five years of funding after evaluation. Mon, 26 Jun 2023 07:54:09 +0200 https://news.ki.se/new-thesis-on-new-treatments-approaches-for-multiple-myeloma-mm Maria Karvouni from the Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine, Huddinge (MedH) is defending her thesis: "Cellular and personalized therapies in Multiple Myeloma with special emphasis on retargeted NK cells" 16 June 2023. Main supervisor is Evren Alici (MedH). Fri, 09 Jun 2023 10:28:28 +0200 https://news.ki.se/prognosis-of-nasopharyngeal-carcinoma Nasopharyngeal carcinoma (NPC) is a type of cancer that occurs in the nasopharynx, which is located behind the nose and above the back of the throat. NPC has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. NPC is difficult to detect early, and treatment usually involves radiation therapy, chemotherapy or a combination of the two. Wed, 07 Jun 2023 13:19:02 +0200 https://news.ki.se/jenny-mjosberg-awarded-the-eric-k-fernstrom-prize-for-young-promising-and-successful-researchers-2023 Jenny Mjösberg at the Department of Medicine in Huddinge at Karolinska Institutet, receives the 2023 Eric K. Fernström Prize for young, promising and successful researchers, for her outstanding research on the role of innate lymphoid cells in various diseases. Thu, 01 Jun 2023 09:17:02 +0200 https://news.ki.se/johan-hartman-and-mattias-rantalainen-awarded-the-2023-prize-for-innovation-and-utilization Karolinska Institutet has decided to award Johan Hartman and Mattias Rantalainen the 2023 Prize for Innovation and Utilization. They are rewarded for improving cancer diagnostics with innovative research and inspiring working methods. Thu, 11 May 2023 09:10:43 +0200 https://news.ki.se/beyond-mammography-complementary-methods-in-breast-imaging Breast cancer is the most common cancer among women and the likelihood of surviving the disease is higher if the cancer is detected early and the tumour is relatively small and not very aggressive. Tue, 09 May 2023 09:35:51 +0200 https://news.ki.se/adjuvant-hormone-therapy-in-breast-cancer-patients-why-do-women-discontinue-treatment-and-what-are-the-consequences Breast cancer is the most common cancer affecting women and many women are being treated to prevent the cancer from returning, for example with adjuvant hormone therapy. This therapy is prescribed as a once-a-day pill for estrogen receptor-positive breast cancer patients (around 80% of all cases) for a duration of at least five years. Thu, 27 Apr 2023 08:46:26 +0200 https://news.ki.se/european-collaboration-enhances-cross-learning-between-healthcare-and-research-raises-hopes-for-cancer-patients Close on 500 colleagues in the cancer field from Karolinska University Hospital and Karolinska Institutet gathered in Aula Medica during this year’s Karolinska CCC conference on 30–31 March. Also attending were Sahlgrenska CCC and Skåne CCC. Wed, 19 Apr 2023 16:43:39 +0200 https://news.ki.se/colorectal-cancer-in-the-mother-linked-to-adverse-pregnancy-outcome In a nationwide Swedish study of 207 births to women with an earlier diagnosis of colorectal cancer (CRC), researchers found an increased risk of both maternal and neonatal adverse outcomes. The study was published in eClinicalMedicine and is a collaboration between Washington University in St Louis and Karolinska Institutet. Fri, 14 Apr 2023 08:37:34 +0200 https://news.ki.se/swedish-cancer-society-grants-sek-549-million-to-ki-researchers Thirteen researchers at Karolinska Institutet have been awarded 54.9 million Swedish kronor from the Swedish Cancer Society. The foundation is distributing a total of SEK 124.3 million to 31 cancer researchers in Sweden. Mon, 27 Mar 2023 17:55:33 +0200 https://news.ki.se/new-method-to-identify-and-explore-functional-proteoforms-and-their-associations-with-drug-response-in-childhood-acute-lymphoblastic-leukemia Researchers at the Department of Oncology-Pathology have together with researchers from The European Molecular Biology Laboratory published a paper in Nature Chemical Biology where they developed a method that can identify important differences between proteins in an unbiased way. Tue, 21 Mar 2023 11:05:50 +0100 https://news.ki.se/now-local-hospitals-can-determine-how-ai-systems-would-detect-breast-cancer While there are currently a dozen approved AI systems for breast cancer screening, it has been difficult to evaluate their clinical performance objectively. Now, however, there is a Swedish validation platform ready to compare how well AI systems detect signs of breast cancer – and its development has been led by researchers at Karolinska Institutet. Mon, 20 Mar 2023 16:50:04 +0100 https://news.ki.se/immune-cell-gives-possible-explanation-for-sex-differences-in-pancreatic-cancer Immunotherapy is an effective form of therapy for different types of cancer. However, for pancreatic cancer, its effect is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference. The study, which is published in Cancer Research, reveals the presence of an immune cell in women with pancreatic cancer that obstructs the body’s immune response. The results can pave the way for a more sex-specific treatment. Wed, 15 Mar 2023 08:05:03 +0100 https://news.ki.se/life-threatening-side-effects-of-novel-cancer-immunotherapies-could-be-treatable Immunotherapy has been shown to greatly improve survival rates for certain types of cancer. However, in some cases, it can lead to an over-activation of the immune system, which can be dangerous. In a recent review by researchers at Karolinska Institutet, potential therapies have been identified, which might make it possible to continue with immunotherapy even when facing severe side effects. Wed, 08 Mar 2023 13:37:34 +0100 https://news.ki.se/new-immunotherapy-holds-promise-for-ovarian-cancer CAR T-cell therapy, a certain kind of cancer treatment in which the immune system’s T cells are programmed to attack tumour cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer. The researchers, who work at Karolinska Institutet, hope that the discovery will pave the way for a clinical trial to see how effective the treatment is for women with the disease. Mon, 06 Feb 2023 10:11:46 +0100 https://news.ki.se/eu-cancer-conference-a-clear-objective-is-greater-care-equality-throughout-the-eu The Swedish presidency of the EU began in the new year and so much is evident, especially when it comes to issues of healthcare. Anna Martling, chief physician and professor of surgery at Karolinska Institutet, will be leading the EU Cancer Congress, which kicks off in Stockholm on 1 February. Mon, 30 Jan 2023 16:30:55 +0100 https://news.ki.se/protein-movement-reveals-brain-tumours-weak-spot Proteins do not have a single shape, but are more like dynamic robots. But – how do they actually move? And what does this tell us about their function? Laura Orellana describes the movement of proteins using computer simulations – and has discovered a new drug target for glioblastoma brain tumours. Fri, 13 Jan 2023 16:02:34 +0100 https://news.ki.se/the-proteins-that-fix-almost-everything Proteins can make any inventor green with envy. It is proteins that make the body work. But when these same super-substances make mistakes, we may get sick with things like cancer or Alzheimer's disease. The job of researchers is to sort out the proteins when they malfunction. Wed, 11 Jan 2023 15:14:56 +0100 https://news.ki.se/new-method-finds-the-right-treatment-for-breast-cancer-patients Researchers at Karolinska Institutet have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not. The cell-based method has been tested on patients with promising results, according to a study published in PNAS. Tue, 27 Dec 2022 07:00:04 +0100 https://news.ki.se/cellular-messengers-improve-cancer-therapy Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumours sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to a new study published in Cancer Immunology Research by researchers at Karolinska Institutet. Thu, 22 Dec 2022 15:00:06 +0100 https://news.ki.se/cancer-and-allergy-fund-awards-25-million-to-ki-researchers The Cancer and Allergy Fund has awarded a grant of SEK 4.2 million to 23 patient-end projects on cancer and allergies. Of these, fifteen researchers at nine departments at Karolinska Institutet are to share SEK 2.5 million. Tue, 13 Dec 2022 17:13:30 +0100 https://news.ki.se/33-million-sek-to-onkpat-researchers-from-radiumhemmets-forskningsfonder In this year's announcement of project grants from Radiumhemmets Forskningsfonder, OnkPat received a total of 33 million SEK. 32 researchers were granted funding. Fri, 09 Dec 2022 11:26:52 +0100 https://news.ki.se/new-method-for-detecting-multiple-cancers-early When cancer is detected at an early stage, the rates of survival increase drastically, but today only a few cancer types are screened for. An international study led by researchers at Chalmers University of Technology and affiliated with Karolinska Institutet shows that a new, previously untested method can find multiple types of newly formed cancers at the same time – including cancer types that are difficult to detect with comparable methods. The results are published in the journal PNAS. Wed, 07 Dec 2022 08:22:34 +0100 https://news.ki.se/ki-and-cancer-research-horizons-announce-5-year-partnership Karolinska Institutet and Cancer Research UK’s innovation engine, Cancer Research Horizons, have announced a 5-year strategic partnership dedicated to accelerating the translation of academic cancer research into improved treatments for patients. Tue, 29 Nov 2022 14:18:40 +0100 https://news.ki.se/martin-bergo-addresses-the-debate-about-vitamin-pills Even as a child, Martin Bergö wanted to be a scientist. And he did. His biggest discovery so far is that vitamins can worsen the prognosis for cancer patients. Tue, 29 Nov 2022 13:53:14 +0100 https://news.ki.se/new-thesis-on-stomach-cancer Johannes Asplund at the research group Upper GI Surgery, the Department of Molecular Medicine and Surgery, will defend his thesis "Towards an improved survival in gastric cancer" on November 25th, 2022. Main Supervisor is Jesper Lagergren. Fri, 18 Nov 2022 15:17:36 +0100 https://news.ki.se/researchers-at-bionut-receive-grants-from-cancerfonden-2022 Congratulations to all the researchers at the Department of Biosciences and Nutrition (BioNut) who received funding from Cancerfonden for the years 2023-2025. Fri, 18 Nov 2022 09:38:28 +0100 https://news.ki.se/vaccination-with-senescent-cells-reduced-tumor-formation-in-mice Cells that have permanently stopped multiplying, so-called senescent cells, could play an important role in the fight against cancer, according to a new study in mice by researchers at Karolinska Institutet and IRB Barcelona. The study, published in the journal Cancer Discovery, found that vaccination with senescent cancer cells significantly reduced the formation of melanoma and pancreatic cancer tumors in mice. Thu, 03 Nov 2022 11:53:53 +0100 https://news.ki.se/researcher-at-bionut-receives-grant-from-world-wide-cancer-research Professor Staffan Strömblad at the Department of Biosciences and Nutrition, Karolinska Institutet, has received a grant from World Wide Cancer Research for a project on: "How may mechanotransduction prevent cancer?". Wed, 02 Nov 2022 15:35:04 +0100 https://news.ki.se/gene-signature-points-to-prognosis-in-kidney-cancer Among patients with kidney cancer, the activity of four specific genes in the cancer cells seems to be able to predict the risk of the tumour spreading and the patient’s chances of survival. This is shown by researchers from Karolinska Institutet in a preclinical study published in Nature Communications. Mon, 17 Oct 2022 15:31:14 +0200 https://news.ki.se/colonoscopy-screening-for-colorectal-cancer-prevention-not-as-effective-as-previously-believed A randomized study, known by the acronym NordICC – Northern - European Initiative on Colorectal Cancer - shows colonoscopy screening reduces the risk of colorectal cancer by 18 percent. The reduction is much smaller than experts previously assumed. The NordICC study is now published in the New England Journal of Medicine (NEJM). Mon, 10 Oct 2022 08:57:10 +0200 https://news.ki.se/new-thesis-on-avidity-markers-in-thyroid-cancer Joachim Nilsson at the research group Endocrine Surgery, the Department of Molecular Medicine and Surgery, will defend his thesis "Avidity-guided radionuclide therapy for thyroid cancer" on September 30, 2022. Main Supervisor is Catharina Ihre Lundgren. Fri, 23 Sep 2022 09:35:23 +0200 https://news.ki.se/professor-jan-zedenius-elected-president-of-iaes Congratulations to Professor Jan Zedenius who has been elected President of the International Association of Endocrine Surgeons, IAES. IAES is an integrated society of the International Society of Surgery ISS/SIC and the inauguration ceremony was held at the International Surgical Week in Vienna on August 16, 2022. Wed, 31 Aug 2022 16:15:17 +0200 https://news.ki.se/fertility-preservation-measures-do-not-appear-to-increase-the-risk-of-breast-cancer-recurrence Women with a breast cancer diagnosis undergoing procedures for fertility preservation are not at increased risk of recurrence of the disease or disease-specific mortality. This has been shown in a study by Karolinska Institutet that followed the participants for five years on average. The results, published in the journal JAMA Oncology, could in the future provide safety and new hope to women who want to preserve their fertility after cancer treatment with chemotherapy. Thu, 25 Aug 2022 17:00:07 +0200 https://news.ki.se/hopes-of-a-new-curative-treatment-for-children-with-neuroblastoma Children who suffer a relapse of the aggressive cancer known as neuroblastoma have small chances of survival. However, a group including researchers at Karolinska Institutet have now shown that DHODH blockers, which are well-tolerated in humans, can cure neuroblastoma in mice if administered in combination with chemotherapy. The study, published in the journal JCI Insight, paves the way for clinical trials of this combination therapy. Mon, 22 Aug 2022 17:04:59 +0200 https://news.ki.se/svenska-lakaresallskapet-awards-professor-jonas-f-ludvigsson-their-prestigious-jubilee-prize Svenska Läkaresällskapet (The Swedish Medical Society, SLS) has decided to award Professor Jonas F Ludvigsson at Karolinska Institutet with the society's prestigious Jubilee Award. The prize winner is awarded SEK 150,000 and the SLS century medal in silver. Mon, 22 Aug 2022 08:36:37 +0200 https://news.ki.se/breakthrough-in-precision-medicine-for-the-treatment-of-acute-myeloid-leukaemia Researchers at Karolinska Institutet, among others, have studied the benefit of adding an established drug as a novel targeted therapy in the treatment of acute myeloid leukaemia (AML). The results suggest that the drug hydroxyurea can increase treatment efficacy at a relatively low cost. The results, which were published in the Journal of Internal Medicine, could have significant implications for cancer treatment, including in low-income countries. Wed, 10 Aug 2022 11:13:56 +0200 https://news.ki.se/cool-room-temperature-inhibited-cancer-growth-in-mice Turning down the thermostat seems to make it harder for cancer cells to grow, according to a study in mice by researchers at Karolinska Institutet. The study, published in the journal Nature, found that chilly temperatures activate heat-producing brown fat that consumes the sugars the tumors need to thrive. Similar metabolic mechanisms were found in a cancer patient exposed to a lowered room temperature. Wed, 03 Aug 2022 17:00:04 +0200 https://news.ki.se/hormonal-breast-cancer-treatment-reduces-long-term-risk-of-recurrence To investigate the long-term benefit of hormone-lowering treatment, researchers at Karolinska Institutet have done a 20-year follow-up of premenopausal women with breast cancer. The study, published in the Journal of Clinical Oncology, indicates that the treatment provides protection even after a longer period of time and that different patients seem to benefit from different hormonal treatments. Tue, 02 Aug 2022 14:58:53 +0200 https://news.ki.se/activated-surface-proteins-may-reverse-the-development-of-malignant-neuroblastoma-cells In a new study, researchers at Karolinska Institutet show that the activation of specific cell surface proteins – cortisol, oestrogen and vitamin A – in mice with human neuroblastoma cells results in the neuronal differentiation of cancer cells which leads to reduced mortality. The results, published in the Journal of Experimental and Clinical Cancer Research, could, in the future, lead to a more gentle and effective treatment of this severe form of cancer in children. Mon, 25 Jul 2022 16:33:33 +0200 https://news.ki.se/ki-researcher-receives-price-for-best-scientific-publication-in-prostate-cancer Associate Professor Tobias Nordström is awarded the European Association of Urology (EAU) "Prostate Cancer Research Award 2022" for the Stockholm3-test, a blood test that in a better way can identify men who have an increased risk for prostate cancer. Mon, 04 Jul 2022 13:34:36 +0200 https://news.ki.se/new-approach-to-treatment-of-deadly-kidney-cancer Researchers at Karolinska Institutet have linked resistance to treatment for a deadly form of kidney cancer to low mitochondrial content in the cell. When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment. Their findings, which are published in Nature Metabolism, offer hope for more targeted cancer drugs. Mon, 27 Jun 2022 17:00:06 +0200 https://news.ki.se/improved-protein-function-opens-way-for-new-drug-development-concept Researchers at Karolinska Institutet and SciLifeLab describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function. Their innovative technique can lead to improved drugs for diseases involving oxidative stress, such as cancer, Alzheimer’s disease and lung diseases, but the researchers believe it has even greater potential. Thu, 23 Jun 2022 20:00:00 +0200 https://news.ki.se/unique-insight-into-the-inner-workings-of-our-cellular-powerplants Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University have visualized in unprecedented detail the machinery that the cells’ powerhouses, the mitochondria, use to form their proteins. The results, which are published in Nature, raise hopes of more specific antibiotics and new cancer drugs in the future. Wed, 08 Jun 2022 17:00:05 +0200 https://news.ki.se/buying-time-self-inflicted-dna-damage-drives-cancer-cell-resistance-to-radiation-therapy A new study, published in Science, shows how self-inflicted DNA damage uniquely enables tumor cells to endure the genotoxic effects of radiation therapy, allowing them to survive and contribute to tumor reoccurrence. The findings highlight a cancer-specific survival mechanism that could be targeted and used to enhance the tumor cells’ vulnerability to genotoxic cancer treatments. Tue, 03 May 2022 11:12:40 +0200 https://news.ki.se/declines-in-reported-cancers-in-early-phase-of-covid-19-pandemic-in-the-nordic-countries A study from Karolinska Institutet and the Nordic cancer registries shows that cancer notification rates declined in the Nordic countries during the early phase of the COVID-19 pandemic in April-May 2020 compared to previous years. In the fall of 2020, the cancer rates recovered in Denmark, Norway and Iceland, yet only partly in Sweden and Finland. In the Faroe Islands, the changes in cancer rates were not statistically significant. The study was published in International Journal of Cancer. Wed, 27 Apr 2022 10:00:06 +0200 https://news.ki.se/collaboration-around-the-cancer-care-of-the-future Almost 500 employees gathered in Aula Medica on 1 April when Karolinska Comprehensive Cancer Centre (Karolinska CCC) celebrated its second anniversary since accreditation by honouring its employees and the collaboration between Karolinska Institutet and Karolinska University Hospital. Thu, 21 Apr 2022 12:00:53 +0200 https://news.ki.se/new-thesis-on-mri-in-patients-with-cervical-carcinoma Susanne Fridsten at the research group Diagnostic Radiology, Department of Molecular Medicine and Surgery, will defend her thesis "Carcinoma of the uterine cervix: aspects on preoperative staging and assessment of treatment effect using magnetic resonance imaging" on April 21, 2022. Main Supervisor is Lennart Blomqvist. Tue, 19 Apr 2022 11:25:41 +0200 https://news.ki.se/new-thesis-on-the-perspective-of-being-a-family-caregiver-of-a-patient-treated-for-oesophageal-cancer Cecilia Haddad Ringborg at the research group Surgical Care Science, Department of Molecular Medicine and Surgery, will defend her thesis "The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs" on April 1, 2022. Main Supervisor is Pernilla Lagergren. Tue, 22 Mar 2022 14:04:59 +0100 https://news.ki.se/study-identifies-new-protection-mechanism-in-breast-cancer Researchers at Karolinska Institutet have identified a protein that protects against breast tumour growth and that can be linked to a better prognosis in breast cancer patients. The results, which are published in the journal Nature Communications, may contribute to the development of new therapies for difficult-to-treat forms of breast cancer. Tue, 22 Mar 2022 11:01:08 +0100 https://news.ki.se/network-medicine-opens-new-ways-of-understanding-complex-diseases The causes of complex diseases can be identified by representing them in the form of mathematically produced networks. This method was used to find bacteria that drive atopic dermatitis, for example. Wed, 16 Mar 2022 14:41:59 +0100 https://news.ki.se/spider-silk-can-stabilise-cancer-suppressing-protein The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet have now found an unusual way of stabilising the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure. Mon, 14 Mar 2022 16:00:07 +0100 https://news.ki.se/cancer-patients-in-palliative-care-experienced-reduced-fatigue-after-vitamin-d-treatment-with-effects-most-prominent-in-men Fatigue, or severe tiredness and exhaustion, is a distressing condition for many patients with advanced cancer. Unfortunately, good pharmacological treatment options are limited, and the ones available come with a risk of side effects and/or habituation. Wed, 02 Mar 2022 15:10:40 +0100 https://news.ki.se/jessica-had-children-after-cancer When she was 14 years old Jessica Strid was treated for cancer and was told that it would be difficult for her to get pregnant. Today she has two children. ”I am very grateful”, she says. Wed, 23 Feb 2022 11:21:42 +0100 https://news.ki.se/fertility-treatment-help-for-people-who-have-had-cancer Many young people whose fertility have been impaired due to cancer treatment can today be helped to become parents. Kenny Rodriguez-Wallberg, Adjunct Professor at the Department of Oncology and Pathology at Karolinska Institutet and Senior Consultant at Karolinska University Hospital, answers six common questions. Wed, 23 Feb 2022 11:20:50 +0100 https://news.ki.se/rna-molecules-control-repair-of-human-dna-in-cancer-cells A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. The study is published today in the journal Nature Communications. Wed, 23 Feb 2022 11:00:06 +0100 https://news.ki.se/risks-after-treatment-for-cervical-neoplasia-have-declined-over-time The treatment of serious prodromal cervical cancer, CIN3, can cause problems during later pregnancy amongst women of fertile age. A new registry study from Karolinska Institutet shows a higher risk of several adverse pregnancy outcomes after such treatment, but the risks have declined over time and the increased risk of infant death no longer exists. The study, which included a large number of births in Sweden over a 46-year period, is published in The Annals of Internal Medicine. Mon, 07 Feb 2022 23:00:07 +0100 https://news.ki.se/cervical-samples-could-reveal-risk-of-breast-and-ovarian-cancer An international team of scientists, including from Karolinska Institutet, has discovered a means of identifying the risk of breast and ovarian cancer by analysing cell samples from the cervix. By measuring epigenetic changes in cervical samples from over a thousand women, the researchers have found two unique signatures for breast and ovarian cancer. The results are presented in two papers in the journal Nature Communications. Fri, 04 Feb 2022 08:50:40 +0100 https://news.ki.se/targeted-treatment-helped-child-with-neuroblastoma Researchers at Karolinska Institutet and the University of Gothenburg have found another piece of the puzzle in the treatment of the childhood cancer neuroblastoma. A new case report, published in JCO Precision Oncology, describes the successful targeted treatment of a boy with neuroblastoma and a specific mutation. Wed, 02 Feb 2022 10:37:20 +0100 https://news.ki.se/new-blood-test-combined-with-image-based-prostate-cancer-screening-reduces-harms-and-costs The combination of a novel blood test and magnetic resonance imaging (MRI) can reduce overdiagnosis of low-risk cancers as well as societal costs in prostate cancer screening, according to a cost-effectiveness study from Karolinska Institutet published in the journal European Urology. The results provide support for organised prostate cancer testing in Sweden, researchers say. Fri, 28 Jan 2022 09:00:09 +0100 https://news.ki.se/large-international-evaluation-shows-ai-accurately-diagnoses-prostate-cancer KI researchers have together with international collaborators completed a comprehensive international validation of artificial intelligence (AI) for diagnosing and grading prostate cancer. The study, published in Nature Medicine, shows that AI systems can identify and grade prostate cancer in tissue samples from different countries equally well as pathologists. The results suggest AI systems are ready to be responsibly introduced as a complementary tool in prostate cancer care, researchers say. Thu, 13 Jan 2022 18:21:41 +0100 https://news.ki.se/new-findings-may-contribute-to-better-diagnosis-and-treatment-of-liver-cancer In a new study, researchers at Karolinska Institutet have identified the presence of a specific connection between a protein and an lncRNA molecule in liver cancer. By increasing the presence of the lncRNA molecule, the fat depots of the tumor cell decrease, which causes the division of tumor cells to cease, and they eventually die. The study, published in the journal Gut, contributes to increased knowledge that can add to a better diagnosis and future cancer treatments. Wed, 12 Jan 2022 11:00:06 +0100 https://news.ki.se/sek-18-million-awarded-from-the-sjoberg-foundation Five researchers from Karolinska Institutet have been awarded grants from the Sjöberg Foundation, in total a sum of SEK 18.1 million. The foundation supports research with a focus on cancer, health and the environment. Thu, 23 Dec 2021 09:08:04 +0100 https://news.ki.se/international-cancer-award-to-two-ki-researchers KI researchers Bennie Lemmens and Kirsty Spalding have been granted 2021 ASPIRE Awards from The Mark Foundation for Cancer Research for their innovative and bold ideas on cancer research. They are two of a total of 25 award recipients who will jointly receive nearly $9.5 million (SEK 86 million). Wed, 22 Dec 2021 11:59:31 +0100 https://news.ki.se/eleven-ki-researchers-receive-grants-for-research-on-cancer-and-allergies Eleven researchers at five departments at Karolinska Institutet have received funding from Cancer- och Allergifonden (Cancer and Allergy Fund) for their point-of-care research projects on cancer and allergies. The researchers from Karolinska were allocated SEK 2.6 million. In total, the Fund distributed a total of five million SEK to Swedish cancer and allergy research. Wed, 22 Dec 2021 11:22:29 +0100 https://news.ki.se/new-thesis-on-cell-free-dna-and-hereditary-cancer Karin Wallander at the research group Clinical Genetics, Department of Molecular Medicine and Surgery, will defend her thesis "Hereditary predisposition and prognostic prediction in cancer" on December 17, 2021. Main Supervisor is Emma Tham. Wed, 15 Dec 2021 11:08:09 +0100 https://news.ki.se/over-a-quarter-of-a-billion-sek-for-cancer-research-at-ki 79 KI researchers have received a total of SEK 254,450,000 in grants from the Swedish Cancer Society. In addition, four Fellowship prevention grants were also awarded to researchers at KI. In total, the Swedish Cancer Society distributed SEK 850 million, which is the largest amount ever. Thu, 09 Dec 2021 09:29:05 +0100 https://news.ki.se/new-immunotherapy-for-leukemia-discovered Researchers at Karolinska Institutet, University of Oslo and Oslo University Hospital have developed a new kind of immunotherapy for leukemia. The results of a study published in Nature Biotechnology show that the therapy kills cancer cells from patients with acute lymphoblastic leukemia. The researchers now want to conduct a clinical study and also test the method on other types of cancer. Mon, 06 Dec 2021 17:05:06 +0100 https://news.ki.se/ki-researcher-patrik-ernfors-wants-to-understand-pain By building up expertise around how pain arises, he hopes to help find a future solution to chronic pain. Professor Patrik Ernfors writes about failures, his work with the Nobel Prizes and why you need to be open-minded to make new discoveries. Mon, 06 Dec 2021 13:43:29 +0100 https://news.ki.se/more-than-13-msek-from-cancerfonden-to-researchers-at-bionut Congratulations to all the researchers at the Department of Biosciences and Nutrition (BioNut) who received funding from Cancerfonden 2022-2024. We would also like to highlight their special initiative: Fellowship in cancer research in primary prevention, which was awarded to one of our researchers. Tue, 30 Nov 2021 15:35:08 +0100 https://news.ki.se/new-findings-on-bacteria-that-increase-risk-of-pancreatic-cancer Bacteria from the digestive system seem to have the potential to cause damage to pancreatic cells, increasing the risk of malignant tumours. Now for the first time, live bacteria from cystic pancreatic lesions that are precursors to pancreatic cancer, have been analysed by researchers at Karolinska Institutet. The study, which is published in Gut Microbes, can lead to prophylactic interventions using local antibiotics. Wed, 24 Nov 2021 13:00:06 +0100 https://news.ki.se/per-hall-praised-for-his-research-on-breast-cancer-prevention The Breast Cancer Association's award 2021 goes to chief physician and KI professor Per Hall. He is recognized for his broad research on how breast cancer can be prevented and detected early with refined and individual methods. Tue, 23 Nov 2021 17:04:30 +0100 https://news.ki.se/analysis-of-proteins-in-tissue-can-lead-to-improved-cancer-therapy Analysing all the proteins that exist in a tissue type (the so-called proteome) can provide vital information on the causes of diseases and how they can best be treated. We talk to Janne Lehtiö, professor at the Department of Oncology-Pathology, about proteome-based medicine and what it can contribute to personalised cancer therapy. Mon, 22 Nov 2021 17:00:05 +0100 https://news.ki.se/gold-based-cancer-therapy-could-face-competition-from-other-substances The gold complex auranofin has traditionally been used for treating rheumatism but is also being evaluated as a treatment for certain forms of cancer. Researchers at Karolinska Institutet in Sweden now show that other molecules that inhibit the same biological system have a more specific effect than auranofin and therefore may have greater potential as cancer therapies. The results have been published in the journal Redox Biology. Mon, 22 Nov 2021 13:28:07 +0100 https://news.ki.se/new-findings-on-the-link-between-crispr-gene-editing-and-mutated-cancer-cells A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers at Karolinska Institutet have found new links between CRISPR, p53 and other cancer genes that could prevent the accumulation of mutated cells without compromising the gene scissors’ effectiveness. The study, published in Cancer Research, can contribute to tomorrow’s precision medicine. Thu, 18 Nov 2021 10:00:06 +0100 https://news.ki.se/ai-improves-precision-in-breast-cancer-diagnosis Researchers at Karolinska Institutet have developed an AI-based tool that improves the diagnosis of breast cancer tumours and the ability to predict the risk of recurrence. The greater diagnostic precision can lead to more personalised treatment for the large group of breast cancer patients with intermediate risk tumours. The results are published in the scientific journal Annals of Oncology. Thu, 30 Sep 2021 01:05:04 +0200 https://news.ki.se/new-thesis-on-improved-surgical-treatment-of-oesophageal-cancer Eivind Gottlieb-Vedi at the research group Upper GI Surgery, the Department of Molecular Medicine and Surgery, will defend his thesis "Improved surgical treatment of oesophageal cancer" on September 10th, 2021. Main Supervisor is Professor Jesper Lagergren. Thu, 09 Sep 2021 12:33:31 +0200 https://news.ki.se/new-research-shows-a-link-between-cell-identities-and-childhood-cancer-type-neuroblastoma Neuroblastoma is a type of childhood cancer that develops in infants and young children. Whilst it is a relatively rare form of cancer, it is still responsible for approximately 15 percent of all cancer deaths in children. In a new study published today in Nature Communications, researchers at Karolinska Institutet have discovered that low-risk and high-risk neuroblastoma have different cell identities, which can affect the survival rate. Tue, 07 Sep 2021 11:00:05 +0200 https://news.ki.se/new-blood-test-improves-prostate-cancer-screening Researchers at Karolinska Institutet recently reported that magnetic resonance imaging (MRI) could reduce overdiagnoses and thereby improve prostate cancer screening. Now, the same research group has published a study in The Lancet Oncology, which shows that the addition of a novel blood test, the Stockholm3 test, can reduce the number of MRIs performed by a third while further preventing the detection of minor, low-risk tumours. Fri, 13 Aug 2021 00:30:05 +0200 https://news.ki.se/vitamin-d-reduces-the-need-for-opioids-in-palliative-cancer Patients with vitamin D deficiency who received vitamin D supplements had a reduced need for pain relief and lower levels of fatigue in palliative cancer treatment, a randomized and placebo-controlled study by researchers at Karolinska Institutet shows. The study is published in the scientific journal Cancers. Thu, 05 Aug 2021 13:08:26 +0200 https://news.ki.se/new-findings-about-cancer-cell-growth-may-hold-promise-for-future-cancer-treatments For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published in Science Advances, researchers at Karolinska Institutet have investigated the protein eIF4A3 and its role in the growth of cancer cells. The study shows that by blocking or reducing the production of this protein, other processes arise that cause the growth and cell division of cancer cells to cease and eventually die. Wed, 04 Aug 2021 20:00:05 +0200 https://news.ki.se/strengthened-collaboration-with-hungary-in-the-field-of-cancer Karolinska Institutet has signed a collaborative agreement with the Hungarian National Institute of Oncology, NIO. The planned collaboration will primarily take place within the framework of Karolinska Comprehensive Cancer Centre together with Karolinska University Hospital. Fri, 30 Jul 2021 16:01:39 +0200 https://news.ki.se/excess-body-fat-increases-risk-of-digestive-system-cancers Obesity increases the risk of developing cancers of the digestive system and it is the person’s fat mass, rather than size, that is the main obesity-related risk factor for these cancer types, according to a new study published in the journal PLOS Medicine by researchers at the University of Cambridge and Karolinska Institutet. Thu, 29 Jul 2021 20:27:23 +0200 https://news.ki.se/mri-can-cut-overdiagnoses-in-prostate-cancer-screening-by-half Most countries have not introduced nationwide prostate-cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in The New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted biopsies could potentially cut overdiagnoses by half. The results are presented today at the European Association of Urology Congress. Fri, 09 Jul 2021 10:15:04 +0200 https://news.ki.se/former-paediatric-cancer-patient-regained-fertility With the development of more effective treatment for childhood cancer, fertility preservation efforts have become routine at many centers. At the same time, there have been questions about the risks of relapse when re-transplanting ovarian tissue. Now researchers at Karolinska Institutet report on a woman who is expecting her second child after being treated for leukaemia as a teenager. This study, published in Haematologica, may be of great importance to many young women and their families. Thu, 08 Jul 2021 11:09:53 +0200 https://news.ki.se/new-cancer-findings-can-give-wider-access-to-immunotherapy Researchers at Karolinska Institutet publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy. Tue, 06 Jul 2021 09:05:04 +0200 https://news.ki.se/hope-for-children-with-high-risk-neuroblastoma Thanks to many years of translational research, some children with the rare childhood cancer neuroblastoma may now be cured. In a study published in the Journal of Clinical Oncology, researchers at among others Karolinska Institutet and University of Gothenburg write that so-called ALK inhibitors should be tried to treat children with high-risk neuroblastoma. That is after an analysis showed that children with mutations in the ALK gene have poorer prognosis. Thu, 24 Jun 2021 09:02:44 +0200 https://news.ki.se/analysis-of-4000-drugs-reveals-an-alternative-mechanism-for-a-new-anticancer-therapy By analyzing 4,000 drugs’ ability to affect cells’ capacity to produce proteins, researchers at Karolinska Institutet found that an anticancer therapy currently trialed in human patients works differently than previously thought. As many human diseases have alterations in this process called translation, the new knowledge contributes to a better understanding of how translation is regulated and the biological routes that regulate it. The study is published in PLOS Biology. Wed, 02 Jun 2021 16:20:42 +0200 https://news.ki.se/new-findings-provide-hope-for-treatment-of-multiple-myeloma Researchers at Karolinska Institutet have investigated the use of low dose venetoclax, an experimental drug, for the treatment of the heterogeneous cancer disease multiple myeloma in patients who had relapsed on standard therapies. The findings are published in the American Journal of Hematology and provide new hope for the treatment of multiple myeloma. Wed, 19 May 2021 08:36:10 +0200 https://news.ki.se/new-marker-predicts-benefit-of-radiotherapy-for-early-stage-breast-cancer A study involving researchers at Karolinska Institutet and University of Gothenburg has found that low levels of a protein called PDGFRb are associated with particularly good results of radiotherapy in women with early-stage breast cancer. The study, which is published in the journal Clinical Cancer Research, also suggests that the efficacy of radiotherapy can be improved with drugs that block this protein. Wed, 05 May 2021 09:05:05 +0200 https://news.ki.se/intestinal-polyps-in-close-relatives-can-increase-risk-of-colorectal-cancer Cancer of the colon and rectum is one of the deadliest forms of cancer, and has in recent years affected growing numbers of young people. In the largest registry study to date, researchers at Karolinska Institutet and Harvard University in the USA demonstrate a possible connection between colorectal polyps in close relatives and the risk of developing colorectal cancer. The study, which is published in The British Medical Journal, is of potential consequence for screening procedures. Tue, 04 May 2021 11:30:06 +0200 https://news.ki.se/we-congratulate-francesca-castoldi-at-bionut Francesca Castoldi, at the Department of Biosciences and Nutrition (BioNut), KI, has been awarded a research grant of 300 000 SEK from the Alex and Eva Wallström Foundation for scientific research and education. Wed, 14 Apr 2021 16:08:35 +0200 https://news.ki.se/increased-risk-of-liver-cancer-in-patients-with-non-alcoholic-fatty-liver Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer. Wed, 14 Apr 2021 09:06:02 +0200 https://news.ki.se/ten-ki-researchers-receive-funding-from-the-swedish-childhood-cancer-foundation Ten researchers at Karolinska Institutet are granted funding through the Swedish Childhood Cancer Foundation's latest funding call, which in total distributes a little more than SEK 65 million. The grants include a six-year research position and several postdoctoral positions. Thu, 08 Apr 2021 09:54:54 +0200 https://news.ki.se/cancer-researchers-aim-to-reach-a-wider-audience On April 29, KI will host a digital event focusing on cancer research, where researchers and professors will gather to talk about their ground-breaking research. Yvonne Wengström is one of the organizers and hopes for strong participation and an interactive dialogue on research in the field. Wed, 07 Apr 2021 14:58:26 +0200 https://news.ki.se/erb-suggested-as-additional-treatment-in-prostate-cancer The standard treatment for advanced metastatic prostate cancer (PCa) is androgen deprivation therapy (ADT). And even if this is efficient in the short term, 1/3 of PCa will become resistant to ADT and develop castration-resistant prostate cancer. A new study, by Karolinska Institutet and others, shows that estrogen receptor β (ERβ) agonists together with ADT could be considered useful in the treatment. Mon, 29 Mar 2021 09:34:51 +0200 https://news.ki.se/lower-dose-of-oestrogen-receptor-modulator-seems-to-reduce-risk-of-breast-cancer While the drug tamoxifen reduces the risk of developing breast cancer and prevents recurrence, the side-effects cause many women to discontinue their treatment. A study involving researchers at Karolinska Institutet in Stockholm has now found that a much lower dose than the standard produces a good effect with fewer adverse reactions in women who have yet to enter the menopause. The study, which has been published in the Journal of Clinical Oncology, can play a significant role in the treatment. Thu, 18 Mar 2021 21:00:04 +0100 https://news.ki.se/ai-method-can-detect-precursors-to-cervical-cancer Using artificial intelligence and mobile digital microscopy, researchers hope to create screening tools that can detect precursors to cervical cancer in women in resource-limited settings. A study led by researchers at Karolinska Institutet and University of Helsinki now shows that AI screenings of pap smears carried out with portable scanners were comparable to analyses done by pathologists. The results are published in the journal JAMA Network Open. Wed, 17 Mar 2021 16:00:04 +0100 https://news.ki.se/new-research-on-mitochondrial-function-can-play-significant-part-in-serious-disease Disorders of the cells’ energy supply can cause a number of serious diseases, but also seem to be connected to ageing. More research is needed on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet shows how an important molecule inside the mitochondria affects their function in mice and fruit flies. The study, which is published in Science Advances, adds valuable knowledge on formerly relatively unexplored protein modifications. Fri, 19 Feb 2021 20:00:04 +0100 https://news.ki.se/anticancer-drug-may-improve-outcome-for-severe-covid-19-patients Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020. On average, blood oxygen levels, body temperature and inflammatory markers significantly improved in patients treated with a single dose of bevacizumab in addition to standard care. The research is published in Nature Communications. Fri, 05 Feb 2021 11:00:03 +0100 https://news.ki.se/new-potential-therapeutic-target-for-ovarian-cancer A subset of immune cells called gamma delta T cells are associated with increased survival in patients with advanced ovarian cancer, researchers at Karolinska Institutet report in the scientific journal Science Translational Medicine. The findings suggest that promoting gamma delta T cell responses may be a therapeutic option for ovarian cancer, researchers say. Thu, 21 Jan 2021 08:47:56 +0100 https://news.ki.se/weaker-skin-barrier-leads-to-faster-uptake-of-chemicals The ability of our skin to protect us from chemicals is something we inherit. Some people are less well-protected which could imply an increased risk of being afflicted by skin disease or cancer. A new study from Karolinska Institutet that has been published in Environmental Health Perspectives shows how the rate of uptake of common chemicals is faster in people with a genetically weakened skin barrier. Wed, 13 Jan 2021 15:00:00 +0100 https://news.ki.se/new-grant-from-the-swedish-childhood-cancer-foundation Congratulations to Peter Zaphiropoulos, at the Department of Biosciences and Nutrition, who received 1 million SEK in project grants from the Swedish Childhood Cancer Foundation 2020 for a project on Circular RNA in medulloblastoma. Tue, 12 Jan 2021 16:25:16 +0100 https://news.ki.se/anna-martling-named-cancer-researcher-of-the-year The Swedish Cancer Society has awarded the prestigious title Cancer Researcher of the Year 2021 to Anna Martling, professor of surgery at Karolinska Institutet and senior consultant colorectal surgeon at Karolinska University Hospital, as well as dean of KI Nord. Mon, 11 Jan 2021 15:32:04 +0100 https://news.ki.se/sek-12-million-awarded-from-the-sjoberg-foundation Three researchers from Karolinska Institutet have been awarded grants from the Sjöberg Foundation, in total a sum of SEK 12 million. The foundation supports research with a focus on cancer, health and the environment. Thu, 17 Dec 2020 08:00:04 +0100 https://news.ki.se/novel-principle-for-cancer-treatment-shows-promising-effect Researchers at Karolinska Institutet report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumour growth in mice, without significantly affecting healthy cells. Wed, 16 Dec 2020 17:00:03 +0100 https://news.ki.se/new-research-identifies-which-t-cells-patrol-the-body The blood is the main source of studies on the immune system, despite the fact that most diseases are combated by immune cells in the body’s tissues. A new study from Karolinska Institutet and the University of Pennsylvania has identified which immune cells patrol the human body’s tissues and circulate back into the blood. The study, which is published in Cell, shows that not all T cells do this – some are found mostly in the blood where they constitute a unique part of our immune system. Thu, 10 Dec 2020 17:00:03 +0100 https://news.ki.se/best-doctoral-thesis-in-cancer-research-2019 Tânia Costa at the Department of Biosciences and Nutrition is the receiver of the Dan Grandér Memorial Prize 2020 for the best doctoral thesis in the area of cancer research at Karolinska Institutet during 2019. With a comprehensive and yet focused thesis, spanning from molecular mechanisms to patient outcome, illuminating the role of PAK 4 in tumor development and prognosis. Fri, 04 Dec 2020 11:43:09 +0100 https://news.ki.se/insights-into-nasopharyngeal-carcinoma-risks-and-prognosis Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It is known that the interaction of Epstein-Barr Virus infection, environmental and lifestyle factors, and genetic susceptibility, contributes to NPC carcinogenesis. Mon, 30 Nov 2020 13:17:10 +0100 https://news.ki.se/new-type-of-immunotherapy-may-pave-the-way-for-better-cancer-treatments Immunotherapy for cancer has made great advances and many patients can now receive effective treatments that were not available ten years ago. However, there are certain types of cancer that do not respond to existing immunotherapy. A study from Karolinska Institutet in Sweden published in Proceedings of the National Academy of Sciences (PNAS) reports on a new kind of immunotherapy that gives hope of more treatment options for cancer in the future. Mon, 23 Nov 2020 21:00:03 +0100 https://news.ki.se/frozen-eggs-and-ovarian-tissue-helped-women-conceive-children-after-breast-cancer Women with breast cancer whose eggs or ovarian tissue were frozen had more children after their diagnosis than women who did not undergo fertility preservation using those methods before start of cancer treatment. That is according to a study by researchers at Karolinska Institutet in Sweden, published in JAMA Oncology. According to the researchers, the result highlights the importance of reproductive counseling and fertility preservation for women who are diagnosed with cancer at a young age. Thu, 19 Nov 2020 17:00:04 +0100 https://news.ki.se/ki-receives-sek-290-million-from-cancer-society Researchers at Karolinska Institutet have been awarded a grant of SEK 290 million from the Swedish Cancer Society, meaning that over one third of the total grant of SEK 709 million, divided amongst eleven universities, is going to cancer research at KI. Two of the recipients are associate professor Mattias Rantalainen and Professor Fang Fang. Fri, 13 Nov 2020 15:10:12 +0100 https://news.ki.se/bionut-researchers-awarded-45-million-sek-from-the-swedish-cancer-society The Swedish cancer society has on November 11th awarded 709 million SEK to cancer research in Sweden. Among them were ten researchers from the Department of Biosciences and Nutrition (BioNut) at KI, who were granted a total of 45.2 million SEK. The grants cover the years 2021- 2023. We wish to congratulate all our researchers to the grants received! Thu, 12 Nov 2020 10:48:57 +0100 https://news.ki.se/anti-depressant-repurposed-to-treat-childhood-cancer A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments. The findings, from researchers at Karolinska Institutet in Sweden and MD Anderson Cancer Centre in Texas, ignite hope of novel treatment strategies against this disease. The study is published in the journal Cancer Research. Fri, 06 Nov 2020 09:15:03 +0100 https://news.ki.se/study-shows-how-exercise-stalls-cancer-growth-through-the-immune-system People with cancer who exercise generally have a better prognosis than inactive patients. Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth in mice: Physical activity changes the metabolism of the immune system’s cytotoxic T cells and thereby improves their ability to attack cancer cells. The study is published in the journal eLife. Mon, 26 Oct 2020 10:58:03 +0100 https://news.ki.se/newly-discovered-mechanism-controls-cancer-cell-growth-and-metabolism In a new study published in the journal Cell Death & Differentiation researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. Thu, 22 Oct 2020 08:51:58 +0200 https://news.ki.se/sek-10-million-awarded-to-research-on-myelodysplastic-syndrome The Tobias Foundation grant in 2020 has been awarded to Magnus Tobiasson and Eva Hellström Lindberg, both researchers at Karolinska Institutet. The grant amounts to SEK 10 million over a five-year period. It will support research on early detection of relapse after stem cell transplantation for patients with myelodysplastic syndrome. Tue, 20 Oct 2020 09:03:00 +0200 https://news.ki.se/improved-survival-for-cancer-patients-in-a-large-nordic-comparison A comprehensive comparison of cancer survival between the Nordic countries shows improvements for all countries over time with previously observed differences attenuated. The reasons for these improvements are likely multifactorial. Previous studies comparing cancer survival between the Nordic countries have found marked differences, with a notably poorer survival in Danish patients. Mon, 19 Oct 2020 13:06:33 +0200 https://news.ki.se/hpv-vaccine-effective-against-cervical-cancer Women vaccinated against HPV have a significantly lower risk of developing cervical cancer, and the positive effect is most pronounced for women vaccinated at a young age. That is according to a large study by researchers at Karolinska Institutet in Sweden published in New England Journal of Medicine. Wed, 30 Sep 2020 23:00:07 +0200 https://news.ki.se/women-could-conceive-after-ovarian-tumours Women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, a study from Karolinska Institutet in Sweden published in Fertility & Sterility shows. Natural fertility was preserved in most of them and only a small proportion required assisted reproductive treatment such as in vitro fertilization. Survival in the group was also as high as in women who had undergone radical surgical for treatment of similar tumours. Fri, 25 Sep 2020 13:13:11 +0200 https://news.ki.se/ai-as-good-as-the-average-radiologist-in-identifying-breast-cancer Researchers at Karolinska Institutet and Karolinska University Hospital in Sweden have compared the ability of three different artificial intelligence (AI) algorithms to identify breast cancer based on previously taken mammograms. The best algorithm proved to be as accurate as the average radiologist. The results, published in JAMA Oncology, may lead the way in reorganising breast cancer screening for the future. Thu, 27 Aug 2020 17:00:04 +0200 https://news.ki.se/promising-new-treatment-of-advanced-skin-cancer A new type of immunotherapy for the skin cancer malignant melanoma shows promising results. Three severely ill patients are now long-term survivors. The study, published in OncoImmunology, is the result of a collaboration between researchers at Karolinska Institutet and Karolinska University Hospital. Fri, 07 Aug 2020 13:56:55 +0200 https://news.ki.se/new-ways-to-study-how-cancer-arises In an interdisciplinary study combining stem cell biology and tumor biology, researchers from Karolinska Institutet (as well as Uppsala and Lund University, together with researchers in Canada, Germany and France), have succeeded in creating a new type of stem cell models for studies on cancer of the brain. The study was recently published in PNAS. Thu, 06 Aug 2020 16:07:52 +0200 https://news.ki.se/increased-risk-of-small-bowel-cancer-in-individuals-with-celiac-disease-but-absolute-numbers-are-low Through a unique database, KI researchers have studied the risk of small bowel cancer in individuals with celiac disease. Principal investigator Louise Emilsson, affiliated researcher at the Department of Medical Epidemiology and Biostatistics, associate professor at HELSAM, Oslo University and co-author Jonas F Ludvigsson, professor at Karolinska Institutet, reflect on their work recently published in Gastroenterology. Thu, 16 Jul 2020 13:28:47 +0200 https://news.ki.se/unique-global-online-tool-paves-the-way-for-more-individualised-cancer-treatments Making the latest research results available to doctors increases the opportunities for finding better individualised cancer treatment. For a few years, researchers at Karolinska Insititutet and several other universities have been working on building a digital tool which will make global genomic data easily available as support for treatment decisions. Tue, 07 Jul 2020 11:10:06 +0200 https://news.ki.se/steep-rise-in-skin-cancer-since-1960s The risk of developing more than one skin melanoma over a ten-year period has seen a ten-fold increase in Sweden since the 1960s, a new study by researchers at Karolinska Institutet and Lund University published in The Journal of the National Cancer Institute reports. The researchers suspect that the increase is due to a change in holiday customs with more active sunbathing and overseas trips to southern climes. Wed, 24 Jun 2020 08:05:02 +0200 https://news.ki.se/significant-association-between-income-and-survival-after-surgery-for-lung-cancer Patients with low income have a higher risk of death following surgery for lung cancer compared with patients with high income. The association remains even after taking prevalence of common comorbidities, and other factors that are known to influence the risk of death, into account. This is according to a study published in the journal Thorax by researchers at Karolinska Institutet in Sweden. Mon, 22 Jun 2020 10:54:27 +0200 https://news.ki.se/ki-researchers-part-of-new-imi-consortium-seeking-to-develop-research-tools Researchers at Karolinska Institutet are part of a consortium granted almost 66 million euros (690 million Swedish kronor) by the european Innovative Medicines Initiative (IMI) and other parties. The funds will be used to develop, test and facilitate access to chemical substances and other research tools that could pave the way for new drug targets and treatments of diseases within areas such as inflammation and cancer. Mon, 08 Jun 2020 14:20:32 +0200 https://news.ki.se/inflammatory-bowel-disease-ibd-and-small-bowel-cancer-a-binational-study In a population-based cohort study from Sweden and Denmark of patients with inflammatory bowel disease (IBD) during 1969-2017 and matched reference individuals from the general population, Ola Olén, Jonas F Ludvigsson and colleagues found that IBD patients had an increased risk of small bowel cancer. Mon, 01 Jun 2020 14:42:29 +0200 https://news.ki.se/etiology-and-prognosis-of-gastric-and-esophageal-cancer-explored The focus of Isabella Ekheden's thesis is on gastric and esophageal cancer – gastroesophageal cancers - that are some of the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance with the potential of lowering the disease burden. Fri, 29 May 2020 15:53:21 +0200 https://news.ki.se/joint-effort-to-develop-whole-genome-sequencing-for-patients-with-acute-leukemia A new study has been initiated to evaluate whole-genome and RNA-sequencing as a first line diagnostic approach for patients in Sweden with acute leukemia. The study is conducted jointly by the national R&D platform Genomic Medicine Sweden and the biotech company Illumina – and is coordinated from Karolinska Institutet. Thu, 28 May 2020 09:59:00 +0200 https://news.ki.se/new-understanding-of-rna-movements-can-be-used-to-treat-cancer Research from Karolinska Institutet published today in Nature shows that an RNA molecule involved in preventing tumour formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer. Wed, 27 May 2020 17:00:08 +0200 https://news.ki.se/adapting-cancer-care-to-covid-19-pandemic Comprehensively adapting cancer care and clinical cancer research to the COVID-19 pandemic is a necessity, researchers and doctors at Karolinska Institutet and Karolinska University Hospital write in a paper published in the journal Nature Medicine. In it, seven top European cancer centres propose adaptations to protect patients. Wed, 29 Apr 2020 14:22:10 +0200 https://news.ki.se/erc-proof-of-concept-for-a-new-treatment-for-severe-pneumonia-and-fibrosis Thomas Helleday’s research group has been awarded a prestigious grant from the European Research Council (ERC) for the sixth time. The latest ERC Proof of Concept Grant is aimed at the development of new anti-inflammatory drugs for lung diseases such as fibrosis. Mon, 27 Apr 2020 12:30:05 +0200 https://news.ki.se/first-in-sweden-to-have-oeci-accreditation-as-comprehensive-cancer-centre Karolinska Institutet and Karolinska University Hospital are the first institutions in Sweden to be accredited as a Comprehensive Cancer Centre by the Organisation of European Cancer Institutes (OECI). Tue, 07 Apr 2020 10:59:47 +0200 https://news.ki.se/stress-during-cancer-diagnostic-workup Qing Shen’s thesis aims to increase our understanding of cancer diagnostic workup, by investigating different stress-related health outcomes during the critical time period of cancer evaluation, diagnosis and treatment, and also provide evidence for a potential effective treatment approach to attenuate excessive risks of stress-related health outcomes. Thu, 02 Apr 2020 13:14:52 +0200 https://news.ki.se/polyps-and-colorectal-cancer-risk Patients with polyps have a higher risk of colorectal cancer, and those with sessile serrated polyps, tubulovillous adenomas, and villous adenomas had a higher colorectal cancer mortality. Tue, 17 Mar 2020 07:00:04 +0100 https://news.ki.se/hpv-infections-can-be-eliminated-if-both-boys-and-girls-are-vaccinated The human papillomavirus (HPV) causes, amongst other diseases, cancer of the cervix and oropharynx. A Swedish-Finnish study published in The Journal of Infectious Diseases now shows that the most oncogenic HPV types can be eliminated, but only if both girls and boys are vaccinated. Both genders will be offered vaccination in Sweden as of 2020. Thu, 12 Mar 2020 11:43:21 +0100 https://news.ki.se/low-dose-aspirin-linked-to-reduced-liver-cancer-risk Among adults with chronic viral hepatitis at high risk of liver cancer, those who took low-dose aspirin long-term were less likely to develop liver cancer or to die from liver-related causes. The findings come from a study published in the New England Journal of Medicine and conducted by a team led by investigators at Karolinska Institutet and Örebro University Hospital in Sweden and Massachusetts General Hospital in the U.S. Wed, 11 Mar 2020 22:00:06 +0100 https://news.ki.se/chemotherapy-rewires-a-novel-resistance-promoting-signaling-pathway-in-ovarian-cancer Researchers from Karolinska Institutet along with clinicians from the Karolinska University Hospital have discovered a new molecular mechanism of cell oncogenic signaling switch, which is induced by platinum chemotherapy and contributes to treatment resistance in ovarian cancer. Wed, 04 Mar 2020 15:00:17 +0100 https://news.ki.se/crohns-disease-linked-to-increased-risk-of-colorectal-cancer Researchers from Karolinska Institutet, Örebro University and Aarhus University, Denmark, have published the largest study to date on the risk of colorectal cancer in Crohn's disease. The article is published in the journal The Lancet Gastroenterology Hepatology. Sat, 15 Feb 2020 03:00:00 +0100 https://news.ki.se/new-opportunity-for-cancer-drug-development After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer. Tue, 21 Jan 2020 11:00:00 +0100 https://news.ki.se/cheap-drug-may-alleviate-treatment-resistance-in-leukemia A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. This is the conclusion of a study in mice and human blood cells performed at Karolinska Institutet and SciLifeLab and published in the medical journal EMBO Molecular Medicine. The researchers will now launch a clinical study to test the new combination treatment in patients. Fri, 17 Jan 2020 12:00:00 +0100 https://news.ki.se/colorectal-cancer-risk-remains-despite-modern-treatment-for-ulcerative-colitis Patients with the inflammatory bowel disease ulcerative colitis have a higher risk of dying from colorectal cancer, despite modern therapy, even though the risk has declined in recent years. This is according to a new study published in the scientific journal The Lancet by a team of Swedish and Danish researchers. Fri, 10 Jan 2020 00:30:00 +0100 https://news.ki.se/ai-can-be-used-to-detect-and-grade-prostate-cancer Researchers at Karolinska Institutet have developed a method based on artificial intelligence for histopathological diagnosis and grading of prostate cancer. The AI-system has the potential to solve one of the bottlenecks in today’s prostate cancer histopathology by providing more accurate diagnosis and better treatment decisions. The study, presented in The Lancet Oncology, shows that the AI-system is as good at identifying and grading prostate cancer as world-leading uro-pathologists. Thu, 09 Jan 2020 00:30:00 +0100 https://news.ki.se/free-tool-simplifies-cancer-research Researchers at Karolinska Institutet have developed a new method for identifying which proteins are affected by specific drugs. The tool and the results it has already generated have been made freely available online. The method is described in the scientific journal Nature Communications. Mon, 16 Dec 2019 11:00:00 +0100 https://news.ki.se/new-principle-for-activation-of-cancer-genes-discovered Researchers have long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic. Now, researchers at Karolinska Institutet in Sweden have found a new mechanism that renders one canonical driver of cancer overactive. The findings, published in Nature Genetics, create conditions for brand new strategies to fight cancer. Fri, 29 Nov 2019 09:57:04 +0100 https://news.ki.se/thesis-on-sex-differences-in-cancer-risk-and-survival On Friday December 6, 2019 Cecilia Radkiewicz defended her thesis "Sex differences in cancer risk and survival". Wed, 20 Nov 2019 15:24:54 +0100 https://news.ki.se/lithium-can-reverse-radiation-damage-after-brain-tumour-treatment Children who have received radiotherapy for a brain tumour can develop cognitive problems later in life. In their studies on mice, researchers at Karolinska Institutet have now shown that the drug lithium can help to reverse the damage caused long after it has occurred. The study is published in the journal Molecular Psychiatry and the researchers are now planning to test the treatment in clinical trials. Thu, 14 Nov 2019 06:00:00 +0100 https://news.ki.se/potential-drug-targets-for-glioblastoma-identified Researchers at Karolinska Institutet have identified 10 tumour-specific potential drug targets for the brain tumour glioblastoma. The results are presented in the scientific journal Cell Reports. Tue, 05 Nov 2019 17:13:48 +0100 https://news.ki.se/applying-to-become-a-comprehensive-cancer-centre Karolinska University Hospital and Karolinska Institutet are the first in Sweden to apply for an accredited Comprehensive Cancer Center (CCC) by the Organization of European Cancer Institutes (OECI). On October 23-24 an is taking place at Karolinska University Hospital. Wed, 23 Oct 2019 14:15:07 +0200 https://news.ki.se/new-diagnostic-method-finds-aggressive-tumours Researchers at Karolinska Institutet have developed a new cheap method that can identify highly heterogeneous tumours that tend to be very aggressive, and therefore need to be treated more aggressively. The technique is presented in the scientific journal Nature Communications. Fri, 18 Oct 2019 11:00:00 +0200 https://news.ki.se/ki-collaboration-projects-awarded-eur-19-million-in-erc-synergy-grants Two research projects at Karolinska Institutet have been awarded synergy grants from the European Research Council (ERC). In total, the researchers and their international partners were awarded about EUR 19 million (SEK 209 million) over a six-year period for studies that aim to widen our understanding of disease-causing fat cells and unlock new cancer treatments. Fri, 11 Oct 2019 12:00:00 +0200 https://news.ki.se/new-method-provides-vehicles-for-rna-vaccines A new way of producing nanoparticles that can function as carriers in so-called mRNA vaccines has been developed by researchers at the Hong Kong node of Karolinska Institutet – the Ming Wai Lau Centre for Reparative Medicine – and the MIT, USA. Using the method, which is described in the scientific journal Nature Biotechnology, the researchers have identified a new class of carrier molecules that inhibit tumour growth and prolong survival in mouse models of cancer. Mon, 30 Sep 2019 17:00:00 +0200 https://news.ki.se/risk-factors-in-recurrent-dysplasia-identified Women have an increased risk of high-grade cervical lesions returning after surgery if there have been lesions in the resection margin, especially if high-risk HPV (human papillomavirus) is found in the follow-up test, reports a new longitudinal study from Karolinska Institutet published in The American Journal of Obstetrics and Gynecology. The researchers also found that many other diseases can be independent risk factors in lesion recurrence. Tue, 17 Sep 2019 10:00:00 +0200 https://news.ki.se/fertility-sparing-surgery-is-as-good-as-radical-surgery-for-early-ovarian-cancer Young women with early stage ovarian cancer can undergo fertility-preserving surgery without affecting the safety of their cancer treatment, researchers from Karolinska Institutet in Sweden report in a national study published in the journal Gynecologic Oncology. Wed, 04 Sep 2019 11:00:00 +0200 https://news.ki.se/they-are-awarded-the-erc-starting-grant Three researchers at Karolinska Institutet have been awarded the ERC Starting Grant 2019: Jenny Mjösberg, Maria Genander, and newly recruited Pia Dosenovic. Their projects concern inflammatory bowel disease, esophageal cancers, and HIV vaccine, respectively. In all, the ERC will support 408 early-career researchers from around the world with its prestigious starting grant this year. Tue, 03 Sep 2019 12:32:00 +0200 https://news.ki.se/smaller-operational-margins-just-as-safe-in-high-risk-melanoma The standard treatment for aggressive skin cancer is to surgically remove the tumour. Researchers at Karolinska Institutet in Sweden now show that a 2 cm operational margin is sufficient, as opposed to the close to 4 cm margin previously applied by surgeons. For the study, which is published in The Lancet, the researchers monitored over 900 patients for an average span of 19 years after surgery. Fri, 05 Jul 2019 00:30:00 +0200 https://news.ki.se/genetic-imbalance-in-immune-system-linked-to-biliary-tract-cancer Patients with biliary tract cancer have altered genetic architecture in some immune system receptor systems. This has been shown by researchers at Karolinska Institutet in Sweden in a new study published in the journal Gastroenterology. It is hoped that the discovery will lead to new effective immunotherapy for these difficult to treat tumour types. Wed, 26 Jun 2019 10:46:23 +0200 https://news.ki.se/a-new-method-to-select-the-right-treatment-for-advanced-prostate-cancer Researchers at Karolinska Institutet in Sweden have identified blood-based biomarkers that may determine which patients will benefit from continued hormonal therapy for advanced prostate cancer. The results are published in the journal JAMA Oncology. The researchers envision that this discovery may eventually result in a test that contributes to a more personalised treatment of the disease. Fri, 24 May 2019 12:39:50 +0200 https://news.ki.se/il-1-inhibitors-may-reduce-radiation-induced-vascular-damage Radiation therapy against cancer can increase the risk of cardiovascular disease much later in life, as the radiation causes chronic inflammation of the exposed blood vessels. In a new study published in the European Heart Journal, researchers from Karolinska Institutet in Sweden have shown that these inflammations can be treated with IL-1 inhibitors. Thu, 23 May 2019 14:42:04 +0200 https://news.ki.se/inhibition-of-ribosome-biogenesis-as-a-novel-approach-for-multi-stage-cancer-treatment Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Karolinska Institutet shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications. Fri, 10 May 2019 13:31:14 +0200 https://news.ki.se/identification-of-mechanisms-controlling-fibroblast-functions-in-ductal-breast-carcinoma-in-situ Carina Strell and colleagues in the Arne Östman research group has published an article in Journal of the National Cancer Institute investigating mechanisms controlling fibroblast functions in ductal breast carcinoma in situ (DCIS). Tue, 30 Apr 2019 09:31:51 +0200 https://news.ki.se/cxcl14ackr2-signaling-in-the-tumor-microenvironment-enhance-metastasis-and-shorten-survival-of-breast-cancer-patients In the present study Elin Sjöberg and colleagues in the Arne Östman research group have identified that cancer associated fibroblast (CAF)-produced CXCL14 re-activates a developmental program that promote migration and invasion of cancer cells, leading to increased formation of lung metastasis in mice. They also identified a novel CXCL14-signaling component, ACKR2, which is important for the tumor-promoting effects of CXCL14. Mon, 29 Apr 2019 12:12:51 +0200 https://news.ki.se/new-thesis-person-centered-care-supported-by-an-interactive-app-for-patients-with-pancreatic-cancer-following-surgery Thu, 11 Apr 2019 14:52:08 +0200 https://news.ki.se/awards-from-the-swedish-cancer-society-to-onkpat Fri, 05 Apr 2019 09:16:18 +0200 https://news.ki.se/screening-also-prevents-rare-types-of-cervical-cancer Thu, 04 Apr 2019 07:00:01 +0200 https://news.ki.se/they-are-the-2019-wallenberg-scholars Three researchers at Karolinska Institutet have been appointed Wallenberg Scholar in 2019: Ernest Arenas, Sten Linnarsson, and Randal S. Johnson. The researchers – among the foremost in their field in Sweden – receive SEK 18 million each from the Wallenberg Foundations in the form of a five-year grant for free research. Mon, 25 Mar 2019 09:10:00 +0100 https://news.ki.se/oral-bacteria-in-pancreas-linked-to-more-aggressive-tumours Thu, 14 Mar 2019 09:00:01 +0100 https://news.ki.se/new-research-prize-in-memory-of-professor-dan-grander Fri, 22 Feb 2019 13:18:00 +0100 https://news.ki.se/first-dan-grander-memorial-prize The first Dan Grandér memorial prize for best thesis at Karolinska Institutet in Cancer Research has been awarded to Dr Nicholas Valerie, Department of Oncology-Pathology. Mon, 18 Feb 2019 14:37:17 +0100 https://news.ki.se/new-insight-into-cell-receptors-opens-the-way-for-tailored-cancer-drugs New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. Fri, 08 Feb 2019 14:37:43 +0100 https://news.ki.se/olli-kallioniemi-receives-the-annual-research-prize-of-the-finnish-medical-society-duodecim Fri, 11 Jan 2019 12:20:12 +0100 https://news.ki.se/new-insights-into-a-rare-type-of-cancer-open-novel-avenues-of-study Mon, 07 Jan 2019 16:01:06 +0100 https://news.ki.se/new-digital-decision-support-gives-gravely-ill-cancer-patients-the-right-fracture-treatment Mon, 17 Dec 2018 11:10:32 +0100 https://news.ki.se/hpv-type-16-or-18-in-young-women-predicts-risk-of-cervical-cancer Mon, 10 Dec 2018 06:01:00 +0100 https://news.ki.se/sandra-jernstrom-wins-scholar-award Thu, 06 Dec 2018 12:17:37 +0100 https://news.ki.se/an-oesophageal-cancer-day-receives-ki-engagement-grant Thu, 29 Nov 2018 13:52:09 +0100 https://news.ki.se/michel-sadelain-lecture-at-karolinska-institutet Mon, 26 Nov 2018 11:46:23 +0100 https://news.ki.se/new-inflammation-inhibitor-discovered Thu, 15 Nov 2018 20:00:00 +0100 https://news.ki.se/breast-cancer-cells-become-invasive-by-changing-their-identity-0 Tue, 06 Nov 2018 11:26:15 +0100 https://news.ki.se/immunotherapy-effective-against-hereditary-melanoma Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year’s Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics. Mon, 08 Oct 2018 08:00:00 +0200 https://news.ki.se/high-risk-hpv-linked-to-improved-survival-in-cervical-cancer Wed, 03 Oct 2018 09:51:30 +0200 https://news.ki.se/new-drug-candidate-makes-cancer-cells-more-sensitive-to-radiotherapy Tue, 25 Sep 2018 11:10:34 +0200 https://news.ki.se/discovery-of-a-new-mechanism-for-cancer-cells-to-repair-their-dna-and-development-of-a-novel-anti-cancer-drug Fri, 21 Sep 2018 15:07:28 +0200 https://news.ki.se/susanne-schlisio-and-collaborators-publish-in-cell-reports Mon, 13 Aug 2018 11:27:59 +0200 https://news.ki.se/michael-landreh-david-lane-sonia-lain-and-co-workers-publish-in-the-journal-of-physical-chemistry-letters Tue, 10 Jul 2018 09:40:21 +0200 https://news.ki.se/combination-of-blood-test-and-imaging-improves-detection-of-prostate-cancer Mon, 09 Jul 2018 12:00:00 +0200 https://news.ki.se/a-new-inhibitor-targeting-the-oncoprotein-myc-implications-for-cancer-drug-development Mon, 02 Jul 2018 09:26:53 +0200 https://news.ki.se/kaisa-lehtis-profile-is-featured-on-academianet MTC researcher Kaisa Lehti is featured on AcademiaNet, after a nomination by the Swedish Research Council. Mon, 25 Jun 2018 15:11:48 +0200 https://news.ki.se/detection-of-cancer-therapy-resistance-mechanism-can-help-to-fight-resistant-tumours Tue, 12 Jun 2018 15:40:32 +0200 https://news.ki.se/genome-editing-tool-could-increase-cancer-risk Mon, 11 Jun 2018 17:01:00 +0200 https://news.ki.se/anti-inflammatory-strategy-stops-aggressive-childhood-cancer Mon, 28 May 2018 16:09:34 +0200 https://news.ki.se/malignant-melanoma-he-would-never-start-a-family Yvonne Brandberg will always remember the young man struck down by cancer in the prime of life. His fate motivated her to try to convince more people to sunbathe more sensibly. Mon, 28 May 2018 10:35:03 +0200 https://news.ki.se/obituary-of-seymour-h-levitt Thu, 26 Apr 2018 14:07:19 +0200 https://news.ki.se/aggressive-breast-cancer-has-resistant-tumour-cells-already-prior-to-chemotherapy Thu, 19 Apr 2018 18:01:00 +0200 https://news.ki.se/several-researchers-at-onkpat-receives-funding-for-their-positions-from-the-swedish-cancer-society Wed, 28 Mar 2018 15:08:33 +0200 https://news.ki.se/marcus-ladds-ingeborg-van-leeuwen-sonia-lain-et-al-publish-in-nature-communications Researchers in the Sonia lain and David Lane groups at MTC have recently published in the journal Nature Communications. Tue, 27 Mar 2018 10:08:38 +0200 https://news.ki.se/new-biomarkers-for-neuroblastoma Tue, 13 Mar 2018 11:00:24 +0100 https://news.ki.se/an-integrated-workflow-combines-proteomics-and-genomics-data-to-discover-unknown-coding-regions-in-the-human-genome Professor Janne Lehtiö and coworkers at the department of Oncology-Pathology have published an article in Nature Communications describing their new Integrated Proteogenomics Analysis Workflow (IPAW). The method enables a more reliable identification of novel peptides. Tue, 06 Mar 2018 13:47:09 +0100 https://news.ki.se/breast-cancers-spread-routes-mapped Tue, 27 Feb 2018 08:00:00 +0100 https://news.ki.se/successful-nk-cell-based-immunotherapy-for-leukaemia Researchers at Karolinska Institutet have explored NK cell-based immunotherapy on patients with treatment-resistant leukaemia. The study, which is published in the scientific journal Clinical Cancer Research, shows that the new therapy is effective against several types of leukaemia. Tue, 20 Feb 2018 08:00:00 +0100 https://news.ki.se/possible-new-principle-for-cancer-therapy A study published in Science Translational Medicine shows that small molecules that specifically inhibit an important selenium-containing enzyme may be useful in combating cancer. When researchers at Karolinska Institutet treated cancer in mice using these molecules, they observed rapid tumoricidal effects. Researchers now hope that this new principle for cancer treatment will eventually be developed for use in humans. Thu, 15 Feb 2018 09:09:50 +0100 https://news.ki.se/oestrogen-causes-neuroblastoma-cells-to-mature-into-neurons Mon, 29 Jan 2018 10:04:44 +0100 https://news.ki.se/michael-landreh-david-lane-sonia-lain-marcus-ladds-et-al-publish-in-cell-chemical-biology In a study published in Cell Chemical Biology this week, researchers from MTC (Michael Landreh, David Lane, Sonia Lain, Marcus Ladds et al), KTH, Uppsala University, and the University of Oxford, used a new strategy to find out how anticancer drugs bind to the membrane protein dehydroorotate dehydrogenase (DHODH), a new cancer target. Fri, 19 Jan 2018 09:28:52 +0100 https://news.ki.se/factor-that-doubles-the-risk-of-death-from-breast-cancer-identified Fri, 19 Jan 2018 08:00:00 +0100 https://news.ki.se/flying-membrane-protein-aids-cancer-drug-design Thu, 18 Jan 2018 18:00:44 +0100 https://news.ki.se/new-way-to-target-the-growth-of-breast-cancer-cells Wed, 17 Jan 2018 13:48:49 +0100 https://news.ki.se/mechanism-that-converts-white-fat-to-brown-identified-in-jem-publication Mon, 08 Jan 2018 09:25:07 +0100 https://news.ki.se/family-members-without-inherited-mutation-have-increased-risk-of-melanoma Fri, 08 Dec 2017 08:00:00 +0100 https://news.ki.se/alcohol-abuse-drug-antabuse-kills-cancer-cells Thu, 07 Dec 2017 12:08:29 +0100 https://news.ki.se/mapping-biological-functions-of-nudix-enzymes Thu, 16 Nov 2017 14:42:38 +0100 https://news.ki.se/harder-for-t-cells-to-fight-cancer-in-absence-of-vegf-a Tue, 14 Nov 2017 08:00:00 +0100 https://news.ki.se/breast-cancer-recurrence-risk-lingers-longer-than-expected Thu, 09 Nov 2017 06:00:00 +0100 https://news.ki.se/previous-screening-results-important-for-smear-test-decision-after-age-60 Wed, 25 Oct 2017 08:15:56 +0200 https://news.ki.se/study-of-protein-expression-in-mouse-ovarian-follicles In a recent publication in Molecular Human Reproduction, researchers at OnkPat could identify the specific proteome profiling of mouse ovarian follicles at three different developmental stages. To do that, the researchers isolated the follicles and cultured them in vitro. This is the first protein mapping of ovarian follicles ever published. Tue, 24 Oct 2017 13:42:07 +0200 https://news.ki.se/the-first-projects-to-start-at-the-new-research-center-medtechlabs MedTechLabs is now open – the research centre formed by a close collaboration between Karolinska Institutet (KI), the Royal Institute of Technology (KTH) and Stockholm County Council (SLL). The objective of the centre’s first project is to develop technology to improve diagnosis and treatment of patients who have, for example, suffered a stroke. Tue, 10 Oct 2017 16:10:18 +0200 https://news.ki.se/3d-microscopy-gives-more-accurate-cancer-diagnosis Tue, 03 Oct 2017 08:00:00 +0200 https://news.ki.se/inflammatory-bowel-disease-in-childhood-associated-with-increased-risk-of-cancer Thu, 21 Sep 2017 08:00:00 +0200 https://news.ki.se/thorough-analysis-reveals-immune-system-dynamics Wed, 30 Aug 2017 08:00:00 +0200 https://news.ki.se/new-strategy-against-childhood-cancer Wed, 26 Jul 2017 15:16:23 +0200 https://news.ki.se/new-potential-treatment-for-aggressive-types-of-childhood-cancer Tue, 11 Jul 2017 08:01:11 +0200 https://news.ki.se/test-identifies-breast-cancer-patients-with-very-low-risk-of-death Thu, 29 Jun 2017 17:30:00 +0200 https://news.ki.se/new-possible-target-for-cancer-treatment Wed, 07 Jun 2017 15:21:50 +0200 https://news.ki.se/two-junior-researchers-at-onkpat-receives-funding-for-their-positions-from-the-swedish-cancer-society Tue, 28 Mar 2017 09:45:37 +0200 https://news.ki.se/onkpat-professor-earns-prestigious-grant-from-erc Thu, 23 Mar 2017 12:41:13 +0100 https://news.ki.se/review-in-seminars-in-cancer-biology Researchers at OnkPat together with Italian researchers review recent studies on the acidic tumor environment and how this affects tumor growth and therapeutic efficacy. Fri, 10 Mar 2017 15:33:38 +0100 https://news.ki.se/the-importance-of-friendship-in-a-new-novel-about-cancer When researcher and oncologist Peter Strang writes textbooks, he does so with a certain distance: everything is based on fact. Writing a novel requires a different kind of presence, such as for example trying to imagine what it is like to have been diagnosed with cancer and to be a patient. Tue, 07 Mar 2017 08:08:31 +0100 https://news.ki.se/new-treatment-for-childhood-cancer-demonstrate-increased-survival Thu, 02 Mar 2017 19:30:02 +0100 https://news.ki.se/increased-survival-with-new-treatment-for-aggressive-form-of-childhood-cancer Thu, 02 Mar 2017 06:00:00 +0100 https://news.ki.se/cold-can-help-burn-dangerous-fat Fri, 24 Feb 2017 10:53:53 +0100 https://news.ki.se/new-method-reduces-adverse-effects-of-rectal-cancer-treatment Fri, 10 Feb 2017 09:26:00 +0100 https://news.ki.se/jonas-bergh-earns-visiting-professorship-at-oxford-university Fri, 13 Jan 2017 09:51:58 +0100 https://news.ki.se/protein-that-inhibits-and-reduces-the-effects-of-chemotherapy-identified Thu, 12 Jan 2017 13:51:59 +0100 https://news.ki.se/onkpat-researcher-receives-funding-from-ssmf Mon, 09 Jan 2017 15:16:54 +0100 https://news.ki.se/in-memory-of-professor-georg-klein-1925-2016 KI researcher Georg Klein passed away on 10 December 2016. He was professor emeritus of tumour biology at Karolinska Institutet, and a researcher at the Department of Microbiology, Tumour and Cell Biology (MTC). He was, among other things, a member of the Nobel Assembly at Karolinska Institutet and in later years became known as an author and award-winning essayist. Mon, 12 Dec 2016 10:21:28 +0100 https://news.ki.se/millions-to-onkpat-researchers-from-the-erling-persson-family-foundation The Erling-Persson Family Foundation has awarded a large grant to a KTH project where OnkPat's Rolf Lewensohn and Kristina Viktorsson have key roles. Tue, 22 Nov 2016 10:09:16 +0100 https://news.ki.se/tailored-dense-dose-chemotherapy-for-early-breast-cancer-does-not-result-in-significant-improvement-in-recurrence-free-survival-0 Among women with high-risk early breast cancer, the use of tailored dose-dense chemotherapy compared with standard adjuvant chemotherapy did not result in a statistically significant improvement in breast cancer recurrence-free survival, and nonhematologic toxic effects were more frequent in the tailored dose-dense group, according to a study appearing in the November 8 issue of JAMA. Mon, 14 Nov 2016 14:45:24 +0100 https://news.ki.se/study-explains-mechanisms-behind-glioblastoma-influence-on-the-immune-system-0 Glioblastomas exert an influence on the microglia, immune cells of the brain, which causes them to stimulate cancer growth rather than attacking it. In a study published in the journal Nature Immunology, an international research team led from Karolinska Institutet now explains the molecular mechanisms behind this action. Tue, 13 Sep 2016 13:37:30 +0200 https://news.ki.se/active-hedgehog-signalling-in-connective-tissue-cells-protects-against-colon-cancer Mon, 08 Aug 2016 09:22:19 +0200 https://news.ki.se/new-method-provides-better-information-on-gene-expression Fri, 01 Jul 2016 10:01:03 +0200 https://news.ki.se/onkpat-professors-leading-strategic-cancer-work Fri, 17 Jun 2016 09:43:10 +0200 https://news.ki.se/newly-discovered-mechanism-may-restrict-breast-cancer-growth Charlotte Rolny and colleagues at the Department of Oncology-Pathology have discovered a new mechanism that could be the key to a new strategy to restrict breast cancer growth. Wed, 08 Jun 2016 14:28:16 +0200 https://news.ki.se/cancer-can-be-combated-with-reprogrammed-macrophage-cells Thu, 19 May 2016 18:00:00 +0200 https://news.ki.se/early-hpv-vaccination-provides-the-best-protection Wed, 09 Mar 2016 08:00:00 +0100 https://news.ki.se/long-learning-curve-for-surgeons-operating-on-oesophageal-cancer Tue, 08 Mar 2016 08:00:00 +0100 https://news.ki.se/pregnancy-does-not-increase-risk-of-hodgkin-lymphoma-recurrence Tue, 15 Dec 2015 08:00:00 +0100 https://news.ki.se/combination-therapy-can-prevent-cytostatic-resistance Wed, 25 Nov 2015 11:15:00 +0100 https://news.ki.se/sonia-lain-appointed-professor Sonia Lain has been appointed Professor. Wed, 18 Nov 2015 14:19:02 +0100 https://news.ki.se/weekday-of-surgery-affects-oesophageal-cancer-surgery-prognosis Wed, 18 Nov 2015 11:04:49 +0100 https://news.ki.se/51-million-sek-to-13-researchers-at-the-department Wed, 04 Nov 2015 17:03:26 +0100 https://news.ki.se/sleep-proteins-in-new-dna-repair-mechanism Thu, 01 Oct 2015 08:15:00 +0200 https://news.ki.se/blood-vessel-cells-help-tumours-evade-the-immune-system Mon, 24 Aug 2015 08:15:00 +0200 https://news.ki.se/kenny-rodriguez-wallberg-it-was-a-true-miracle-to-everybody-present Her research recently yielded eagerly awaited results: A miracle baby. Kenny Rodriguez-Wallberg was present at the birth. Tue, 26 May 2015 15:14:10 +0200 https://news.ki.se/how-cancer-tricks-the-lymphatic-system-into-spreading-tumours Mon, 11 May 2015 12:35:00 +0200 https://news.ki.se/knowledge-on-ephb-signalling-may-improve-intestinal-cancer-treatment Thu, 02 Apr 2015 08:00:00 +0200 https://news.ki.se/rare-dna-and-rna-jitters-may-explain-random-mutations Fri, 13 Mar 2015 20:28:45 +0100 https://news.ki.se/anna-martling-its-when-you-meet-the-patient-that-the-circle-closes Research breakthroughs are not just about new discoveries. Anna Martling tells us how a long period spent on development meant that she was able to offer a patient life-saving treatment. Tue, 24 Feb 2015 16:58:36 +0100 https://news.ki.se/new-general-concept-for-the-treatment-of-cancer Thu, 03 Apr 2014 07:45:00 +0200 https://news.ki.se/study-clarifies-how-oncogenes-increase-cell-stiffness Fri, 24 Jan 2014 00:00:00 +0100 https://news.ki.se/clue-to-how-the-circulatory-system-is-wired A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers at Karolinska Institutet, and Heinrich Heine University Düsseldorf, Germany. The knowledge might open up new opportunities for future cancer therapy. The study is published in the scientific journal PNAS. Tue, 26 Nov 2013 13:51:15 +0100 https://news.ki.se/even-low-levels-of-air-pollution-increases-risk-of-cancer Wed, 10 Jul 2013 00:00:00 +0200 https://news.ki.se/a-step-closer-a-new-myeloma-drug Tue, 18 Jun 2013 00:00:00 +0200 https://news.ki.se/faster-biological-ageing-linked-to-increased-cancer-risk Wed, 27 Mar 2013 00:00:00 +0100 https://news.ki.se/increased-survival-rates-for-patients-with-hodgkin-lymphoma Mon, 18 Mar 2013 00:00:00 +0100 https://news.ki.se/trackable-drug-filled-nanoparticles-a-potential-weapon-against-cancer Fri, 01 Mar 2013 00:00:00 +0100 https://news.ki.se/cancer-drug-a-possible-treatment-for-ms Thu, 21 Feb 2013 00:00:00 +0100 https://news.ki.se/high-risk-of-cardiovascular-diseases-amongst-swedish-born-and-immigrant-ms-patients Mon, 04 Feb 2013 00:00:00 +0100 https://news.ki.se/under-twisted-dna-origami-delivers-cancer-drugs-to-tumours Thu, 13 Sep 2012 08:00:00 +0200 https://news.ki.se/global-epidemic-of-gullet-cancer Mon, 27 Aug 2012 00:00:00 +0200 https://news.ki.se/new-method-enables-smarter-analysis-of-individual-cells Only by viewing a Georges Seurat painting at close range can you appreciate the hidden complexities of pointillism – small, distinct dots of color applied to form an image from a distance. Similarly, biologists and geneticists have long sought to analyze profiles of genes at the single cell level but technology limitations have only allowed a view from afar. Mon, 23 Jul 2012 00:00:00 +0200 https://news.ki.se/dental-plaque-may-increase-risk-of-cancer Tue, 12 Jun 2012 00:00:00 +0200 https://news.ki.se/sex-differences-in-fertility-information-to-young-cancer-patients Tue, 29 May 2012 00:00:00 +0200 https://news.ki.se/link-between-cadmium-in-food-and-breast-cancer Thu, 15 Mar 2012 00:00:00 +0100 https://news.ki.se/mapping-of-protein-inhibitors-facilitates-development-of-tailor-made-anticancer-agents Mon, 20 Feb 2012 00:00:00 +0100 https://news.ki.se/processed-meat-may-increase-pancreatic-cancer-risk Fri, 13 Jan 2012 00:00:00 +0100 https://news.ki.se/new-mechanism-of-pancreatic-cancer-discovered Mon, 31 May 2010 00:00:00 +0200