https://ki.se RSS News Listing https://news.ki.se/early-surgery-for-crohns-disease-patients-questioned-in-new-swedish-study A new study from Karolinska Institutet challenges previous findings that suggested early surgery is more beneficial in the long term than medical treatment for patients with Crohn’s disease. The study replicates a Danish registry study using Swedish data and finds that the results are not comparable. The study was published in Clinical Gastroenterology and Hepatology. Fri, 12 Sep 2025 14:53:05 +0200 https://news.ki.se/some-heart-attack-patients-can-benefit-from-screening-for-stomach-ulcer-bacteria Not all acute myocardial infarction patients should be offered routine screening for the stomach ulcer bacterium Helicobacter pylori. However, it is possible that some patient groups with an elevated risk of post-infarction gastrointestinal bleeding benefit from such a test, concludes a large-scale study from Karolinska Institutet and Södersjukhuset published in the journal JAMA. Mon, 01 Sep 2025 08:35:10 +0200 https://news.ki.se/inflammatory-bowel-disease-possibly-accelerates-dementia New research from Karolinska Institutet demonstrates a link between inflammatory bowel disease and faster cognitive decline among dementia patients. The study, which is published in the scientific journal Gut, indicates a need for personalised treatments, researchers say. Tue, 22 Jul 2025 17:10:08 +0200 https://news.ki.se/no-evidence-that-drugs-trigger-microscopic-colitis-in-older-people There is a perception that common drugs such as ibuprofen and SSRI preparations can trigger the intestinal disease microscopic colitis (MC). However, a new study from Karolinska Institutet and Harvard Medical School suggests that this is not the case – meaning that patients with MC do not need to stop taking important medications. Mon, 30 Jun 2025 23:00:13 +0200 https://news.ki.se/international-study-maps-the-prevalence-of-inflammatory-bowel-disease-ibd The Consortium Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) now publish data on the global prevalence of inflammatory bowel disease (IBD) in Nature. Researchers from Karolinska Institutet have contributed to the study. While the number of people with incident IBD is relatively constant in Sweden, the prevalence is increasing and 1 per cent of the Swedish population is now estimated to have IBD. Wed, 30 Apr 2025 17:12:44 +0200 https://news.ki.se/thesis-on-the-interplay-between-inflammatory-bowel-disease-and-kidney-diseases A new thesis from Karolinska Institutet aims to advance our understanding of the bidirectional relationship between inflammatory bowel disease (IBD) and chronic kidney diseases (CKD) through large-scale epidemiological studies utilizing real-world data. Mon, 17 Feb 2025 10:21:42 +0100 https://news.ki.se/celiac-disease-linked-to-chronic-liver-disease Patients with celiac disease face an increased risk of developing any chronic liver disease. This risk increase can persist for at least 25 years after celiac diagnosis. The findings from a national study from Karolinska Institutet published in Lancet Regional Health - Europe underscore clinical vigilance to signs of liver disease in patients with celiac disease to prevent major adverse liver outcomes. Fri, 10 Jan 2025 07:52:07 +0100 https://news.ki.se/epidemiology-and-health-economics-in-gastrointestinal-diseases A new thesis from Karolinska Institutet shows the significant societal economic burdens posed by two chronic inflammatory gastrointestinal diseases; eosinophilic esophagitis (EoE) and microscopic colitis (MC). Both diseases cause long-term inflammation in the digestive system and can lead to additional health problems. Tue, 03 Dec 2024 10:33:44 +0100 https://news.ki.se/first-molecule-identified-that-promotes-gut-healing-while-inhibiting-tumour-progression Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumour growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer. The results are published in the journal Nature. Wed, 20 Nov 2024 17:26:15 +0100 https://news.ki.se/new-discoveries-reveal-that-trp14-txndc17-is-a-crucial-enzyme-for-cysteine-metabolism-and-disease-resistance New findings from an international collaborative project highlight the pivotal role of TRP14 in health and disease. Fri, 05 Jul 2024 14:00:22 +0200 https://news.ki.se/inflammatory-bowel-disease-may-increase-risk-of-heart-failure Inflammatory bowel disease (IBD) is associated with a slightly increased risk of heart failure up to 20 years after diagnosis, according to a comprehensive registry study from Karolinska Institutet published in the European Heart Journal. Tue, 21 May 2024 19:30:12 +0200 https://news.ki.se/gut-microbes-can-affect-covid-vaccine-response Researchers from Karolinska Institutet have discovered that the gut microbiome can influence how well people respond to mRNA COVID vaccines. The study, published in the journal npj Biofilms and Microbiomes, suggests that certain bacteria in the gut can enhance the immune response to the vaccine, whereas other bacteria may weaken it. Thu, 04 Jan 2024 11:22:14 +0100 https://news.ki.se/no-increase-in-cancer-risk-for-most-patients-with-reflux-disease Reflux disease manifests as acid regurgitation and heartburn and is a known risk factor for oesophageal cancer. However, a new study published in The BMJ by researchers at Karolinska Institutet now reports that the majority of patients do not have a higher risk of cancer. A large-scale study from three Nordic countries shows that the cancer risk is only elevated in patients whom gastroscopy reveals to have changes in the oesophageal mucosa. Wed, 13 Sep 2023 11:00:06 +0200 https://news.ki.se/statins-linked-to-lower-risk-of-cancer-in-patients-with-ulcerative-colitis Cholesterol-lowering statins might protect patients with ulcerative colitis from developing and dying from colorectal cancer. Statin treatment was also associated with a lower risk of death regardless of cause in patients with ulcerative colitis or Crohn's disease. This is according to a study by researchers at Karolinska Institutet published in eClinicalMedicine. Fri, 01 Sep 2023 08:44:30 +0200 https://news.ki.se/high-risk-of-severe-infections-among-individuals-with-nonalcoholic-fatty-liver-disease In a nationwide Swedish study involving more than 12,000 individuals with nonalcoholic fatty liver disease (NAFLD), researchers found a significantly increased risk of severe infections requiring hospital admission. The study was published in Clinical Gastroenterology and Hepatology. Mon, 29 May 2023 10:15:42 +0200 https://news.ki.se/microscopic-colitis-and-the-risk-of-acute-pancreatitis In a nationwide Swedish study of more than 12,000 patients with microscopic colitis (MC), researchers from Sahlgrenska University Hospital and Karolinska Institutet found an increased risk of acute pancreatitis compared to the general population. The study has been published in The American Journal of Gastroenterology. Wed, 24 May 2023 10:33:11 +0200 https://news.ki.se/researchers-map-the-immunology-of-the-gut-in-children-with-ibd Researchers from Karolinska Institutet and Sachs’ Children and Youth Hospital have mapped the immune system in the gut of children with inflammatory bowel disease (IBD). The results, which were published in Cell Reports Medicine, can be used to design more targeted therapies. Tue, 09 May 2023 17:06:15 +0200 https://news.ki.se/normal-gastrointestinal-biopsy-not-protective-against-later-ibd A Swedish study which followed more than 450,000 individuals after lower or upper gastrointestinal biopsy, suggests that symptoms of IBD (inflammatory bowel disease) may start significantly before disease shows up on biopsy. The results were published in the open access journal PLOS Medicine on Feb 23. Fri, 24 Feb 2023 08:26:03 +0100 https://news.ki.se/new-thesis-on-magnetic-resonance-imaging-mri-in-diagnosis-and-prognosis-of-primary-sclerosing-cholangitis Aristeidis Grigoriadis, from the Gastroenterology and Rheumatology Unit at the Department of Medicine, Huddinge (MedH) will defend his thesis "Magnetic resonance imaging as a tool for diagnosis, evaluation and prognosis in patients with primary sclerosing cholangitis" on February 17, 2023. Main Supervisor is Annika Bergquist (MedH). Wed, 15 Feb 2023 15:02:01 +0100 https://news.ki.se/common-immune-cells-can-prevent-intestinal-healing B cells are critical to the proper functioning of the immune system. However, researchers at Karolinska Institutet have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel damage, preventing the tissue from healing. The results, which are presented in the journal Immunity, can be of significance to the treatment of inflammatory bowel disease. Fri, 02 Dec 2022 17:00:06 +0100 https://news.ki.se/diverticular-disease-associated-with-cancer-outside-gastrointestinal-tract Through the ESPRESSO cohort, researchers from Massachusetts General Hospital, Boston, University of Newcastle, Australia, University of Washington, Seattle, and Karolinska Institutet examined the risk of cancer among 75,000 patients with a diagnosis of diverticular disease and colorectal histopathology. The paper is now published in JNCI, the Journal of the National Cancer Institute. Fri, 28 Oct 2022 11:28:53 +0200 https://news.ki.se/epidemiology-of-microscopic-colitis-risk-of-associated-disorders-and-death Microscopic colitis is the most recently recognized inflammatory condition of the large intestine in which abnormal reactions of the immune system cause inflammation of the inner lining of the colon. At present, more than 10,000 people in Sweden are estimated to be living with the disease. Previously, insufficient awareness and knowledge of microscopic colitis have led to underdiagnosis of the disorder, leaving patients untreated. Tue, 24 May 2022 08:58:21 +0200 https://news.ki.se/new-knowledge-on-lymphoid-cell-maturity-could-lead-to-more-effective-ibd-therapies A research group at Karolinska Institutet in Sweden has analysed how certain immune cells known as innate lymphoid cells (ILCs) develop into mature cells that play a part in inflammatory bowel disease (IBD). The findings could pave the way for more effective treatments against IBD, a disease that causes considerable suffering and that is linked to an increased risk of colorectal cancer. The results are published today in the journal Science Immunology. Fri, 15 Apr 2022 20:00:05 +0200 https://news.ki.se/colonic-gene-mapping-gives-insights-into-intestinal-diseases Using a technique called spatial transcriptomics, researchers at Karolinska Institutet have analysed the gene expression in the mouse colon and created a map showing where in the tissue individual genes are expressed. When they superimposed previously known human transcription data onto the map, the researchers gained new insights into inflammatory bowel disease (IBD). The study is published in the journal Nature Communications. Fri, 11 Feb 2022 11:00:05 +0100 https://news.ki.se/the-link-between-heart-attack-and-stomach-ulcer-bacteria A new study is due to examine whether the post-infarction prognosis can be improved by treating the stomach ulcer bacterium helicobacter pylori. The study is to be led by Robin Hofmann, cardiologist and researcher at the Department of Clinical Research and Education, Stockholm South General (Söder) Hospital, Karolinska Institutet. Fri, 28 Jan 2022 11:21:23 +0100 https://news.ki.se/modern-humans-developed-a-more-effective-protection-against-oxidative-stress Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden have now studied one such protein, glutathione reductase, which protects against oxidative stress. They show that the risk for inflammatory bowel disease and vascular disease is increased several times in people carrying the Neanderthal variant. Wed, 05 Jan 2022 20:00:07 +0100 https://news.ki.se/immune-cells-in-the-human-biliary-system-mapped Researchers at Karolinska Institutet have analysed and described in detail the immune cells residing in the human bile duct. The findings may pave the way for new treatment strategies against disorders of the bile duct, which are often linked to immunological processes. The study is published in the journal Science Translational Medicine. Wed, 23 Jun 2021 20:00:04 +0200 https://news.ki.se/intestinal-polyps-in-close-relatives-can-increase-risk-of-colorectal-cancer Cancer of the colon and rectum is one of the deadliest forms of cancer, and has in recent years affected growing numbers of young people. In the largest registry study to date, researchers at Karolinska Institutet and Harvard University in the USA demonstrate a possible connection between colorectal polyps in close relatives and the risk of developing colorectal cancer. The study, which is published in The British Medical Journal, is of potential consequence for screening procedures. Tue, 04 May 2021 11:30:06 +0200 https://news.ki.se/large-genetic-study-sheds-light-on-the-causes-of-hemorrhoids Although hemorrhoids are a common health problem, relatively little is known about the field, possibly because many people find them difficult to talk about. Researchers linked to Karolinska Institutet have been involved in a study that has analysed the genomes of almost a million people and found previously unknown causes of severe hemorrhoids. The study, which is published in the journal Gut, also reveals links to other gastrointestinal diseases. Fri, 23 Apr 2021 11:23:12 +0200 https://news.ki.se/genetic-cause-of-severe-liver-disease-discovered Liver transplantation is currently the only treatment available for the severe liver disease PSC. Now, however, researchers at Karolinska Institutet and Oslo University have discovered the first reported genetic mutation that causes PSC. The study, which is published in Science Translational Medicine, opens new paths to future treatments. Wed, 24 Feb 2021 20:00:04 +0100 https://news.ki.se/new-fundamental-knowledge-of-the-abdominal-brain Researchers at Karolinska Institutet have succeeded in mapping the neuron types comprising the enteric nervous system in the intestine of mice. The study, which is published today in the scientific journal Nature Neuroscience, also describes how the different neurons form during fetal development, a process that follows different principles to brain neurons. Mon, 07 Dec 2020 17:00:04 +0100 https://news.ki.se/antibiotics-associated-with-increased-risk-of-inflammatory-bowel-disease Antibiotics use, particularly antibiotics with greater spectrum of microbial coverage, may be associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes ulcerative colitis and Crohn’s disease. That is according to a study by researchers at Karolinska Institutet in Sweden and Harvard Medical School in the U.S., published in the journal The Lancet Gastroenterology & Hepatology. The association remained when patients were compared with their siblings. Tue, 18 Aug 2020 00:30:03 +0200 https://news.ki.se/inflammatory-bowel-disease-ibd-and-small-bowel-cancer-a-binational-study In a population-based cohort study from Sweden and Denmark of patients with inflammatory bowel disease (IBD) during 1969-2017 and matched reference individuals from the general population, Ola Olén, Jonas F Ludvigsson and colleagues found that IBD patients had an increased risk of small bowel cancer. Mon, 01 Jun 2020 14:42:29 +0200 https://news.ki.se/etiology-and-prognosis-of-gastric-and-esophageal-cancer-explored The focus of Isabella Ekheden's thesis is on gastric and esophageal cancer – gastroesophageal cancers - that are some of the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance with the potential of lowering the disease burden. Fri, 29 May 2020 15:53:21 +0200 https://news.ki.se/newly-discovered-mechanism-can-explain-increased-risk-of-dementia Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer’s & Dementia. Fri, 08 May 2020 06:30:07 +0200 https://news.ki.se/celiac-disease-linked-to-increased-mortality People with celiac disease have increased risk of dying prematurely, despite increased awareness of the disease in recent years and better access to gluten-free food. This is according to a new study from Karolinska Institutet in Sweden and Columbia University in the U.S. published in the prestigious journal JAMA. Celiac disease was linked to increased risk of death from cardiovascular disease, cancer and respiratory disease. Tue, 07 Apr 2020 17:13:00 +0200 https://news.ki.se/colorectal-cancer-risk-remains-despite-modern-treatment-for-ulcerative-colitis Patients with the inflammatory bowel disease ulcerative colitis have a higher risk of dying from colorectal cancer, despite modern therapy, even though the risk has declined in recent years. This is according to a new study published in the scientific journal The Lancet by a team of Swedish and Danish researchers. Fri, 10 Jan 2020 00:30:00 +0100 https://news.ki.se/more-funding-from-kaw-to-four-ki-researchers Four researchers at Karolinska Institutet have been granted a total of SEK 28 million in additional funding from the Knut and Alice Wallenberg Foundation (KAW). Two of these researchers are also promoted from Wallenberg Academy Fellows (WAF) to Wallenberg Scholars. Wed, 11 Dec 2019 17:57:47 +0100 https://news.ki.se/study-rejects-link-between-common-ibd-drug-and-serious-infections-in-children In a new register-based study, Swedish and Danish researchers show that common drugs for Inflammatory Bowel Disease (IBD), so called TNF-α inhibitors, are not linked to increased risk of serious infections in children. Previous studies have shown an increased risk in corresponding adult patients. The results are published in The Lancet Gastroenterology & Hepatology. Thu, 05 Sep 2019 08:00:00 +0200 https://news.ki.se/increased-risk-of-psychiatric-disorders-in-children-with-ibd Children with Inflammatory Bowel Disease (IBD) run a greater risk of psychiatric disorders, according to a new study from Karolinska Institutet in Sweden published in JAMA Pediatrics. The researchers claim that more psychological support and longer follow-up is needed for the children affected and their parents. Mon, 19 Aug 2019 17:03:13 +0200 https://news.ki.se/new-method-divides-patients-with-ulcerative-colitis-in-groups Researchers at Karolinska Institutet in Sweden have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct groups. The findings are published in the journal Nature Communications, and the researchers hope that the method can also be used to subdivide other autoimmune diseases. Fri, 28 Jun 2019 11:23:49 +0200 https://news.ki.se/jonas-ludvigsson-published-paper-of-the-year-in-the-american-journal-of-gastroenterology Tue, 16 Apr 2019 10:46:53 +0200 https://news.ki.se/online-cbt-helps-children-with-stomach-pains Fri, 07 Dec 2018 10:27:11 +0100 https://news.ki.se/increased-mortality-in-children-with-inflammatory-bowel-disease Thu, 18 Oct 2018 14:47:40 +0200 https://news.ki.se/genetic-link-to-ibs-identified-in-women Fri, 06 Apr 2018 09:15:07 +0200 https://news.ki.se/older-people-with-bowel-disease-receive-older-medicines Mon, 13 Nov 2017 13:09:10 +0100 https://news.ki.se/inflammatory-bowel-disease-in-childhood-associated-with-increased-risk-of-cancer Thu, 21 Sep 2017 08:00:00 +0200 https://news.ki.se/relapse-rare-in-young-men-after-antireflux-surgery Wed, 13 Sep 2017 08:00:00 +0200 https://news.ki.se/heartburn-medicine-can-increase-risk-of-kidney-disease Wed, 02 Aug 2017 18:01:40 +0200 https://news.ki.se/new-mutational-patterns-in-gastrointestinal-tract-cancers Mon, 08 Jun 2015 17:10:00 +0200 https://news.ki.se/anna-martling-its-when-you-meet-the-patient-that-the-circle-closes Research breakthroughs are not just about new discoveries. Anna Martling tells us how a long period spent on development meant that she was able to offer a patient life-saving treatment. Tue, 24 Feb 2015 16:58:36 +0100 https://news.ki.se/genetically-related-etec-have-spread-globally-and-over-time Mon, 10 Nov 2014 17:05:00 +0100 https://news.ki.se/first-screen-for-genetic-risk-factors-of-ibs-in-the-general-population Wed, 24 Sep 2014 08:00:00 +0200 https://news.ki.se/new-study-links-irritable-bowel-syndrome-to-defective-gene-and-heart-disease Fri, 21 Mar 2014 09:32:01 +0100 https://news.ki.se/study-suggests-human-genes-influence-gut-microbial-composition Mon, 07 Jan 2013 00:00:00 +0100 https://news.ki.se/genetics-of-infection-at-the-basis-of-inflammatory-bowel-disease Thu, 01 Nov 2012 00:00:00 +0100 https://news.ki.se/rare-gene-variants-linked-to-inflammatory-bowel-disease Sun, 09 Oct 2011 00:00:00 +0200 https://news.ki.se/gene-variant-linked-to-ibs Tue, 07 Jun 2011 23:00:00 +0200 https://news.ki.se/29-new-gene-variants-linked-to-ulcerative-colitis Mon, 07 Feb 2011 00:00:00 +0100 https://news.ki.se/30-new-gene-variants-linked-to-crohns-disease Mon, 22 Nov 2010 00:00:00 +0100 https://news.ki.se/diarrhea-disorder-giardiasis-caused-by-two-different-parasite-species Fri, 21 Aug 2009 00:00:00 +0200