https://ki.se RSS News Listing https://news.ki.se/fatty-liver-in-pregnancy-may-increase-risk-of-preterm-birth Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study from Karolinska Institutet published in the journal eClinicalMedicine. Fri, 09 May 2025 10:00:12 +0200 https://news.ki.se/fatty-liver-linked-to-increased-risk-of-death-from-several-diseases A comprehensive study from Karolinska Institutet shows that people with fatty liver disease have almost twice the mortality rate of the general population. They have an increased risk of dying from both liver diseases and common diseases such as cancer and cardiovascular disease, according to the study published in The Journal of Hepatology. Mon, 24 Mar 2025 08:00:14 +0100 https://news.ki.se/combined-screening-can-detect-liver-damage-in-diabetes-patients New research from Karolinska Institutet highlights the possibility of screening people with type 2 diabetes for liver damage at the same time as they undergo screening for eye disease. The study is published in Lancet Gastroenterology and Hepatology. Fri, 13 Dec 2024 00:30:10 +0100 https://news.ki.se/new-research-reveals-two-types-of-fatty-liver-disease Researchers at Karolinska Institutet and the University of Gothenburg have identified two types of metabolic-associated fatty liver disease – a liver-specific type and a systemic type that affects other organs and tissues. The discovery could lead to improved diagnosis and treatment of this growing patient group. Two studies are published back-to-back in Nature Medicine. Mon, 09 Dec 2024 15:00:11 +0100 https://news.ki.se/studying-inflammatory-liver-disease Patients with primary sclerosing cholangitis (PSC) often develop liver failure and the risk of cancer is high. Annika Bergquist hopes her research will add to the understanding of the disease and lead to more efficacious treatment. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October. Mon, 02 Sep 2024 09:00:15 +0200 https://news.ki.se/study-shows-how-oestrogen-protects-against-fatty-liver New research from Karolinska Institutet shows how oestrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic. The study, published in Molecular Systems Biology, shows how a new drug under development could become a future treatment for fatty liver disease and liver cancer. Fri, 08 Mar 2024 12:10:08 +0100 https://news.ki.se/researchers-use-the-eye-as-a-window-to-study-liver-health Researchers at Karolinska Institutet have developed a method to study liver function and disease without requiring invasive procedures. After transplanting liver cells into the eye of mice, the cornea can be used as a window into the body to monitor liver health over time. The study is published in the journal Nature Communications. Thu, 01 Feb 2024 15:51:05 +0100 https://news.ki.se/popular-diabetes-drug-may-also-reduce-the-risk-of-severe-liver-disease Ozempic and other GLP1 agonists are associated with a reduced risk of developing cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease, according to a nationwide study from Karolinska Institutet published in the journal Gut. Tue, 23 Jan 2024 18:00:15 +0100 https://news.ki.se/long-live-the-liver Many Swedes live with fatty liver – and it doesn’t have to be dangerous. But for some, it kicks off a course of disease in which persistent inflammation leads to cirrhosis. Medicinsk Vetenskap has talked to researchers who look after the liver – the behemoth of the belly that has a somewhat magical ability to recover, along with enormous overcapacity. Wed, 27 Dec 2023 11:17:49 +0100 https://news.ki.se/statins-tested-for-severe-liver-disease In an unbiased cross-checking of a wide array of health registers, an exciting connection emerged. Could a common and cheap blood lipid lowering drug from the standard repertoire help patients with the liver diseases PSC? This question is now the subject of a clinical trial. Wed, 27 Dec 2023 11:16:15 +0100 https://news.ki.se/the-intricate-art-of-liver-surgery It is possible to remove 80 per cent of a healthy liver without it losing its function. But how much can be removed from a diseased liver in which some tissue is already lost? This issue is central to reducing mortality after liver surgery. Wed, 27 Dec 2023 11:09:00 +0100 https://news.ki.se/mini-livers-and-the-hunt-for-new-drugs-to-treat-fatty-liver-disease Professor Magnus Ingelman-Sundberg has come up with a way to produce tiny livers, called liver spheroids. Wed, 27 Dec 2023 11:07:18 +0100 https://news.ki.se/liver-cancer-and-severe-liver-disease-more-common-if-a-close-relative-has-fatty-liver-disease Close relatives of people with metabolic-associated fatty liver disease have a higher risk of developing liver cancer and dying from liver-related diseases, according to a national study from Karolinska Institutet published in The Journal of Hepatology. This means that family members could also benefit from the lifestyle advice that is currently only given to patients, the researchers conclude. Fri, 08 Sep 2023 12:54:52 +0200 https://news.ki.se/antibody-candidate-for-treating-serious-liver-disease There is currently no drug for treating non-alcoholic fatty liver disease, which affects many people with type 2 diabetes and which can result in other serious liver diseases. A study led by researchers from Karolinska Institutet has now identified a drug candidate for the treatment of fatty liver. The preclinical study, published in the Journal of Hepatology, indicates that an antibody that blocks the protein VEGF-B presents a possible therapeutic option for fatty liver disease. Fri, 03 Feb 2023 09:43:02 +0100 https://news.ki.se/new-treatment-principle-for-chronic-hepatitis-b-and-d-infections A new immunological treatment against hepatitis B and D viruses, both of which can cause liver cancer, shows promising results in animal models. Results from the treatment, which is being developed by researchers at Karolinska Institutet, have been published in the journal Gut. Fri, 26 Aug 2022 11:30:27 +0200 https://news.ki.se/new-findings-may-contribute-to-better-diagnosis-and-treatment-of-liver-cancer In a new study, researchers at Karolinska Institutet have identified the presence of a specific connection between a protein and an lncRNA molecule in liver cancer. By increasing the presence of the lncRNA molecule, the fat depots of the tumor cell decrease, which causes the division of tumor cells to cease, and they eventually die. The study, published in the journal Gut, contributes to increased knowledge that can add to a better diagnosis and future cancer treatments. Wed, 12 Jan 2022 11:00:06 +0100 https://news.ki.se/immune-cells-in-the-human-biliary-system-mapped Researchers at Karolinska Institutet have analysed and described in detail the immune cells residing in the human bile duct. The findings may pave the way for new treatment strategies against disorders of the bile duct, which are often linked to immunological processes. The study is published in the journal Science Translational Medicine. Wed, 23 Jun 2021 20:00:04 +0200 https://news.ki.se/increased-risk-of-liver-cancer-in-patients-with-non-alcoholic-fatty-liver Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer. Wed, 14 Apr 2021 09:06:02 +0200 https://news.ki.se/genetic-cause-of-severe-liver-disease-discovered Liver transplantation is currently the only treatment available for the severe liver disease PSC. Now, however, researchers at Karolinska Institutet and Oslo University have discovered the first reported genetic mutation that causes PSC. The study, which is published in Science Translational Medicine, opens new paths to future treatments. Wed, 24 Feb 2021 20:00:04 +0100 https://news.ki.se/even-mild-fatty-liver-disease-is-linked-to-increased-mortality Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the scientific journal Gut. Mon, 12 Oct 2020 14:44:40 +0200 https://news.ki.se/blood-tests-can-predict-the-risk-of-liver-cirrhosis Repeated measurements of the biomarker FIB-4 in the blood every few years can predict the risk of developing severe liver disease, according to a new study from Karolinska Institutet published in the Journal of Hepatology. The risk of liver cirrhosis increases if the levels of this biomarker rise between two testing occasions. Wed, 01 Jul 2020 12:05:03 +0200 https://news.ki.se/low-dose-aspirin-linked-to-reduced-liver-cancer-risk Among adults with chronic viral hepatitis at high risk of liver cancer, those who took low-dose aspirin long-term were less likely to develop liver cancer or to die from liver-related causes. The findings come from a study published in the New England Journal of Medicine and conducted by a team led by investigators at Karolinska Institutet and Örebro University Hospital in Sweden and Massachusetts General Hospital in the U.S. Wed, 11 Mar 2020 22:00:06 +0100 https://news.ki.se/new-possible-treatment-strategy-against-fatty-liver-disease Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine. Wed, 26 Feb 2020 20:00:05 +0100 https://news.ki.se/better-methods-needed-for-predicting-risk-of-liver-disease While blood samples can reliably identify people with a low risk of developing severe liver disease, better methods are needed in primary care for identifying people in most need of care. These are some of the conclusions of a large registry-based study by researchers at Karolinska Institutet published in the esteemed journal Gastroenterology. Fri, 27 Sep 2019 08:30:00 +0200 https://news.ki.se/early-contact-with-needle-exchange-programme-reduces-hepatitis-c-infection People who inject drugs and who are female, homeless or amphetamine users often share needles and syringes, and consequently run a higher risk of infection hepatitis C virus infection that affect the liver. However, as a new doctoral thesis from Karolinska Institutet demonstrates, early contact with a needle-exchange programme can have a protective effect. Mon, 03 Jun 2019 14:02:39 +0200 https://news.ki.se/researchers-learn-more-about-severe-liver-disease Approximately one out of every ten people with hepatitis B are coinfected with hepatitis D, which is among the most serious liver conditions. Researchers at Karolinska Institutet and their German colleagues have described the impact of chronic hepatitis D on parts of the immune system. The study was published in the Journal of Hepatology. Wed, 15 May 2019 11:12:05 +0200 https://news.ki.se/promising-results-for-new-acute-porphyria-treatment Acute porphyria is a group of uncommon diseases that can cause severe, potentially life-threatening attacks of abdominal pain, nausea, vomiting and paralysis. Liver transplantation is currently the only effective treatment available for the most seriously afflicted patients. A clinical trial conducted in collaboration with researchers at Karolinska Institutet in Sweden now shows that a new drug candidate can prevent attacks in these patients. The study is published in The New England Journal of Wed, 06 Feb 2019 23:05:05 +0100 https://news.ki.se/immune-system-does-not-recover-despite-cured-hepatitis-c-infection Mon, 11 Jun 2018 11:01:52 +0200 https://news.ki.se/new-strategy-to-cure-chronic-hepatitis-b-infection Thu, 17 May 2018 12:42:21 +0200