https://ki.se RSS News Listing https://news.ki.se/tiny-tweaks-to-micrornas-uncover-big-insights-into-gene-control Researchers at Karolinska Institutet and Uppsala University have developed a powerful new technique to better understand how tiny molecules in our cells, called microRNAs, control which genes are turned on or off — a discovery that could improve how we study diseases from cancer to neurodevelopmental disorders. Wed, 30 Apr 2025 07:43:03 +0200 https://news.ki.se/new-light-controlled-crispr-tool-enhances-precision-in-genetic-research A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in Nucleic Acids Research, introduces BLU-VIPR, a method that allows researchers to control the gene-editing tool CRISPR using light. This innovation could significantly enhance our understanding of gene functions in complex organisms. Fri, 28 Mar 2025 10:45:55 +0100 https://news.ki.se/new-study-on-micrornas-could-lead-to-better-fertility-treatment Researchers at Karolinska Institutet have mapped how small RNA molecules, such as the recently Nobel Prize-awarded microRNAs, control cell development in the human embryo during the first days after fertilisation. The findings, published in Nature Communications, may eventually contribute to improved fertility treatment. Wed, 16 Oct 2024 11:00:08 +0200 https://news.ki.se/key-molecule-in-wound-healing-identified A new study from Karolinska Institutet and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of hard-to-heal wounds. Tue, 08 Oct 2024 12:54:45 +0200 https://news.ki.se/the-nobel-prize-in-physiology-or-medicine-a-groundbreaking-discovery-that-has-finally-been-rewarded Victor Ambros and Gary Ruvkun share this year's Nobel Prize in Physiology or Medicine. They are being awarded for their discovery of microRNAs, which play a crucial role in the development of complex organisms. Research is underway at Karolinska Institutet on how these small molecules can be applied clinically. Tue, 08 Oct 2024 12:10:14 +0200 https://news.ki.se/the-nobel-prize-in-physiology-or-medicine-2024-to-victor-ambros-and-gary-ruvkun The Nobel Assembly at Karolinska Institutet has decided to award the 2024 Nobel Prize in Physiology or Medicine jointly to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation. Mon, 07 Oct 2024 11:35:10 +0200 https://news.ki.se/new-technology-maps-where-and-how-cells-read-their-genome A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and how to treat them. Wed, 15 Mar 2023 17:00:04 +0100 https://news.ki.se/unexpected-finding-on-the-3d-organization-of-chromosomes New findings reveal an advanced, unexpected two-way communication between the function and organization of chromosomes in the cell nucleus. Previous research shows that the organization of chromosomal DNA into loops regulates gene reading (transcription) and chromosome copying (replication). The new results show that, in turn, transcription and replication control chromosome looping, thus revealing a new interplay known to be important in avoiding diseases, such as cancer. Mon, 13 Jun 2022 10:33:28 +0200 https://news.ki.se/brief-expression-of-gene-editing-tools-helped-with-progeria-in-mice In a new study in Nature Communications, researchers at Karolinska Institutet and the Institute for Basic Science in South Korea have shown how short-term expression of gene editing tools can be used to repair the mutation that causes progeria. Thu, 02 Jun 2022 11:48:27 +0200 https://news.ki.se/new-tool-reveals-function-of-enigmatic-gene-sequences While the large proportion of our genome that does not instruct our cells to form proteins has been harder to study than protein-coding genes, it has been shown to have vital physiological functions. Scientists at Karolinska Institutet have now developed new high-precision tools able to identify what these noncoding sequences do. The study, which is published in the journal Nature Genetics, may eventually contribute to the development of new, targeted drugs. Thu, 03 Mar 2022 17:00:08 +0100 https://news.ki.se/gene-networks-can-explain-up-to-60-percent-of-hereditary-risk-of-cardiovascular-disease Researchers at Karolinska Institutet and the Icahn School of Medicine at Mount Sinai in USA, have mapped how genes work together to cause cardiovascular disease. The study published in Nature Cardiovascular Research, suggests that that nearly 60 percent of the risk associated with coronary artery disease may be explained by regulatory gene networks. Thu, 13 Jan 2022 08:43:58 +0100 https://news.ki.se/new-findings-on-the-link-between-crispr-gene-editing-and-mutated-cancer-cells A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers at Karolinska Institutet have found new links between CRISPR, p53 and other cancer genes that could prevent the accumulation of mutated cells without compromising the gene scissors’ effectiveness. The study, published in Cancer Research, can contribute to tomorrow’s precision medicine. Thu, 18 Nov 2021 10:00:06 +0100 https://news.ki.se/long-term-exercise-impacts-genes-involved-in-metabolic-health Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health. This is according to a new study published in the journal Cell Reports by researchers at Karolinska Institutet in Sweden and the University of San Diego in the U.S. Sex differences found in untrained individuals were also dramatically reduced with long-term training. The results may have implications for metabolic disease prevention. Tue, 23 Jun 2020 17:00:03 +0200 https://news.ki.se/new-understanding-of-rna-movements-can-be-used-to-treat-cancer Research from Karolinska Institutet published today in Nature shows that an RNA molecule involved in preventing tumour formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer. Wed, 27 May 2020 17:00:08 +0200 https://news.ki.se/breakthrough-in-sex-chromosome-regulation Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine. The study is published in Nature Structural and Molecular Biology. Thu, 03 Oct 2019 17:00:00 +0200 https://news.ki.se/new-crispr-cas9-variant-may-boost-precision-in-gene-editing Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play a role in gene therapies that require high precision. The study by researchers from Karolinska Institutet’s Ming Wai Lau Centre of Reparative Medicine in Hong Kong is published in the journal PNAS. Tue, 01 Oct 2019 07:33:02 +0200 https://news.ki.se/they-are-the-2019-wallenberg-scholars Three researchers at Karolinska Institutet have been appointed Wallenberg Scholar in 2019: Ernest Arenas, Sten Linnarsson, and Randal S. Johnson. The researchers – among the foremost in their field in Sweden – receive SEK 18 million each from the Wallenberg Foundations in the form of a five-year grant for free research. Mon, 25 Mar 2019 09:10:00 +0100 https://news.ki.se/oestrogen-causes-neuroblastoma-cells-to-mature-into-neurons Mon, 29 Jan 2018 10:04:44 +0100 https://news.ki.se/children-with-alagille-syndrome-have-malformed-bile-ducts Tue, 21 Nov 2017 12:54:49 +0100 https://news.ki.se/new-possible-target-for-cancer-treatment Wed, 07 Jun 2017 15:21:50 +0200 https://news.ki.se/scientists-reveal-how-epigenetic-changes-in-dna-are-interpreted Fri, 05 May 2017 06:00:00 +0200 https://news.ki.se/hope-for-new-treatment-for-huntingtons-disease Mon, 20 Feb 2017 08:00:00 +0100 https://news.ki.se/short-rna-molecules-mapped-in-single-cell Mon, 31 Oct 2016 14:17:32 +0100 https://news.ki.se/new-molecular-test-can-reveal-biological-age Tue, 08 Sep 2015 09:00:00 +0200 https://news.ki.se/language-of-gene-switches-unchanged-across-the-evolution Tue, 17 Mar 2015 13:00:41 +0100 https://news.ki.se/protein-coding-junk-genes-may-be-linked-to-cancer Mon, 18 Nov 2013 00:00:00 +0100 https://news.ki.se/learning-the-alphabet-of-gene-control Fri, 18 Jan 2013 00:00:00 +0100 https://news.ki.se/gene-switch-important-in-cancer-discovered Fri, 02 Nov 2012 00:00:00 +0100