https://ki.se RSS News Listing https://news.ki.se/natural-killer-cells-remember-and-effectively-target-ovarian-cancer Researchers at Karolinska Institutet have uncovered a unique ability of a special subtype of natural killer cells in the immune system, called adaptive NK cells, to remember ovarian tumours and effectively attack them. The discovery, published in Cancer Immunology Research, could pave the way for new, more powerful immunotherapies for difficult-to-treat cancers. Mon, 28 Apr 2025 16:07:55 +0200 https://news.ki.se/new-thesis-on-optimizing-treatment-for-lung-cancer-patients Hi Marcus Skribek, doctoral student at the Department of Oncology-Pathology. On November 8 you will defend your thesis ”Strategies for optimizing immune checkpoint inhibition in advanced non-small cell lung cancer”. Mon, 21 Oct 2024 10:59:40 +0200 https://news.ki.se/future-cancer-treatment-and-fertility In recent years, the treatment landscape for solid tumors has undergone a notable change. With new cancer treatments, the future looks brighter for many young cancer patients, making fertility issues and future family planning an important aspect. Six specialists in oncology and onco-fertility at the Department of Oncology-Pathology join forces to compile knowledge and recommendations on this important issue. Wed, 13 Mar 2024 07:51:27 +0100 https://news.ki.se/new-method-is-better-able-to-map-immune-response-and-paves-way-for-new-treatments A new method, developed at Karolinska Institutet, KTH Royal Institute of Technology and SciLifeLab, can identify unique immune cell receptors and their location in tissue, a study published in the journal Science reports. The researchers predict that the method will improve the ability to identify which immune cells contribute to disease processes and open up opportunities to develop novel therapies for numerous diseases. Fri, 08 Dec 2023 08:14:19 +0100 https://news.ki.se/immunotherapy-that-eliminates-mutated-cancer-cells-shows-promising-effect Researchers at Karolinska Institutet and the University of Oslo present a new type of immunotherapy that attacks cancer cells with a specific mutation. A study published in the journal Nature Cancer shows promising effects on patient cells in mice and offers hope for patients with acute myeloid leukaemia (AML), a cancer that has proven difficult to treat. Mon, 02 Oct 2023 17:08:50 +0200 https://news.ki.se/new-thesis-on-new-treatments-approaches-for-multiple-myeloma-mm Maria Karvouni from the Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine, Huddinge (MedH) is defending her thesis: "Cellular and personalized therapies in Multiple Myeloma with special emphasis on retargeted NK cells" 16 June 2023. Main supervisor is Evren Alici (MedH). Fri, 09 Jun 2023 10:28:28 +0200 https://news.ki.se/memory-killer-cells-can-improve-survival-for-melanoma-patients Our skin contains specialised long-lived killer cells that protect against intruders. Researchers at Karolinska Institutet and the University of Copenhagen have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma. The study is published in the journal Immunity. Fri, 02 Jun 2023 17:00:05 +0200 https://news.ki.se/immune-cell-gives-possible-explanation-for-sex-differences-in-pancreatic-cancer Immunotherapy is an effective form of therapy for different types of cancer. However, for pancreatic cancer, its effect is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference. The study, which is published in Cancer Research, reveals the presence of an immune cell in women with pancreatic cancer that obstructs the body’s immune response. The results can pave the way for a more sex-specific treatment. Wed, 15 Mar 2023 08:05:03 +0100 https://news.ki.se/life-threatening-side-effects-of-novel-cancer-immunotherapies-could-be-treatable Immunotherapy has been shown to greatly improve survival rates for certain types of cancer. However, in some cases, it can lead to an over-activation of the immune system, which can be dangerous. In a recent review by researchers at Karolinska Institutet, potential therapies have been identified, which might make it possible to continue with immunotherapy even when facing severe side effects. Wed, 08 Mar 2023 13:37:34 +0100 https://news.ki.se/new-immunotherapy-holds-promise-for-ovarian-cancer CAR T-cell therapy, a certain kind of cancer treatment in which the immune system’s T cells are programmed to attack tumour cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer. The researchers, who work at Karolinska Institutet, hope that the discovery will pave the way for a clinical trial to see how effective the treatment is for women with the disease. Mon, 06 Feb 2023 10:11:46 +0100 https://news.ki.se/cellular-messengers-improve-cancer-therapy Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumours sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to a new study published in Cancer Immunology Research by researchers at Karolinska Institutet. Thu, 22 Dec 2022 15:00:06 +0100 https://news.ki.se/new-cancer-findings-can-give-wider-access-to-immunotherapy Researchers at Karolinska Institutet publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy. Tue, 06 Jul 2021 09:05:04 +0200 https://news.ki.se/double-antibody-against-sars-cov-2-prevents-therapy-resistant-variants An international consortium that includes researchers at Karolinska Institutet has developed a ‘double antibody’ that targets two different sites of the SARS-CoV-2 virus, thereby preventing the virus from mutating to resist the therapy. A study published in the scientific journal Nature shows that the antibody potently neutralises SARS-CoV-2 and its variants and protects against COVID-19 in mice. Thu, 25 Mar 2021 11:00:03 +0100 https://news.ki.se/new-research-identifies-which-t-cells-patrol-the-body The blood is the main source of studies on the immune system, despite the fact that most diseases are combated by immune cells in the body’s tissues. A new study from Karolinska Institutet and the University of Pennsylvania has identified which immune cells patrol the human body’s tissues and circulate back into the blood. The study, which is published in Cell, shows that not all T cells do this – some are found mostly in the blood where they constitute a unique part of our immune system. Thu, 10 Dec 2020 17:00:03 +0100 https://news.ki.se/new-type-of-immunotherapy-may-pave-the-way-for-better-cancer-treatments Immunotherapy for cancer has made great advances and many patients can now receive effective treatments that were not available ten years ago. However, there are certain types of cancer that do not respond to existing immunotherapy. A study from Karolinska Institutet in Sweden published in Proceedings of the National Academy of Sciences (PNAS) reports on a new kind of immunotherapy that gives hope of more treatment options for cancer in the future. Mon, 23 Nov 2020 21:00:03 +0100 https://news.ki.se/promising-new-treatment-of-advanced-skin-cancer A new type of immunotherapy for the skin cancer malignant melanoma shows promising results. Three severely ill patients are now long-term survivors. The study, published in OncoImmunology, is the result of a collaboration between researchers at Karolinska Institutet and Karolinska University Hospital. Fri, 07 Aug 2020 13:56:55 +0200 https://news.ki.se/three-ki-led-coronavirus-projects-selected-in-eu-funding-round Three coronavirus projects coordinated by researchers at Karolinska Institutet have moved onto the grant negotiation phase in a bid for 9 million euros (95 million kronor) in EU funding. The projects aim to find a vaccine, immunotherapies and neutralizing antibodies against SARS-CoV-2 and are being coordinated by KI’s Matti Sällberg, Qiang Pan Hammarström and Benjamin Murrell. Fri, 06 Mar 2020 19:54:43 +0100 https://news.ki.se/new-centre-of-excellence-at-ki-for-treatment-of-cancer Karolinska Institutet is granted funding from Vinnova to start a new centre of excellence. The centre will focus on developing next-generation immunotherapy based on NK-cells for the treatment of cancer. Tue, 02 Jul 2019 12:59:54 +0200 https://news.ki.se/dna-origami-a-precise-measuring-tool-for-optimal-antibody-effectiveness Mon, 14 Jan 2019 17:00:39 +0100 https://news.ki.se/michel-sadelain-lecture-at-karolinska-institutet Mon, 26 Nov 2018 11:46:23 +0100 https://news.ki.se/immunotherapy-effective-against-hereditary-melanoma Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year’s Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics. Mon, 08 Oct 2018 08:00:00 +0200 https://news.ki.se/new-disease-model-to-facilitate-development-of-als-and-ms-drugs Mon, 16 Apr 2018 17:03:00 +0200 https://news.ki.se/successful-nk-cell-based-immunotherapy-for-leukaemia Researchers at Karolinska Institutet have explored NK cell-based immunotherapy on patients with treatment-resistant leukaemia. The study, which is published in the scientific journal Clinical Cancer Research, shows that the new therapy is effective against several types of leukaemia. Tue, 20 Feb 2018 08:00:00 +0100 https://news.ki.se/new-tool-demonstrates-differences-in-human-immune-systems Tue, 11 Jul 2017 08:00:00 +0200 https://news.ki.se/novel-role-for-neutrophils-elucidated Wed, 03 Aug 2016 10:15:44 +0200