https://ki.se RSS News Listing https://news.ki.se/hunting-down-the-genetics-of-serious-liver-disease Fatty liver results from overweight and obesity and it is a common disease leading to cirrhosis and liver cancer. Stefano Romeo is investigating the genetic basis of the diseases to identify novel therapeutic strategies. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 9 October. Fri, 29 Aug 2025 10:00:14 +0200 https://news.ki.se/genes-reveal-why-some-older-people-suffer-from-frailty A new study has identified genetic variants linked to brain function, immune defence and metabolism that contribute to the development of frailty in older people. The study, published in Nature Aging by researchers from Karolinska Institutet, provides new biological insights into the onset of frailty. Tue, 05 Aug 2025 11:22:24 +0200 https://news.ki.se/gene-therapy-restored-hearing-in-deaf-patients Gene therapy can improve hearing in children and adults with congenital deafness or severe hearing impairment, a new study involving researchers at Karolinska Institutet reports. Hearing improved in all ten patients, and the treatment was well-tolerated. The study was conducted in collaboration with hospitals and universities in China and is published in the journal Nature Medicine. Wed, 02 Jul 2025 11:00:10 +0200 https://news.ki.se/what-do-we-know-about-genes-and-environmental-factors-in-autism Associate Professor Kristiina Tammimies conducts frontline research on the medical, genetic, and molecular underpinnings of autism and other neurodevelopmental disorders. Among other things, she and her research team are working on the complex and much debated issue of heredity versus environment as a cause of autism. Wed, 25 Jun 2025 13:32:22 +0200 https://news.ki.se/a-gene-variant-increases-the-risk-of-long-covid An international team of researchers has found a genetic link to long-term symptoms after COVID-19. The identified gene variant is located close to the FOXP4 gene, which is known to affect lung function. The study, published in Nature Genetics, was led by researchers at Karolinska Institutet in Sweden and the Institute for Molecular Medicine Finland. Wed, 21 May 2025 18:18:28 +0200 https://news.ki.se/atm-mutations-in-chronic-lymphocytic-leukemia In chronic lymphocytic leukemia (CLL), certain recurrent genetic alterations are known to influence disease progression and survival. One important abnormality is the loss of part of chromosome 11, del(11q), which is associated with a more aggressive disease course. However, it has remained unclear whether mutations in the ATM gene, which is also located in this region, have a similar impact. Mon, 05 May 2025 14:17:22 +0200 https://news.ki.se/new-swedish-initiative-to-integrate-research-and-healthcare A groundbreaking national initiative, Precision Omics Initiative Sweden (PROMISE), aims to connect research with healthcare and establish Sweden as a world leader in data-driven precision medicine. The vision was recently published in the scientific journal Nature Medicine. Fri, 04 Apr 2025 11:37:12 +0200 https://news.ki.se/new-light-controlled-crispr-tool-enhances-precision-in-genetic-research A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in Nucleic Acids Research, introduces BLU-VIPR, a method that allows researchers to control the gene-editing tool CRISPR using light. This innovation could significantly enhance our understanding of gene functions in complex organisms. Fri, 28 Mar 2025 10:45:55 +0100 https://news.ki.se/new-thesis-on-novel-genetic-causes-of-childhood-cancer-predisposition Carolina Maya-González, from the research group Rare Diseases at the Department of Molecular Medicine and Surgery, will defend her thesis "Novel genetic causes of childhood cancer predisposition" on March 21st, 2025. Main supervisor is Ann Nordgren. Tue, 18 Feb 2025 10:22:33 +0100 https://news.ki.se/mapping-of-a-gigantic-salamander-genome-reveals-secrets-of-regeneration Researchers at Karolinska Institutet have mapped the genome of the Iberian ribbed newt and revealed how the composition and organization of the DNA are linked to its ability to regenerate entire body parts. Wed, 29 Jan 2025 12:19:49 +0100 https://news.ki.se/global-study-pinpoints-genes-for-depression-across-ethnicities New genetic risk factors for depression have been identified across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity. The world’s largest and most diverse genetic study ever of major depression has revealed nearly 300 previously unknown genetic links to the condition. Wed, 15 Jan 2025 08:10:32 +0100 https://news.ki.se/new-imaging-method-enables-detailed-rna-analysis-of-the-whole-brain Researchers at Karolinska Institutet and Karolinska University Hospital have developed a microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to a study in Science. Fri, 22 Nov 2024 09:07:54 +0100 https://news.ki.se/mapping-of-atherosclerotic-plaque-cells-may-predict-future-risk-of-stroke-or-heart-attack In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future. Wed, 20 Nov 2024 10:30:32 +0100 https://news.ki.se/complex-diagnoses-can-be-solved-with-new-technology Using a new technique, long-read sequencing, that allows DNA to be analyzed in much greater detail than before, a team of Swedish clinicians and researchers has discovered an unexpected complexity in chromosomal abnormalities. The study opens the door to more precise and effective treatment of patients with rare diseases that currently lack clear diagnoses. Mon, 04 Nov 2024 13:48:22 +0100 https://news.ki.se/call-for-interest-short-course-on-human-organoids-model-systems-for-human-biology-and-medicine Are you a doctoral student at KI specializing in Genetics and Genomics, Neurosciences, Biomedicine, Biotechnology, or Physiology? Do you want to dive deep into the latest advancements in stem cells, iPSC characterization, and 3D organoid technology? Wed, 02 Oct 2024 10:21:58 +0200 https://news.ki.se/gene-therapy-effective-in-hereditary-blindness Bothnia dystrophy is a form of hereditary blindness, prevalent in the region Västerbotten in Sweden. A new study at Karolinska Institutet published in Nature Communications shows that gene therapy can improve vision in patients with the disease. Tue, 10 Sep 2024 13:56:26 +0200 https://news.ki.se/seeking-a-better-understanding-of-mitochondrial-diseases Mitochondrial diseases are inherited and often affect children. With no effective treatment currently available, Anna Wredenberg hopes to discover more about mitochondrial function in order to improve both diagnosis and treatment. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 3 October. Thu, 05 Sep 2024 09:00:14 +0200 https://news.ki.se/new-technique-allows-comprehensive-genetic-testing-of-embryos Researchers from Karolinska Institutet and Maastricht University have developed a technique that enables the examination of embryos for all known genetic abnormalities with a single test. The new method is more accurate and faster than existing techniques, increasing the chance of a healthy child for parents at increased risk of inherited conditions. The research was published today in Nature Communications Mon, 02 Sep 2024 13:04:01 +0200 https://news.ki.se/new-genetic-markers-for-adrenal-cancer-may-predict-survival A new study from Karolinska Institutet shows that 45 genes may play a crucial role in the prognosis of patients with adrenal cancer. The findings, published in the journal ESMO Open, give hope for a better diagnostic tool than is currently available. Thu, 27 Jun 2024 08:09:31 +0200 https://news.ki.se/ki-is-part-of-the-scilake-cancer-knowledge-graph Researchers from the Clinical Genetics Group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, have set up a collaboration with the Centre for Research and Technology in Greece to make publicly available resources in biology and cancer more accessible to the research community. The teams are developing a first-of-its-kind cancer knowledge graph, as part of the SciLake Project involving partners across Europe. Mon, 03 Jun 2024 09:26:46 +0200 https://news.ki.se/early-genetic-development-of-the-brain-mapped In an article published in Nature, researchers from Karolinska Institutet present an atlas of the early development of the brain. The atlas can be used, among other things, to find out what went wrong in the development of brain tumors in children and also to find new treatments. Thu, 02 May 2024 11:47:53 +0200 https://news.ki.se/new-study-seeks-hereditary-causes-of-childhood-cancer Follow-up and treatment of children with cancer is significantly improved when inherited genetic causes are also investigated, according to a new Swedish study. The results of the research study involving some 50 researchers and clinicians from across Sweden have been published in The Lancet Regional Health – Europe. Tue, 02 Apr 2024 13:32:02 +0200 https://news.ki.se/oliver-billker-is-awarded-the-medicine-doctor-axel-hirsch-prize-2024 Umeå professor Oliver Billker is awarded the Medicine Doctor Axel Hirsch prize 2024 for his outstanding research in the field of malaria. Fri, 01 Mar 2024 11:24:36 +0100 https://news.ki.se/inherited-genetic-mutations-can-predict-interval-breast-cancer An investigation conducted by researchers at Karolinska Institutet has led to a discovery in breast cancer diagnostics and treatments that could reshape screening programs and clinical approaches. The study, published in JAMA Oncology, unravels the impact of rare genetic variants on interval breast cancers, providing new insights into tailored screening strategies. Thu, 25 Jan 2024 17:06:19 +0100 https://news.ki.se/review-article-describing-the-role-of-p53-as-a-target-for-novel-cancer-therapies The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by professor Klas G Wiman and colleagues at the Department of Oncology-Pathology describes how p53 could be used as a target for new cancer therapies. Tue, 19 Dec 2023 13:12:40 +0100 https://news.ki.se/using-whole-genome-sequencing-in-the-diagnostics-of-acute-lymphoblastic-leukemia-in-children A new Swedish study shows that whole genome sequencing can detect clinically relevant genomic abnormalities in acute lymphoblastic leukemia, ALL, and has great potential to be implemented in the diagnostic setting. The study was carried out by researchers within the Clinical Genetics group at the Department of Molecular Medicine and Surgery, the Genomic Medicine Sweden for haematology and published in the scientific journal Frontiers in Oncology. Mon, 21 Aug 2023 08:58:24 +0200 https://news.ki.se/an-unexpected-doorway-into-the-ear-opens-new-possibilities-for-hearing-restoration An international team of researchers has developed a new method to deliver drugs into the inner ear, according to a new study in Science Translational Medicine. The discovery was possible by harnessing the natural flow of fluids in the brain and employing a little-understood backdoor into the cochlea. When combined to deliver a gene therapy that repairs inner ear hair cells, the researchers were able to restore hearing in deaf mice. Wed, 28 Jun 2023 22:00:04 +0200 https://news.ki.se/new-gene-discovery-gives-hope-of-fighting-severe-ms A new study in Nature by an international team including researchers at Karolinska Institutet has identified the first genetic variant associated with disease severity in multiple sclerosis. The finding opens the door to the development of treatments that fight disease progression – a great unmet need facing people with MS. Wed, 28 Jun 2023 17:00:05 +0200 https://news.ki.se/patients-with-rare-diseases-diagnosed-after-international-hackathon Almost a hundred experts from 27 countries took part in a hackathon on June 17–18 to identify diseases in 14 patients lacking diagnoses. “Four of them have now received an answer and we’re confident that more are to come,” says professor and consultant Ann Nordgren, who was one of the organizers of the event. Tue, 20 Jun 2023 10:58:24 +0200 https://news.ki.se/the-viking-disease-can-be-due-to-gene-variants-inherited-from-neanderthals Many men in northern Europe over the age of 60 suffer from the so-called Viking disease, which means that the fingers lock in a bent position. Now researchers at Karolinska Institutet, together with colleagues, have used data from over 7,000 affected individuals to look for genetic risk factors for the disease. The findings, which have been published in Molecular Biology and Evolution, show that three of the strongest risk factors are inherited from Neanderthals. Wed, 14 Jun 2023 23:05:04 +0200 https://news.ki.se/improved-diagnostics-of-neuromuscular-disorders-by-comprehensive-whole-genome-sequencing A new Swedish study on the etiology of neuromuscular disorders has been published in the scientific journal Frontiers in Neurology. The study was carried out by researchers in the Rare Diseases group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, in collaboration with doctors at Karolinska University Hospital. Tue, 23 May 2023 09:50:40 +0200 https://news.ki.se/cost-effective-to-diagnose-intellectual-disabilities-with-whole-genome-sequencing Researchers at Karolinska Institutet and Karolinska University Hospital have together with health economists at Linköping University analyzed costs for various methods to diagnose genetic causes of intellectual disability. The study, published in Scientific Reports, shows that the costs when using whole genome sequencing as a first-line diagnostic test were lower compared to chromosomal microarray analysis. Thu, 04 May 2023 10:33:53 +0200 https://news.ki.se/genomes-from-240-mammalian-species-explain-human-disease-risks Why is it that certain mammals have an exceptional sense of smell, some hibernate, and yet others, including humans, are predisposed to disease? In a major international research project where researchers at Karolinska Institutet participated, has surveyed and analysed the genomes of 240 different mammals. The results, now published in 11 articles in the journal Science, shows which regions have important functions in mammals. Fri, 28 Apr 2023 07:54:31 +0200 https://news.ki.se/nature-study-reveals-new-mechanism-for-dna-folding A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics. Their findings provide new insights into chromosomal processes that are vital to both normal development and to prevent disease. Wed, 19 Apr 2023 17:00:00 +0200 https://news.ki.se/new-technology-maps-where-and-how-cells-read-their-genome A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and how to treat them. Wed, 15 Mar 2023 17:00:04 +0100 https://news.ki.se/genetic-analysis-can-reduce-adverse-drug-reactions-by-30-per-cent Patients can experience 30 per cent fewer serious adverse reactions if their drugs are tailored to their genes, reports a study published in The Lancet. A European collaboration involving researchers from Karolinska Institutet suggests that a genetic analysis prior to drug therapy could significantly reduce suffering and healthcare costs. Fri, 03 Feb 2023 09:24:56 +0100 https://news.ki.se/serious-eating-disorder-arfid-is-highly-heritable-according-to-new-twin-study ARFID is strongly influenced by genetic factors, according to a twin study examining this relatively new type of eating disorder. The study has been published in the journal JAMA Psychiatry by researchers at Karolinska Institutet. Thu, 02 Feb 2023 11:11:52 +0100 https://news.ki.se/svante-paabo-highlighted-the-neanderthal-in-us When Svante Pääbo talked about the importance of Neanderthals, the audience in Aula Medica listened carefully. The Nobel Laureate in Physiology or Medicine explained, among other things, that we carry their genes and that they may have been more sensitive than we think. Mon, 12 Dec 2022 12:52:05 +0100 https://news.ki.se/svante-paabo-on-his-nobel-experience-its-been-a-bit-overwhelming Svante Pääbo hasn’t even collected his 2022 Nobel Prize in Physiology or Medicine yet. Still, the director of the Max Planck Institute for Evolutionary Anthropology is already dreaming of making new ground-breaking discoveries. Wed, 07 Dec 2022 10:11:15 +0100 https://news.ki.se/inflammation-amplifies-the-effect-of-genetic-risk-variants-for-schizophrenia Schizophrenia patients have fewer connections between nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain. Researchers at Karolinska Institutet now report in Nature Communications that the levels of protein from the relevant risk gene are elevated in first-episode patients and that inflammation further increases the expression of the risk gene.  Thu, 03 Nov 2022 11:00:05 +0100 https://news.ki.se/nobel-laureate-svante-paabo-shows-us-where-we-came-from Where do we originate from? And who are we? Thanks to Svante Pääbo, 2022 Nobel Laureate in Physiology or Medicine, we know more about what make us uniquely human. We also know what we have in common with our, now-extinct, closest relatives. Wed, 05 Oct 2022 09:37:53 +0200 https://news.ki.se/timeline-of-the-neanderthals-a-family-history-with-health-effects From pregnancies and depression to COVID-19. Neanderthals are physically extinct, but their genes live on. For better or worse, they still affect our health today. We are publishing this timeline, previously published in the magazine Medicinsk Vetenskap, due to the fact that researcher Svante Pääbo has been awarded the Nobel Prize in Physiology or Medicine in 2022. Tue, 04 Oct 2022 15:54:48 +0200 https://news.ki.se/hugo-zeberg-on-his-nobel-prize-awarded-colleague-ive-learnt-a-lot-from-him Many people were delighted to hear that Professor Svante Pääbo has been awarded the 2022 Nobel Prize in Physiology or Medicine, particularly so Hugo Zeberg, researcher at Karolinska Institutet. He has collaborated with Svante Pääbo for years, not least on the work to find Neanderthal genes that can influence how ill different people become after contracting the COVID-19 virus. Mon, 03 Oct 2022 18:43:55 +0200 https://news.ki.se/the-nobel-prize-in-physiology-or-medicine-2022-to-svante-paabo The Nobel Prize in Physiology or Medicine 2022 has been awarded to Svante Pääbo for his discoveries concerning the genomes of extinct hominins and human evolution. Mon, 03 Oct 2022 11:40:48 +0200 https://news.ki.se/genetic-and-environmental-factors-contribute-to-the-overlap-between-depression-and-endocrine-metabolic-disorders Depression is common in individuals with endocrine-metabolic disorders and vice versa. In a study involving 2.2 million people in the Swedish population, researchers at Karolinska Institutet confirmed that individuals with endocrine-metabolic disorders have increased rates of depression and found that there are also higher rates of depression in their siblings. The study is published in the American Journal of Psychiatry. Wed, 28 Sep 2022 15:59:17 +0200 https://news.ki.se/type-1-diabetes-linked-to-higher-risk-of-mental-health-problems-in-patients-and-family Both children with type 1 diabetes and their closest family members are at increased risk of mental health problems compared with those without the disease, according to a large study by researchers at Karolinska Institutet published in the journal Diabetes Care. The findings underscore the need for psychological consulting for both children and their families in diabetes care. Mon, 01 Aug 2022 14:00:06 +0200 https://news.ki.se/evolution-caught-in-action Primary cilia are signaling structures projecting off cell surfaces like antennae. In humans, many different cell types are ciliated. The molecular underpinnings of making and maintaining ciliary identities and functional specializations often are crucial for cell functionality. Recently, researchers have found how the main ciliogenic transcription factor protein controlling overall cilia biology can switch to control ciliary specializations and thereby alters cell behavioral output. Mon, 25 Apr 2022 13:19:24 +0200 https://news.ki.se/biggest-study-of-its-kind-implicates-specific-genes-in-schizophrenia Scientists have analysed DNA from more than 300,000 people with and without the psychiatric disorder in the largest genetic study of schizophrenia to date and have identified a great number of specific genes that could play important roles in the psychiatric disorder. A companion paper published in parallel strengthens these findings by pointing to a similar genetic and biological basis for this disorder. Both studies are published today in the leading international journal Nature. Sat, 09 Apr 2022 17:35:15 +0200 https://news.ki.se/covid-19-genetic-risk-variant-protects-against-hiv The major genetic risk variant for severe COVID-19, one we inherited from Neandertals, is associated with a 27 percent lower risk of HIV infection. This is according to a new study from Karolinska Institutet in Sweden and the Max Planck Institute for Evolutionary Anthropology in Germany published in the journal PNAS. Mon, 21 Feb 2022 21:00:05 +0100 https://news.ki.se/analysing-sperm-can-detect-rare-genetic-variants Researchers from Karolinska Institutet have analysed blood and sperm samples from healthy parents to children with genetic syndromes and the results indicate that germline mosaicism is underestimated as a cause to syndromes and that the level of the genetic variant is higher in sperm than in blood.  The study was recently published in Molecular Genetics & Genomic Medicine. Wed, 16 Feb 2022 19:40:00 +0100 https://news.ki.se/protective-gene-variant-against-covid-19-identified An international metastudy led by researchers at Karolinska Institutet has identified a specific gene variant that protects against severe COVID-19 infection. The researchers managed to pinpoint the variant by studying people of different ancestries, a feat they say highlights the importance of conducting clinical trials that include people of diverse descents. The results are published in the journal Nature Genetics. Thu, 13 Jan 2022 17:00:06 +0100 https://news.ki.se/modern-humans-developed-a-more-effective-protection-against-oxidative-stress Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden have now studied one such protein, glutathione reductase, which protects against oxidative stress. They show that the risk for inflammatory bowel disease and vascular disease is increased several times in people carrying the Neanderthal variant. Wed, 05 Jan 2022 20:00:07 +0100 https://news.ki.se/new-thesis-on-cell-free-dna-and-hereditary-cancer Karin Wallander at the research group Clinical Genetics, Department of Molecular Medicine and Surgery, will defend her thesis "Hereditary predisposition and prognostic prediction in cancer" on December 17, 2021. Main Supervisor is Emma Tham. Wed, 15 Dec 2021 11:08:09 +0100 https://news.ki.se/meet-kristina-haugaa-medhs-new-professor Kristina Haugaa is the new Professor of Cardiology at the Department of Medicine in Huddinge, since October 11. "I'm eager and thrilled to conduct cardiology research at Karolinska Institutet". Fri, 29 Oct 2021 12:19:38 +0200 https://news.ki.se/excess-body-fat-increases-risk-of-digestive-system-cancers Obesity increases the risk of developing cancers of the digestive system and it is the person’s fat mass, rather than size, that is the main obesity-related risk factor for these cancer types, according to a new study published in the journal PLOS Medicine by researchers at the University of Cambridge and Karolinska Institutet. Thu, 29 Jul 2021 20:27:23 +0200 https://news.ki.se/the-frequency-of-incorrectly-attributed-paternity-is-lower-than-previously-thought Determining who is the biological father of a child is a sensitive subject, but the answer can be crucial in important issues. In a nationwide study published in the Journal of Internal Medicine, researchers from Karolinska Institutet, by using two different models, have been able to show that the proportion of incorrectly established paternities in Sweden is as low as 1.7 percent, a figure that has decreased over time. Fri, 23 Jul 2021 10:10:27 +0200 https://news.ki.se/new-genetic-knowledge-about-cluster-headache Researchers at Karolinska Institutet, together with British colleagues, have conducted the largest study to date in search of genetic markers about cluster headache. In the long term, it can hopefully pave the way for more effective treatments. The study is published in the scientific journal Annals of Neurology. Wed, 14 Jul 2021 21:04:34 +0200 https://news.ki.se/genetic-risk-factors-for-severe-covid-19-identified In March 2020, thousands of researchers across the globe joined forces to answer the question of why some COVID-19 patients develop a severe, life-threatening disease, while others manage with mild or no symptoms. A comprehensive summary of their findings to date, based on the analyses of nearly 50,000 patients and published in Nature today, reveals 13 genetic regions that are strongly associated with infection or severe COVID-19. Thu, 08 Jul 2021 17:00:04 +0200 https://news.ki.se/precision-medicine-new-opportunity-for-complex-diseases New review article looks at readiness prior to the implementation of genomics-based precision medicine in complex diseases. The extensive work has been led by researchers at Karolinska Institutet and Lund University and has been carried out together with some 30 researchers throughout Sweden. The results are now being published in the Journal of Internal Medicine, JIM. Mon, 05 Jul 2021 11:09:04 +0200 https://news.ki.se/contact-with-sperm-donors-aroused-many-emotions Sweden was the first country in the world to introduce open-identity sperm donation, whereby adult children are entitled to obtain information about their donors. Researchers at Karolinska Institutet have now explored how such contacts and relations affect the parents of these young men and women. The study, which is published in Human Reproduction, shows that mothers often find it easier to accept the new situation. Mon, 21 Jun 2021 13:49:02 +0200 https://news.ki.se/new-method-of-gene-analysis-prevents-early-death-in-familial-hypercholesterolemia Researchers at Karolinska Institutet have investigated how a newly developed algorithm in connection with gene analysis can be used to improve the possibilities of preventing premature vascular disease and death in individuals with the hereditary lipid disorder, familial hypercholesterolemia. The findings, published in the Journal of Internal Medicine, show how the method can lead to faster and more cost-effective investigations in such families. Mon, 07 Jun 2021 07:56:33 +0200 https://news.ki.se/more-precise-diagnoses-made-possible-with-whole-genome-sequencing More than 1,200 people with rare diseases have received a diagnosis thanks to the integration of large-scale genomics into the Stockholm region’s healthcare system. This is according to a study from Karolinska Institutet in Sweden that analysed the result of the first five years of collaboration on whole genome sequencing between Karolinska University Hospital and SciLifeLab. The work, published in Genome Medicine, constitutes a major leap forward in the emerging field of precision medicine. Wed, 17 Mar 2021 02:00:04 +0100 https://news.ki.se/differences-related-to-sexual-orientation-found-in-the-brain A large brain imaging study involving researchers at Karolinska Institutet demonstrates that same-sex sexual behaviour-related differences in the brain exist. Patterns in the brain that differentiate between men and women were less pronounced in non-heterosexual individuals, and some of the brain differences could be linked to a genetic predisposition for non-heterosexuality. The study is published in the scientific journal Human Brain Mapping. Fri, 26 Feb 2021 15:00:05 +0100 https://news.ki.se/genetic-cause-of-severe-liver-disease-discovered Liver transplantation is currently the only treatment available for the severe liver disease PSC. Now, however, researchers at Karolinska Institutet and Oslo University have discovered the first reported genetic mutation that causes PSC. The study, which is published in Science Translational Medicine, opens new paths to future treatments. Wed, 24 Feb 2021 20:00:04 +0100 https://news.ki.se/one-in-five-has-a-mutation-that-provides-superior-resilience-to-cold Almost one in five people lacks the protein α-actinin-3 in their muscle fibre. Researchers at Karolinska Institutet now show that more of the skeletal muscle of these individuals comprises slow-twitch muscle fibres, which are more durable and energy-efficient and provide better tolerance to low temperatures than fast-twitch muscle fibres. The results are published in The American Journal of Human Genetics. Wed, 17 Feb 2021 17:00:03 +0100 https://news.ki.se/neandertal-gene-variants-both-increase-and-decrease-the-risk-for-severe-covid-19 Last year, researchers at Karolinska Institutet and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany showed that a major genetic risk factor for severe COVID-19 is inherited from Neandertals. Now the same researchers show, in a study published in PNAS, that Neandertals also contributed a protective variant. Half of all people outside Africa carry a Neandertal gene variant that reduces the risk of needing intensive care for COVID-19 by 20 percent. Tue, 16 Feb 2021 18:51:33 +0100 https://news.ki.se/gene-variants-increase-risk-of-addisons-disease Variants of nine genes increase the risk of developing Addison’s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison’s disease. The findings help increase knowledge about what causes the disease. The study was conducted by researchers at Karolinska Institutet and University of Bergen, Norway, and is published in the journal Nature Communications. Thu, 11 Feb 2021 11:00:04 +0100 https://news.ki.se/erc-grant-for-research-on-synthetic-nanoparticles Samir El Andaloussi, researcher at the Department of Laboratory Medicine, has been awarded the 2020 European Research Council Consolidator Grant for the project “Release of engineered Extracellular vesicles for delivery of Biotherapeutics”. Wed, 09 Dec 2020 12:47:08 +0100 https://news.ki.se/early-signs-of-alzheimers-disease-in-people-with-downs-syndrome Researchers at Karolinska Institutet have studied the incidence and regional distribution of Alzheimer’s disease biomarkers in the brains of people with Down’s syndrome. The results can bring new possibilities for earlier diagnosis and preventive treatment of dementia. The study is published in Molecular Neurodegeneration. Mon, 23 Nov 2020 06:00:04 +0100 https://news.ki.se/neandertal-gene-variant-increases-risk-of-severe-covid-19 A study published in Nature shows that a segment of DNA that causes their carriers to have an up to three times higher risk of developing severe COVID-19 is inherited from Neandertals. The study was conducted by researchers at Karolinska Institutet and Max Planck Institute for Evolutionary Anthropology. Wed, 30 Sep 2020 11:00:04 +0200 https://news.ki.se/immunological-cause-of-severe-covid-19-identified More than 10 percent of young and previously healthy people who develop severe COVID-19 have misguided antibodies that attack the immune system itself, and another 3.5 percent carry a specific genetic mutation. This is according to new research published in Science by an international consortium involving researchers at Karolinska Institutet in Sweden. Fri, 25 Sep 2020 08:24:10 +0200 https://news.ki.se/us-army-grant-towards-the-development-of-genetic-techniques-for-the-treatment-of-duchenne-muscular-dystrophy Researchers at KI have received funding from the United States Army for the development of genetic engineering methods to alleviate or cure the disease Duchenne muscular dystrophy (DMD), the most common form of genetic neuromuscular disease in children. Thu, 24 Sep 2020 17:15:05 +0200 https://news.ki.se/publication-in-nature-genetics-high-definition-likelihood-inference-of-genetic-correlations-across-human-complex-traits Evaluating the genetic correlations across our phenotypes is of essential importance for understanding disease etiology and other potential causality. The new method – published in the journal Nature Genetics – vastly improves our power in estimating genetic correlations using the huge established resources from genome-wide association studies. Wed, 01 Jul 2020 16:06:52 +0200 https://news.ki.se/long-term-exercise-impacts-genes-involved-in-metabolic-health Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health. This is according to a new study published in the journal Cell Reports by researchers at Karolinska Institutet in Sweden and the University of San Diego in the U.S. Sex differences found in untrained individuals were also dramatically reduced with long-term training. The results may have implications for metabolic disease prevention. Tue, 23 Jun 2020 17:00:03 +0200 https://news.ki.se/lack-of-mitochondria-causes-severe-disease-in-children Researchers at Karolinska Institutet have discovered that excessive degradation of the power plants of our cells plays an important role in the onset of mitochondrial disease in children. These inherited metabolic disorders can have severe consequences such as brain dysfunction and neurological impairment. The study is published in EMBO Molecular Medicine. Thu, 11 Jun 2020 12:00:06 +0200 https://news.ki.se/joint-effort-to-develop-whole-genome-sequencing-for-patients-with-acute-leukemia A new study has been initiated to evaluate whole-genome and RNA-sequencing as a first line diagnostic approach for patients in Sweden with acute leukemia. The study is conducted jointly by the national R&D platform Genomic Medicine Sweden and the biotech company Illumina – and is coordinated from Karolinska Institutet. Thu, 28 May 2020 09:59:00 +0200 https://news.ki.se/women-with-neandertal-gene-give-birth-to-more-children One in three women in Europe inherited the receptor for progesterone from Neandertals – a gene variant associated with increased fertility, fewer bleedings during early pregnancy and fewer miscarriages. This is according to a study published in Molecular Biology and Evolution by researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden. Tue, 26 May 2020 16:02:59 +0200 https://news.ki.se/parkinsons-disease-may-start-in-the-gut Researchers at Karolinska Institutet and the University of North Carolina have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was that cells from the gut's nervous system are involved in Parkinson's disease, indicating that the disease may start there. Mon, 27 Apr 2020 17:00:07 +0200 https://news.ki.se/new-paper-on-the-swedish-twin-registry-as-a-research-infrastructure Twin Research and Human Genetics has just published an overview article of the Swedish Twin Registry (STR). The registry has developed into an infrastructure of broad utility, aiming to provide a resource for epidemiological and molecular studies of twins. Thu, 28 Nov 2019 15:33:00 +0100 https://news.ki.se/ki-researchers-in-the-2019-highly-cited-list Twelve researchers at Karolinska Institutet qualify for the annual list of highly cited researchers compiled by Web of Science. Tue, 19 Nov 2019 12:44:45 +0100 https://news.ki.se/new-genetic-analysis-improves-diagnosis-of-intellectual-disability Whole-genome sequencing can be used to diagnose intellectual disability more accurately than other methods of genetic analysis, researchers at Karolinska Institutet report in the scientific journal Genome Medicine. Whole-genome sequencing using analytical tools developed by the researchers will now be introduced for first-line clinical diagnosis at Karolinska University Laboratory in Sweden. Thu, 07 Nov 2019 06:00:00 +0100 https://news.ki.se/thesis-on-new-software-for-detection-of-chromosomal-structural-variants Jesper Eisfeldt from the research group Rare Diseases will defend his thesis "Characterization of structural chromosomal variants by massively parallel sequencing" on November 8th, 2019. Main Supervisor is Anna Lindstrand. Tue, 29 Oct 2019 13:51:59 +0100 https://news.ki.se/breakthrough-in-sex-chromosome-regulation Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine. The study is published in Nature Structural and Molecular Biology. Thu, 03 Oct 2019 17:00:00 +0200 https://news.ki.se/new-crispr-cas9-variant-may-boost-precision-in-gene-editing Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play a role in gene therapies that require high precision. The study by researchers from Karolinska Institutet’s Ming Wai Lau Centre of Reparative Medicine in Hong Kong is published in the journal PNAS. Tue, 01 Oct 2019 07:33:02 +0200 https://news.ki.se/major-genome-map-of-ms Researchers at Karolinska Institutet have taken part in the largest study to date on the genetic risk factors for multiple sclerosis (MS). The study, which is published today in the journal Science, corroborates earlier studies and provides new clues as to what causes this neurological disease. The resulting map will prove a vital resource for future researchers and could one day lead to new, more potent drugs. Thu, 26 Sep 2019 20:00:00 +0200 https://news.ki.se/improved-mapping-of-swedish-genes People – or more specifically just Swedes – are more like chimpanzees than previously known. This is indicated in a genetic mapping of one thousand Swedish individuals, where new DNA sequences that should be included in the reference genome have been identified. The study is published in the scientific journal Molecular Biology and Evolution. Wed, 25 Sep 2019 06:00:00 +0200 https://news.ki.se/thesis-on-socioeconomic-influences-on-late-life-health-and-mortality Title: Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay  Mon, 16 Sep 2019 10:36:46 +0200 https://news.ki.se/no-single-gene-can-predict-an-individuals-sexual-orientation Genes cannot be used to determine an individual’s sexual orientation. A study published in the journal Science found only five out of hundreds of thousands genetic variants occurred somewhat more often in people who had had same-sex partners. This suggests human sexuality is influenced by a complex mix of genetic and environmental factors, according to the researchers. The study is based on data from the UK Biobank, the U.S. company 23andMe and the Swedish Twin Registry at Karolinska Institutet. Thu, 29 Aug 2019 12:04:58 +0200 https://news.ki.se/mutation-behind-incurable-disease-mapped Wed, 10 Apr 2019 12:52:13 +0200 https://news.ki.se/first-disease-caused-by-defective-myoglobin-discovered Wed, 27 Mar 2019 11:00:00 +0100 https://news.ki.se/dna-puzzle-uncovers-rare-chromosome-defects Using puzzle pieces from four different DNA analyses, researchers at Karolinska Institutet have been able to map three extremely complex chromosome aberrations. This has given families answers about the cause of their children’s serious symptoms. The study was published in the scientific journal PLOS Genetics and the goal is to produce a test to be used in the clinic. Mon, 11 Feb 2019 11:10:56 +0100 https://news.ki.se/new-insights-into-how-genes-are-activated Wed, 02 Jan 2019 19:00:01 +0100 https://news.ki.se/giedre-grigelioniene-interviewed-on-her-collaboration-with-a-nobel-prize-winner Most researchers will never come close to winning a Nobel Prize. But some are fortunate enough to work with one of the 200 or so living Nobel legends of the research world. In the magazine Medical Science no 4 2018, there is a news article where three KI researchers are interviewed about their collaborations. Mon, 10 Dec 2018 14:08:00 +0100 https://news.ki.se/genetic-risk-score-for-autism-associated-with-outcome-in-cbt Mon, 26 Nov 2018 09:59:12 +0100 https://news.ki.se/genomic-medicine-sweden-receives-sek-438-million-from-vinnova Wed, 21 Nov 2018 07:30:00 +0100 https://news.ki.se/interviews-with-richard-rosenquist-about-the-eric-initiative-on-cll Mon, 12 Nov 2018 10:10:44 +0100 https://news.ki.se/new-national-initiative-for-precision-medicine-genomic-medicine-sweden Mon, 09 Jul 2018 13:36:00 +0200 https://news.ki.se/mechanism-controlling-multiple-sclerosis-risk-identified Tue, 19 Jun 2018 11:01:00 +0200 https://news.ki.se/cell-types-underlying-schizophrenia-identified Scientists at Karolinska Institutet in Sweden and University of North Carolina, USA, have identified the cell types underlying schizophrenia in a new study published in Nature Genetics. The findings offer a roadmap for the development of new therapies to target the condition. Mon, 21 May 2018 17:00:50 +0200 https://news.ki.se/new-mutation-behind-heart-failure-identified Thu, 12 Apr 2018 07:00:00 +0200 https://news.ki.se/genetic-link-to-ibs-identified-in-women Fri, 06 Apr 2018 09:15:07 +0200 https://news.ki.se/genetic-analysis-can-improve-depression-therapy The failure of drugs such as SSRIs, used to treat depression, can be a result of genetic variations in patients. Variations within the gene that encodes the CYP2C19 enzyme results in extreme differences in the levels of escitalopram achieved in patients, according to a new study published in The American Journal of Psychiatry. Prescribing the dose of escitalopram based on a patient’s specific genetic constitution would greatly improve therapeutic outcomes. Fri, 12 Jan 2018 08:11:00 +0100 https://news.ki.se/family-members-without-inherited-mutation-have-increased-risk-of-melanoma Fri, 08 Dec 2017 08:00:00 +0100 https://news.ki.se/genes-behind-higher-education-linked-to-lower-risk-of-alzheimers Thu, 07 Dec 2017 09:02:16 +0100 https://news.ki.se/children-with-alagille-syndrome-have-malformed-bile-ducts Tue, 21 Nov 2017 12:54:49 +0100 https://news.ki.se/genes-influence-what-we-choose-to-look-at Fri, 10 Nov 2017 08:44:59 +0100 https://news.ki.se/ki-researcher-circadian-rhythm-affects-almost-all-functions-of-the-cell This year’s Nobel Prize in Physiology or Medicine has been awarded for work dedicated to the connection between celestial body movements and molecular fluctuations in our cells. Or, in simpler terms, to our internal biological clocks, also known as our circadian rhythm. Tue, 03 Oct 2017 17:11:01 +0200 https://news.ki.se/the-nobel-prize-in-physiology-or-medicine-2017-to-jeffrey-c-hall-michael-rosbash-and-michael-w-young Mon, 02 Oct 2017 11:36:11 +0200 https://news.ki.se/mutations-occurring-after-fertilisation-could-play-a-role-in-autism Wed, 26 Jul 2017 15:33:49 +0200 https://news.ki.se/bilateral-tinnitus-can-be-hereditary Researchers have been able to demonstrate the hereditary nature of certain forms of tinnitus. Bilateral tinnitus – that is, tinnitus in both ears – has been shown to depend on genetic factors, particularly in men. The twin study, which is published in the journal Genetics in Medicine, was conducted by researchers at Karolinska Institutet together with colleagues from GENYO in Granada, Spain, as part of the European research network TINNET. Thu, 09 Mar 2017 16:00:00 +0100 https://news.ki.se/hope-for-new-treatment-for-huntingtons-disease Mon, 20 Feb 2017 08:00:00 +0100 https://news.ki.se/how-our-cells-use-mothers-and-fathers-genes Tue, 27 Sep 2016 14:53:41 +0200 https://news.ki.se/newly-discovered-gene-critical-to-embryos-first-days Wed, 14 Sep 2016 08:01:01 +0200 https://news.ki.se/genes-responsible-for-risk-of-heart-attack-stroke-and-related-cardiometabolic-diseases-identified Fri, 19 Aug 2016 11:15:11 +0200 https://news.ki.se/genes-linked-to-peoples-bowel-habits Wed, 10 Aug 2016 13:45:18 +0200 https://news.ki.se/how-a-particular-gene-protects-against-aggressive-breast-cancer Tue, 09 Aug 2016 14:46:42 +0200 https://news.ki.se/many-unexpected-genetic-variants-hamper-personalised-medicine In recent decades much hope was based on the development of personalised drug treatments, in which genetic tests determine the choice and optimal dose of medication for each individual patient. However, the real breakthrough is still to be seen, and now researchers at Karolinska Institutet show in two separate scientific papers that many more gene variants affect how a person responds to medication than previously thought – and thus that today’s analytical tools are too coarse. Wed, 16 Dec 2015 08:00:00 +0100 https://news.ki.se/possible-mechanism-for-symptoms-in-bipolar-disorder-discovered Tue, 15 Dec 2015 10:10:00 +0100 https://news.ki.se/complex-grammar-of-the-genomic-language Mon, 09 Nov 2015 17:05:00 +0100 https://news.ki.se/51-million-sek-to-13-researchers-at-the-department Wed, 04 Nov 2015 17:03:26 +0100 https://news.ki.se/new-mechanism-discovered-behind-infant-epilepsy Thu, 03 Sep 2015 11:05:00 +0200 https://news.ki.se/sex-crimes-more-common-in-certain-families Thu, 09 Apr 2015 08:00:00 +0200 https://news.ki.se/human-gene-identified-for-tolerance-to-an-environmental-hazard Studies conducted at Karolinska Institutet and Uppsala University show that some indigenous groups in the Andes of northern Argentina have increased resistance to arsenic. The researchers also identified the gene that underlies the altered metabolism and protects against exposure to arsenic. This study is the first to show that some humans have genetically adapted to a polluted environment. Wed, 04 Mar 2015 09:58:21 +0100 https://news.ki.se/genetically-related-etec-have-spread-globally-and-over-time Mon, 10 Nov 2014 17:05:00 +0100 https://news.ki.se/genetic-differences-provide-many-hints-at-causes-of-autism Thu, 30 Oct 2014 14:54:49 +0100 https://news.ki.se/genes-linked-to-repeated-violent-crime An international research team led from Karolinska Institutet have identified two genes that may be linked to an increased disposition to engage in repeated acts of violence. The findings are being published in the journal Molecular Psychiatry, and are based on genetic analysis of people convicted of various crimes. Wed, 29 Oct 2014 09:59:49 +0100 https://news.ki.se/major-differences-in-gene-activity-in-skeletal-muscle-of-women-and-men Tue, 30 Sep 2014 16:41:00 +0200 https://news.ki.se/first-screen-for-genetic-risk-factors-of-ibs-in-the-general-population Wed, 24 Sep 2014 08:00:00 +0200 https://news.ki.se/personalised-medicine-against-hereditary-immunodeficiency Thu, 14 Aug 2014 10:00:00 +0200 https://news.ki.se/common-variation-genes-behind-the-risk-of-autism A number of relatively common gene variations combined may increase the risk of autism. These are the findings of a new study from Swedish and American researchers published in Nature Genetics. Mon, 04 Aug 2014 14:21:16 +0200 https://news.ki.se/gene-behind-unhealthy-adipose-tissue-identified Fri, 23 May 2014 07:30:00 +0200 https://news.ki.se/meb-recruits-two-international-top-scientists Fri, 16 May 2014 14:41:03 +0200 https://news.ki.se/environment-as-important-as-genes-in-understanding-autism Mon, 05 May 2014 09:57:25 +0200 https://news.ki.se/new-findings-on-neurogenesis-in-the-spinal-cord Wed, 05 Mar 2014 12:10:00 +0100 https://news.ki.se/early-atherosclerotic-plaques-in-the-vessel-wall-regress-completely-when-cholesterol-levels-are-lowered Fri, 28 Feb 2014 08:15:00 +0100 https://news.ki.se/children-with-old-fathers-more-likely-to-have-psychiatric-disorder Wed, 26 Feb 2014 22:05:00 +0100 https://news.ki.se/rare-genetic-mutations-contribute-to-schizophrenia-risk Wed, 22 Jan 2014 00:00:00 +0100 https://news.ki.se/modest-familial-risks-for-multiple-sclerosis Wed, 22 Jan 2014 00:00:00 +0100 https://news.ki.se/jumping-genes-cause-tumour-in-fruit-flies Thu, 16 Jan 2014 00:00:00 +0100 https://news.ki.se/barcodes-help-researchers-measure-gene-activity Sun, 22 Dec 2013 11:00:45 +0100 https://news.ki.se/new-gene-responsible-for-cleft-lip-and-palate-syndrome-identified Thu, 19 Dec 2013 00:00:00 +0100 https://news.ki.se/several-risk-genes-for-sjogrens-syndrome-identified Mon, 07 Oct 2013 00:00:00 +0200 https://news.ki.se/another-48-genetic-variants-associated-with-ms Sun, 29 Sep 2013 00:00:00 +0200 https://news.ki.se/a-non-coding-rna-gatekeeper-of-gene-expression Tue, 17 Sep 2013 00:00:00 +0200 https://news.ki.se/new-risk-genes-for-schizophrenia-discovered Mon, 26 Aug 2013 00:00:00 +0200 https://news.ki.se/genetic-overlap-between-schizophrenia-and-depression Sun, 11 Aug 2013 00:00:00 +0200 https://news.ki.se/ivf-for-male-infertility-linked-to-increased-risk-of-intellectual-disability-in-children Wed, 03 Jul 2013 00:00:00 +0200 https://news.ki.se/new-method-of-mass-producing-high-quality-dna Mon, 03 Jun 2013 00:00:00 +0200 https://news.ki.se/genetic-variants-linked-to-educational-level Thu, 30 May 2013 00:00:00 +0200 https://news.ki.se/longer-telomeres-after-treatment-with-lithium Fri, 24 May 2013 00:00:00 +0200 https://news.ki.se/common-genes-responsible-for-adhd-schizophrenia-and-bipolar-disorder Thu, 23 May 2013 00:00:00 +0200 https://news.ki.se/spruce-genome-of-importance-for-medical-research Thu, 23 May 2013 00:00:00 +0200 https://news.ki.se/nano-messenger-opens-way-for-new-cancer-treatment Tue, 21 May 2013 00:00:00 +0200 https://news.ki.se/older-grandfathers-pass-on-autism-risk-through-generations Thu, 21 Mar 2013 00:00:00 +0100 https://news.ki.se/new-gene-variant-may-explain-psychotic-features-in-bipolar-disorder Tue, 05 Mar 2013 00:00:00 +0100 https://news.ki.se/new-type-of-gene-that-regulates-tumour-suppressor-pten-identified Mon, 25 Feb 2013 00:00:00 +0100 https://news.ki.se/study-suggests-human-genes-influence-gut-microbial-composition Mon, 07 Jan 2013 00:00:00 +0100 https://news.ki.se/genetics-of-infection-at-the-basis-of-inflammatory-bowel-disease Thu, 01 Nov 2012 00:00:00 +0100 https://news.ki.se/inheritance-of-mitochondrial-disease-determined-when-mother-is-still-an-embryo Sun, 07 Oct 2012 00:00:00 +0200 https://news.ki.se/no-higher-risk-of-acute-leukaemia-in-close-relatives Thu, 15 Dec 2011 00:00:00 +0100 https://news.ki.se/rare-gene-variants-linked-to-inflammatory-bowel-disease Sun, 09 Oct 2011 00:00:00 +0200 https://news.ki.se/unexpected-function-of-dyslexia-gene Mon, 20 Jun 2011 00:00:00 +0200 https://news.ki.se/gene-variant-linked-to-ibs Tue, 07 Jun 2011 23:00:00 +0200 https://news.ki.se/northern-and-southern-swedes-are-genetically-different Fri, 11 Feb 2011 00:00:00 +0100 https://news.ki.se/29-new-gene-variants-linked-to-ulcerative-colitis Mon, 07 Feb 2011 00:00:00 +0100 https://news.ki.se/30-new-gene-variants-linked-to-crohns-disease Mon, 22 Nov 2010 00:00:00 +0100 https://news.ki.se/large-scale-analysis-identifies-32-genetic-loci-for-obesity Tue, 12 Oct 2010 00:00:00 +0200 https://news.ki.se/gene-mapping-explains-childhood-asthma Thu, 23 Sep 2010 00:00:00 +0200 https://news.ki.se/gene-variant-connected-with-lung-function-and-risk-of-copd Thu, 17 Dec 2009 00:00:00 +0100 https://news.ki.se/children-of-older-fathers-more-likely-to-have-bipolar-disorder Tue, 02 Sep 2008 00:00:00 +0200