https://ki.se RSS News Listing https://news.ki.se/the-nobel-prize-in-chemistry-helps-us-understand-the-building-blocks-of-life David Baker, USA, has succeeded in creating entirely new proteins – the building blocks of life that control all biological processes in the body. He shares the Nobel Prize in Chemistry 2024 with Demis Hassabis and John M. Jumper of Google DeepMind, UK, who have developed the AI tool AlphaFold2. “Now it can take minutes instead of years to get a good idea of what a protein looks like and how it may function,” says KI professor Luca Jovine, who intitiated a collaboration with DeepMind early on. Thu, 10 Oct 2024 08:00:30 +0200 https://news.ki.se/new-discovery-reveals-how-the-egg-controls-sperm-entry After the egg has been fertilized by a sperm, the surrounding egg coat tightens, mechanically preventing the entry of additional sperm and the ensuing death of the embryo. This is according to a new study led by researchers at Karolinska Institutet and published in the journal Cell. The work also explains how mutations in egg coat proteins can cause female infertility and may eventually lead to new contraceptive methods. Thu, 14 Mar 2024 16:00:08 +0100 https://news.ki.se/how-a-natural-protein-can-help-fight-alzheimers-disease A new study published in Nature Communications gives insights into the underlying mechanisms of the formation of protein clumps in Alzheimer’s disease. The study, led by researchers from Karolinska Institutet, could pave the way for new treatments for this devastating neurodegenerative disorder. Fri, 02 Feb 2024 10:17:28 +0100 https://news.ki.se/spider-silk-can-stabilise-cancer-suppressing-protein The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet have now found an unusual way of stabilising the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure. Mon, 14 Mar 2022 16:00:07 +0100 https://news.ki.se/crystallography-cryo-em-and-alphafold-a-perfect-trio-sheds-light-on-key-human-antibacterial-proteins A team led by Karolinska Institutet has combined Artificial Intelligence (AI) with structural biology to gain insights into two similar proteins that prevent bacterial infection in the urinary tract and the gastrointestinal system. Their results are published in "Nature Structural & Molecular Biology". Fri, 11 Mar 2022 07:28:46 +0100 https://news.ki.se/artificial-intelligence-takes-structural-biology-to-the-next-level A scientist at Karolinska Institutet reports that machine learning can be used to gain insights into molecular events that change the shape of proteins after they are made, regulating their ability to interact with each other. This suggests that artificial intelligence (AI) may allow us, in the future, to accurately simulate highly complex biological scenarios in silico as well as leverage this information for therapeutic intervention. Thu, 07 Oct 2021 10:25:55 +0200 https://news.ki.se/how-we-can-bypass-the-limitations-of-spiders We can produce spider silk fibers stronger than those created by the spiders themselves. This according to the Professors Jan Johansson (KI) and Anna Rising (KI and SLU). Mon, 22 Feb 2021 13:29:59 +0100 https://news.ki.se/14-million-sek-in-grants-from-the-swedish-research-council-awarded-to-bionut-researchers We wish to congratulate Luca Jovine, Juha Kere, Janne Johansson and Eckardt Treuter at the Department of Biosciences and Nutrition, who have been awarded grants from the Swedish Research Council within the area of Medicine and Health as well as the area of Natural and Engineering Sciences for the years 2020-2024. Thu, 05 Nov 2020 16:14:51 +0100 https://news.ki.se/doudna-held-sjostrand-lecture-and-met-researchers This year’s Sjöstrand lecture was held by Professor Jennifer Doudna, best known for having developed the CRISPR/Cas-9 tool with professor Emanuelle Charpentier. Apart from the lecture itself, she was also involved in several activities during the day at which she met researchers and students from SciLifeLab and Karolinska Institutet. “I’ve read about her work and never thought I’d get to present my own project to such an important pioneer,” says KI researcher Mihaela Zabulica. Tue, 27 Aug 2019 15:22:54 +0200 https://news.ki.se/new-cell-structure-discovered-by-ki-researchers Tue, 23 Oct 2018 08:33:44 +0200 https://news.ki.se/structural-map-of-bacterial-toxins-raises-hopes-for-new-anti-infectives Mon, 17 Sep 2018 12:05:26 +0200 https://news.ki.se/mapping-biological-functions-of-nudix-enzymes Thu, 16 Nov 2017 14:42:38 +0100 https://news.ki.se/3d-images-show-how-sperm-binds-to-the-egg-surface Thu, 15 Jun 2017 18:22:07 +0200