https://ki.se RSS News Listing https://news.ki.se/fighting-parasitic-diseases-in-rwanda-lazare-ntirenganyas-research-aims-to-make-treatments-safer-for-children Lazare Ntirenganya successfully passed his ISP review at Karolinska Institutet on 17 September. With a background in pharmacy and public health methodology, his doctoral research focuses on drug safety and interactions in the treatment of parasitic infections among school-aged children in Rwanda. Building on years of experience from the PROFORMA project, his work aims to improve the effectiveness and safety of mass drug administration programs. Fri, 19 Sep 2025 17:27:55 +0200 https://news.ki.se/the-department-of-fyfa-turns-75 The Department of Physiology and Pharmacology celebrated 75 years since its royal inauguration on the Solna campus during 2024. But FyFa's history goes further back than that - and looks forward to many years of community and outstanding research and teaching. On 23 April, the department celebrates with a full day of lectures and a Dragons’ Den. Fri, 09 May 2025 11:05:59 +0200 https://news.ki.se/continued-medication-important-for-heart-failure-patients Patients who have been treated for heart failure and experience an improvement of their pump function, are still at higher risk of heart-related death or hospitalisation if they stop taking heart failure medications. This is according to a new study from Karolinska Institutet published in the top-ranked journal Circulation. Mon, 17 Mar 2025 10:00:10 +0100 https://news.ki.se/report-from-the-proforma-project-closure-symposium After six successful years, the PROFORMA project, coordinated by Professor Eleni Aklillu, has come to an end. To celebrate all the achievements and the new PhDs within the project, a closure symposium was recently held in Stockholm, Sweden. Wed, 26 Feb 2025 16:58:52 +0100 https://news.ki.se/antidepressants-linked-to-faster-cognitive-decline-in-dementia New research suggests that antidepressants can accelerate cognitive decline in people with dementia. At the same time, some drugs appear to be less harmful than others, which can help doctors make better treatment decisions, according to the study published in BMC Medicine. Tue, 25 Feb 2025 07:54:40 +0100 https://news.ki.se/new-treatment-for-ptsd-oxygen-in-a-hyperbaric-chamber-shows-promising-results Researchers in Israel have found that (HBOT) may alleviate PTSD, a mental health condition affecting many after traumatic events. Fri, 29 Nov 2024 14:20:43 +0100 https://news.ki.se/no-link-found-between-popular-diabetes-medication-and-suicide There has been concern that common diabetes drugs could increase the risk of suicide and self-harm. In a new study, led by researchers at Karolinska Institutet and published in Jama Internal Medicine, no such risk increase was observed. Wed, 04 Sep 2024 09:33:09 +0200 https://news.ki.se/annual-pregart-project-consortium-meeting-held-in-ethiopia The Annual PREGART Project Consortium meeting took place from August 5-6, 2024, at Haile Resort in Hawassa City, Ethiopia. The event brought together over 60 participants, including consortium members, government stakeholders, and representatives from the Ministry of Health, the Ethiopian Food and Drug Authority, and partner organizations. Attendees gathered to review the project’s progress, share insights, and outline plans for the year ahead. Mon, 02 Sep 2024 16:37:49 +0200 https://news.ki.se/new-rer-cto-project-launched-to-enhance-clinical-trial-oversight-in-sub-saharan-africa A new project RER-CTO (Regulatory and Ethics Readiness for Clinical Trials Oversight) aimed at achieving excellence and harmonization in clinical trial oversight across sub-Saharan Africa has been launched, backed by nearly 1 million euros in funding from the Global Health EDCTP3 Joint Undertaking. Mon, 02 Sep 2024 11:53:58 +0200 https://news.ki.se/meet-abbie-barry-phd-who-consultant-advancing-public-health-in-africa Abbie Barry is a public health specialist and project manager with extensive expertise in pharmacovigilance, public health epidemiology, and disease control. She currently works as a consultant for the World Health Organization (WHO) Regional Office for Africa, where she focuses on conducting desk research and epidemiological analysis to identify strategic investment areas and develop targeted interventions aimed at reducing the disease burden across the African continent. Mon, 02 Sep 2024 11:27:31 +0200 https://news.ki.se/new-knowledge-about-cell-receptors-paves-the-way-for-new-drugs-against-intestinal-tumours A new study from Karolinska Institutet published in Nature Communications provides valuable insights into the activation of receptors on the cell surface. The knowledge opens up for new targeted therapies and drugs against intestinal tumours, among other things. Thu, 29 Aug 2024 10:31:25 +0200 https://news.ki.se/rwanda-team-visits-addis-ababa-for-clinical-trial-training The Rwanda Clinical Trial Capacity Strengthening Team has visited Addis Ababa University. The team included members from the University of Rwanda, Rwanda Biomedical Center, and Rwanda FDA. The purpose of the visit was to learn how The Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa) set up a clinical trial training program. The visit was facilitated by Professor Eleni Aklillu from Karolinska Institutet and Professor Eyasu Makonnen from CDT Africa. Wed, 21 Aug 2024 17:14:21 +0200 https://news.ki.se/ai-accelerates-the-pace-of-development-of-new-drugs-for-brain-diseases AI, artificial intelligence, can be used to identify molecules with great potential to be developed into new drugs for mental illnesses, according to researchers from Karolinska Institutet, among others. The study, which has been presented in the journal Science Advances, and conducted on mice, shows that AI with high precision can contribute to more effective future treatments for conditions such as psychosis. Fri, 09 Aug 2024 11:13:04 +0200 https://news.ki.se/meet-dr-joseph-kabatende-working-with-regulatory-system-strengthening-in-eastern-and-southern-africa Dr Joseph Kabatende is a Health Products and Regulatory Systems Specialist working for the WHO. He completed his PhD in 2023 from Karolinska Institutet, Sweden after defending his doctoral thesis entitled “Pharmacovigilance of Mass Drug Administration for Control of Schistosomiasis and Soil Transmitted Helminths in Rwanda". Mon, 15 Apr 2024 09:34:29 +0200 https://news.ki.se/popular-diabetes-drugs-do-not-increase-thyroid-cancer-risk-study-suggests Drugs known as GLP-1 analogues have become increasingly popular to treat diabetes and obesity, but there have been concerns that they might increase the risk of thyroid cancer. Now an extensive Scandinavian study led by researchers at Karolinska Institutet has found no evidence of such a link. The study is published in The BMJ. Wed, 10 Apr 2024 08:30:11 +0200 https://news.ki.se/no-link-between-paracetamol-use-during-pregnancy-and-autism-or-adhd-in-children In the largest epidemiologic study to date of the risk of giving birth to a child with autism, ADHD or intellectual disability following acetaminophen use during pregnancy, researchers found no association. The study is now published in JAMA. Tue, 09 Apr 2024 17:00:00 +0200 https://news.ki.se/new-study-shows-how-the-crimean-congo-haemorrhagic-fever-virus-enters-our-cells Researchers at Karolinska Institutet, in collaboration with JLP Health and others, have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are published in Nature Microbiology and are an important step in the development of drugs against the deadly disease. Thu, 28 Mar 2024 17:00:12 +0100 https://news.ki.se/towards-elimination-of-schistosomiasis-and-soil-transmitted-helminths-meet-dr-tigist-dires-gebreyesus Tigist Dires Gebreyesus is an Ethiopian public health specialist with a master’s in public health from University of Gondar, Ethiopia. She has been working within the Ethiopian Food and Drug Authority, the former Ethiopian Food, Medicine and Healthcare Administration and Control Authority. In December 2023, Dr Gebreyesus defended her doctoral thesis that was part of the PROFORMA project at Karolinska Institutet, Department of Global Public Health. Wed, 27 Mar 2024 15:52:46 +0100 https://news.ki.se/phd-candidate-adam-mitangu-fimbo-investigates-the-safety-and-efficacy-of-mass-drug-administration-drugs Adam Mitangu Fimbo is a doctoral student at Karolinska Institutet, but not for much longer. On April 26 he will defend is doctoral thesis titled Pharmacovigilance of Mass Drug Administration as Preventive Chemotherapy to Control and Eliminate Lymphatic Filariasis in Tanzania. Meet the Director General of Tanzania Medicines and Medical Devices Authority, and expert on the safety and quality of drug administration. Tue, 12 Mar 2024 07:26:19 +0100 https://news.ki.se/popular-diabetes-drug-may-also-reduce-the-risk-of-severe-liver-disease Ozempic and other GLP1 agonists are associated with a reduced risk of developing cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease, according to a nationwide study from Karolinska Institutet published in the journal Gut. Tue, 23 Jan 2024 18:00:15 +0100 https://news.ki.se/new-findings-on-long-term-treatment-of-adhd-and-link-to-cardiovascular-disease A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases. This is according to two new studies led by researchers from Karolinska Institutet and published in The Lancet Psychiatry and JAMA Psychiatry. Tue, 28 Nov 2023 07:54:24 +0100 https://news.ki.se/anti-rheumatic-drugs-could-prevent-thyroid-disease Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study by researchers from Karolinska Institutet published in the Journal of Internal Medicine. Wed, 22 Nov 2023 10:06:29 +0100 https://news.ki.se/common-heart-medicine-associated-with-lower-rates-of-violence Beta blockers, which are widely used to treat heart conditions and high blood pressure, are associated with a lower risk of being charged with a violent crime, according to a new register-based study from Karolinska Institutet and the University of Oxford. The results have been published in PLOS Medicine. Tue, 31 Jan 2023 20:00:04 +0100 https://news.ki.se/critical-illness-myopathy-common-condition-in-intensive-care-patients Critical illness myopathy (CIM) is a common complication affecting ventilator-treated intensive care patients, which can lead to increased mortality/morbidity, prolonged hospital care, impaired patient quality of life, and increased healthcare costs. reported molecular pathogenesis of CIM during prolonged ICU stay, and potential diagnostic biomarkers and therapeutic targets. The study was recently published in Journal of Cachexia, Sarcopenia and Muscle. Mon, 19 Dec 2022 10:16:36 +0100 https://news.ki.se/adhd-medication-for-amphetamine-addiction-linked-to-reduced-risk-of-hospitalisation-and-death The ADHD medication lisdexamfetamine was associated with the lowest risk of hospitalisation and death in people with amphetamine addiction, when medications generally used among persons with substance use disorders were compared. This is shown in a large registry-based study by researchers at Karolinska Institutet in Sweden in collaboration with the University of Eastern Finland and Niuvanniemi Hospital, published in JAMA Psychiatry. Wed, 16 Nov 2022 17:00:04 +0100 https://news.ki.se/covid-19-linked-to-excessive-destruction-of-connections-between-nerve-cells-in-new-brain-model Researchers at Karolinska Institutet have in a new study used cellular reprogramming to create human three-dimensional brain models and infected these models with SARS-CoV-2. In infected models, the brain immune cells excessively eliminated synapses and acquired a gene expression pattern mimicking what has been observed in neurodegenerative disorders. The findings could help to identify new treatments against persistent cognitive symptoms after a Covid-19 infection. Wed, 19 Oct 2022 13:49:59 +0200 https://news.ki.se/professor-magnus-ingelman-sundberg-is-awarded-the-rt-williams-distinguished-scientific-achievement-award Magnus Ingelman-Sundberg at the Department of Physiology and Pharmacology is awarded with the R.T. Williams Distinguished Scientific Achievement Award 2022. In recognition of his outstanding scientific contributions in the field of drug research. Fri, 02 Sep 2022 13:02:14 +0200 https://news.ki.se/nitrogen-oxide-research-has-resulted-in-surprisingly-few-new-clinical-methods-and-treatments In a recently published review article in Cell, researchers Jon Lundberg and Eddie Weitzberg at the Department of Physiology and Pharmacology at Karolinska Institutet summarize research in nitric oxide (NO) with a focus on what is happening right now. Thu, 04 Aug 2022 17:00:08 +0200 https://news.ki.se/new-group-of-antibacterial-molecules-identified Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria. Since the properties of the molecules can easily be altered chemically, the hope is to develop new, effective antibiotics with few side effects. The findings have been published in the scientific journal PNAS. Wed, 17 Nov 2021 08:02:16 +0100 https://news.ki.se/new-findings-on-how-ketamine-acts-against-depression The discovery that the anaesthetic ketamine can help people with severe depression has raised hopes of finding new treatment options for the disease. Researchers at Karolinska Institutet have now identified novel mechanistic insights of how the drug exerts its antidepressant effect. The findings have been published in the journal Molecular Psychiatry. Wed, 11 Aug 2021 02:00:05 +0200 https://news.ki.se/analysis-of-4000-drugs-reveals-an-alternative-mechanism-for-a-new-anticancer-therapy By analyzing 4,000 drugs’ ability to affect cells’ capacity to produce proteins, researchers at Karolinska Institutet found that an anticancer therapy currently trialed in human patients works differently than previously thought. As many human diseases have alterations in this process called translation, the new knowledge contributes to a better understanding of how translation is regulated and the biological routes that regulate it. The study is published in PLOS Biology. Wed, 02 Jun 2021 16:20:42 +0200 https://news.ki.se/ki-researchers-receive-a-eur-600000-research-grant-from-the-foundation-for-research-in-rheumatology Researchers from the Department of Physiology and Pharmacology at Karolinska Institutet, together with researchers from Uppsala University, the University of Eastern Finland and King's College London, have been awarded a research grant from Foundation for Research in Rheumatology (Foreum), for their project entitled "Autoimmune and molecular mechanisms for pain and fatigue in fibromyalgia". Wed, 21 Apr 2021 16:24:01 +0200 https://news.ki.se/important-advance-in-research-on-future-drugs Most drugs operate via the membranes that surround the body’s cells. A study by researchers at Karolinska Institutet has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, plays a part in chronic inflammation and cancer. The study, which is published in the journal Nature Communications, can make a significant contribution to the development of future drugs. Fri, 19 Mar 2021 11:00:04 +0100 https://news.ki.se/carl-sellgren-majkowitz-receives-swedish-foundations-starting-grant Swedish Foundations' Starting Grant 2020 is awarded to KI researcher, Carl Sellgren Majkowitz for his research in schizophrenia. Thu, 25 Feb 2021 13:29:51 +0100 https://news.ki.se/proteomic-analysis-reveals-when-and-how-which-proteins-are-degraded-in-cancer-cells-by-autophagy-pathways A fundamental process by which cellular components are degraded is Autophagy. Defects in Autophagy pathways are strongly associated with multiple human diseases, including neurodegenerative disorders and cancer. Despite their importance, to date, a comprehensive characterization of the extent and selectivity for Autophagic degradomes has remained largely uncharacterized. Researchers at Karolinska Institutet have in two studies published in the journal Autophagy mapped out how this happens. Wed, 20 Jan 2021 13:45:54 +0100 https://news.ki.se/erc-grant-for-research-on-synthetic-nanoparticles Samir El Andaloussi, researcher at the Department of Laboratory Medicine, has been awarded the 2020 European Research Council Consolidator Grant for the project “Release of engineered Extracellular vesicles for delivery of Biotherapeutics”. Wed, 09 Dec 2020 12:47:08 +0100 https://news.ki.se/gene-analysis-may-increase-the-effect-of-antidepressant-and-antipsychotic-drugs In a new study published in the journal JAMA Psychiatry, researchers at Karolinska Institutet have studied CYP2C19 and CYP2D6 genes impact on treatment with antidepressants and antipsychotic drugs. The study shows that a control of the patient’s genotype can be used to individualize the drug treatment and lead to a more effective treatment. Thu, 26 Nov 2020 14:23:35 +0100 https://news.ki.se/jorge-ruas-appointed-professor-of-molecular-physiology Congratulations Jorge Ruas, newly appointed Professor of molecular physiology at the Department of Physiology and Pharmacology, Karolinska Institutet. Thu, 05 Nov 2020 15:49:20 +0100 https://news.ki.se/new-analysis-method-can-lead-to-better-cancer-drugs While proteins on the surface of cells are the targets for most drugs, refined methods are needed to analyse how these membrane proteins are organised. Researchers at Karolinska Institutet have developed a new DNA-based analytical method that could contribute to the development of future drugs for breast and other cancers. The study is published in Nature Nanotechnology. Mon, 02 Nov 2020 17:00:03 +0100 https://news.ki.se/the-torgny-h-svensson-award-to-promote-scandinavian-research-in-neuropsychopharmacology At the initiative of Torgny's former PhD students and colleagues, a scientific prize has been initiated in Torgny's honor, the Torgny H. Svensson Award. The prize is awarded during the SCNP's annual conference where the recipient of the prize is offered to give a scientific lecture. Wed, 02 Sep 2020 08:09:56 +0200 https://news.ki.se/research-project-within-neuropsychoimmunology-receives-a-research-grant-from-hjarnfonden Sophie Erhardt's research group, at the Department of Physiology and Pharmacology Karolinska Institutet, has been awarded a research grant of in total SEK 1,200,000 from The Swedish Brain Foundation. Thu, 09 Jul 2020 09:27:56 +0200 https://news.ki.se/in-memory-of-the-late-professor-emeritus-torgny-h-svensson Professor emeritus Torgny Svensson has passed away following complications of covid-19 on Friday, June 12th, at the age of 75. He will be sorely missed by his family, as well as friends and colleagues in Sweden and around the world. Wed, 01 Jul 2020 15:27:16 +0200 https://news.ki.se/newly-discovered-mechanism-can-explain-increased-risk-of-dementia Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer’s & Dementia. Fri, 08 May 2020 06:30:07 +0200 https://news.ki.se/in-memory-of-the-late-professor-emeritus-folke-sjoqvist We have lost our former director, colleague and friend, Professor emeritus Folke Sjöqvist, who passed away peacefully on 30 March at the age of 86 after a protracted illness. He is sorely missed by his wife Margareta and four children and their families, as well as friends and colleagues in Sweden and around the world. Tue, 07 Apr 2020 10:37:20 +0200 https://news.ki.se/christopher-cederroth-receives-the-geraldine-dietz-fox-young-investigator-award-0 The Association for Research in Otolaryngology (ARO) announce Christopher Cederroth as the recipient for The Geraldine Dietz Fox Young Investigator Award at the 2020 ARO Annual MidWinter Meeting. Christopher Cederroth got the prestigious award for his hearing and tinnitus research. Tue, 07 Apr 2020 09:10:21 +0200 https://news.ki.se/new-opportunity-for-cancer-drug-development After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer. Tue, 21 Jan 2020 11:00:00 +0100 https://news.ki.se/pawel-kozielewicz-molecular-pharmacology-highlighted-trainee-author-january-2020 Congratulations Pawel Kozielewicz! You are the Highlighted Trainee Author for the January 2020 Issue of Molecular Pharmacology. Fri, 10 Jan 2020 13:14:27 +0100 https://news.ki.se/they-are-awarded-sff-grants-to-collaborate-with-industry Two researchers at Karolinska Institutet are awarded the Strategic Mobility Grant from the Swedish Foundation for Strategic Research (SSF). The aim of the SSF mobility programme is to increase exchange between Swedish universities and industry by funding researchers’ work with a project managed by the other part. Wed, 18 Dec 2019 10:54:59 +0100 https://news.ki.se/ki-researchers-in-the-2019-highly-cited-list Twelve researchers at Karolinska Institutet qualify for the annual list of highly cited researchers compiled by Web of Science. Tue, 19 Nov 2019 12:44:45 +0100 https://news.ki.se/carl-sellgren-receives-the-2019-one-mind-kaiser-permanente-rising-star-research-award One Mind Rising Star Awards was launched in 2005 and is awarded each year to draw attention to and financially support pioneering research on brain injuries and mental illness. Fri, 13 Sep 2019 09:09:07 +0200 https://news.ki.se/statins-can-prevent-liver-cancer Fat-soluble statins can prevent liver cancer and reduce mortality in patients with chronic viral hepatitis. These are findings from a study conducted by researchers at Karolinska Institutet in Sweden, among others. The study is published in Annals of Internal Medicine. Tue, 20 Aug 2019 08:23:06 +0200 https://news.ki.se/hormonal-therapy-has-a-long-term-effect-in-breast-cancer Researchers at Karolinska Institutet in Sweden have investigated the long-term effect of hormonal therapy in women with the most common types of hormone-sensitive breast cancer. The results, presented in the journal JAMA Oncology, show that the treatment has a protective effect against distant metastatic cancer for both so-called Luminal A and Luminal B breast cancer subtypes, and a long-term effect for women diagnosed with Luminal A cancer. Fri, 09 Aug 2019 08:50:59 +0200 https://news.ki.se/unexpected-effect-of-ms-drug Researchers at Karolinska Institutet in Sweden have studied the mechanism of action of a drug used to treat multiple sclerosis. The results, which are published in the journal Nature Communications, show that the drug affects cells in the innate immune system and that there is an unexpected link between therapeutic effect and an increase in the production of reactive oxygen species. Fri, 12 Jul 2019 11:01:05 +0200 https://news.ki.se/genetic-analysis-can-provide-better-dosage-of-antipsychotic-drugs An initial gene analysis may yield better outcomes when patients are treated with the antipsychotic drugs risperidone and aripiprazole. A novel study shows how the activity of a specific enzyme, which metabolises the two drugs, affects the individual dose that should be given for optimal treatment. The study is published in The Lancet Psychiatry and has been conducted by researchers at Karolinska Institutet, in collaboration with the Diakonhjemmet Hospital in Oslo, Norway. Tue, 16 Apr 2019 08:00:00 +0200 https://news.ki.se/export-of-nitric-oxide-bioactivity-from-the-red-blood-cell More than 20 years ago an American research group released a spectacular idea that the red blood cell was capable of exporting the signaling molecule nitric oxide (NO) and by this mechanism participate in the classical physiological phenomenon known as hypoxic vasodilation, i.e. that our blood vessels automatically widen when oxygen levels become lower to ensure oxygen delivery to tissues (Jia Nature 1996). Thu, 28 Mar 2019 09:25:44 +0100 https://news.ki.se/study-on-regenerative-angiogenesis-in-humans-shows-encouraging-results Wed, 20 Feb 2019 11:05:00 +0100 https://news.ki.se/ki-signs-agreement-with-the-international-union-of-basic-and-clinical-pharmacology Mon, 11 Feb 2019 09:48:32 +0100 https://news.ki.se/new-insight-into-cell-receptors-opens-the-way-for-tailored-cancer-drugs New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. Fri, 08 Feb 2019 14:37:43 +0100 https://news.ki.se/new-possible-target-for-treating-major-common-diseases There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. In a new study published in Science Signaling, they identify how these receptors are activated in the cell membrane and the processes that are then triggered within the cell. Tue, 04 Dec 2018 20:00:00 +0100 https://news.ki.se/new-project-to-improve-drugs-safety-in-east-africa In recent years access to drugs and vaccines has been increasing in many African countries, but the systems for monitoring treatment effects and reporting side-effects require further development. Karolinska Institutet will now lead an international collaboration project on pharmacovigilance – drugs safety – in four countries in East Africa. Tue, 04 Sep 2018 09:27:52 +0200 https://news.ki.se/new-scientific-model-reveals-interaction-between-blood-vessels-and-neurons-in-the-brain Mon, 20 Aug 2018 17:01:00 +0200 https://news.ki.se/medications-that-cause-dry-mouth-increase-the-risk-for-tooth-loss-in-persons-with-dementia Fri, 06 Jul 2018 13:58:28 +0200 https://news.ki.se/possible-new-principle-for-cancer-therapy A study published in Science Translational Medicine shows that small molecules that specifically inhibit an important selenium-containing enzyme may be useful in combating cancer. When researchers at Karolinska Institutet treated cancer in mice using these molecules, they observed rapid tumoricidal effects. Researchers now hope that this new principle for cancer treatment will eventually be developed for use in humans. Thu, 15 Feb 2018 09:09:50 +0100 https://news.ki.se/asthma-drug-potential-treatment-for-aortic-aneurysm Tue, 06 Feb 2018 08:00:00 +0100 https://news.ki.se/calcium-transfer-may-open-up-to-new-ways-of-treating-alzheimers-disease Fri, 02 Feb 2018 13:52:40 +0100 https://news.ki.se/genetic-analysis-can-improve-depression-therapy The failure of drugs such as SSRIs, used to treat depression, can be a result of genetic variations in patients. Variations within the gene that encodes the CYP2C19 enzyme results in extreme differences in the levels of escitalopram achieved in patients, according to a new study published in The American Journal of Psychiatry. Prescribing the dose of escitalopram based on a patient’s specific genetic constitution would greatly improve therapeutic outcomes. Fri, 12 Jan 2018 08:11:00 +0100 https://news.ki.se/alcohol-abuse-drug-antabuse-kills-cancer-cells Thu, 07 Dec 2017 12:08:29 +0100 https://news.ki.se/receptor-dynamics-provide-new-potential-for-pharmaceutical-developments The dynamics among certain so-called G protein-coupled receptors, of vital importance for the function of cells in the body, are different than previously believed. This has been reported by researchers from Karolinska Institutet in the journal Nature Communications. As these types of receptors are the target for many different medicines, the new finding opens the doors to completely new opportunities within pharmacology and pharmaceutical development. Wed, 09 Aug 2017 13:14:13 +0200 https://news.ki.se/impotence-medicine-associated-with-reduced-long-term-risk-of-death-after-heart-attack Fri, 10 Mar 2017 09:26:28 +0100 https://news.ki.se/safe-to-take-influenza-drugs-during-pregnancy Wed, 01 Mar 2017 08:00:00 +0100 https://news.ki.se/tore-curstedts-curosurf-helped-millions-of-preterm-babies In the spring of 2016, KI researcher Tore Curstedt was nominated for a Lifetime Achievement Award by the European Patent Office for having devoted his life to Curosurf, a drug that has helped to activate the lungs of millions of preterm babies. Thu, 09 Jun 2016 17:09:24 +0200 https://news.ki.se/older-rheumatoid-arthritis-drug-is-more-effective-against-ms-than-newer-costlier-drug Fri, 15 Apr 2016 12:52:46 +0200 https://news.ki.se/new-principle-for-brain-controlled-hormone-secretion Fri, 15 Apr 2016 08:00:00 +0200 https://news.ki.se/new-nanoparticle-technology-to-decipher-structure-and-function-of-membrane-proteins Tue, 08 Mar 2016 13:29:53 +0100 https://news.ki.se/type-2-diabetes-drug-can-exhaust-insulin-producing-cells Fri, 12 Feb 2016 08:00:00 +0100 https://news.ki.se/many-unexpected-genetic-variants-hamper-personalised-medicine In recent decades much hope was based on the development of personalised drug treatments, in which genetic tests determine the choice and optimal dose of medication for each individual patient. However, the real breakthrough is still to be seen, and now researchers at Karolinska Institutet show in two separate scientific papers that many more gene variants affect how a person responds to medication than previously thought – and thus that today’s analytical tools are too coarse. Wed, 16 Dec 2015 08:00:00 +0100 https://news.ki.se/combination-therapy-can-prevent-cytostatic-resistance Wed, 25 Nov 2015 11:15:00 +0100 https://news.ki.se/one-step-closer-to-a-new-drug-for-alcohol-dependence Wed, 14 Oct 2015 11:28:30 +0200 https://news.ki.se/study-analyses-link-between-psychotropic-drugs-and-homicide-risk Mon, 01 Jun 2015 09:10:00 +0200 https://news.ki.se/heart-failure-drugs-beneficial-even-in-presence-of-kidney-disease Sat, 23 May 2015 11:10:00 +0200 https://news.ki.se/tuberculosis-drug-can-improve-effect-of-cbt Mon, 18 May 2015 09:00:00 +0200 https://news.ki.se/swedish-scientists-show-the-impact-of-approved-drugs-on-human-proteins Fri, 23 Jan 2015 10:41:24 +0100 https://news.ki.se/causal-link-between-antibiotics-and-childhood-asthma-dismissed Mon, 01 Dec 2014 09:56:59 +0100 https://news.ki.se/beta-blockers-could-benefit-patients-with-hfpef Sun, 16 Nov 2014 17:58:00 +0100 https://news.ki.se/new-immunological-findings-provide-possible-therapy-for-cardiovascular-disease Fri, 14 Nov 2014 08:10:00 +0100 https://news.ki.se/oestrogen-possible-treatment-in-menopause-also-at-increased-risk-of-cardiovascular-disease Wed, 22 Oct 2014 15:15:15 +0200 https://news.ki.se/aimed-at-more-effective-analgesic Per-Johan Jakobsson, professor of translational inflammatory research, wants to gain a better understanding of chronic inflammatory diseases such as rheumatism with the aid of proteomics, the large-scale analysis of proteins. His research on prostaglandins may lead to more efficacious drugs for pain and fever in the long term. Mon, 13 Oct 2014 11:33:16 +0200 https://news.ki.se/personalised-medicine-against-hereditary-immunodeficiency Thu, 14 Aug 2014 10:00:00 +0200 https://news.ki.se/new-findings-explain-why-we-stop-growing-at-one-point Fri, 09 May 2014 13:43:12 +0200 https://news.ki.se/antipsychotics-associated-with-reduced-rate-of-violent-crime Thu, 08 May 2014 09:49:17 +0200 https://news.ki.se/new-general-concept-for-the-treatment-of-cancer Thu, 03 Apr 2014 07:45:00 +0200 https://news.ki.se/new-discovery-paves-the-way-for-medicine-for-people-with-hearing-disabilities Thu, 27 Feb 2014 18:05:00 +0100 https://news.ki.se/new-drug-candidate-starves-dormant-cancer-cells Tue, 18 Feb 2014 17:02:00 +0100 https://news.ki.se/acidic-tumour-ph-inhibits-drug-effect Tue, 11 Feb 2014 09:00:01 +0100 https://news.ki.se/new-approach-prevents-thrombosis-without-increasing-the-risk-of-bleeding Thu, 06 Feb 2014 16:06:46 +0100 https://news.ki.se/promising-results-for-swedish-cancer-drug-candidate Fri, 06 Dec 2013 14:04:59 +0100 https://news.ki.se/tailored-doses-of-cytostatic-improve-survival-rate Wed, 23 Oct 2013 00:00:00 +0200 https://news.ki.se/no-serious-adverse-reactions-to-hpv-vaccination Wed, 09 Oct 2013 00:00:00 +0200 https://news.ki.se/antipsychotic-drug-for-dementia-can-be-replaced Fri, 20 Sep 2013 00:00:00 +0200 https://news.ki.se/technological-breakthrough-paves-the-way-for-better-drugs Fri, 05 Jul 2013 00:00:00 +0200 https://news.ki.se/aspirin-triggered-resolvin-protects-against-cognitive-decline-after-surgery Mon, 27 May 2013 00:00:00 +0200 https://news.ki.se/cortisone-can-increase-risk-of-acute-pancreatitis Tue, 26 Feb 2013 00:00:00 +0100 https://news.ki.se/cancer-drug-a-possible-treatment-for-ms Thu, 21 Feb 2013 00:00:00 +0100 https://news.ki.se/vitamin-c-supplements-linked-to-kidney-stones Tue, 05 Feb 2013 00:00:00 +0100 https://news.ki.se/no-increased-risk-of-stillbirth-and-infant-mortality-when-a-pregnant-woman-uses-ssri-drugs Wed, 02 Jan 2013 00:00:00 +0100 https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke In a study in mice, scientists at Karolinska Institutet in Sweden have discovered a new potential therapy that may reduce brain damage following stroke in type 2 diabetic patients. The suggested drug is already approved for the treatment of type 2 diabetes. However, the scientists hope that this new results, presented in the scientific journal Diabetes, also opens up the possibility to decrease brain injury after stroke in other patient groups with a high stroke risk. Tue, 04 Dec 2012 00:00:00 +0100 https://news.ki.se/possible-new-therapy-for-the-treatment-of-a-common-blood-cancer Wed, 05 Sep 2012 00:00:00 +0200 https://news.ki.se/study-shows-efficacy-of-new-rheumatoid-arthritis-drug Thu, 09 Aug 2012 00:00:00 +0200 https://news.ki.se/potential-new-drug-for-alcohol-dependence Fri, 27 Jul 2012 00:00:00 +0200 https://news.ki.se/recovery-from-stroke-more-likely-with-rtpa Thu, 24 May 2012 00:00:00 +0200 https://news.ki.se/fewer-suicides-after-antidepressive-treatment-for-schizophrenia Tue, 08 May 2012 00:00:00 +0200 https://news.ki.se/research-breakthrough-for-drugs-via-the-skin Thu, 26 Apr 2012 00:00:00 +0200 https://news.ki.se/new-knowledge-on-the-pharmacology-of-dopamine-stabilisers A study from Karolinska Institutet shows that a new drug for Huntington's disease – pridopidine or dopamine stabiliser ACR16 – might operate via previously unknown mechanisms of action. Fri, 24 Feb 2012 00:00:00 +0100 https://news.ki.se/expectant-mothers-on-ssris-risk-newborns-with-high-blood-pressure-in-the-lungs Fri, 13 Jan 2012 00:00:00 +0100 https://news.ki.se/newly-discovered-role-for-enzyme-in-neurodegenerative-diseases Thu, 10 Mar 2011 00:00:00 +0100 https://news.ki.se/sunlight-can-influence-the-breakdown-of-medicines-in-the-body Wed, 09 Mar 2011 00:00:00 +0100 https://news.ki.se/new-cell-therapy-a-promising-atherosclerosis-treatment Tue, 01 Mar 2011 00:00:00 +0100 https://news.ki.se/chemotherapy-used-to-combat-severe-swine-flu Fri, 17 Dec 2010 00:00:00 +0100 https://news.ki.se/aortic-aneurysm-treatable-with-asthma-drugs Tue, 16 Nov 2010 00:00:00 +0100