https://ki.se RSS News Listing https://news.ki.se/lifestyle4health-network-and-the-cell-an-evening-of-inspiration-for-teachers On 9 September, around 20 teachers and school staff gathered at The Cell in Stockholm for an evening focused on life science, education and how research can become more accessible and useful in the classroom. Fri, 18 Sep 2026 17:21:48 +0200 https://news.ki.se/women-experienced-less-pain-during-iud-insertion-using-a-new-method A simple method involving local anaesthesia in the uterus can reduce pain during IUD insertion, according to a new study from the Karolinska Institutet, published in the journal JAMA. The method also increased the proportion of women who found the procedure tolerable. The results may encourage more women to choose an IUD as a method for contraception. Thu, 17 Sep 2026 17:00:08 +0200 https://news.ki.se/looking-for-potential-public-health-risks How do common things like nicotine products and hormone treatments affect public health? Cecilia Magnusson is hoping to find out. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 8 October. Tue, 08 Sep 2026 09:00:11 +0200 https://news.ki.se/study-highlights-risk-groups-for-a-severe-side-effect-of-diabetes-treatment Patients with type 2 diabetes who have high blood glucose levels, low body weight, or a history of ketoacidosis are at increased risk of developing this serious condition when treated with so-called SGLT2 inhibitors. A study led by researchers at Karolinska Institutet also shows that the risk persists throughout the entire course of treatment. Wed, 02 Sep 2026 00:30:08 +0200 https://news.ki.se/disease-patterns-may-guide-lifestyle-interventions-in-older-adults Older adults living with several chronic diseases, a condition known as multimorbidity, may respond differently to interventions aimed at preventing disability, depending on the combination of diseases they have. A new study, published in Nature Aging and led by researchers at Karolinska Institutet and Università Cattolica del Sacro Cuore in Rome, suggests that looking at patterns of multimorbidity, rather than individual diseases alone, could help make prevention more personalised. Mon, 31 Aug 2026 16:04:50 +0200 https://news.ki.se/longer-meal-intervals-linked-to-faster-disease-accumulation-in-older-adults Older adults who typically had longer intervals between meals accumulated chronic diseases more rapidly over time than those with shorter intervals, according to a study from Karolinska Institutet published in the Journal of Internal Medicine. The association was most pronounced among people aged 78 years and older. Thu, 20 Aug 2026 13:08:25 +0200 https://news.ki.se/gut-flora-enhances-the-health-benefits-of-vegetables Researchers at Karolinska Institutet have discovered that gut bacteria can convert dietary nitrate and iron into protective molecules that may reduce the risk of cardiovascular and metabolic diseases. The study, published in Cell, reveals a new way in which the gut microbiota helps protect vital bodily functions. Wed, 19 Aug 2026 17:00:08 +0200 https://news.ki.se/new-tool-measures-the-biological-age-of-cells Researchers at Karolinska Institutet and Stockholm University have developed a new tool that estimates a cell’s biological age by analysing its gene activity. In the journal Advanced Science, they also demonstrate how the tool can be used to identify substances that influence cellular ageing. Tue, 18 Aug 2026 11:34:45 +0200 https://news.ki.se/blood-thinning-medication-linked-to-slower-cognitive-decline People with both atrial fibrillation and Alzheimer’s disease who are treated with modern NOAC blood-thinning medicines may experience a slower rate of cognitive decline. This is shown by a study from Karolinska Institutet published in the European Heart Journal. Wed, 12 Aug 2026 13:00:10 +0200 https://news.ki.se/ki-researchers-contribute-to-new-who-guidelines-on-dementia-risk-reduction Professor Miia Kivipelto and other researchers at Karolinska Institutet have contributed to the development of the World Health Organization’s updated guidelines on reducing the risk of cognitive decline and dementia. The recommendations provide countries with an evidence-based framework for prevention and could help address risk factors associated with up to 45 per cent of dementia cases worldwide. Thu, 23 Jul 2026 15:25:45 +0200 https://news.ki.se/metabolic-syndrome-linked-to-faster-brain-ageing People with metabolic syndrome tend to have brains that appear older than their actual age, according to a new study published in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association. The new findings provide fresh insights into the biological processes that may link metabolic health to the brain. Tue, 14 Jul 2026 16:08:11 +0200 https://news.ki.se/brain-tau-spreads-differently-in-early-and-late-onset-alzheimers-disease The amount and distribution of the tau protein in the brain differs between early and late-onset Alzheimer's disease. This is shown by a new study from Karolinska Institutet published in the journal European Journal of Nuclear Medicine and Molecular Imaging. The results also indicate that blood tests do not always reflect changes in the brain. Fri, 26 Jun 2026 09:36:39 +0200 https://news.ki.se/healthier-diet-linked-to-lower-dementia-in-older-adults-at-risk A healthier diet may be associated with a lower risk of dementia among older adults, including those with blood biomarkers indicating an increased biological risk of Alzheimer's disease pathology. This is shown in a new study from Karolinska Institutet published in JAMA Network Open. Fri, 26 Jun 2026 07:35:04 +0200 https://news.ki.se/weather-affects-preschool-childrens-activity-levels Sunshine, heat, cold and rain all play a role in how active preschool children are during the day. This is shown by a new study from Karolinska Institutet, published in the journal Environmental Research, in which researchers have linked children’s activity patterns to everyday weather conditions. Thu, 04 Jun 2026 15:33:02 +0200 https://news.ki.se/sexual-problems-common-after-cancer-in-young-adults Many young adults who have been treated for cancer experience sexual problems. This is shown in a doctoral dissertation at Karolinska Institutet, which also highlights gaps in information provided by the healthcare system. Tue, 19 May 2026 09:45:40 +0200 https://news.ki.se/single-dose-of-psilocybin-provided-rapid-relief-from-depression-in-new-study A single dose of the psychedelic substance psilocybin can provide rapid relief from depressive symptoms – within just a few days. This is shown by the first randomised, double-blind study in Sweden of psilocybin for depression. The effect persisted for over three months, according to researchers at Karolinska Institutet. Fri, 15 May 2026 17:00:09 +0200 https://news.ki.se/mai-lis-hellenius-named-most-promising-over-60 KI researcher Mai‑Lis Hellenius has been named the winner in the Health category of the Most Promising Over 60 award 2026. She receives the award in recognition of her long‑standing and dedicated work to make research on lifestyle and health understandable, relevant, and accessible to a broad audience. Tue, 28 Apr 2026 12:54:05 +0200 https://news.ki.se/anaemia-linked-to-increased-cancer-risk Anaemia detected in healthcare is associated with an increased risk of both cancer and higher mortality. This is shown in a new population-based study from Karolinska Institutet, published in BMJ Oncology. The findings may help guide clinical follow-up of patients with anaemia in routine care. Thu, 09 Apr 2026 11:05:45 +0200 https://news.ki.se/long-covid-associated-with-increased-risk-of-cardiovascular-disease People with long COVID are at increased risk of developing cardiovascular disease, according to a new study from Karolinska Institutet published in eClinicalMedicine. The results show that the risk of conditions such as cardiac arrhythmias and coronary artery disease is higher even among those who were not hospitalised during the acute infection. Thu, 02 Apr 2026 01:30:06 +0200 https://news.ki.se/digital-cbt-reduced-cardiac-related-anxiety-and-improved-health-following-heart-attack Digital CBT treatment reduced cardiac-related anxiety and improved patients' quality of life and physical function after a heart attack. This is shown in a new randomised study published in Journal of the American College of Cardiology, in which researchers at Karolinska Institutet compared digital CBT with standard care. Wed, 25 Mar 2026 10:00:08 +0100 https://news.ki.se/children-with-obesity-are-at-risk-of-illness-despite-normal-test-results Children living with obesity but showing no signs of metabolic complications still have a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life. A new study from the Karolinska Institutet, published in JAMA Pediatrics, also shows that these children benefit greatly from obesity treatment. Mon, 23 Mar 2026 16:01:08 +0100 https://news.ki.se/high-meat-consumption-linked-to-lower-dementia-risk-in-genetic-risk-group Older people with a genetic risk of Alzheimer's disease did not experience the expected increase in cognitive decline and dementia risk if they consumed relatively large amounts of meat. This is shown in a new study from Karolinska Institutet published in JAMA Network Open. The results may contribute to the development of more individually tailored dietary advice. Thu, 19 Mar 2026 16:00:16 +0100 https://news.ki.se/exercise-and-nutritional-drinks-can-reduce-the-need-for-care-in-dementia A simple combination of daily physical exercise and protein-rich nutritional drinks appears to offer significant health benefits for people with dementia. In a new study from Karolinska Institutet, not only did the participants' physical ability improve, but after three months the researchers also saw signs that they were able to manage more everyday tasks themselves. The study is published in the journal Alzheimer's and Dementia. Wed, 18 Feb 2026 08:55:26 +0100 https://news.ki.se/ai-assistant-sundi-gives-lifestyle-advice-according-to-current-research When the AI service Sundi is now being launched in Sweden, users will receive individualised support to achieve their personal health goals. The advice is based on the latest research that is updated and reviewed by doctors and researchers. Sundi is a non-profit initiative from Bosch Health Campus (BHC) in Stuttgart and Charité – Universitätsmedizin in Berlin in collaboration with researchers from Karolinska Institutet who review the research content. Mon, 09 Feb 2026 09:43:34 +0100 https://news.ki.se/gender-equality-universally-linked-to-physical-capacity Fitness amongst young adults varies widely from one country to another, and is strongly associated with both socioeconomic development and gender equality, a new study from Karolinska Institutet published in the Journal of Sport and Health Science reports. The results indicate that levels of development and gender equality in a society can affect differences in physical capacity and therefore public health in general. Thu, 23 Oct 2025 10:50:41 +0200 https://news.ki.se/new-gene-discovery-aids-heart-disease-prevention By analyzing large amounts of data, researchers at Karolinska Institutet have developed a system for classifying individuals into different risk groups for atherosclerosis. The results enable early detection of the disease, which can lead to personalized preventive care. Thu, 23 Oct 2025 09:11:18 +0200 https://news.ki.se/stomach-acid-medicine-tied-to-higher-infection-risk-in-pregnancy Pregnant women who use proton pump inhibitors, a common medicine for heartburn, run a slightly higher risk of developing infections during pregnancy and after childbirth. This is shown in a new registry study from Karolinska Institutet, published in the journal The Lancet Obstetrics, Gynaecology & Women’s Health. Thu, 09 Oct 2025 00:30:11 +0200 https://news.ki.se/increased-risk-of-depression-and-psychosis-after-childbirth-among-mothers Depression and psychosis are more common in women after childbirth than before, but the risk of suicide attempts decreases. This is shown by two new studies from Karolinska Institutet. The results suggest that national guidelines for screening can help women get help earlier. Thu, 25 Sep 2025 18:00:10 +0200 https://news.ki.se/missing-first-mammogram-raises-breast-cancer-death-risk Women who miss their first mammogram run a higher risk of being diagnosed with advanced breast cancer and dying from the disease. This is shown in a new study from Karolinska Institutet published in the scientific journal BMJ. Thu, 25 Sep 2025 08:41:36 +0200 https://news.ki.se/protein-in-urine-can-predict-risk-of-dementia A study shows that people with higher levels of the protein albumin in their urine are at increased risk of developing dementia. The study, led by researchers at Karolinska Institutet, is published in the scientific journal Journal of Internal Medicine. Wed, 24 Sep 2025 08:21:16 +0200 https://news.ki.se/metabolic-syndrome-linked-to-increased-risk-of-parkinsons-disease People with metabolic syndrome are at increased risk of developing Parkinson's disease, according to a new study by researchers at Karolinska Institutet. The findings, published in the journal Neurology, highlight the importance of early detection and treatment of metabolic risk factors. Thu, 21 Aug 2025 09:23:44 +0200 https://news.ki.se/rising-colorectal-cancer-among-young-adults-in-sweden According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s. The study also shows that mortality is elevated in both younger and older patients for up to ten years after diagnosis. Thu, 14 Aug 2025 11:59:45 +0200 https://news.ki.se/adhd-medication-linked-to-lower-risk-of-suicide-attempts-substance-abuse-and-criminality People who take medication for ADHD have a lower risk of suicide attempts, substance abuse, traffic accidents, and criminality than people with ADHD who do not take medication. This is shown in a new study by researchers from Karolinska Institutet and University of Southampton, published in the journal BMJ. Thu, 14 Aug 2025 09:10:47 +0200 https://news.ki.se/genes-reveal-why-some-older-people-suffer-from-frailty A new study has identified genetic variants linked to brain function, immune defence and metabolism that contribute to the development of frailty in older people. The study, published in Nature Aging by researchers from Karolinska Institutet, provides new biological insights into the onset of frailty. Tue, 05 Aug 2025 11:22:24 +0200 https://news.ki.se/centenarians-develop-diseases-more-slowly Reaching the age of 100 does not necessarily mean a life fraught with illness. A new study from Karolinska Institutet shows that centenarians not only live longer, they also stay healthier than other older people, with fewer diseases that develop more slowly. Mon, 04 Aug 2025 18:06:35 +0200 https://news.ki.se/new-study-shows-increased-suicide-risk-among-healthcare-workers A new study from Karolinska Institutet shows that healthcare workers in Sweden have a higher risk of suicide compared to other occupational groups with similar professional levels. The study highlights the risks for physicians, registered nurses, and assistant nurses in particular. Mon, 28 Jul 2025 17:12:41 +0200 https://news.ki.se/healthy-diet-can-slow-down-chronic-diseases-in-older-people A healthy diet can slow down the accumulation of chronic diseases in older adults, while inflammatory diets accelerate it. This is shown by a new study from Karolinska Institutet published in Nature Aging. Mon, 28 Jul 2025 15:13:45 +0200 https://news.ki.se/premenstrual-symptoms-linked-to-increased-risk-of-cardiovascular-disease Women diagnosed with premenstrual symptoms have a slightly increased risk of developing cardiovascular disease later in life. This is shown by a new study from Karolinska Institutet published in Nature Cardiovascular Research. Fri, 11 Jul 2025 11:12:04 +0200 https://news.ki.se/adults-who-have-survived-childhood-cancer-are-at-increased-risk-of-severe-covid-19 People who have survived cancer as children are at higher risk of developing severe COVID-19, even decades after their diagnosis. This is shown by a new study from Karolinska Institutet published in the journal The Lancet Regional Health – Europe. Fri, 04 Jul 2025 09:09:59 +0200 https://news.ki.se/planned-c-sections-increase-the-risk-of-certain-childhood-cancers Children born by planned C-section have an increased risk of developing acute lymphoblastic leukaemia (ALL) later in life. This is shown by a study conducted by researchers at Karolinska Institutet. The researchers emphasise that the risk remains low. Fri, 04 Jul 2025 09:00:06 +0200 https://news.ki.se/no-evidence-that-drugs-trigger-microscopic-colitis-in-older-people There is a perception that common drugs such as ibuprofen and SSRI preparations can trigger the intestinal disease microscopic colitis (MC). However, a new study from Karolinska Institutet and Harvard Medical School suggests that this is not the case – meaning that patients with MC do not need to stop taking important medications. Mon, 30 Jun 2025 23:00:13 +0200 https://news.ki.se/new-drug-for-diabetes-and-obesity-shows-promising-results Lower blood sugar and increased fat burning – without negatively affecting appetite or muscle mass. These are some of the most promising effects of a new potential drug treatment for people with type 2 diabetes and obesity, according to a new study published in the journal Cell by researchers from Karolinska Institutet and Stockholm University. Mon, 23 Jun 2025 17:06:27 +0200 https://news.ki.se/cervical-cancer-affects-both-the-mental-health-and-finances-of-families A new Swedish registry study shows that women who are affected by cervical cancer are not only at risk of mental health and financial difficulties themselves – their children and partners also appear to be negatively affected. The study is published in the prestigious scientific Journal of the National Cancer Institute. Tue, 10 Jun 2025 20:59:03 +0200 https://news.ki.se/thesis-on-physical-activity-and-physical-capacity-in-older-adults Manne Godhe, PhD student at the Sports Medicine research group, the Department of Molecular Medicine and Surgery, will defend his thesis "Physical Activity and Fitness Measurements in Healthy Older Adults and Osteoarthrities Patients Undergoing Total Hip Arthroplasty" on May 23, 2025. Main Supervisor is Eva Andersson. Fri, 16 May 2025 15:25:54 +0200 https://news.ki.se/adult-onset-type-1-diabetes-increases-risk-of-cardiovascular-disease-and-death A new study in the European Heart Journal shows that people who develop type 1 diabetes in adulthood have an increased risk of cardiovascular disease and death, and that those diagnosed later in life do not have a better prognosis than those diagnosed earlier. The study, conducted by researchers at Karolinska Institutet, points to smoking, poor glucose control and obesity as the main risk factors. Wed, 14 May 2025 09:00:14 +0200 https://news.ki.se/higher-cigarette-taxes-may-improve-childhood-survival A higher tax on cigarettes in low and middle-income countries can help to reduce child mortality, especially amongst the poorest children, a new study led by researchers at Karolinska Institutet and published in The Lancet Public Health suggests. Wed, 30 Apr 2025 09:55:35 +0200 https://news.ki.se/heart-valve-abnormality-is-associated-with-malignant-arrhythmias People with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders, even after successful valve surgery. This is according to a new study from Karolinska Institutet and Karolinska University Hospital in Sweden published in the European Heart Journal. The condition is more common in women and younger patients with valve disorder and can, in the worst case, lead to sudden cardiac arrest. Tue, 15 Apr 2025 08:00:15 +0200 https://news.ki.se/researchers-have-mapped-the-genetics-of-cardiovascular-disease Researchers at Swedish institutions, including Karolinska Institutet, have identified gene variants that increase the risk of atherosclerosis. The goal is for these new findings to enable earlier detection of atherosclerosis and improved treatment of cardiovascular diseases such as heart attack and stroke. The study has been published in the journal Nature Communications. Mon, 31 Mar 2025 11:23:44 +0200 https://news.ki.se/fatty-liver-linked-to-increased-risk-of-death-from-several-diseases A comprehensive study from Karolinska Institutet shows that people with fatty liver disease have almost twice the mortality rate of the general population. They have an increased risk of dying from both liver diseases and common diseases such as cancer and cardiovascular disease, according to the study published in The Journal of Hepatology. Mon, 24 Mar 2025 08:00:14 +0100 https://news.ki.se/a-healthy-lifestyle-may-counteract-diabetes-associated-brain-ageing Type 2 diabetes and prediabetes are associated with accelerated brain ageing, according to a new study from Karolinska Institutet published in the journal Diabetes Care. The good news is that this may be counteracted by a healthy lifestyle. Wed, 28 Aug 2024 13:00:13 +0200 https://news.ki.se/can-lifestyle-habits-influence-common-diseases That was the title of the KI-Lifestyle4Health open seminar on June 3rd, 2024. The answer, as perhaps expected, was yes, but participants also got the opportunity to listen and discuss research-based examples and practical trials. Wed, 05 Jun 2024 16:20:57 +0200 https://news.ki.se/new-health-app-to-promote-healthy-lifestyle-behaviours Researchers at Karolinska Institutet, in collaboration with Sophiahemmet University and LongLife Active AB, have developed an AI-assisted mobile health app with the potential to promote lifestyle behaviours. Wed, 05 Jun 2024 10:17:37 +0200 https://news.ki.se/scaling-up-of-a-healthy-school-start The project "A Healthy School Start" is a family support program developed by the research group Community Nutrition and Physical Activity at the Department of Global Public Health, to offer an adapted approach for student health and teachers to provide support to families with children on healthy lifestyles. The program has been positively received by politicians in Region Stockholm, who have now allocated funds in the budget for further dissemination. Fri, 15 Mar 2024 13:07:54 +0100 https://news.ki.se/long-live-the-liver Many Swedes live with fatty liver – and it doesn’t have to be dangerous. But for some, it kicks off a course of disease in which persistent inflammation leads to cirrhosis. Medicinsk Vetenskap has talked to researchers who look after the liver – the behemoth of the belly that has a somewhat magical ability to recover, along with enormous overcapacity. Wed, 27 Dec 2023 11:17:49 +0100 https://news.ki.se/learn-to-live-a-healthier-life-a-popular-science-workshop-by-lifestyle4health On Saturday, November 18th, the KI Network Lifestyle4Health welcomed the public to an informative afternoon at Medicinska Föreningen at Karolinska Institutet. The afternoon was filled with lectures, health marker measurements, and practical "patient cases" that participants could analyse to suggest recommendations for lifestyle changes. Fri, 22 Dec 2023 11:31:16 +0100 https://news.ki.se/method-of-improving-young-peoples-wellbeing-tested-in-more-cities According to UNICEF, approximately one in five young people suffer from mental health issues, which in turn often leads to risk-taking with alcohol, tobacco and drugs. In the long run, it can cause lifelong health impairments in adulthood. In a three-year project coordinated by Karolinska Institutet, a method used to improve young people’s wellbeing in India, Kenya, the U.S. and Colombia is being evaluated to see if it can work in other parts of the world. Fri, 01 Sep 2023 13:03:31 +0200 https://news.ki.se/childhood-obesity-linked-to-increased-risk-of-different-forms-of-diabetes-in-adulthood Child obesity is linked to increased risk of developing diabetes in adulthood, both autoimmune forms of diabetes and different forms of type 2 diabetes, a new study published in Diabetologia reports. The risk of developing the most insulin-resistant form of diabetes is, for example, three times as high in children with obesity. Tue, 28 Feb 2023 13:11:30 +0100 https://news.ki.se/new-professorship-at-karolinska-institutet-centred-on-prevention Thanks to donations from numerous actors, Karolinska Institutet is now able to create a new professorship in prevention medicine. The professorship is named after its patron, HRH Prince Daniel. Thu, 16 Feb 2023 11:48:20 +0100 https://news.ki.se/women-and-men-have-different-risk-factors-for-type-2-diabetes Type 2 diabetes is a common disease, affecting 10 % of the adult world population, in which heredity and overweight are known risk factors. In a new study at Karolinska Institutet, researchers show that women and men with a predisposition to diabetes have different risk factors forecasting type 2 diabetes and prediabetes. The results were recently published in the journal Frontiers in Endocrinology. Mon, 13 Feb 2023 17:30:00 +0100 https://news.ki.se/two-awardees-selected-for-the-ki-lifestyle4health-best-paper-award-2022 Congratulations to the winners of this year’s KI Lifestyle4Health Best paper award for junior researchers. In this occasion, two, of many fantastic publications that were nominated, shared the first place: Thu, 13 Oct 2022 10:19:11 +0200 https://news.ki.se/understanding-health-inequities-and-how-to-reduce-them Have a car. Don’t be poor. Don’t have a stressful job. Age, gender and socioeconomics are some of the factors that affect your risk of developing an illness and of dying prematurely. Sweden has set the goal of levelling out influenceable health gaps within one generation. But is this goal realistic? And why is it so difficult to achieve? Read an article series about health inequities from the Swedish magazine Medicinsk Vetenskap. Fri, 23 Sep 2022 12:48:49 +0200 https://news.ki.se/stockholm-public-health-lectures-agenda-for-reducing-cannabis-use-and-crime-in-stockholm-county 18 May The Centre for Epidemiology and Community Medicine at Region Stockholm and the Department of Global Public Health at KI invite to the lecture Agenda for reducing cannabis use and crime in Stockholm County. The lecture is based on a series of reports from the Centre on cannabis-related problems among young people in Stockholm County, with themes such as links between cannabis and lethal violence, the geography of cannabis crimes, attitudes to cannabis and health care consumption. Mon, 04 Apr 2022 17:03:31 +0200 https://news.ki.se/new-thesis-about-behavioral-and-psychological-symptoms-of-dementia-bpsd-0 Hi Emilia Schwertner, PhD student at the Division of Clinical Geriatrics, NVS. On January 21 you will defend your thesis ”Factors associated with behavioral and psychological symptoms of dementia”, what's the main focus of the thesis? Mon, 17 Jan 2022 15:49:05 +0100 https://news.ki.se/long-term-exercise-impacts-genes-involved-in-metabolic-health Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health. This is according to a new study published in the journal Cell Reports by researchers at Karolinska Institutet in Sweden and the University of San Diego in the U.S. Sex differences found in untrained individuals were also dramatically reduced with long-term training. The results may have implications for metabolic disease prevention. Tue, 23 Jun 2020 17:00:03 +0200