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Nils-Göran Larsson receives a project grant in Endocrinology & Metabolism of DKK 2 million from the Novo Nordisk Foundation. We’ve talked to him about the project that investigates the role of mitochondria in the development of obesity-associated insulin resistance.
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According to many observations, certain virus infections may play a part in the autoimmune attack that leads to type 1 diabetes. Researchers at Karolinska Institutet in Sweden and their Finnish colleagues have now produced a vaccine for these viruses in the hope that it could provide protection against the disease. The study is published today in the scientific journal Science Advances.
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Use of sodium glucose cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes may help to lower the risk of serious kidney problems, according to a Scandinavian study led by researchers at Karolinska Institutet. The findings, now published in the journal The BMJ, provide support for the use of SGLT2 inhibitors in a broad range of patients with type 2 diabetes, according to the researchers.
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Two clinical researchers at KI have been appointed Wallenberg Clinical Scholars 2020. The individual funding of SEK 15 million from Knut and Alice Wallenberg Foundation provides Anca Catrina and Mikael Rydén with the opportunity to deepen their research and disseminate their results in healthcare.
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Dr Franz Matschinsky, Professor of Biochemistry and Biophysics, Institute for Diabetes, Obesity and Metabolism Perelman School of Medicine, Philadelphia receives the 2020 Rolf Luft Award for the discovery that glucokinase (GK) is the sensor controlling glucose-stimulated insulin secretion in the pancreatic beta cell.
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Researchers at Karolinska Institutet have deciphered the diabetogenic role of a certain type of calcium channel in insulin-secreting beta cells. The researchers believe that blockade of these channels could be a potential new treatment strategy for diabetes. The study is published in the scientific journal PNAS.
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Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has since long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular mechanism linking these two diseases. The study is published in the scientific journal PNAS.
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Hello there, Sergiu Catrina - Associate Professor, Specialist Physician and Research Leader for the Growth and Metabolism Group at the Department of Molecular Medicine and Surgery.
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Children born to women who underwent gastric bypass surgery before becoming pregnant had a lower risk of major birth defects than children born to women who had severe obesity at the start of their pregnancy. That’s according to a matched cohort study by researchers at Karolinska Institutet and Örebro University published in the scientific journal JAMA. The findings indicate that weight-loss and improved blood sugar control could reduce the risk of major birth defects.
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Drivers, factory workers, and cleaners are three times more likely to develop type 2 diabetes than teachers and physiotherapists. Researchers at Karolinska Institutet in Sweden have studied how the occurrence of diabetes differs between occupations in Sweden. The results are being published in the scientific journal Diabetologia and are also presented at the European diabetes conference in Barcelona in September.
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The new type of drugs for type 2 diabetes, the so-called SGLT2 inhibitors, are associated with a reduced risk of heart failure and death as well as of major cardiovascular events, a major Scandinavian registry study led from Karolinska Institutet reports in The BMJ.
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The paper's motto was: ”Among women with diabetes and high HbA1c, there is a risk that the fetus too early the outside world will see”

The winning study was led by Professor Jonas F Ludvigsson, Department of Medical Epidemiology and Biostatistics, KI, and shows that pregnant women with type 1 diabetes are at increased risk of pregnancy complications, including preterm birth. With increasing HbA1c the risk of preterm birth increased further.
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The hormone secreting part of the pancreas, the islets of Langerhans, has a unique cyto-architecture that allows functional interrelationships between the different cell types. Somatostatin is secreted by the delta cell and is an effective inhibitor of the insulin secreting beta cell and the glucagon secreting alpha cell. According to a novel study from Karolinska Instiutet, published in the journal Nature Communications, the delta cell can thereby indirectly affect glucose homeostasis
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People with undetected glucose disorders run a higher risk of both myocardial infarction and periodontitis, according to a study published in the journal Diabetes Care by researchers at Karolinska Institutet. The results demonstrate the need of greater collaboration between dentistry and healthcare, say the researchers, and possibly of screening for diabetes at dental clinics.
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By the time type 1 diabetes is diagnosed, most of the insulin-producing beta cells have already been destroyed. Now, using an innovative transplantation technique, researchers at Karolinska Institutet and University of Miami Miller School of Medicine have been able to intervene to save the beta cells in mice by discovering early signs of the disease. The study is published in Diabetologia, the scientific journal of the European Association for the Study of Diabetes (EASD).
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Pregnant women with type 1 diabetes are at increased risk of delivering their baby prematurely. The risk increases as blood sugar levels rise, however women who maintain the recommended levels also risk giving birth prematurely. These are the findings from researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden, published in Annals of Internal Medicine.
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The ERC Advanced Grant is one of the most prestigious funding programmes for research in Europe. Per-Olof Berggren, professor of experimental endocrinology at Karolinska Institutet, is now awarded this grant for the second time.
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Olov Andersson, docent at the Department of Cell and Molecular Biology at Karolinska Institutet, is the recipient of The Leif C. Groop award for outstanding research for his research in zebrafish that could lead to new treatments for diabetes. Awarded by the Lund University Diabetes Centre and sponsored by Novo Nordisk Sweden.
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Professor Mitchell Lazar at Perelman School of Medicine, University of Pennsylvania, Philadelphia has been selected as recipient of the Rolf Luft Award 2019.
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Knowledge of a newly discovered genetic disorder, which means that a person cannot produce the protein TXNIP (thioredoxin interacting protein) in their cells, can open for the development of new diabetes drugs. This is shown in a study from Karolinska Institutet published in the journal Diabetes.
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It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study by researchers at Karolinska Institutet and the University of Miami Miller School of Medicine, USA. The findings, published in the scientific journal Cell Metabolism, have important implications for certain diabetes treatments.
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Jorge Ruas, Associate Professor at the Department of Physiology and Pharmacology at Karolinska Institutet, is the recipient of The Leif C. Groop award for outstanding diabetes research for his work on muscle and exercise physiology and critical signalling pathways in skeletal muscle, liver and fat tissue.
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Obesity and reduced insulin sensitivity are common in polycystic ovary syndrome, PCOS. New research based on animal studies, and to be published in the journal PNAS, reveals that the hormone adiponectin can protect against these changes.
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Investigators at Karolinska Institutet have identified a potential therapeutic target for treatment of obesity-associated metabolic diseases such as type 2 diabetes and nonalcoholic hepatic steatosis. The work, performed in collaboration with scientists at the University of California, Berkeley and Danderyd Hospital, is published in Cell Reports.
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09-06-2023