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Researchers at Karolinska Institutet have explored NK cell-based immunotherapy on patients with treatment-resistant leukaemia. The study, which is published in the scientific journal Clinical Cancer Research, shows that the new therapy is effective against several types of leukaemia.

A study published in Science Translational Medicine shows that small molecules that specifically inhibit an important selenium-containing enzyme may be useful in combating cancer. When researchers at Karolinska Institutet treated cancer in mice using these molecules, they observed rapid tumoricidal effects. Researchers now hope that this new principle for cancer treatment will eventually be developed for use in humans.

In a study published in Cell Chemical Biology this week, researchers from MTC (Michael Landreh, David Lane, Sonia Lain, Marcus Ladds et al), KTH, Uppsala University, and the University of Oxford, used a new strategy to find out how anticancer drugs bind to the membrane protein dehydroorotate dehydrogenase (DHODH), a new cancer target.

In a recent publication in Molecular Human Reproduction, researchers at OnkPat could identify the specific proteome profiling of mouse ovarian follicles at three different developmental stages. To do that, the researchers isolated the follicles and cultured them in vitro. This is the first protein mapping of ovarian follicles ever published.

MedTechLabs is now open – the research centre formed by a close collaboration between Karolinska Institutet (KI), the Royal Institute of Technology (KTH) and Stockholm County Council (SLL). The objective of the centre’s first project is to develop technology to improve diagnosis and treatment of patients who have, for example, suffered a stroke.

Researchers at OnkPat together with Italian researchers review recent studies on the acidic tumor environment and how this affects tumor growth and therapeutic efficacy.

When researcher and oncologist Peter Strang writes textbooks, he does so with a certain distance: everything is based on fact. Writing a novel requires a different kind of presence, such as for example trying to imagine what it is like to have been diagnosed with cancer and to be a patient.

The Erling-Persson Family Foundation has awarded a large grant to a KTH project where OnkPat's Rolf Lewensohn and Kristina Viktorsson have key roles.

Among women with high-risk early breast cancer, the use of tailored dose-dense chemotherapy compared with standard adjuvant chemotherapy did not result in a statistically significant improvement in breast cancer recurrence-free survival, and nonhematologic toxic effects were more frequent in the tailored dose-dense group, according to a study appearing in the November 8 issue of JAMA.

Glioblastomas exert an influence on the microglia, immune cells of the brain, which causes them to stimulate cancer growth rather than attacking it. In a study published in the journal Nature Immunology, an international research team led from Karolinska Institutet now explains the molecular mechanisms behind this action.