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Nick Tobin, Arian Lundberg and colleagues have shown the broad clinical utility of the Recurrence Score and PAM50 breast cancer gene signatures in two papers published simultaneously in Clinical Cancer Research.

Researchers at OnkPat have found that breast cancer stem cells are dependent on a certain estrogen receptor to survive. The findings, which are presented in Journal of the National Cancer Institute opens up for new treatment strategies for breast cancer.

Among women with high-risk early breast cancer, the use of tailored dose-dense chemotherapy compared with standard adjuvant chemotherapy did not result in a statistically significant improvement in breast cancer recurrence-free survival, and nonhematologic toxic effects were more frequent in the tailored dose-dense group, according to a study appearing in the November 8 issue of JAMA.

Charlotte Rolny and colleagues at the Department of Oncology-Pathology have discovered a new mechanism that could be the key to a new strategy to restrict breast cancer growth.

Low-educated and immigrant women run a lower risk of breast cancer occurrence than highly educated women and women born in Sweden. However, the risk of dying from breast cancer is higher for those low-educated and immigrant women that do get the diagnose – a development that has occurred in Sweden during the last ten years. This according to a new study from the Karolinska Institutet based on the records of some 5 million women between 1961 and 2007.