Lectures and seminars Workshop in Advanced Quantitative Genetics Using Twin and Family Data
09-06-2022 3:00 pm Add to iCal
Welcome to this workshop in Advanced Quantitative Genetics Using Twin and Family Data! The workshop is arranged within the Doctoral Programme in Epidemiology with support from the Strategic Research Programme in Epidemiology (SFO Epi).
Overview
Quantitative genetic modelling using twin- and/or family data often serves as an important part in investigations of etiology of diseases/traits/phenotypes. However, advanced implementations, such as estimation of genetic correlations, often requires in-depth knowledge of statistical models, as well as understanding of statistical software and programming. The most common statistical framework for twin and family based quantitative genetic modelling are structural equation models (SEMs).
Content
The framework of SEMs will be presented with a focus on how it is used in twin- and family based quantitative genetic modelling. Statistical theory and practical implementations in OpenMx will be covered for topics ranging from ‘simple’ univariate heritability analyses, through bivariate analyses estimating e.g. genetic correlations, to more complex models. Although the emphasis will be on the statistical models, we will discuss assumptions, strengths and weaknesses of using different type of relatives and designs.
Instructors
Ralf Kuja-Halkola, PhD, Ass. Professor, MEB, KI, Mark Taylor, Principal researcher, MEB, Cen Chen, PhD student, MEB.
Target group
Doctoral students, Postdocs, Master students, junior and senior researchers. It is recommended to have basic understanding of genetics, and at least some familiarity of programming in the statistical software R.