Lectures and seminars PML nuclear bodies: biogenesis, biochemical function(s) and physiopathology
Speaker: Hugues de Thé, Hopital St Louis & College de France, Paris
Host: Maria Masucci, CMB
Hugues de Thé M.D. Ph.D. is Professor of molecular oncology at the Collège de France and physician at Hospital St. Louis, Paris. After making significant contributions to Retinoic Acid signaling during his MD/PhD training, he played a key role in the discovery of the PML/RARA oncoprotein, the driver of acute promyelocytic leukemia. Since, he investigated how PML/RARA drives leukemogenesis and the mechanisms underlying the exquisite clinical response to RA and arsenic. This led him to address issues of transcriptional control, cell biology, proteolysis and mouse modeling. In particular, he established the key role of therapy-induced PML/RARA degradation and PML nuclear bodies in APL response, crafting the physio-pathological bases for definitive curative regimens, first established in mice and subsequently in patients.