Lectures and seminars MBB seminar: "Regulation of cell fate decisions in early B cell activation” with Taras Kreslavskiy
Welcome to a lecture on "Regulation of cell fate decisions in early B cell activation" with Taras Kreslavskiy.
Taras Kreslavskiy, Department of Medicine, Solna, Karolinska Institutet
To prepare please read:
- Glaros, V., et al. Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response. Immunity 54, 2005-2023 e2010 (2021).
- Rauschmeier, R., et al. Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis. J Exp Med 219(2022).
- Kreslavsky, T., et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol 18, 442-455 (2017).
- Rauschmeier, R., et al. Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity. EMBO J 38, e101233 (2019).
Taras obtained his PhD from and did a short postdoc in the laboratory of Harald von Boehmer at the Dana-Farber Cancer Research Institute at Harvard University working on alpha-beta versus gamma-delta T cell lineage choice, transcriptional regulation of innate-like T cells and, as a member of the Immunological Genome Project (Immgen) consortium, transcriptional regulation of T cell development. He then undertook a postdoc in the laboratory of Meinrad Busslinger (IMP, Vienna) where he worked on transcriptional regulation of humoral immunity. He joined the Karolinska Institutet as an assistant professor and started his lab at the Department of Medicine, Solna in 2018.