Conferences and symposiums Focus on severe suffering - Refining severe disease models and procedures

24-08-2022 1:00 pm to
25-08-2022 4:15 pm Add to iCal
Campus Solna Eva and Georg Klein lecture hall, Biomedicum, floor 3, Solnavägen 9, Solna

Welcome to an international conference on laboratory animal welfare and refining severe disease models and procedure. The conference is jointly organised by Karolinska Institutet and RSPCA UK. This event is reserved for persons directly involved in the care and use of laboratory animals in research.

Registration - deadline for registration is 5 August 2022

"Refining severe disease models and procedures"

Please register using an email address associated with a designated establishment, Government agency or other relevant professional body up front. Only registrations with a professional e-mail address will be accepted.

Contact

For questions, please send an email to awb@ki.se.

Programme

11:30-13:00
Arrival and Conference Check in

Light lunch is served to registered participants.

13:00-13:05
Welcome
13:05-13:20
Update on the 'Focus on Severe Suffering' initiative

Speaker

Penny Hawkins, RSPCA, UK

13:20-13:30
Use of PREPARE to identify refinements of severe models and procedures

Speaker

Adrian Smith, Norecopa, Norway

13:30-13:45
Avoiding and minimising suffering in animal models and procedures

Speakers

  • Elisabet Andersson, Karolinska Institutet
  • Dagmar Galter, Karolinska Institutet
13:45-14:55
Case studies in basic and applied research
13:45-14:15
Applying the Roadmap in practice – examples from a pharma company

Speaker

Thomas Bertelsen, Novo Nordisk, Denmark

14:15-14:35
Painful conditions in translation – insights from antibody transfer studies

Speaker

Camilla Svensson, Karolinska Institutet

14:35-14:55
Modelling neurodegenerative disorders in mice with minimal loss – our experience with Parkinson's Disease

Speaker

Carina Plewnia, Karolinska Institutet

14:55-15:10
Coffee break
15:10-15:40
Less invasive, the same outcome - approach modifications to investigate cardiovascular disease

Speaker

Hong Jin, Karolinska Institutet

15:40-16:00
Severity assessment and refinement in bile duct ligation models

Speaker

Dietmar Zechner, Universität Rostock, Germany

16:00-16:20
Panel discussion
16:00-16:30
Break
16:30-17:15
Keynote: How does rodent housing affect severity and mortality?

Speaker

Georgia Mason, University of Guelph, Canada

17:15-19:00
Close and networking with drinks

Day One ends at 19:00.

08:30-09:30
Registration and coffee
09:30-09:40
Reflections on Day One and Introduction to Day Two
09:40-11:40
Retrospective assessment / Post-Approval Monitoring
09:40-10:10
Danish 3R-Center and Danish National Committee: Conclusions from taking a closer look at the animals exposed to the highest level of severity in Denmark

Speaker

Jan Lund Ottesen, Danish 3R-Center/Danish National Committee, Denmark

10:10-10:30
Following the development and outcome of projects - how the Animal Welfare Body (AWB) contributes to retrospective assessment

Speaker

Nelleke Verhave, Leiden University, The Netherlands

10:30-10:50
View from the Swedish Central Laboratory Animal Ethics Committee (CDFN)

Speaker

Ann-Christine Eklöf, CDFN

10:50-11:25
Breakout discussion (including coffee)

Following the development and outcome of projects, including how bodies such as the AWB, AEC and IACUC address the task, how National Committees can contribute, and how this can help to avoid severe suffering in future projects

11:25-11:40
Feedback and discussion
11:40-12:40
Case studies in regulatory testing
11:40-12:00
Review of animal testing requirements in WHO Guidelines for vaccines and biological therapeutics: a proposal to implement 3Rs principles

Speaker

Elliot Lilley, NC3Rs, United Kingdom

12:00-12:40
Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

Speaker

Ioanna Katsiadaki, CEFAS

12:20-12:40
DTaP vaccines: an overview of initiatives to reduce animal suffering in human vaccine batch release

Speaker

Morgane Florens, Sciensano, Belgium

12:40-13:00
A new group housing approach for non-human primates in metabolism studies

Speaker

John Kendrick, Labcorp, USA

13:00-14:15
Lunch (preregistered participants only)
14:15-16:15
Looking to the future
14:15-14:25
Introduction

Speaker

Penny Hawkins, RSPCA, Storbritannien

14:25-14:40
How an industry body like AFPIA can help members to reduce 'severe' suffering

Speaker

Jan Lund Ottesen, EFPIA, Denmark

14:40-14:55
The International Culture of Care Network

Speaker

Thomas Bertelsen, Novo Nordisk, Danmark

14:55-15:10
Vets, severity and welfare: the Good, the Bad and the Ugly

Speaker

Rafael Frias, European Society for Laboratory Animal Veterinarians (ESLAV), France

15:10-15:20
AAALAC perspectives for harmonization

Speaker

Javier Guillen, AAALAC, Spain

15:20-16:00
Panel discussion
16:00-16:15
Closing comments and take-home messages

Day Two ends at 16:15.