Half-time seminars Half-time control Hemantha Mallapura
Title: Automated microfluidic-based production of PET radioligands for clinical and preclinical use
Principal Supervisor
Research Specialist Sangram Nag, Department of Clinical Neuroscience, Karolinska Institutet
Co-supervisors
Professor Christer Halldin, Department of Clinical Neuroscience, Karolinska Institutet
Professor Bengt Långström, Department of Chemistry, Uppsala University
Vice VD Ludovic Le Meunier, PMB-Alcen, Frankrike
Half-time reveiw board
Professor Nicole Pamme, Department of Materials and Environmental Chemistry, Stockholm University
Dr. Johnny Vercouillie, School of Pharmacie, University of Tours
Dr. Philip Miller, Department of Chemistry, Imperial College London
Brief description
This project aims to produce clinically applicable Positron Emission Tomography (PET) radioligands with carbon-11 (11C), fluorine-18 (18F) and gallium-68 (68Ga) isotopes using a microfluidic cassette-based iMiDEV™ automated radiosynthesizer for clinical and preclinical applications. In addition, developing and optimizing experimental conditions for [11C]methyl iodide synthesis ([11C]CH3I) using a non-thermal plasma method and [11C]CH3I is one of the most used methylating agents in 11C radiochemistry.