Lectures and seminars Guest seminar - Dr. Eugene Kim, Max Planck Institute of Biophysics

12-09-2022 1:00 pm - 2:00 pm Add to iCal
Campus Solna Peter Reichard in Biomedicum

Title: DNA loop extrusion by Smc5/6 complexes.

Time and location: Peter Reichard lecture hall, Biomedicum floor 3, September 12, 13.00
Host: Camilla Björkegren

Dr. Kim’s research interest:

“Our group aims to unravel the molecular mechanisms governing 3D genome organization: how chromatins are folded and twisted, and how these topologies affect genome functions. To this end, we will employ single-molecule fluorescence imaging, single-molecule force spectroscopy, and correlative light and electron microscopy techniques to probe and interrogate individual molecules in vitro. By studying individual biochemical processes that constitute genome packaging at high spatiotemporal resolution, we hope to extract the universal principles that underlie chromosome organization across all forms of life.”

Selected publications/preprint

The Smc5/6 complex is a DNA loop extruding motor
Pradhan B, Kanno T, Igarashi M.U,  Baaske M.D, Wong J. S. K,  Jeppsson K,  Björkegren K, Kim E.
BioRxiv, May 2022

Condensin-driven loop extrusion on supercoiled DNA.
Kim E, Gonzalez AM, Pradhan B, van der Torre J, Dekker C
Nat Struct Mol Biol 2022 Jul;29(7):719-727

DNA-loop extruding condensin complexes can traverse one another.
Kim E, Kerssemakers J, Shaltiel IA, Haering CH, Dekker C
Nature 2020 03;579(7799):438-442

Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.
Elbatsh AMO, Kim E, Eeftens JM, Raaijmakers JA, van der Weide RH, García-Nieto A, Bravo S, Ganji M, Uit de Bos J, Teunissen H, Medema RH, de Wit E, Haering CH, Dekker C, Rowland BD
Mol Cell 2019 12;76(5):724-737.e5

Real-time imaging of DNA loop extrusion by condensin.
Ganji M, Shaltiel IA, Bisht S, Kim E, Kalichava A, Haering CH, Dekker C
Science 2018 04;360(6384):102-105