Dissertations Dissertation: Shailesh Kumar Samal

02-06-2022 1:00 pm Add to iCal
Campus Solna Atrium, Nobels väg 12b and on Zoom

Title: Immune Mechanisms and Potential Immunological Treatment in Atherosclerosis

Our immune system is an important and central part of the defence mechanisms of our body. It carries out various important functions such as protecting us from invading microorganisms, removing dead cells, and producing antibodies for future defence. For this, proper synchronization between the innate and adaptive immunity is required. Our innate immune system acts as the first line of defence by eliminating non-specifically various pathogens and by activating antigen-presenting cells (APCs) that inform B-cells and T-cells of the adaptive immune system. B-cells can exhibit more specific actions against pathogens by an intricately regulated production of antibodies directed against antigens expressed by the pathogens. T-cells can produce cytokines and chemokines to alarm the complete immune system recruiting immune cells such as natural killer cells, mast cells and neutrophils. The immune system can also produce antibodies against self-antigens (autoantibodies). Autoantibodies can have pathogenic effects that cause autoimmune diseases such as Systemic Lupus Erythematosis. Interestingly, it has been shown recently that autoantibodies can also have protective effects alleviating diseases such as lupus nephritis and atherosclerosis. This thesis focuses specifically on homeostatic functions of the human autoantibodies anti-phoshorylcholine (anti-PC) and anti-malondialdehyde (anti-MDA) and their prevalence in cardiovascular disease (CVD) and chronic kidney disease (CKD).

Principal supervisor:

Johan Frostegård, Professor, Institute of Environmental Medicine, Karolinska Institutet

Co-supervisors:

Prof. Leon Schurgers and Prof. Chris Reutelingsperger, Maastricht University,

Department of Biochemistry, Cardiovascular Research Institute Maastricht.

Opponent:

Prof. Nobuyo Maeda, Department of Medicine, University of North Carolina, USA

Examination board: 

Prof Allan Sirsjö, Department of Medical Sciences, Örebro University

Dr. Karolina Kublickiene, Department of Clinical Science Intervention and Technology, Karolinska Institutet

Dr. Per T Larsson, Karolinska University Hospital, Karolinska Institutet

 

Participation through Zoom:

https://ki-se.zoom.us/j/69552824723

Meeting ID: 695 5282 4723

 

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Shailesh Samal Research assistant