Lectures and seminars Crossing Borders webinar – “Extra-adrenal glucocorticoid synthesis in the intestinal mucosa: implications for local immune homeostasis and cancer development”
Warm welcome to the next Crossing Borders webinar! Thomas Brunner, University of Konstanz, Germany, will talk about “Extra-adrenal glucocorticoid synthesis in the intestinal mucosa: implications for local immune homeostasis and cancer development”.
We are happy to welcome Thomas Brunner to give a talk with the following abstract:
Glucocorticoids as medical drugs have an important application in the treatment of inflammatory diseases and cancer. Seventy years ago, glucocorticoids were, however, first discovered as endogenous stress hormones, primarily produced by the adrenal glands in response to emotional, physical and immunological stress. Recent years have led to the discovery and characterization of alternative sources of these immunoregulatory steroid hormones. Our group discovered for the first-time glucocorticoid synthesis in the intestinal mucosa in response to immunological stress. In this presentation I will discuss the transcriptional regulation of intestinal steroidogenesis, its implication in the regulation of inflammatory processes of the intestine, and how colorectal tumors have high-jacked glucocorticoid synthesis to evade destruction by the immune system.
The webinar will be held online via Zoom.
Register to the webinar here.
We will send you the information for Zoom via mail.