Lectures and seminars CBB bioinformatics seminar with Nick Tobin: "Genomic Oncology: Reclassifying tumour cell cycle activity in terms of it’s tissue of origin"

Genomic alterations resulting in loss of control over the cell cycle is a fundamental hallmark of human malignancies. Whilst pan-cancer studies have broadly assessed tumour genomics and their impact on oncogenic pathways, analyses taking the baseline signalling levels in normal tissue into account are lacking. To this end, we aimed to reclassify the cell cycle activity of tumours in terms of their tissue of origin and determine the DNA mutations, chromosome arm-level changes and signalling pathways driving cell cycle activity. Combining normal tissue and pan-cancer data from over 13,000 samples we demonstrate that tumours of gynaecological origin show the highest levels of baseline corrected cell cycle activity, partially owing to hormonal signalling and gene expression changes. We also show that normal and tumour tissues can be separated into groups (quadrants) of low/high cell cycle activity potentially indicating an upper limit on these activity levels in tumours.

Before the seminar, a limited number of sandwiches and drinks will be served on a “First come – first served” basis starting 12:00. Show up early and network!

The seminar is held in English.