Lectures and seminars Back-to-back seminars: ”Circulating tumour DNA to monitor the complexity of cancer” and "Chromatin regulators in cancer"
Welcome to back-to-back research seminars with Professors Sarah-Jane Dawson and Mark Dawson , University of Melbourne, Australia.
”Circulating tumour DNA to monitor the complexity of cancer”
Professor Sarah-Jane Dawson, Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne.
Professor Sarah-Jane Dawson
Professor Sarah-Jane Dawson is a clinician-scientist. She obtained her medical degree from the University of Melbourne in 1998, and trained as a medical oncologist in Melbourne, Australia. She completed her PhD at the University of Cambridge, UK. Following postdoctoral studies at the Cancer Research UK Cambridge Institute, she returned to Melbourne in 2014 to head the Molecular Biomarkers and Translational Genomics Laboratory at the Peter MacCallum Cancer Centre. She also holds a joint appointment with the Centre of Cancer Research at The University of Melbourne (since 2016). Her current research interests are focused on the development of noninvasive blood-based biomarkers ('liquid biopsies') for clinical application, including early detection, risk stratification and disease monitoring in cancer management. The Dawson Lab
Recent selected publications
E. Zozaya-Valdes, S.Q. Wong, J. Raleigh, A. Hatzimihalis, S. Ftouni, A.T. Papenfuss, S. Sandhu, M.A. Dawson, S.J. Dawson*
Detection of cell-free microbial DNA using a contaminant-controlled analysis framework Genome Biology 2021, Jun 23;22(1):187
Zivanovic Bujak, C-F. Weng, M.J. Silva, M. Yeung, L. Lo, S. Ftouni, C. Litchfield, Y-A. Ko, K. Kuykhoven, C. Van Geelen, S. Chandrashekar, M.A. Dawson, S. Loi, S.Q. Wong and SJ. Dawson* - “Circulating tumor DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: a cohort study”. PLOS Medicine, 2020, Oct 1; 17(10);e1003363.
R. Agarwal, Y-C. Chan, C.S. Tam, T. Hunter, D. Vassiliadis, C. Teh, R. Thijssen, P. Yeh, S.Q. Wong, S. Ftouni, E.Y.N. Lam, M.A. Anderson, C. Pott, O. Gilan, C.C. Bell, K. Knezevic, P. Blombery, K. Rayeroux, A. Zordan, J. Li, D.C. S. Huang, M. Wall, J.F. Seymour, D. Gray, A.W. Roberts, M.A. Dawson* and SJ. Dawson* - "Dynamic molecular monitoring reveals that SWI/SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma". Nature Medicine. 2019 Jan; 25(1):119-129.
”Chromatin regulators in cancer: Molecular mechanisms and therapeutic opportunities”
Professor Mark Dawson, Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne.
Professor Mark Dawson
Professor Mark Dawson is a clinician-scientist and the Associate Director of Research Translation at the Peter MacCallum Cancer Centre. He graduated with a medical degree from the University of Melbourne in 1999, and subsequently trained as a haematologist in Melbourne, Australia. He was awarded a General Sir John Monash Fellowship and Cambridge Commonwealth Trust Fellowship, which he used to complete his PhD at the University of Cambridge in 2010. Following his PhD, he was awarded the inaugural Wellcome Trust Beit Prize Fellowship to pursue his research into epigenetic regulation of leukaemia stem cells. He returned to Melbourne in 2014 where his current research interest is studying chromatin regulation in normal development and cancer. Peter MacCallum Cancer Centre
Recent selected publications
N.J. Dharan, P. Yeh, M. Bloch, M. Yeung, D. Baker, J. Guinto, N. Roth, S. Ftouni, K. Ognenovska, D. Smith, J.F. Hoy, I. Woolley, C. Pell, D.J. Templeton, N. Fraser, N. Rose, J. Hutchinson, K. Petoumenos*, S.J. Dawson*, M.N. Polizzotto* & M.A. Dawson* - HIV is associated with an increased risk of age-related clonal haematopoiesis among older adults – Nature Medicine, 2021 Jun;27(6):1006-1011
O. Gilan, I. Rioja, K. Knezevic, M.J. Bell, M.M. Yeung, N.R. Harker, E.Y.N. Lam, C.W. Chung, P. Bamborough, M. Petretich, M. Urh, S.J. Atkinson, A.K. Bassil, E.J. Roberts, D. Vassiliadis, M.L. Burr, A.G.S. Preston, C. Wellaway, T. Werner, J.R. Gray, A.M. Michon, T. Gobbetti, V. Kumar, P.E Soden, A. Haynes, J. Vappiani, D.F. Tough, S. Taylor, S.J. Dawson, M. Bantscheff, M. Lindon, G. Drewes, E.H. Demont, D.L. Daniels, P. Grandi, R.K. Prinjha & M.A. Dawson – “Selective targeting of BD1 and BD2 of the BET proteins in cancer and immune-inflammation”. Science; 2020 Apr 24; 368(6489):387-394.
L. MacPherson, J. Anokye, M.M. Yeung, E.Y.N. Lam, Y-C. Chan, C-F. Weng, P. Yeh, K. Knezevic, M.S. Butler, A. Hoegl, K-L. Chan, M.L. Burr, L.J. Gearing, T. Willson, J. Liu, J. Choi, Y. Yang, R.A. Bilardi, H. Falk, N. Nguyen, P. Stupple, T.S. Peat, M. Zhang, M. de Silva, C. Carrasco-Pozo, V.M. Avery, P.S. Khoo, O. Dolezal, M.L. Dennis, S. Nuttall, R. Surjadi, J. Newman, B. Ren, D.J. Leaver, Y. Sun, J.B. Baell, O. Dovey, G.S. Vassiliou, F. Grebien, S.J. Dawson, I.P. Street, B.J. Monahan, C.J. Burns, C. Choudhary, M.E. Blewitt, A.K. Voss, T.Thomas & M.A. Dawson – “HBO1 is required for the maintenance of leukaemia stem cells”. Nature; 2020 Jan; 577(7789):266-270.